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Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University Evanston, Illinois 60201
Department of Biology, Thimann Laboratories, University of California Santa Cruz, California 95064
Address requests for reprints to: Daniel I. H. Linzer, Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2153 Sheridan Road, Evanston, Illinois 60201.
Abstract
The mouse midpregnancy lactogen or placental lactogen I (mPL-I) is encoded by a 1.0-kilobase mRNA that appears transiently during gestation, with maximal amounts accumulating in the placenta at day 10 of pregnancy. Several cDNA clones for mPL-I have been isolated from a 
gt11 expression library constructed from day 10-placental RNA. The cDNA sequence indicates that mPL-I is synthesized as a 224 amino acid precursor, and is secreted as a 194 amino acid glycosylated hormone. The deduced amino acid sequence of mPL-I is highly homologous to the known members of the PRL family in the mouse, and hybridization analysis indicates that the mouse genome contains several mPL-I genes. Introduction of the mPL-I cDNA in an expression vector into cultured mouse cells results in the synthesis and secretion of glycosylated mPL-I protein that is recognized by anti-mPL-I antiserum and is biologically active.
FOOTNOTES
This research was supported by NIH Grants HD-14966 and RR-08132 and the National Science Foundation Grant PMC-821782 (to F.T.), and by NIH Grant GM-34238, a Basil O'Conner Award from the March of Dimes, and an award from the Searle Scholars Program (to D.L.).
Received for publication August 3, 1987. Accepted for publication September 8, 1987.
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