| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Division of Endocrinology and Metabolism Cedars-Sinai Research Institute-UCLA School of Medicine Los Angeles, California 90048
Pathogenesis of tumor formation in the anterior pituitary has been intensively studied, but the common mechanism involved in pituitary cell transformation and tumorigenesis remains elusive. In this study, we used mRNA differential display PCR to identify mRNAs that are differentially expressed in rat pituitary tumor cells compared with normal pituitary tissue. An mRNA exclusively expressed in pituitary tumor but not in normal pituitary was characterized. Using this pituitary tumor-specific PCR product as a probe to screen a cDNA library constructed from rat pituitary tumor GH4 cells, a cDNA of 974 bp was isolated. This cDNA encodes a novel protein of 199 amino acids, which contains no well characterized functional motifs. The mRNA of this cDNA is detected in normal adult testis and in embryonic liver, where the transcript is about 300 bp shorter and expressed at a much lower level than that detected from pituitary tumor cells. Overexpression of this protein in mouse 3T3 fibroblasts shows that it inhibits cell proliferation and induces cell transformation in vitro. Injection of transfected 3T3 cells into athymic nude mice resulted in tumor formation within 3 weeks in all animals. These results indicate that pituitary tumor cells express a unique and potent transforming gene (PTTG), which may play a role in pituitary tumorigenesis.
This article has been cited by other articles:
 |
|
 |
|
  Y. Tong and T. Eigler Transcriptional targets for pituitary tumor-transforming gene-1 J. Mol. Endocrinol., November 1, 2009; 43(5): 179 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Espina, C. Mendez-Vidal, M. A. Moreno-Mateos, C. Saez, A. Romero-Franco, M. A. Japon, and J. A. Pintor-Toro Induction of Dlk1 by PTTG1 Inhibits Adipocyte Differentiation and Correlates with Malignant Transformation Mol. Biol. Cell, July 15, 2009; 20(14): 3353 - 3362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yan, C. Zhou, X. Lou, Z. Xiao, H. Zhu, Q. Wang, Y. Wang, N. Lu, S. He, Q. Zhan, et al. PTTG Overexpression Promotes Lymph Node Metastasis in Human Esophageal Squamous Cell Carcinoma Cancer Res., April 15, 2009; 69(8): 3283 - 3290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Saidak, R. Mentaverri, and E. M. Brown The Role of the Calcium-Sensing Receptor in the Development and Progression of Cancer Endocr. Rev., April 1, 2009; 30(2): 178 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Quereda and M. Malumbres Cell cycle control of pituitary development and disease J. Mol. Endocrinol., February 1, 2009; 42(2): 75 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Chesnokova, S. Zonis, K. Kovacs, A. Ben-Shlomo, K. Wawrowsky, S. Bannykh, and S. Melmed p21Cip1 restrains pituitary tumor growth PNAS, November 11, 2008; 105(45): 17498 - 17503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Salehi, K. Kovacs, B. W Scheithauer, R. V Lloyd, and M. Cusimano Pituitary tumor-transforming gene in endocrine and other neoplasms: a review and update Endocr. Relat. Cancer, September 1, 2008; 15(3): 721 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhou, Y. Tong, K. Wawrowsky, S. Bannykh, I. Donangelo, and S. Melmed Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors Endocr. Relat. Cancer, September 1, 2008; 15(3): 817 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Limon-Mortes, M. Mora-Santos, A. Espina, J. A. Pintor-Toro, A. Lopez-Roman, M. Tortolero, and F. Romero UV-induced degradation of securin is mediated by SKP1-CUL1-{beta}TrCP E3 ubiquitin ligase J. Cell Sci., June 1, 2008; 121(11): 1825 - 1831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ito, Y. Shimada, T. Kan, S. David, Y. Cheng, Y. Mori, R. Agarwal, B. Paun, Z. Jin, A. Olaru, et al. Pituitary Tumor-Transforming 1 Increases Cell Motility and Promotes Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma Cancer Res., May 1, 2008; 68(9): 3214 - 3224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chesnokova, S. Zonis, T. Rubinek, R. Yu, A. Ben-Shlomo, K. Kovacs, K. Wawrowsky, and S. Melmed Senescence Mediates Pituitary Hypoplasia and Restrains Pituitary Tumor Growth Cancer Res., November 1, 2007; 67(21): 10564 - 10572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A Naves, A. F Daly, J.-F. Vanbellinghen, L. A Casulari, C. Spilioti, A. V Magalhaes, M. F Azevedo, L. A Giacomini, P. P Nascimento, R. O Nunes, et al. Variable pathological and clinical features of a large Brazilian family harboring a mutation in the aryl hydrocarbon receptor-interacting protein gene Eur. J. Endocrinol., October 1, 2007; 157(4): 383 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wierinckx, C. Auger, P. Devauchelle, A. Reynaud, P. Chevallier, M. Jan, G. Perrin, M. Fevre-Montange, C. Rey, D. Figarella-Branger, et al. A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors Endocr. Relat. Cancer, September 1, 2007; 14(3): 887 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rubinek, V. Chesnokova, I. Wolf, K. Wawrowsky, G. Vlotides, and S. Melmed Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells Am J Physiol Cell Physiol, September 1, 2007; 293(3): C1082 - C1092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. V. Sheleg, J.-M. Peloponese, Y.-H. Chi, Y. Li, M. Eckhaus, and K.-T. Jeang Evidence for Cooperative Transforming Activity of the Human Pituitary Tumor Transforming Gene and Human T-Cell Leukemia Virus Type 1 Tax J. Virol., August 1, 2007; 81(15): 7894 - 7901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Bruins, M. J. Jonker, O. Bruning, J. L.A. Pennings, M. M. Schaap, E. M. Hoogervorst, H. van Steeg, T. M. Breit, and A. de Vries Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation Carcinogenesis, August 1, 2007; 28(8): 1814 - 1823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M El-Naggar, M. T Malik, A. Martin, J. P Moore, M. Proctor, T. Hamid, and S. S Kakar Development of cystic glandular hyperplasia of the endometrium in Mullerian inhibitory substance type II receptor-pituitary tumor transforming gene transgenic mice J. Endocrinol., July 1, 2007; 194(1): 179 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Melmed Aryl Hydrocarbon Receptor Interacting Protein and Pituitary Tumorigenesis: Another Interesting Protein J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1617 - 1619. [Full Text] [PDF]
|
|
|
|
|
|
A. F. Daly, J.-F. Vanbellinghen, S. K. Khoo, M.-L. Jaffrain-Rea, L. A. Naves, M. A. Guitelman, A. Murat, P. Emy, A.-P. Gimenez-Roqueplo, G. Tamburrano, et al. Aryl Hydrocarbon Receptor-Interacting Protein Gene Mutations in Familial Isolated Pituitary Adenomas: Analysis in 73 Families J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1891 - 1896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Barlier, J.-F. Vanbellinghen, A. F. Daly, M. Silvy, M.-L. Jaffrain-Rea, J. Trouillas, G. Tamagno, L. Cazabat, V. Bours, T. Brue, et al. Mutations in the Aryl Hydrocarbon Receptor Interacting Protein Gene Are Not Highly Prevalent among Subjects with Sporadic Pituitary Adenomas J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1952 - 1955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Kim, H. Ying, M. C. Willingham, and S.-y. Cheng The pituitary tumor-transforming gene promotes angiogenesis in a mouse model of follicular thyroid cancer Carcinogenesis, May 1, 2007; 28(5): 932 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Bernal and A. Hernandez p53 Stabilization can be Uncoupled from its Role in Transcriptional Activation by Loss of PTTG1/Securin J. Biochem., May 1, 2007; 141(5): 737 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vlotides, T. Eigler, and S. Melmed Pituitary Tumor-Transforming Gene: Physiology and Implications for Tumorigenesis Endocr. Rev., April 1, 2007; 28(2): 165 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Shorts-Cary, M. Xu, J. Ertel, B. K. Kleinschmidt-Demasters, K. Lillehei, I. Matsuoka, S. Nielsen-Preiss, and M. E. Wierman Bone Morphogenetic Protein and Retinoic Acid-Inducible Neural Specific Protein-3 Is Expressed in Gonadotrope Cell Pituitary Adenomas and Induces Proliferation, Migration, and Invasion Endocrinology, March 1, 2007; 148(3): 967 - 975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. van de Pavert, J. Meuleman, A. Malysheva, W. M. Aartsen, I. Versteeg, F. Tonagel, W. Kamphuis, C. J. McCabe, M. W. Seeliger, and J. Wijnholds A Single Amino Acid Substitution (Cys249Trp) in Crb1 Causes Retinal Degeneration and Deregulates Expression of Pituitary Tumor Transforming Gene Pttg1 J. Neurosci., January 17, 2007; 27(3): 564 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Hussaini, C. Trotter, Y. Zhao, R. Abdel-Fattah, S. Amos, A. Xiao, C. U. Agi, G. T. Redpath, Z. Fang, G. K.K. Leung, et al. Matrix Metalloproteinase-9 Is Differentially Expressed in Nonfunctioning Invasive and Noninvasive Pituitary Adenomas and Increases Invasion in Human Pituitary Adenoma Cell Line Am. J. Pathol., January 1, 2007; 170(1): 356 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Vlotides, M. Cruz-Soto, T. Rubinek, T. Eigler, C. J. Auernhammer, and S. Melmed Mechanisms for Growth Factor-Induced Pituitary Tumor Transforming Gene-1 Expression in Pituitary Folliculostellate TtT/GF Cells Mol. Endocrinol., December 1, 2006; 20(12): 3321 - 3335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Kim, J. A. Franklyn, K. Boelaert, M. C. Eggo, J. C. Watkinson, and C. J. McCabe Pituitary Tumor Transforming Gene (PTTG) Stimulates Thyroid Cell Proliferation via a Vascular Endothelial Growth Factor/Kinase Insert Domain Receptor/Inhibitor of DNA Binding-3 Autocrine Pathway J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4603 - 4611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Donangelo, S. Gutman, E. Horvath, K. Kovacs, K. Wawrowsky, M. Mount, and S. Melmed Pituitary Tumor Transforming Gene Overexpression Facilitates Pituitary Tumor Development Endocrinology, October 1, 2006; 147(10): 4781 - 4791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W E Farrell Pituitary tumours: findings from whole genome analyses. Endocr. Relat. Cancer, September 1, 2006; 13(3): 707 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Holland and S. S. Taylor Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction J. Cell Sci., August 15, 2006; 119(16): 3325 - 3336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Fraenkel, J Caloyeras, S-G Ren, and S Melmed Sex-steroid milieu determines diabetes rescue in pttg-null mice. J. Endocrinol., June 1, 2006; 189(3): 519 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Gil-Bernabe, F. Romero, M. C. Limon-Mortes, and M. Tortolero Protein Phosphatase 2A Stabilizes Human Securin, Whose Phosphorylated Forms Are Degraded via the SCF Ubiquitin Ligase. Mol. Cell. Biol., June 1, 2006; 26(11): 4017 - 4027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tfelt-Hansen, D. Kanuparthi, and N. Chattopadhyay The emerging role of pituitary tumor transforming gene in tumorigenesis. Clin. Med. Res., June 1, 2006; 4(2): 130 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Chattopadhyay Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E761 - E770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-I Chao, S.-H. Hsu, and T.-C. Tsou Depletion of Securin Increases Arsenite-Induced Chromosome Instability and Apoptosis via a p53-Independent Pathway Toxicol. Sci., March 1, 2006; 90(1): 73 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Kim, J. A. Franklyn, A. L. Stratford, K. Boelaert, J. C. Watkinson, M. C. Eggo, and C. J. McCabe Pituitary Tumor-Transforming Gene Regulates Multiple Downstream Angiogenic Genes in Thyroid Cancer J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 1119 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Heaney Pituitary tumour pathogenesis. Br. Med. Bull., January 1, 2006; 75-76: 81 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-I Chao and H.-F. Liu The Blockage of Survivin and Securin Expression Increases the Cytochalasin B-Induced Cell Death and Growth Inhibition in Human Cancer Cells Mol. Pharmacol., January 1, 2006; 69(1): 154 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Huang, R. Hatcher, J. P. York, and P. Zhang Securin and Separase Phosphorylation Act Redundantly to Maintain Sister Chromatid Cohesion in Mammalian Cells Mol. Biol. Cell, October 1, 2005; 16(10): 4725 - 4732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G Morris, M. Musat, S. Czirjak, Z. Hanzely, D. M Lillington, M. Korbonits, and A. B Grossman Differential gene expression in pituitary adenomas by oligonucleotide array analysis Eur. J. Endocrinol., July 1, 2005; 153(1): 143 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Stratford, K. Boelaert, L. A. Tannahill, D. S. Kim, A. Warfield, M. C. Eggo, N. J. L. Gittoes, L. S. Young, J. A. Franklyn, and C. J. McCabe Pituitary Tumor Transforming Gene Binding Factor: A Novel Transforming Gene in Thyroid Tumorigenesis J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4341 - 4349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Tsai, S.-J. Lin, Y.-M. Cheng, H.-M. Chen, and L.-Y. C. Wing Expression and Functional Analysis of Pituitary Tumor Transforming Growth Factor-1 in Uterine Leiomyomas J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3715 - 3723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Abbud, I. Takumi, E. M Barker, S.-G. Ren, D.-Y. Chen, K. Wawrowsky, and S. Melmed Early Multipotential Pituitary Focal Hyperplasia in the {alpha}-Subunit of Glycoprotein Hormone-Driven Pituitary Tumor-Transforming Gene Transgenic Mice Mol. Endocrinol., May 1, 2005; 19(5): 1383 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Boelaert, R Yu, L A Tannahill, A L Stratford, F L Khanim, M C Eggo, J S Moore, L S Young, N J L Gittoes, J A Franklyn, et al. PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro J. Mol. Endocrinol., December 1, 2004; 33(3): 663 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Mohammad, D. D. Seachrist, C. C. Quirk, and J. H. Nilson Reexpression of p8 Contributes to Tumorigenic Properties of Pituitary Cells and Appears in a Subset of Prolactinomas in Transgenic Mice that Hypersecrete Luteinizing Hormone Mol. Endocrinol., October 1, 2004; 18(10): 2583 - 2593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tfelt-Hansen, S. Yano, S. Bandyopadhyay, R. Carroll, E. M. Brown, and N. Chattopadhyay Expression of Pituitary Tumor Transforming Gene (PTTG) and Its Binding Protein in Human Astrocytes and Astrocytoma Cells: Function and Regulation of PTTG in U87 Astrocytoma Cells Endocrinology, September 1, 2004; 145(9): 4222 - 4231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bahar, D. J. Simpson, S. J. Cutty, J. E. Bicknell, P. R. Hoban, S. Holley, M. Mourtada-Maarabouni, G. T. Williams, R. N. Clayton, and W. E. Farrell Isolation and Characterization of a Novel Pituitary Tumor Apoptosis Gene Mol. Endocrinol., July 1, 2004; 18(7): 1827 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tfelt-Hansen, P. Schwarz, E. F. Terwilliger, E. M. Brown, and N. Chattopadhyay Calcium-Sensing Receptor Induces Messenger Ribonucleic Acid of Human Securin, Pituitary Tumor Transforming Gene, in Rat Testicular Cancer Endocrinology, December 1, 2003; 144(12): 5188 - 5193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ezzat Pituitary Tumor Pathogenesis--The Hunt for Novel Candidate Genes Continues J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5116 - 5118. [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, Y. Zhou, K. R. Mehta, D. C. Danila, S. Scolavino, S. R. Johnson, and A. Klibanski A Pituitary-Derived MEG3 Isoform Functions as a Growth Suppressor in Tumor Cells J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5119 - 5126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yu, W. Lu, J. Chen, C. J. McCabe, and S. Melmed Overexpressed Pituitary Tumor-Transforming Gene Causes Aneuploidy in Live Human Cells Endocrinology, November 1, 2003; 144(11): 4991 - 4998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Turner, A. L. Harris, S. Melmed, and J. A. H. Wass Angiogenesis in Endocrine Tumors Endocr. Rev., October 1, 2003; 24(5): 600 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lania, G. Mantovani, and A. Spada Genetics of Pituitary Tumors: Focus on G-Protein Mutations Experimental Biology and Medicine, October 1, 2003; 228(9): 1004 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Mohammad, R. A. Abbud, A. F. Parlow, J. S. Lewin, and J. H. Nilson Targeted Overexpression of Luteinizing Hormone Causes Ovary-Dependent Functional Adenomas Restricted to Cells of the Pit-1 Lineage Endocrinology, October 1, 2003; 144(10): 4626 - 4636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. BOELAERT, L. A. TANNAHILL, J. N. BULMER, S. KACHILELE, S. Y. CHAN, D. KIM, N. J. L. GITTOES, J. A. FRANKLYN, M. D. KILBY, and C. J. MCCABE A potential role for PTTG/securin in the developing human fetal brain FASEB J, September 1, 2003; 17(12): 1631 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Boelaert, C. J. McCabe, L. A. Tannahill, N. J. L. Gittoes, R. L. Holder, J. C. Watkinson, A. R. Bradwell, M. C. Sheppard, and J. A. Franklyn Pituitary Tumor Transforming Gene and Fibroblast Growth Factor-2 Expression: Potential Prognostic Indicators in Differentiated Thyroid Cancer J. Clin. Endocrinol. Metab., May 1, 2003; 88(5): 2341 - 2347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Horwitz, I. Miklovsky, A. P. Heaney, S.-G. Ren, and S. Melmed Human Pituitary Tumor-Transforming Gene (PTTG1) Motif Suppresses Prolactin Expression Mol. Endocrinol., April 1, 2003; 17(4): 600 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Wang, E. Moro, K. Kovacs, R. Yu, and S. Melmed Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes PNAS, March 18, 2003; 100(6): 3428 - 3432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Castro, D. Giacomini, A. C. Nagashima, C. Onofri, M. Graciarena, K. Kobayashi, M. Paez-Pereda, U. Renner, G. K. Stalla, and E. Arzt Reduced Expression of the Cytokine Transducer gp130 Inhibits Hormone Secretion, Cell Growth, and Tumor Development of Pituitary Lactosomatotrophic GH3 Cells Endocrinology, February 1, 2003; 144(2): 693 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhou, K. R. Mehta, A. P. Choi, S. Scolavino, and X. Zhang DNA Damage-induced Inhibition of Securin Expression Is Mediated by p53 J. Biol. Chem., January 3, 2003; 278(1): 462 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pascual-Le Tallec, E. Dulmet, X. Bertagna, and Y. de Keyzer Identification of Genes Associated with the Corticotroph Phenotype in Bronchial Carcinoid Tumors J. Clin. Endocrinol. Metab., November 1, 2002; 87(11): 5015 - 5022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Cruz-Soto, M. D. Scheiber, K. A. Gregerson, G. P. Boivin, and N. D. Horseman Pituitary Tumorigenesis in Prolactin Gene-Disrupted Mice Endocrinology, November 1, 2002; 143(11): 4429 - 4436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shibata, N. Haruki, Y. Kuwabara, T. Nishiwaki, J. Kato, N. Shinoda, A. Sato, M. Kimura, H. Koyama, T. Toyama, et al. Expression of PTTG (Pituitary Tumor Transforming Gene) in Esophageal Cancer Jpn. J. Clin. Oncol., July 1, 2002; 32(7): 233 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hagting, N. den Elzen, H. C. Vodermaier, I. C. Waizenegger, J.-M. Peters, and J. Pines Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 J. Cell Biol., June 24, 2002; 157(7): 1125 - 1137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Whitfield, G. Sherlock, A. J. Saldanha, J. I. Murray, C. A. Ball, K. E. Alexander, J. C. Matese, C. M. Perou, M. M. Hurt, P. O. Brown, et al. Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors Mol. Biol. Cell, June 1, 2002; 13(6): 1977 - 2000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Fagin Minireview: Branded from the Start--Distinct Oncogenic Initiating Events May Determine Tumor Fate in the Thyroid Mol. Endocrinol., May 1, 2002; 16(5): 903 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, H. Sun, D. C. Danila, S. R. Johnson, Y. Zhou, B. Swearingen, and A. Klibanski Loss of Expression of GADD45{gamma}, a Growth Inhibitory Gene, in Human Pituitary Adenomas: Implications for Tumorigenesis J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1262 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ben-Jonathan and R. Hnasko Dopamine as a Prolactin (PRL) Inhibitor Endocr. Rev., December 1, 2001; 22(6): 724 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Kakar, L. Chen, R. Puri, S. E. Flynn, and L. Jennes Characterization of a Polyclonal Antibody to Human Pituitary Tumor Transforming Gene 1 (PTTG1) Protein J. Histochem. Cytochem., December 1, 2001; 49(12): 1537 - 1546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Brinkmeier, J. H. Stahl, D. F. Gordon, B. D. Ross, V. D. Sarapura, J. M. Dowding, S. K. Kendall, R. V. Lloyd, E. C. Ridgway, and S. A. Camper Thyroid Hormone-Responsive Pituitary Hyperplasia Independent of Somatostatin Receptor 2 Mol. Endocrinol., December 1, 2001; 15(12): 2129 - 2136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Wang, R. Yu, and S. Melmed Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere Division Mol. Endocrinol., November 1, 2001; 15(11): 1870 - 1879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Heaney, V. Nelson, M. Fernando, and G. Horwitz Transforming Events in Thyroid Tumorigenesis and Their Association with Follicular Lesions J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 5025 - 5032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Romero, M.-C. Multon, F. Ramos-Morales, A. Dominguez, J. A. Bernal, J. A. Pintor-Toro, and M. Tortolero Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase Nucleic Acids Res., March 15, 2001; 29(6): 1300 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ishikawa, A. P. Heaney, R. Yu, G. A. Horwitz, and S. Melmed Human Pituitary Tumor-Transforming Gene Induces Angiogenesis J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 867 - 874. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. N. Clayton, M. Pfeifer, A. B. Atkinson, P. Belchetz, J. A. H. Wass, E. Kyrodimou, M. Vanderpump, D. Simpson, J. Bicknell, and W. E. Farrell Different Patterns of Allelic Loss (Loss of Heterozygosity) in Recurrent Human Pituitary Tumors Provide Evidence for Multiclonal Origins Clin. Cancer Res., October 1, 2000; 6(10): 3973 - 3982. [Abstract] [Full Text]
|
|
|
|
 |
|
 O. Leismann, A. Herzig, S. Heidmann, and C. F. Lehner Degradation of Drosophila PIM regulates sister chromatid separation during mitosis Genes & Dev., September 1, 2000; 14(17): 2192 - 2205. [Abstract] [Full Text]
|
|
|
|
|
|
R. Yu, S.-G. Ren, G. A. Horwitz, Z. Wang, and S. Melmed Pituitary Tumor Transforming Gene (PTTG) Regulates Placental JEG-3 Cell Division and Survival: Evidence from Live Cell Imaging Mol. Endocrinol., August 1, 2000; 14(8): 1137 - 1146. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Nasmyth, J. Peters, and F. Uhlmann Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids Science, May 26, 2000; 288(5470): 1379 - 1384. [Abstract] [Full Text]
|
|
|
|
|
|
Z. Wang and S. Melmed Pituitary Tumor Transforming Gene (PTTG) Transforming and Transactivation Activity J. Biol. Chem., March 10, 2000; 275(11): 7459 - 7461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Wang and S. Melmed Characterization of the Murine Pituitary Tumor Transforming Gene (PTTG) and Its Promoter Endocrinology, February 1, 2000; 141(2): 763 - 771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zou, T. J. McGarry, T. Bernal, and M. W. Kirschner Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis Science, July 16, 1999; 285(5426): 418 - 422. [Abstract] [Full Text]
|
|
|
|
|
|
P. L. M. Dahia and A. B. Grossman The Molecular Pathogenesis of Corticotroph Tumors Endocr. Rev., April 1, 1999; 20(2): 136 - 155. [Abstract] [Full Text]
|
|
|
|
|
|
X. Zhang, G. A. Horwitz, A. P. Heaney, M. Nakashima, T. R. Prezant, M. D. Bronstein, and S. Melmed Pituitary Tumor Transforming Gene (PTTG) Expression in Pituitary Adenomas J. Clin. Endocrinol. Metab., February 1, 1999; 84(2): 761 - 767. [Abstract] [Full Text]
|
|
|
|
|
|
L. Pei Pituitary Tumor-transforming Gene Protein Associates with Ribosomal Protein S10 and a Novel Human Homologue of DnaJ in Testicular Cells J. Biol. Chem., January 29, 1999; 274(5): 3151 - 3158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, G. A. Horwitz, T. R. Prezant, A. Valentini, M. Nakashima, M. D. Bronstein, and S. Melmed Structure, Expression, and Function of Human Pituitary Tumor-Transforming Gene (PTTG) Mol. Endocrinol., January 1, 1999; 13(1): 156 - 166. [Abstract] [Full Text]
|
|
|
|
|
|
S. L. Asa and S. Ezzat The Cytogenesis and Pathogenesis of Pituitary Adenomas Endocr. Rev., December 1, 1998; 19(6): 798 - 827. [Abstract] [Full Text]
|
|
|
|
|
|
L. Pei Genomic Organization and Identification of an Enhancer Element Containing Binding Sites for Multiple Proteins in Rat Pituitary Tumor-transforming Gene J. Biol. Chem., February 27, 1998; 273(9): 5219 - 5225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pei Activation of Mitogen-activated Protein Kinase Cascade Regulates Pituitary Tumor-transforming Gene Transactivation Function J. Biol. Chem., September 29, 2000; 275(40): 31191 - 31198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pei Identification of c-myc as a Down-stream Target for Pituitary Tumor-transforming Gene J. Biol. Chem., March 9, 2001; 276(11): 8484 - 8491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chien and L. Pei A Novel Binding Factor Facilitates Nuclear Translocation and Transcriptional Activation Function of the Pituitary Tumor-transforming Gene Product J. Biol. Chem., June 16, 2000; 275(25): 19422 - 19427. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
