help button home button Endocrine Society Molecular Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ikeda, Y.
Right arrow Articles by Parker, K. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ikeda, Y.
Right arrow Articles by Parker, K. L.

Molecular Endocrinology, Vol 10, 1261-1272, Copyright © 1996 by Endocrine Society

ARTICLES

Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development

Y Ikeda, A Swain, TJ Weber, KE Hentges, E Zanaria, E Lalli, KT Tamai, P Sassone- Corsi, R Lovell-Badge, G Camerino and KL Parker
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Mutations of the orphan nuclear receptors, steroidogenic factor 1 (SF- 1) and DAX-1, cause complex endocrine phenotypes that include impaired adrenal development and hypogonadotrophic hypogonadism. These similar phenotypes suggest that SF-1 and DAX-1 act in the same pathway(s) of endocrine development. To explore this model, we now compare directly their sites of expression. In mouse embryos, SF-1 expression in the urogenital ridge and brain either preceded or coincided with Dax-1 expression, with coordinate expression thereafter in the adrenal cortex, testis, ovary, hypothalamus, and anterior pituitary. The striking colocalization of SF-1 and Dax-1 supports the model that they are intimately linked in a common pathway of endocrine development. The slightly earlier onset of SF-1 expression and its ability to bind specifically to a conserved sequence in the Dax-1 5'-flanking region suggested that SF-1 may activate Dax-1 expression. However, promoter activity of Dax-1 5'-flanking sequences did not require this potential SF-1-responsive element, and Dax-1 expression was unimpaired in knockout mice lacking SF-1, establishing that SF-1 is not required for Dax-1 gene expression in these settings. Although the precise mechanisms remain to be established and may be multifactorial, our results strongly suggest that these two orphan nuclear receptors interact in a common pathway of endocrine development.


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
G.-C. Wu, S. Tomy, and C.-F. Chang
The Expression of nr0b1 and nr5a4 During Gonad Development and Sex Change in Protandrous Black Porgy Fish, Acanthopagrus schlegeli
Biol Reprod, February 1, 2008; 78(2): 200 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. M. Shoemaker, J. Queen, and D. Crews
Response of Candidate Sex-Determining Genes to Changes in Temperature Reveals Their Involvement in the Molecular Network Underlying Temperature-Dependent Sex Determination
Mol. Endocrinol., November 1, 2007; 21(11): 2750 - 2763.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Y. Park, M. Tong, and J. L. Jameson
Distinct Roles for Steroidogenic factor 1 and Desert hedgehog Pathways in Fetal and Adult Leydig Cell Development
Endocrinology, August 1, 2007; 148(8): 3704 - 3710.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
P. Val, J.-P. Martinez-Barbera, and A. Swain
Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage
Development, June 15, 2007; 134(12): 2349 - 2358.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D.-S. Wang, T. Kobayashi, L.-Y. Zhou, B. Paul-Prasanth, S. Ijiri, F. Sakai, K. Okubo, K.-i. Morohashi, and Y. Nagahama
Foxl2 Up-Regulates Aromatase Gene Transcription in a Female-Specific Manner by Binding to the Promoter as Well as Interacting with Ad4 Binding Protein/Steroidogenic Factor 1
Mol. Endocrinol., March 1, 2007; 21(3): 712 - 725.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Mueller, A. Atanasov, I. Cima, N. Corazza, K. Schoonjans, and T. Brunner
Differential Regulation of Glucocorticoid Synthesis in Murine Intestinal Epithelial Versus Adrenocortical Cell Lines
Endocrinology, March 1, 2007; 148(3): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
W. Zheng, J. Yang, Q. Jiang, Z. He, and L. M Halvorson
Liver receptor homologue-1 regulates gonadotrope function
J. Mol. Endocrinol., February 1, 2007; 38(2): 207 - 219.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
C A Wilson and D C Davies
The control of sexual differentiation of the reproductive system and brain
Reproduction, February 1, 2007; 133(2): 331 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. Wilhelm, S. Palmer, and P. Koopman
Sex Determination and Gonadal Development in Mammals
Physiol Rev, January 1, 2007; 87(1): 1 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
G. Benoit, A. Cooney, V. Giguere, H. Ingraham, M. Lazar, G. Muscat, T. Perlmann, J.-P. Renaud, J. Schwabe, F. Sladek, et al.
International Union of Pharmacology. LXVI. Orphan Nuclear Receptors
Pharmacol. Rev., December 1, 2006; 58(4): 798 - 836.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Zhao, Z. Yang, J. K. Phelan, D. A. Wheeler, S. Lin, and E. R. B. McCabe
Zebrafish dax1 Is Required for Development of the Interrenal Organ, the Adrenal Cortex Equivalent
Mol. Endocrinol., November 1, 2006; 20(11): 2630 - 2640.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. K. Iyer, Y.-H. Zhang, and E. R. B. McCabe
Dosage-Sensitive Sex Reversal Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1 (DAX1) (NR0B1) and Small Heterodimer Partner (SHP) (NR0B2) Form Homodimers Individually, as Well as DAX1-SHP Heterodimers
Mol. Endocrinol., October 1, 2006; 20(10): 2326 - 2342.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-H. Song, Y.-Y. Park, H. J. Kee, C. Y. Hong, Y.-S. Lee, S.-W. Ahn, H.-J. Kim, K. Lee, H. Kook, I.-K. Lee, et al.
Orphan Nuclear Receptor Nur77 Induces Zinc Finger Protein GIOT-1 Gene Expression, and GIOT-1 Acts as a Novel Corepressor of Orphan Nuclear Receptor SF-1 via Recruitment of HDAC2
J. Biol. Chem., June 9, 2006; 281(23): 15605 - 15614.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Ragazzon, A.-M. Lefrancois-Martinez, P. Val, I. Sahut-Barnola, C. Tournaire, C. Chambon, J.-L. Gachancard-Bouya, R.-J. Begue, G. Veyssiere, and A. Martinez
Adrenocorticotropin-Dependent Changes in SF-1/DAX-1 Ratio Influence Steroidogenic Genes Expression in a Novel Model of Glucocorticoid-Producing Adrenocortical Cell Lines Derived from Targeted Tumorigenesis
Endocrinology, April 1, 2006; 147(4): 1805 - 1818.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Shima, M. Zubair, S. Ishihara, Y. Shinohara, S. Oka, S. Kimura, S. Okamoto, Y. Minokoshi, S. Suita, and K.-i. Morohashi
Ventromedial Hypothalamic Nucleus-Specific Enhancer of Ad4BP/SF-1 Gene
Mol. Endocrinol., November 1, 2005; 19(11): 2812 - 2823.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
E. De Menis, F. Roncaroli, V. Calvari, V. Chiarini, P. Pauletto, G. Camerino, and N. Cremonini
Corticotroph adenoma of the pituitary in a patient with X-linked adrenal hypoplasia congenita due to a novel mutation of the DAX-1 gene
Eur. J. Endocrinol., August 1, 2005; 153(2): 211 - 215.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
F.-Q. Yu, C.-S. Han, W. Yang, X. Jin, Z.-Y. Hu, and Y.-X. Liu
Activation of the p38 MAPK pathway by follicle-stimulating hormone regulates steroidogenesis in granulosa cells differentially
J. Endocrinol., July 1, 2005; 186(1): 85 - 96.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. J. Bouma, K. H. Albrecht, L. L. Washburn, A. K. Recknagel, G. A. Churchill, and E. M. Eicher
Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells
Development, July 1, 2005; 132(13): 3045 - 3054.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Y. Park, J. J. Meeks, G. Raverot, L. E. Pfaff, J. Weiss, G. D. Hammer, and J. L. Jameson
Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development
Development, May 15, 2005; 132(10): 2415 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. W. Kim, J. C. Havelock, B. R. Carr, and G. R. Attia
The Orphan Nuclear Receptor, Liver Receptor Homolog-1, Regulates Cholesterol Side-Chain Cleavage Cytochrome P450 Enzyme in Human Granulosa Cells
J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1678 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Y. Park and J. L. Jameson
Minireview: Transcriptional Regulation of Gonadal Development and Differentiation
Endocrinology, March 1, 2005; 146(3): 1035 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. D. Hammer, K. L. Parker, and B. P. Schimmer
Minireview: Transcriptional Regulation of Adrenocortical Development
Endocrinology, March 1, 2005; 146(3): 1018 - 1024.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Jo and D. M. Stocco
Regulation of Steroidogenesis and Steroidogenic Acute Regulatory Protein in R2C Cells by DAX-1 (Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X Chromosome, Gene-1)
Endocrinology, December 1, 2004; 145(12): 5629 - 5637.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Qin, D.-m. Gao, Q.-F. Jiang, Q. Zhou, Y.-Y. Kong, Y. Wang, and Y.-H. Xie
Prospero-Related Homeobox (Prox1) Is a Corepressor of Human Liver Receptor Homolog-1 and Suppresses the Transcription of the Cholesterol 7-{alpha}-Hydroxylase Gene
Mol. Endocrinol., October 1, 2004; 18(10): 2424 - 2439.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. L. Britt, P. G. Stanton, M. Misso, E. R. Simpson, and J. K. Findlay
The Effects of Estrogen on the Expression of Genes Underlying the Differentiation of Somatic Cells in the Murine Gonad
Endocrinology, August 1, 2004; 145(8): 3950 - 3960.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. J. Hirvonen-Santti, V. Sriraman, M. Anttonen, S. Savolainen, J. J. Palvimo, M. Heikinheimo, J. S. Richards, and O. A. Janne
Small Nuclear RING Finger Protein Expression during Gonad Development: Regulation by Gonadotropins and Estrogen in the Postnatal Ovary
Endocrinology, May 1, 2004; 145(5): 2433 - 2444.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Kajitani, T. Mizutani, K. Yamada, T. Yazawa, T. Sekiguchi, M. Yoshino, H. Kawata, and K. Miyamoto
Cloning and Characterization of Granulosa Cell High-Mobility Group (HMG)-Box Protein-1, a Novel HMG-Box Transcriptional Regulator Strongly Expressed in Rat Ovarian Granulosa Cells
Endocrinology, May 1, 2004; 145(5): 2307 - 2318.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. L. Bland, R. C. Fowkes, and H. A. Ingraham
Differential Requirement for Steroidogenic Factor-1 Gene Dosage in Adrenal Development Versus Endocrine Function
Mol. Endocrinol., April 1, 2004; 18(4): 941 - 952.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
W. Fan, T. Yanase, Y. Wu, H. Kawate, M. Saitoh, K. Oba, M. Nomura, T. Okabe, K. Goto, J. Yanagisawa, et al.
Protein Kinase A Potentiates Adrenal 4 Binding Protein/Steroidogenic Factor 1 Transactivation by Reintegrating the Subcellular Dynamic Interactions of the Nuclear Receptor with Its Cofactors, General Control Nonderepressed-5/Transformation/ Transcription Domain-Associated Protein, and Suppressor, Dosage-Sensitive Sex Reversal-1: a Laser Confocal Imaging Study in Living KGN Cells
Mol. Endocrinol., January 1, 2004; 18(1): 127 - 141.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Peng, J. W. Kim, W. E. Rainey, B. R. Carr, and G. R. Attia
The Role of the Orphan Nuclear Receptor, Liver Receptor Homologue-1, in the Regulation of Human Corpus Luteum 3{beta}-Hydroxysteroid Dehydrogenase Type II
J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 6020 - 6028.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y.-W. Liu, W. Gao, H.-L. Teh, J.-H. Tan, and W.-K. Chan
Prox1 Is a Novel Coregulator of Ff1b and Is Involved in the Embryonic Development of the Zebra Fish Interrenal Primordium
Mol. Cell. Biol., October 15, 2003; 23(20): 7243 - 7255.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Lalli and P. Sassone-Corsi
DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual Differentiation
Mol. Endocrinol., August 1, 2003; 17(8): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Kawajiri, T. Ikuta, T. Suzuki, M. Kusaka, M. Muramatsu, K. Fujieda, M. Tachibana, and K.-i. Morohashi
Role of the LXXLL-Motif and Activation Function 2 Domain in Subcellular Localization of Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1)
Mol. Endocrinol., June 1, 2003; 17(6): 994 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
M. L. BLAND, M. DESCLOZEAUX, and H. A. INGRAHAM
Tissue Growth and Remodeling of the Embryonic and Adult Adrenal Gland
Ann. N.Y. Acad. Sci., May 1, 2003; 995(1): 59 - 72.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. G. Lehmann, J.-M. Wurtz, J.-P. Renaud, P. Sassone-Corsi, and E. Lalli
Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients
Hum. Mol. Genet., May 1, 2003; 12(9): 1063 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Tajima, A. Dantes, Z. Yao, K. Sorokina, F. Kotsuji, R. Seger, and A. Amsterdam
Down-Regulation of Steroidogenic Response to Gonadotropins in Human and Rat Preovulatory Granulosa Cells Involves Mitogen-Activated Protein Kinase Activation and Modulation of DAX-1 and Steroidogenic Factor-1
J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 2288 - 2299.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Yazawa, T. Mizutani, K. Yamada, H. Kawata, T. Sekiguchi, M. Yoshino, T. Kajitani, Z. Shou, and K. Miyamoto
Involvement of Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein, Steroidogenic Factor 1, and Dax-1 in the Regulation of Gonadotropin-Inducible Ovarian Transcription Factor 1 Gene Expression by Follicle-Stimulating Hormone in Ovarian Granulosa Cells
Endocrinology, May 1, 2003; 144(5): 1920 - 1930.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Mizusaki, K. Kawabe, T. Mukai, E. Ariyoshi, M. Kasahara, H. Yoshioka, A. Swain, and K.-i. Morohashi
Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1) Gene Transcription Is Regulated by Wnt4 in the Female Developing Gonad
Mol. Endocrinol., April 1, 2003; 17(4): 507 - 519.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
N. Y. Gevry, E. Lalli, P. Sassone-Corsi, and B. D. Murphy
Regulation of Niemann-Pick C1 Gene Expression by the 3'5'-Cyclic Adenosine Monophosphate Pathway in Steroidogenic Cells
Mol. Endocrinol., April 1, 2003; 17(4): 704 - 715.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Anttonen, I. Ketola, H. Parviainen, A.-K. Pusa, and M. Heikinheimo
FOG-2 and GATA-4 Are Coexpressed in the Mouse Ovary and Can Modulate Mullerian-Inhibiting Substance Expression
Biol Reprod, April 1, 2003; 68(4): 1333 - 1340.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A.-M. Pulichino, S. Vallette-Kasic, C. Couture, Y. Gauthier, T. Brue, M. David, G. Malpuech, C. Deal, G. Van Vliet, M. De Vroede, et al.
Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency
Genes & Dev., March 15, 2003; 17(6): 711 - 716.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Brown, G. A. Scobie, J. Townsend, R. A. L. Bayne, J. R. Seckl, P. T. K. Saunders, and R. A. Anderson
Identification of a Novel Missense Mutation That Is as Damaging to DAX-1 Repressor Function as a Nonsense Mutation
J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1341 - 1349.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. J. Meeks, S. E. Crawford, T. A. Russell, K.-i. Morohashi, J. Weiss, and J. L. Jameson
Dax1 regulates testis cord organization during gonadal differentiation
Development, March 1, 2003; 130(5): 1029 - 1036.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Suzuki, M. Kasahara, H. Yoshioka, K.-i. Morohashi, and K. Umesono
LXXLL-Related Motifs in Dax-1 Have Target Specificity for the Orphan Nuclear Receptors Ad4BP/SF-1 and LRH-1
Mol. Cell. Biol., January 1, 2003; 23(1): 238 - 249.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
X. Wei, M. Sasaki, H. Huang, V. L. Dawson, and T. M. Dawson
The Orphan Nuclear Receptor, Steroidogenic Factor 1, Regulates Neuronal Nitric Oxide Synthase Gene Expression in Pituitary Gonadotropes
Mol. Endocrinol., December 1, 2002; 16(12): 2828 - 2839.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. Gurates, S. Sebastian, S. Yang, J. Zhou, M. Tamura, Z. Fang, T. Suzuki, H. Sasano, and S. E. Bulun
WT1 and DAX-1 Inhibit Aromatase P450 Expression in Human Endometrial and Endometriotic Stromal Cells
J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4369 - 4377.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. G. Lehmann, E. Lalli, and P. Sassone-Corsi
From the Cover: X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein
PNAS, June 11, 2002; 99(12): 8225 - 8230.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. B. Seminara and W. F. Crowley Jr.
Genetic Approaches to Unraveling Reproductive Disorders: Examples of Bedside to Bench Research in the Genomic Era
Endocr. Rev., June 1, 2002; 23(3): 382 - 392.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Hoyle, V. Narvaez, G. Alldus, R. Lovell-Badge, and A. Swain
Dax1 Expression Is Dependent on Steroidogenic Factor 1 in the Developing Gonad
Mol. Endocrinol., April 1, 2002; 16(4): 747 - 756.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Holter, N. Kotaja, S. Makela, L. Strauss, S. Kietz, O. A. Janne, J.-A. Gustafsson, J. J. Palvimo, and E. Treuter
Inhibition of Androgen Receptor (AR) Function by the Reproductive Orphan Nuclear Receptor DAX-1
Mol. Endocrinol., March 1, 2002; 16(3): 515 - 528.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Koskimies, J. Levallet, P. Sipila, I. Huhtaniemi, and M. Poutanen
Murine Relaxin-Like Factor Promoter: Functional Characterization and Regulation by Transcription Factors Steroidogenic Factor 1 and DAX-1
Endocrinology, March 1, 2002; 143(3): 909 - 919.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. S. Babu, D. L. Bavers, F. Beuschlein, S. Shah, B. Jeffs, J. L. Jameson, and G. D. Hammer
Interaction Between Dax-1 and Steroidogenic Factor-1 in Vivo: Increased Adrenal Responsiveness to ACTH in the Absence of Dax-1
Endocrinology, February 1, 2002; 143(2): 665 - 673.
[Abstract] [Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
C. Tilmann and B. Capel
Cellular and Molecular Pathways Regulating Mammalian Sex Determination
Recent Prog. Horm. Res., January 1, 2002; 57(1): 1 - 18.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Lopez, W. Shea-Eaton, M. D. Sanchez, and M. P. McLean
DAX-1 Represses the High-Density Lipoprotein Receptor Through Interaction with Positive Regulators Sterol Regulatory Element-Binding Protein-1a and Steroidogenic Factor-1
Endocrinology, December 1, 2001; 142(12): 5097 - 5106.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Mizutani, K. Yamada, T. Yazawa, T. Okada, T. Minegishi, and K. Miyamoto
Cloning and Characterization of Gonadotropin-Inducible Ovarian Transcription Factors (GIOT1 and -2) That Are Novel Members of the (Cys)2-(His)2-Type Zinc Finger Protein Family
Mol. Endocrinol., October 1, 2001; 15(10): 1693 - 1705.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Jeffs, J. J. Meeks, M. Ito, F. A. Martinson, M. M. Matzuk, J. L. Jameson, and L. D. Russell
Blockage of the Rete Testis and Efferent Ductules by Ectopic Sertoli and Leydig Cells Causes Infertility in Dax1-Deficient Male Mice
Endocrinology, October 1, 2001; 142(10): 4486 - 4495.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Sugawara, S. Abe, N. Sakuragi, Y. Fujimoto, E. Nomura, K. Fujieda, M. Saito, and S. Fujimoto
RIP 140 Modulates Transcription of the Steroidogenic Acute Regulatory Protein Gene through Interactions with Both SF-1 and DAX-1
Endocrinology, August 1, 2001; 142(8): 3570 - 3577.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Z. J. Wang, B. Jeffs, M. Ito, J. C. Achermann, R. N. Yu, D. B. Hales, and J. L. Jameson
Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1
PNAS, June 20, 2001; (2001) 141543298.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. J. B. Aylwin, J. P. Welch, C. L. Davey, J. F. Geddes, D. F. Wood, G. M. Besser, A. B. Grossman, J. P. Monson, and J. M. Burrin
The Relationship between Steroidogenic Factor 1 and DAX-1 Expression and in Vitro Gonadotropin Secretion in Human Pituitary Adenomas
J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2476 - 2483.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. B. Seminara and W. F. Crowley Jr.
Perspective: The Importance of Genetic Defects in Humans in Elucidating the Complexities of the Hypothalamic-Pituitary-Gonadal Axis
Endocrinology, June 1, 2001; 142(6): 2173 - 2177.
[Full Text] [PDF]