Fig. 4. Cyp11a1L/L Mice Had Attenuated Circadian Corticosterone Rhythm and Stress Response
A, Plasma corticosterone concentrations from 8-wk-old +/+ (n = 4 or 5) and L/L (n = 6 or 7) male mice at different times of the day; B and C, plasma corticosterone concentration (B) and plasma ACTH concentration (C) in 8- to 12-wk-old +/+ (n = 8), +/L (n = 8 or 10), and L/L (n = 8) male mice at basal conditions or restrained in 50-ml conical tubes for 10 min are shown as mean ± SEM. *, P < 0.05; **, P < 0.01 compared with the wild-type mice.