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Molecular Endocrinology Vol. 1, No. 6 435-440
doi:10.1210/mend-1-6-435
Copyright © 1987 by the Endocrine Society.
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Estrogen-Induced Decrease of Glucocorticoid Receptor Messenger Ribonucleic Acid Concentration in Rat Anterior Pituitary Gland

A. Peiffer and N. Barden

Ontogénèse et Génètique Moléculaire, Laval University Hospital Center Ste-Foy, Québec G1V 4G2, Canada

Address correspondence and requests for reprints to: Dr. N. Barden, Unité d'Ontogénèse et Génétique Moléculaire, CHUL, 2705 Boulevard Laurier, Ste-Foy, Québec G1V 4G2, Canada.

Abstract

Using Northern blots and hybridization techniques, we have identified an approximately 6.5 kilobase glucocorticoid receptor mRNA species in rat anterior pituitary gland. Ovariectomy resulted in an approximately 2-fold increase in glucocorticoid receptor mRNA concentrations. This effect was maximal 8 days after surgery and glucocorticoid receptor mRNA levels remained elevated for at least up to 4 weeks. Administration of 17-β-estradiol completely reversed the ovariectomy-induced increase in glucocorticoid receptor mRNA content of pituitary gland. Treatment of rats with corticosterone did not influence the ovariectomy-induced increase in glucocorticoid receptor mRNA content, indicating that this increase is not mediated via effects on circulating glucocorticoid levels or availability. In situ hybridization experiments confirmed the ovariectomyinduced increase in glucocorticoid receptor mRNA content and indicated that this action is widely distributed throughout the anterior pituitary gland.

FOOTNOTES

This work was supported by the Medical Research Council of Canada by a grant (to N.B.).

Received for publication February 24, 1987. Accepted for publication March 31, 1987.




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