help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pettersson, K.
Right arrow Articles by Gustafsson, J.-A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pettersson, K.
Right arrow Articles by Gustafsson, J.-A.
Molecular Endocrinology 11 (10): 1486-1496
Copyright © 1997 by The Endocrine Society

Mouse Estrogen Receptor ß Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor {alpha}

Katarina Pettersson, Kaj Grandien, George G. J. M. Kuiper and Jan-Åke Gustafsson

Department of Medical Nutrition and Center for Biotechnology, Karolinska Institute, S-14186 Huddinge, Sweden

The recent discovery that an additional estrogen receptor subtype is present in various rat tissues has advanced our understanding of the mechanisms underlying estrogen signaling. Here we report on the cloning of the cDNA encoding the mouse homolog of estrogen receptor-ß (ERß) and the functional characterization of mouse ERß protein. ERß is shown to have overlapping DNA-binding specificity with that of the estrogen receptor-{alpha} (ER{alpha}) and activates transcription of reporter gene constructs containing estrogen-response elements in transient transfections in response to estradiol. Using a mammalian two-hybrid system, the formation of heterodimers of the ERß and ER{alpha} subtypes was demonstrated. Furthermore, ERß and ER{alpha} form heterodimeric complexes with retained DNA-binding ability and specificity in vitro. In addition, DNA binding by the ERß/ER{alpha} heterodimer appears to be dependent on both subtype proteins. Taken together these results suggest the existence of two previously unrecognized pathways of estrogen signaling; I, via ERß in cells exclusively expressing this subtype, and II, via the formation of heterodimers in cells expressing both receptor subtypes.




This article has been cited by other articles:


Home page
 J EndocrinolHome page
C. Engdahl, C. Jochems, J.-A. Gustafsson, P. T van der Saag, H. Carlsten, and M. K Lagerquist
In vivo activation of gene transcription via oestrogen response elements by a raloxifene analogue
J. Endocrinol., December 1, 2009; 203(3): 349 - 356.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Ogino, H. Katoh, S. Kuraku, and G. Yamada
Evolutionary History and Functional Characterization of Androgen Receptor Genes in Jawed Vertebrates
Endocrinology, December 1, 2009; 150(12): 5415 - 5427.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
T. T. B. Vo and E.-B. Jeung
An Evaluation of Estrogenic Activity of Parabens Using Uterine Calbindin-D9k Gene in an Immature Rat Model
Toxicol. Sci., November 1, 2009; 112(1): 68 - 77.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
Z. Papoutsi, C. Zhao, M. Putnik, J.-A. Gustafsson, and K. Dahlman-Wright
Binding of estrogen receptor {alpha}/{beta} heterodimers to chromatin in MCF-7 cells
J. Mol. Endocrinol., August 1, 2009; 43(2): 65 - 72.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. Massinen, K. Tammimies, I. Tapia-Paez, H. Matsson, M.-E. Hokkanen, O. Soderberg, U. Landegren, E. Castren, J.-A. Gustafsson, E. Treuter, et al.
Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia
Hum. Mol. Genet., August 1, 2009; 18(15): 2802 - 2812.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. Shao, M. Nutu, B. Weijdegard, E. Egecioglu, J. Fernandez-Rodriguez, L. Karlsson-Lindahl, K. Gemzell-Danielsson, C. Bergh, and H. Billig
Clomiphene Citrate Causes Aberrant Tubal Apoptosis and Estrogen Receptor Activation in Rat Fallopian Tube: Implications for Tubal Ectopic Pregnancy
Biol Reprod, June 1, 2009; 80(6): 1262 - 1271.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
H. H Ortega, N. R Salvetti, and V. Padmanabhan
Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance
Reproduction, May 1, 2009; 137(5): 865 - 877.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-H. Yang, S. N. Sarkar, R. Liu, E. J. Perez, X. Wang, Y. Wen, L.-J. Yan, and J. W. Simpkins
Estrogen Receptor {beta} as a Mitochondrial Vulnerability Factor
J. Biol. Chem., April 3, 2009; 284(14): 9540 - 9548.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Brown, J. Ning, J. A. Ferreira, J. L. Bogener, and D. B. Lubahn
Estrogen receptor-{alpha} and -{beta} and aromatase knockout effects on lower limb muscle mass and contractile function in female mice
Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E854 - E861.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
A. Cignarella, C. Bolego, V. Pelosi, C. Meda, A. Krust, C. Pinna, R. M. Gaion, E. Vegeto, and A. Maggi
Distinct Roles of Estrogen Receptor-{alpha} and {beta} in the Modulation of Vascular Inducible Nitric-Oxide Synthase in Diabetes
J. Pharmacol. Exp. Ther., January 1, 2009; 328(1): 174 - 182.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
A. M Davis, J. Mao, B. Naz, J. A Kohl, and C. S Rosenfeld
Comparative effects of estradiol, methyl-piperidino-pyrazole, raloxifene, and ICI 182 780 on gene expression in the murine uterus
J. Mol. Endocrinol., October 1, 2008; 41(4): 205 - 217.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. L. Gonzales, M. J. Tetel, and C. K. Wagner
Estrogen Receptor (ER) {beta} Modulates ER{alpha} Responses to Estrogens in the Developing Rat Ventromedial Nucleus of the Hypothalamus
Endocrinology, September 1, 2008; 149(9): 4615 - 4621.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
A. Orgaard and L. Jensen
The Effects of Soy Isoflavones on Obesity
Experimental Biology and Medicine, September 1, 2008; 233(9): 1066 - 1080.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Ruegg, E. Swedenborg, D. Wahlstrom, A. Escande, P. Balaguer, K. Pettersson, and I. Pongratz
The Transcription Factor Aryl Hydrocarbon Receptor Nuclear Translocator Functions as an Estrogen Receptor {beta}-Selective Coactivator, and Its Recruitment to Alternative Pathways Mediates Antiestrogenic Effects of Dioxin
Mol. Endocrinol., February 1, 2008; 22(2): 304 - 316.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Fan, H.-J. Kim, M. Warner, and J.-A. Gustafsson
Estrogen receptor beta is essential for sprouting of nociceptive primary afferents and for morphogenesis and maintenance of the dorsal horn interneurons
PNAS, August 21, 2007; 104(34): 13696 - 13701.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. K. Gruvberger-Saal, P.-O. Bendahl, L. H. Saal, M. Laakso, C. Hegardt, P. Eden, C. Peterson, P. Malmstrom, J. Isola, A. Borg, et al.
Estrogen Receptor {beta} Expression Is Associated with Tamoxifen Response in ER{alpha}-Negative Breast Carcinoma
Clin. Cancer Res., April 1, 2007; 13(7): 1987 - 1994.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
P. Galluzzo, F. Caiazza, S. Moreno, and M. Marino
Role of ER{beta} palmitoylation in the inhibition of human colon cancer cell proliferation
Endocr. Relat. Cancer, March 1, 2007; 14(1): 153 - 167.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Titolo, F. Cai, and D. D. Belsham
Coordinate Regulation of Neuropeptide Y and Agouti-Related Peptide Gene Expression by Estrogen Depends on the Ratio of Estrogen Receptor (ER) {alpha} to ER{beta} in Clonal Hypothalamic Neurons
Mol. Endocrinol., September 1, 2006; 20(9): 2080 - 2092.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. F. Kritzer
Regional, Laminar and Cellular Distribution of Immunoreactivity for ER{beta} in the Cerebral Cortex of Hormonally Intact, Postnatally Developing Male and Female Rats
Cereb Cortex, August 1, 2006; 16(8): 1181 - 1192.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
G. Hasenbrink, A. Sievernich, L. Wildt, J. Ludwig, and H. Lichtenberg-Frate
Estrogenic effects of natural and synthetic compounds including tibolone assessed in Saccharomyces cerevisiae expressing the human estrogen {alpha} and {beta} receptors
FASEB J, July 1, 2006; 20(9): 1552 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Yamamoto, R. Moore, H. A. Hess, G. L. Guo, F. J. Gonzalez, K. S. Korach, R. R. Maronpot, and M. Negishi
Estrogen Receptor {alpha} Mediates 17{alpha}-Ethynylestradiol Causing Hepatotoxicity
J. Biol. Chem., June 16, 2006; 281(24): 16625 - 16631.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. R. Meyer, E. Haas, and M. Barton
Gender Differences of Cardiovascular Disease: New Perspectives for Estrogen Receptor Signaling
Hypertension, June 1, 2006; 47(6): 1019 - 1026.
[Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. Singh, J. A. Dykens, and J. W. Simpkins
Novel Mechanisms for Estrogen-Induced Neuroprotection.
Experimental Biology and Medicine, May 1, 2006; 231(5): 514 - 521.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
H. N. Jabbour, R. W. Kelly, H. M. Fraser, and H. O. D. Critchley
Endocrine Regulation of Menstruation
Endocr. Rev., February 1, 2006; 27(1): 17 - 46.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Bodo, A. E. Kudwa, and E. F. Rissman
Both Estrogen Receptor-{alpha} and -{beta} Are Required for Sexual Differentiation of the Anteroventral Periventricular Area in Mice
Endocrinology, January 1, 2006; 147(1): 415 - 420.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Ciana, A. Brena, P. Sparaciari, E. Bonetti, D. Di Lorenzo, and A. Maggi
Estrogenic Activities in Rodent Estrogen-Free Diets
Endocrinology, December 1, 2005; 146(12): 5144 - 5150.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
L. A. Gilad, T. Bresler, J. Gnainsky, P. Smirnoff, and B. Schwartz
Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells
J. Endocrinol., June 1, 2005; 185(3): 577 - 592.
[Abstract] [Full Text] [PDF]

Home page
 Proc R Soc BHome page
M.B Hawkins, J Godwin, D Crews, and P Thomas
The distributions of the duplicate oestrogen receptors ER-{beta}a and ER-{beta}b in the forebrain of the Atlantic croaker (Micropogonias undulatus): evidence for subfunctionalization after gene duplication
Proc R Soc B, March 22, 2005; 272(1563): 633 - 641.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
S. H. Kim, A. Tamrazi, K. E. Carlson, and J. A. Katzenellenbogen
A Proteomic Microarray Approach for Exploring Ligand-initiated Nuclear Hormone Receptor Pharmacology, Receptor Selectivity, and Heterodimer Functionality
Mol. Cell. Proteomics, March 1, 2005; 4(3): 267 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. A. Hopp, H. L. Weiss, I. S. Parra, Y. Cui, C. K. Osborne, and S. A. W. Fuqua
Low Levels of Estrogen Receptor {beta} Protein Predict Resistance to Tamoxifen Therapy in Breast Cancer
Clin. Cancer Res., November 15, 2004; 10(22): 7490 - 7499.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
C. Zhao, L. Xu, M. Otsuki, G. Toresson, K. Koehler, Q. Pan-Hammarstrom, L. Hammarstrom, S. Nilsson, J.-A. Gustafsson, and K. Dahlman-Wright
Identification of a functional variant of estrogen receptor beta in an African population
Carcinogenesis, November 1, 2004; 25(11): 2067 - 2073.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
B Horard, A Castet, P-L Bardet, V Laudet, V Cavailles, and J-M Vanacker
Dimerization is required for transactivation by estrogen-receptor-related (ERR) orphan receptors: evidence from amphioxus ERR
J. Mol. Endocrinol., October 1, 2004; 33(2): 493 - 509.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. E. Kudwa, J.-A. Gustafsson, and E. F. Rissman
Estrogen Receptor {beta} Modulates Estradiol Induction of Progestin Receptor Immunoreactivity in Male, But Not in Female, Mouse Medial Preoptic Area
Endocrinology, October 1, 2004; 145(10): 4500 - 4506.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A.G.B. Hurst, D.W. Goad, M. Mohan, and J.R. Malayer
Independent Downstream Gene Expression Profiles in the Presence of Estrogen Receptor {alpha} or {beta}
Biol Reprod, October 1, 2004; 71(4): 1252 - 1261.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
A Bardin, N Boulle, G Lazennec, F Vignon, and P Pujol
Loss of ER{beta} expression as a common step in estrogen-dependent tumor progression
Endocr. Relat. Cancer, September 1, 2004; 11(3): 537 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. O'Lone, M. C. Frith, E. K. Karlsson, and U. Hansen
Genomic Targets of Nuclear Estrogen Receptors
Mol. Endocrinol., August 1, 2004; 18(8): 1859 - 1875.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J.-x. Zhang, D. C. Labaree, G. Mor, and R. B. Hochberg
Estrogen to Antiestrogen with a Single Methylene Group Resulting in an Unusual Steroidal Selective Estrogen Receptor Modulator
J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3527 - 3535.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S.-H. Yang, R. Liu, E. J. Perez, Y. Wen, S. M. Stevens Jr., T. Valencia, A.-M. Brun-Zinkernagel, L. Prokai, Y. Will, J. Dykens, et al.
Mitochondrial localization of estrogen receptor {beta}
PNAS, March 23, 2004; 101(12): 4130 - 4135.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. L. Arnett-Mansfield, A. deFazio, P. A. Mote, and C. L. Clarke
Subnuclear Distribution of Progesterone Receptors A and B in Normal and Malignant Endometrium
J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1429 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
U. I. L. Modder, A. Sanyal, A. E. Kearns, J. D. Sibonga, E. Nishihara, J. Xu, B. W. O'Malley, E. L. Ritman, B. L. Riggs, T. C. Spelsberg, et al.
Effects of Loss of Steroid Receptor Coactivator-1 on the Skeletal Response to Estrogen in Mice
Endocrinology, February 1, 2004; 145(2): 913 - 921.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Paruthiyil, H. Parmar, V. Kerekatte, G. R. Cunha, G. L. Firestone, and D. C. Leitman
Estrogen Receptor {beta} Inhibits Human Breast Cancer Cell Proliferation and Tumor Formation by Causing a G2 Cell Cycle Arrest
Cancer Res., January 1, 2004; 64(1): 423 - 428.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Patrone, T. N. Cassel, K. Pettersson, Y.-S. Piao, G. Cheng, P. Ciana, A. Maggi, M. Warner, J.-A. Gustafsson, and M. Nord
Regulation of Postnatal Lung Development and Homeostasis by Estrogen Receptor {beta}
Mol. Cell. Biol., December 1, 2003; 23(23): 8542 - 8552.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. K. Cheng, B. K. C. Chow, and P. C. K. Leung
An Activator Protein 1-Like Motif Mediates 17{beta}-Estradiol Repression of Gonadotropin-Releasing Hormone Receptor Promoter via an Estrogen Receptor {alpha}-Dependent Mechanism in Ovarian and Breast Cancer Cells
Mol. Endocrinol., December 1, 2003; 17(12): 2613 - 2629.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Ikeda, A. Nagai, M.-A. Ikeda, and S. Hayashi
Sexually Dimorphic and Estrogen-Dependent Expression of Estrogen Receptor {beta} in the Ventromedial Hypothalamus during Rat Postnatal Development
Endocrinology, November 1, 2003; 144(11): 5098 - 5104.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Otsuki, H. Gao, K. Dahlman-Wright, C. Ohlsson, N. Eguchi, Y. Urade, and J.-A. Gustafsson
Specific Regulation of Lipocalin-Type Prostaglandin D Synthase in Mouse Heart by Estrogen Receptor {beta}
Mol. Endocrinol., September 1, 2003; 17(9): 1844 - 1855.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
J. Matthews and J.-A. Gustafsson
Estrogen Signaling: A Subtle Balance Between ER{alpha} and ER{beta}
Mol. Interv., August 1, 2003; 3(5): 281 - 292.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Frasor, D. H. Barnett, J. M. Danes, R. Hess, A. F. Parlow, and B. S. Katzenellenbogen
Response-Specific and Ligand Dose-Dependent Modulation of Estrogen Receptor (ER) {alpha} Activity by ER{beta} in the Uterus
Endocrinology, July 1, 2003; 144(7): 3159 - 3166.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. F. Couse, M. M. Yates, V. R. Walker, and K. S. Korach
Characterization of the Hypothalamic-Pituitary-Gonadal Axis in Estrogen Receptor (ER) Null Mice Reveals Hypergonadism and Endocrine Sex Reversal in Females Lacking ER{alpha} But Not ER{beta}
Mol. Endocrinol., June 1, 2003; 17(6): 1039 - 1053.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. A. W. Fuqua, R. Schiff, I. Parra, J. T. Moore, S. K. Mohsin, C. K. Osborne, G. M. Clark, and D. C. Allred
Estrogen Receptor {beta} Protein in Human Breast Cancer: Correlation with Clinical Tumor Parameters
Cancer Res., May 15, 2003; 63(10): 2434 - 2439.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. W. Mitra, E. Hoskin, J. Yudkovitz, L. Pear, H. A. Wilkinson, S. Hayashi, D. W. Pfaff, S. Ogawa, S. P. Rohrer, J. M. Schaeffer, et al.
Immunolocalization of Estrogen Receptor {beta} in the Mouse Brain: Comparison with Estrogen Receptor {alpha}
Endocrinology, May 1, 2003; 144(5): 2055 - 2067.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Bai and V. Giguere
Isoform-Selective Interactions between Estrogen Receptors and Steroid Receptor Coactivators Promoted by Estradiol and ErbB-2 Signaling in Living Cells
Mol. Endocrinol., April 1, 2003; 17(4): 589 - 599.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. K. Lindberg, S. Moverare, S. Skrtic, H. Gao, K. Dahlman-Wright, J.-A. Gustafsson, and C. Ohlsson
Estrogen Receptor (ER)-{beta} Reduces ER{alpha}-Regulated Gene Transcription, Supporting a "Ying Yang" Relationship between ER{alpha} and ER{beta} in Mice
Mol. Endocrinol., February 1, 2003; 17(2): 203 - 208.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. A. Henderson, P. T. K. Saunders, A. Moffett-King, N. P. Groome, and H. O. D. Critchley
Steroid Receptor Expression in Uterine Natural Killer Cells
J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 440 - 449.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. J. Jakimiuk, S. R. Weitsman, H.-W. Yen, M. Bogusiewicz, and D. A. Magoffin
Estrogen Receptor {alpha} and {beta} Expression in Theca and Granulosa Cells from Women with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5532 - 5538.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. B. Hodgin and N. Maeda
Minireview: Estrogen and Mouse Models of Atherosclerosis
Endocrinology, December 1, 2002; 143(12): 4495 - 4501.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
S. B. Pillai, J. M. Jones, and R. D. Koos
Treatment of Rats with 17{beta}-Estradiol or Relaxin Rapidly Inhibits Uterine Estrogen Receptor {beta}1 and {beta}2 Messenger Ribonucleic Acid Levels
Biol Reprod, December 1, 2002; 67(6): 1919 - 1926.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. O. D. Critchley, T. A. Henderson, R. W. Kelly, G. S. Scobie, L. R. Evans, N. P. Groome, and P. T. K. Saunders
Wild-Type Estrogen Receptor (ER{beta}1) and the Splice Variant (ER{beta}cx/{beta}2) Are Both Expressed within the Human Endometrium throughout the Normal Menstrual Cycle
J. Clin. Endocrinol. Metab., November 1, 2002; 87(11): 5265 - 5273.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. A. Schreihofer, D. F. Rowe, E. F. Rissman, E. M. Scordalakes, J.-a. Gustafsson, and M. A. Shupnik
Estrogen Receptor-{alpha} (ER{alpha}), But Not ER{beta}, Modulates Estrogen Stimulation of the ER{alpha}-Truncated Variant, TERP-1
Endocrinology, November 1, 2002; 143(11): 4196 - 4202.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Vasudevan, S. Ogawa, and D. Pfaff
Estrogen and Thyroid Hormone Receptor Interactions: Physiological Flexibility by Molecular Specificity
Physiol Rev, October 1, 2002; 82(4): 923 - 944.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K.-i. Matsuda, I. Ochiai, M. Nishi, and M. Kawata
Colocalization and Ligand-Dependent Discrete Distribution of the Estrogen Receptor (ER){alpha} and ER{beta}
Mol. Endocrinol., October 1, 2002; 16(10): 2215 - 2230.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
W. N. Jefferson, J. F. Couse, E. Padilla-Banks, K. S. Korach, and R. R. Newbold
Neonatal Exposure to Genistein Induces Estrogen Receptor (ER){alpha} Expression and Multioocyte Follicles in the Maturing Mouse Ovary: Evidence for ER{beta}-Mediated and Nonestrogenic Actions
Biol Reprod, October 1, 2002; 67(4): 1285 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Buteau-Lozano, M. Ancelin, B. Lardeux, J. Milanini, and M. Perrot-Applanat
Transcriptional Regulation of Vascular Endothelial Growth Factor by Estradiol and Tamoxifen in Breast Cancer Cells: A Complex Interplay between Estrogen Receptors {alpha} and {beta}
Cancer Res., September 1, 2002; 62(17): 4977 - 4984.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
X. Ni, R. C. Nicholson, B. R. King, E.-C. Chan, M. A. Read, and R. Smith
Estrogen Represses whereas the Estrogen-Antagonist ICI 182780 Stimulates Placental CRH Gene Expression
J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3774 - 3778.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H.-J. Huang, J. D. Norris, and D. P. McDonnell
Identification of a Negative Regulatory Surface within Estrogen Receptor {alpha} Provides Evidence in Support of a Role for Corepressors in Regulating Cellular Responses to Agonists and Antagonists
Mol. Endocrinol., August 1, 2002; 16(8): 1778 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-M. Liu, C. Albanese, C. M. Anderson, K. Hilty, P. Webb, R. M. Uht, R. H. Price Jr., R. G. Pestell, and P. J. Kushner
Opposing Action of Estrogen Receptors alpha and beta on Cyclin D1 Gene Expression
J. Biol. Chem., June 28, 2002; 277(27): 24353 - 24360.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
B. L. Riggs, S. Khosla, and L. J. Melton III
Sex Steroids and the Construction and Conservation of the Adult Skeleton
Endocr. Rev., June 1, 2002; 23(3): 279 - 302.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. T. K. Saunders, M. R. Millar, S. Macpherson, D. S. Irvine, N. P. Groome, L. R. Evans, R. M. Sharpe, and G. A. Scobie
ER{beta}1 and the ER{beta}2 Splice Variant (ER{beta}cx/{beta}2) Are Expressed in Distinct Cell Populations in the Adult Human Testis
J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2706 - 2715.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Lopez, M. D. Sanchez, W. Shea-Eaton, and M. P. McLean
Estrogen Activates the High-Density Lipoprotein Receptor Gene via Binding to Estrogen Response Elements and Interaction with Sterol Regulatory Element Binding Protein-1A
Endocrinology, June 1, 2002; 143(6): 2155 - 2168.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. Menuet, E. Pellegrini, I. Anglade, O. Blaise, V. Laudet, O. Kah, and F. Pakdel
Molecular Characterization of Three Estrogen Receptor Forms in Zebrafish: Binding Characteristics, Transactivation Properties, and Tissue Distributions
Biol Reprod, June 1, 2002; 66(6): 1881 - 1892.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G. J. Pepe, R. B. Billiar, M. G. Leavitt, N. C. Zachos, J. A. Gustafsson, and E. D. Albrecht
Expression of Estrogen Receptors {alpha} and {beta} in the Baboon Fetal Ovary
Biol Reprod, April 1, 2002; 66(4): 1054 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. Nie, Q. Zhou, E. Jassim, P. T.K. Saunders, and R. A. Hess
Differential Expression of Estrogen Receptors {alpha} and {beta} in the Reproductive Tractsof Adult Male Dogs and Cats
Biol Reprod, April 1, 2002; 66(4): 1161 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. F. Rissman, A. L. Heck, J. E. Leonard, M. A. Shupnik, and J.-A. Gustafsson
Disruption of estrogen receptor beta gene impairs spatial learning in female mice
PNAS, March 19, 2002; 99(6): 3996 - 4001.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. V. Pham and M. R. Rosen
Sex, hormones, and repolarization
Cardiovasc Res, February 15, 2002; 53(3): 740 - 751.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Orikasa, Y. Kondo, S. Hayashi, B. S. McEwen, and Y. Sakuma
Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: Implication in luteinizing hormone surge
PNAS, February 14, 2002; (2002) 52707299.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M.F. Kritzer
Regional, Laminar, and Cellular Distribution of Immunoreactivity for ER{alpha} and ER{beta} in the Cerebral Cortex of Hormonally Intact, Adult Male and Female Rats
Cereb Cortex, February 1, 2002; 12(2): 116 - 128.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
C. J. Gruber, W. Tschugguel, C. Schneeberger, and J. C. Huber
Production and Actions of Estrogens
N. Engl. J. Med., January 31, 2002; 346(5): 340 - 352.
[Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
B. McEwen
Estrogen Actions Throughout the Brain
Recent Prog. Horm. Res., January 1, 2002; 57(1): 357 - 384.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. S. McEwen
Genome and Hormones: Gender Differences in Physiology: Invited Review: Estrogens effects on the brain: multiple sites and molecular mechanisms
J Appl Physiol, December 1, 2001; 91(6): 2785 - 2801.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Greco, E. A. Allegretto, M. J. Tetel, and J. D. Blaustein
Coexpression of ER{beta} with ER{alpha} and Progestin Receptor Proteins in the Female Rat Forebrain: Effects of Estradiol Treatment
Endocrinology, December 1, 2001; 142(12): 5172 - 5181.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Warnmark, A. Wikstrom, A. P. H. Wright, J.-A. Gustafsson, and T. Hard
The N-terminal Regions of Estrogen Receptor alpha and beta Are Unstructured in Vitro and Show Different TBP Binding Properties
J. Biol. Chem., November 30, 2001; 276(49): 45939 - 45944.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. H. Faulds, K. Pettersson, J.-A. Gustafsson, and L.-A. Haldosen
Cross-Talk Between ERs and Signal Transducer and Activator of Transcription 5 Is E2 Dependent and Involves Two Functionally Separate Mechanisms
Mol. Endocrinol., November 1, 2001; 15(11): 1929 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. R. Levin
Genome and Hormones: Gender Differences in Physiology: Invited Review: Cell localization, physiology, and nongenomic actions of estrogen receptors
J Appl Physiol, October 1, 2001; 91(4): 1860 - 1867.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Lu, Y. Kiriyama, K. Y. Lee, and V. Giguere
Transcriptional Regulation of the Estrogen-inducible pS2 Breast Cancer Marker Gene by the ERR Family of Orphan Nuclear Receptors
Cancer Res., September 1, 2001; 61(18): 6755 - 6761.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
C. M. Klinge
Estrogen receptor interaction with estrogen response elements
Nucleic Acids Res., July 15, 2001; 29(14): 2905 - 2919.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. R. Wood, V. S. Likhite, M. A. Loven, and A. M. Nardulli
Allosteric Modulation of Estrogen Receptor Conformation by Different Estrogen Response Elements
Mol. Endocrinol., July 1, 2001; 15(7): 1114 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Cardenas, K.A. Burke, R.M. Bigsby, W.F. Pope, and K.P. Nephew
Estrogen Receptor {beta} in the Sheep Ovary During the Estrous Cycle and Early Pregnancy
Biol Reprod, July 1, 2001; 65(1): 128 - 134.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. F. Palter, A. B. Tavares, A. Hourvitz, J. D. Veldhuis, and E. Y. Adashi
Are Estrogens of Import to Primate/Human Ovarian Folliculogenesis?
Endocr. Rev., June 1, 2001; 22(3): 389 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Pasqualini, D. Guivarc'h, J.-V. Barnier, B. Guibert, J.-D. Vincent, and P. Vernier
Differential Subcellular Distribution and Transcriptional Activity of {{Sigma}}E3, {{Sigma}}E4, and {{Sigma}}E3-4 Isoforms of the Rat Estrogen Receptor-{{alpha}}
Mol. Endocrinol., June 1, 2001; 15(6): 894 - 908.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
L. J. Havrilesky, C. P. McMahon, E. K. Lobenhofer, R. Whitaker, J. R. Marks, and A. Berchuck
Relationship Between Expression of Coactivators and Corepressors of Hormone Receptors and Resistance of Ovarian Cancers to Growth Regulation by Steroid Hormones
Reproductive Sciences, April 1, 2001; 8(2): 104 - 113.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
M. E. Quaedackers, C. E. Van Den Brink, S. Wissink, R. H. M. M. Schreurs, J.-A. Gustafsson, P. T. Van Der Saag, and B. Van Der Burg
4-Hydroxytamoxifen Trans-Represses Nuclear Factor-{{kappa}}B Activity in Human Osteoblastic U2-OS Cells through Estrogen Receptor (ER){{alpha}}, and Not through ER{{beta}}
Endocrinology, March 1, 2001; 142(3): 1156 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Yokogawa, K. Miya, T. Sekido, Y. Higashi, M. Nomura, R. Fujisawa, K. Morito, Y. Masamune, Y. Waki, S. Kasugai, et al.
Selective Delivery of Estradiol to Bone by Aspartic Acid Oligopeptide and Its Effects on Ovariectomized Mice
Endocrinology, March 1, 2001; 142(3): 1228 - 1233.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Kirma, K. Gill, U. Mandava, and R. R. Tekmal
Overexpression of Aromatase Leads to Hyperplasia and Changes in the Expression of Genes Involved in Apoptosis, Cell Cycle, Growth, and Tumor Suppressor Functions in the Mammary Glands of Transgenic Mice
Cancer Res., March 1, 2001; 61(5): 1910 - 1918.
[Abstract] [Full Text]

Home page
 Pharmacol. Rev.Home page
R. Clarke, F. Leonessa, J. N. Welch, and T. C. Skaar
Cellular and Molecular Pharmacology of Antiestrogen Action and Resistance
Pharmacol. Rev., March 1, 2001; 53(1): 25 - 72.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Kamegai, H. Tamura, T. Shimizu, S. Ishii, H. Sugihara, and I. Wakabayashi
Estrogen Receptor (ER){{alpha}}, But Not ER{beta}, Gene Is Expressed in Growth Hormone-Releasing Hormone Neurons of the Male Rat Hypothalamus
Endocrinology, February 1, 2001; 142(2): 538 - 543.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. K. Kang, K.-C. Choi, C.-J. Tai, N. Auersperg, and P. C. K. Leung
Estradiol Regulates Gonadotropin-Releasing Hormone (GnRH) and its Receptor Gene Expression and Antagonizes the Growth Inhibitory Effects of GnRH in Human Ovarian Surface Epithelial and Ovarian Cancer Cells
Endocrinology, February 1, 2001; 142(2): 580 - 588.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. A. Harris, R. A. Henderson, R. A. Bhat, and B. S. Komm
Regulation of Metallothionein II Messenger Ribonucleic Acid Measures Exogenous Estrogen Receptor-{beta} Activity in SAOS-2 and LNCaPLN3 Cells
Endocrinology, February 1, 2001; 142(2): 645 - 652.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. POTIER, S. J. ELLIOT, I. TACK, O. LENZ, G. E. STRIKER, L. J. STRIKER, and M. KARL
Expression and Regulation of Estrogen Receptors in Mesangial Cells: Influence on Matrix Metalloproteinase-9
J. Am. Soc. Nephrol., February 1, 2001; 12(2): 241 - 251.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
E. D. Lephart, S. B. Call, R. W. Rhees, N. A. Jacobson, K. Scott Weber, J. Bledsoe, and C. Teuscher
Neuroendocrine Regulation of Sexually Dimorphic Brain Structure and Associated Sexual Behavior in Male Rats Is Genetically Controlled
Biol Reprod, February 1, 2001; 64(2): 571 - 578.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
J. E. Compston
Sex Steroids and Bone
Physiol Rev, January 1, 2001; 81(1): 419 - 447.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. Kurita, K.-j. Lee, P. T.K. Saunders, P. S. Cooke, J. A. Taylor, D. B. Lubahn, C. Zhao, S. Mäkelä, J.-A. Gustafsson, R. Dahiya, et al.
Regulation of Progesterone Receptors and Decidualization in Uterine Stroma of the Estrogen Receptor-{{alpha}} Knockout Mouse
Biol Reprod, January 1, 2001; 64(1): 272 - 283.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1997 by The Endocrine Society