help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tamai, K. T.
Right arrow Articles by Sassone-Corsi, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tamai, K. T.
Right arrow Articles by Sassone-Corsi, P.

Molecular Endocrinology, Vol 10, 1561-1569, Copyright © 1996 by Endocrine Society

ARTICLES

Hormonal and developmental regulation of DAX-1 expression in Sertoli cells

KT Tamai, L Monaco, TP Alastalo, E Lalli, M Parvinen and P Sassone-Corsi
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, C. U. de Strasbourg, France.

Mutations in the human DAX-1 gene lead to X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. DAX-1 has been proposed to play a role in steroidogenesis because it is highly expressed in adrenocortical and testicular Leydig cells and because loss-of-function mutations lead to low serum levels of steroid hormones. Recent reports of DAX-1 expression in hypothalamus and pituitary, however, suggest additional functions for this protein. Here we demonstrate that DAX-1 is expressed in Sertoli cells of rat testis. This expression is regulated during spermatogenesis and peaks during the androgen- sensitive phase of the spermatogenic cycle. In addition, we show that DAX-1 expression in Sertoli cells is regulated developmentally. Maximum levels are present in the rat between postnatal days 20 and 30, during the first spermatogenic wave. Moreover, we show that activation of the cAMP-signaling pathway by the pituitary hormone FSH leads to a potent down-regulation of DAX-1 expression in cultured Sertoli cells. This down-regulation requires transcription and de novo protein synthesis. Taken together, these data indicate that DAX-1 expression in Sertoli cells may influence the development of spermatogenic cells in response to steroid and pituitary hormones.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
B. Nedumaran, S. Hong, Y.-B. Xie, Y.-H. Kim, W.-Y. Seo, M.-W. Lee, C. H. Lee, S.-H. Koo, and H.-S. Choi
DAX-1 Acts as a Novel Corepressor of Orphan Nuclear Receptor HNF4{alpha} and Negatively Regulates Gluconeogenic Enzyme Gene Expression
J. Biol. Chem., October 2, 2009; 284(40): 27511 - 27523.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. R. Manna, I. T. Huhtaniemi, and D. M. Stocco
Mechanisms of Protein Kinase C Signaling in the Modulation of 3',5'-Cyclic Adenosine Monophosphate-Mediated Steroidogenesis in Mouse Gonadal Cells
Endocrinology, July 1, 2009; 150(7): 3308 - 3317.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. R. Manna, M. T. Dyson, Y. Jo, and D. M. Stocco
Role of Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X Chromosome, Gene 1 in Protein Kinase A- and Protein Kinase C-Mediated Regulation of the Steroidogenic Acute Regulatory Protein Expression in Mouse Leydig Tumor Cells: Mechanism of Action
Endocrinology, January 1, 2009; 150(1): 187 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Zhou, R. H. Oakley, and J. A. Cidlowski
DAX-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X-Chromosome, Gene 1) Selectively Inhibits Transactivation But Not Transrepression Mediated by the Glucocorticoid Receptor in a LXXLL-Dependent Manner
Mol. Endocrinol., July 1, 2008; 22(7): 1521 - 1534.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
P J O'Shaughnessy, L Hu, and P J Baker
Effect of germ cell depletion on levels of specific mRNA transcripts in mouse Sertoli cells and Leydig cells
Reproduction, June 1, 2008; 135(6): 839 - 850.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Charron, J.-Y. Chern, and W. W. Wright
The Cathepsin L First Intron Stimulates Gene Expression in Rat Sertoli Cells
Biol Reprod, May 1, 2007; 76(5): 813 - 824.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
P. R Manna, Y. Jo, and D. M Stocco
Regulation of Leydig cell steroidogenesis by extracellular signal-regulated kinase 1/2: role of protein kinase A and protein kinase C signaling
J. Endocrinol., April 1, 2007; 193(1): 53 - 63.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
G. Benoit, A. Cooney, V. Giguere, H. Ingraham, M. Lazar, G. Muscat, T. Perlmann, J.-P. Renaud, J. Schwabe, F. Sladek, et al.
International Union of Pharmacology. LXVI. Orphan Nuclear Receptors
Pharmacol. Rev., December 1, 2006; 58(4): 798 - 836.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Zhao, Z. Yang, J. K. Phelan, D. A. Wheeler, S. Lin, and E. R. B. McCabe
Zebrafish dax1 Is Required for Development of the Interrenal Organ, the Adrenal Cortex Equivalent
Mol. Endocrinol., November 1, 2006; 20(11): 2630 - 2640.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Dantzer, M. Mark, D. Quenet, H. Scherthan, A. Huber, B. Liebe, L. Monaco, A. Chicheportiche, P. Sassone-Corsi, G. de Murcia, et al.
Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis
PNAS, October 3, 2006; 103(40): 14854 - 14859.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. A. Helguero, M. Hedengran Faulds, C. Forster, J.-A. Gustafsson, and L.-A. Haldosen
DAX-1 Expression Is Regulated during Mammary Epithelial Cell Differentiation
Endocrinology, July 1, 2006; 147(7): 3249 - 3259.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Ragazzon, A.-M. Lefrancois-Martinez, P. Val, I. Sahut-Barnola, C. Tournaire, C. Chambon, J.-L. Gachancard-Bouya, R.-J. Begue, G. Veyssiere, and A. Martinez
Adrenocorticotropin-Dependent Changes in SF-1/DAX-1 Ratio Influence Steroidogenic Genes Expression in a Novel Model of Glucocorticoid-Producing Adrenocortical Cell Lines Derived from Targeted Tumorigenesis
Endocrinology, April 1, 2006; 147(4): 1805 - 1818.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. K. Rao, J. Pham, J. S. Imam, J. A. MacLean, D. Murali, Y. Furuta, A. P. Sinha-Hikim, and M. F. Wilkinson
Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis
Genes & Dev., January 15, 2006; 20(2): 147 - 152.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M.-C. Battista, M. Otis, M. Cote, A. Laforest, M. Peter, E. Lalli, and N. Gallo-Payet
Extracellular Matrix and Hormones Modulate DAX-1 Localization in the Human Fetal Adrenal Gland
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5426 - 5431.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
F.-Q. Yu, C.-S. Han, W. Yang, X. Jin, Z.-Y. Hu, and Y.-X. Liu
Activation of the p38 MAPK pathway by follicle-stimulating hormone regulates steroidogenesis in granulosa cells differentially
J. Endocrinol., July 1, 2005; 186(1): 85 - 96.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Jo and D. M. Stocco
Regulation of Steroidogenesis and Steroidogenic Acute Regulatory Protein in R2C Cells by DAX-1 (Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X Chromosome, Gene-1)
Endocrinology, December 1, 2004; 145(12): 5629 - 5637.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K.-H. Song, Y.-Y. Park, K. C. Park, C. Y. Hong, J. H. Park, M. Shong, K. Lee, and H.-S. Choi
The Atypical Orphan Nuclear Receptor DAX-1 Interacts with Orphan Nuclear Receptor Nur77 and Represses Its Transactivation
Mol. Endocrinol., August 1, 2004; 18(8): 1929 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
G. Pinon-Lataillade, C. Masson, J. Bernardino-Sgherri, V. Henriot, P. Mauffrey, Y. Frobert, S. Araneda, and J. F. Angulo
KIN17 encodes an RNA-binding protein and is expressed during mouse spermatogenesis
J. Cell Sci., July 15, 2004; 117(16): 3691 - 3702.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Lalli and P. Sassone-Corsi
DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual Differentiation
Mol. Endocrinol., August 1, 2003; 17(8): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. G. Lehmann, J.-M. Wurtz, J.-P. Renaud, P. Sassone-Corsi, and E. Lalli
Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients
Hum. Mol. Genet., May 1, 2003; 12(9): 1063 - 1072.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Tajima, A. Dantes, Z. Yao, K. Sorokina, F. Kotsuji, R. Seger, and A. Amsterdam
Down-Regulation of Steroidogenic Response to Gonadotropins in Human and Rat Preovulatory Granulosa Cells Involves Mitogen-Activated Protein Kinase Activation and Modulation of DAX-1 and Steroidogenic Factor-1
J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 2288 - 2299.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Yazawa, T. Mizutani, K. Yamada, H. Kawata, T. Sekiguchi, M. Yoshino, T. Kajitani, Z. Shou, and K. Miyamoto
Involvement of Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein, Steroidogenic Factor 1, and Dax-1 in the Regulation of Gonadotropin-Inducible Ovarian Transcription Factor 1 Gene Expression by Follicle-Stimulating Hormone in Ovarian Granulosa Cells
Endocrinology, May 1, 2003; 144(5): 1920 - 1930.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Charron, J. N. DeCerbo, and W. W. Wright
A GC-Box Within the Proximal Promoter Region of the Rat Cathepsin L Gene Activates Transcription in Sertoli Cells of Sexually Mature Rats
Biol Reprod, May 1, 2003; 68(5): 1649 - 1656.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Charron, J. S. Folmer, and W. W. Wright
A 3-Kilobase Region Derived from the Rat Cathepsin L Gene Directs In Vivo Expression of a Reporter Gene in Sertoli Cells in a Manner Comparable to That of the Endogenous Gene
Biol Reprod, May 1, 2003; 68(5): 1641 - 1648.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. K. Rao, C. M. Wayne, M. L. Meistrich, and M. F. Wilkinson
Pem Homeobox Gene Promoter Sequences that Direct Transcription in a Sertoli Cell-Specific, Stage-Specific, and Androgen-Dependent Manner in the Testis in Vivo
Mol. Endocrinol., February 1, 2003; 17(2): 223 - 233.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Osman, C. Murigande, A. Nadakal, and A. M. Capponi
Repression of DAX-1 and Induction of SF-1 Expression. TWO MECHANISMS CONTRIBUTING TO THE ACTIVATION OF ALDOSTERONE BIOSYNTHESIS IN ADRENAL GLOMERULOSA CELLS
J. Biol. Chem., October 18, 2002; 277(43): 41259 - 41267.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Salvi, F. Gomez, M. Fiaux, D. Schorderet, J. L. Jameson, J. C. Achermann, R. C. Gaillard, and F. P. Pralong
Progressive Onset of Adrenal Insufficiency and Hypogonadism of Pituitary Origin Caused by a Complex Genetic Rearrangement within DAX-1
J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4094 - 4100.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. G. Lehmann, E. Lalli, and P. Sassone-Corsi
From the Cover: X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein
PNAS, June 11, 2002; 99(12): 8225 - 8230.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Hoyle, V. Narvaez, G. Alldus, R. Lovell-Badge, and A. Swain
Dax1 Expression Is Dependent on Steroidogenic Factor 1 in the Developing Gonad
Mol. Endocrinol., April 1, 2002; 16(4): 747 - 756.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Holter, N. Kotaja, S. Makela, L. Strauss, S. Kietz, O. A. Janne, J.-A. Gustafsson, J. J. Palvimo, and E. Treuter
Inhibition of Androgen Receptor (AR) Function by the Reproductive Orphan Nuclear Receptor DAX-1
Mol. Endocrinol., March 1, 2002; 16(3): 515 - 528.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. S. Babu, D. L. Bavers, F. Beuschlein, S. Shah, B. Jeffs, J. L. Jameson, and G. D. Hammer
Interaction Between Dax-1 and Steroidogenic Factor-1 in Vivo: Increased Adrenal Responsiveness to ACTH in the Absence of Dax-1
Endocrinology, February 1, 2002; 143(2): 665 - 673.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. R. B. McCabe
Vulnerability within a Robust Complex System--DAX-1 Mutations and Steroidogenic Axis Development
J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 41 - 43.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Sugawara, S. Abe, N. Sakuragi, Y. Fujimoto, E. Nomura, K. Fujieda, M. Saito, and S. Fujimoto
RIP 140 Modulates Transcription of the Steroidogenic Acute Regulatory Protein Gene through Interactions with Both SF-1 and DAX-1
Endocrinology, August 1, 2001; 142(8): 3570 - 3577.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. J. Tremblay and R. S. Viger
Nuclear Receptor Dax-1 Represses the Transcriptional Cooperation Between GATA-4 and SF-1 in Sertoli Cells
Biol Reprod, April 1, 2001; 64(4): 1191 - 1199.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
E. Lalli, K. Ohe, C. Hindelang, and P. Sassone-Corsi
Orphan Receptor DAX-1 Is a Shuttling RNA Binding Protein Associated with Polyribosomes via mRNA
Mol. Cell. Biol., July 1, 2000; 20(13): 4910 - 4921.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
Mutational Analysis of DAX1 in Patients with Hypogonadotropic Hypogonadism or Pubertal Delay
J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4497 - 4500.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
X-Linked Adrenal Hypoplasia Congenita: A Mutation in DAX1Expands the Phenotypic Spectrum in Males and Females
J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4501 - 4509.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Caron, S. Imbeaud, A. Bennet, M. Plantavid, G. Camerino, and P. Rochiccioli
Combined Hypothalamic-Pituitary-Gonadal Defect in a Hypogonadic Man with a Novel Mutation in the DAX-1 Gene
J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3563 - 3569.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Kawabe, T. Shikayama, H. Tsuboi, S. Oka, K. Oba, T. Yanase, H. Nawata, and K.-i. Morohashi
Dax-1 as One of the Target Genes of Ad4BP/SF-1
Mol. Endocrinol., August 1, 1999; 13(8): 1267 - 1284.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
J. Kim, D. Prawitt, N. Bardeesy, E. Torban, C. Vicaner, P. Goodyer, B. Zabel, and J. Pelletier
The Wilms' Tumor Suppressor Gene (wt1) Product Regulates Dax-1 Gene Expression during Gonadal Differentiation
Mol. Cell. Biol., March 1, 1999; 19(3): 2289 - 2299.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Lalli, M. H. Melner, D. M. Stocco, and P. Sassone-Corsi
DAX-1 Blocks Steroid Production at Multiple Levels
Endocrinology, October 1, 1998; 139(10): 4237 - 4243.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. A. Crawford, C. Dorn, Y. Sadovsky, and J. Milbrandt
Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1
Mol. Cell. Biol., May 1, 1998; 18(5): 2949 - 2956.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
R. Viger, C Mertineit, J. Trasler, and M Nemer
Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Mullerian inhibiting substance promoter
Development, January 7, 1998; 125(14): 2665 - 2675.
[Abstract] [PDF]

Home page
 Endocr. Rev.Home page
M. Simoni, J. Gromoll, and E. Nieschlag
The Follicle-Stimulating Hormone Receptor: Biochemistry, Molecular Biology, Physiology, and Pathophysiology
Endocr. Rev., December 1, 1997; 18(6): 739 - 773.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. Zhang, J. S. Thomsen, L. Johansson, J.-A. Gustafsson, and E. Treuter
DAX-1 Functions as an LXXLL-containing Corepressor for Activated Estrogen Receptors
J. Biol. Chem., December 15, 2000; 275(51): 39855 - 39859.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1996 by The Endocrine Society