help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bonnelye, E.
Right arrow Articles by Fournier, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bonnelye, E.
Right arrow Articles by Fournier, B.
Molecular Endocrinology 11 (7): 905-916
Copyright © 1997 by The Endocrine Society

The ERR-1 Orphan Receptor Is a Transcriptional Activator Expressed During Bone Development

Edith Bonnelye1, Jean Marc Vanacker1, Tanja Dittmar, Agnes Begue, Xavier Desbiens, David T. Denhardt, Jane E. Aubin, Vincent Laudet and Brigitte Fournier

Endocrin’os group (E.B., J.M.V., A.B., V.L.), CNRS UMR 319 Mécanismes du développement et de la Cancérisation Institut de Biologie de Lille, 59021 Lille Cedex France, Novartis Pharma AG (T.D., B.F.), K125 9–17, P11002 Basel, Switzerland Department of Biological Sciences (D.T.D.), Rutgers University, Piscataway, New Jersey 08855, Department of Anatomy and Cell Biology (J.E.A.), University of Toronto, Toronto, M5S 1A8 Canada Centre de Biologie Cellulaire du Développement (X.D.) Université des Sciences et Techniques de Lille Villeneuve d’Ascq, France

We studied the expression of estrogen-related receptor ERR-1 during mouse embryonic development. ERR-1 mRNA is present in bones formed by both the endochondral and intramembranous routes, and the onset of its expression coincides with bone formation. By RT-PCR experiments, we found that ERR-1, but not the related receptor ERR-2, is expressed in osteoblastic osteosarcoma cell lines as well as in primary osteoblastic cell populations derived from normal human bone. By gel shift analysis we found that ERR-1 binds as a monomer specifically to the SFRE sequence (SF-1-responsive-element; TCAAGGTCA). Mutation analysis revealed that both the core AGGTCA motif and the TCA 5'-extension are required for efficient ERR-1 binding. In transient transfection assays, ERR-1 acts as a potent transactivator through the SFRE sequence. This effect is cell-specific since ERR-1 activates transcription in the rat osteosarcoma cell line ROS 17.2/8 as well as in HeLa, NB-E, and FREJ4 cells but not in COS1 and HepG2 cells. Notably, the osteopontin (a protein expressed by osteoblasts and released in the bone matrix) gene promoter is a target for ERR-1 transcriptional regulation. Our findings suggest a role for ERR-1 in bone development and metabolism.




This article has been cited by other articles:


Home page
 J. Virol.Home page
C. R. Ondracek, C. N. Rushing, V. C. Reese, C. E. Oropeza, and A. McLachlan
Peroxisome Proliferator-Activated Receptor {gamma} Coactivator 1{alpha} and Small Heterodimer Partner Differentially Regulate Nuclear Receptor-Dependent Hepatitis B Virus Biosynthesis
J. Virol., December 1, 2009; 83(23): 12535 - 12544.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. R. Ondracek, V. C. Reese, C. N. Rushing, C. E. Oropeza, and A. McLachlan
Distinct Regulation of Hepatitis B Virus Biosynthesis by Peroxisome Proliferator-Activated Receptor {gamma} Coactivator 1{alpha} and Small Heterodimer Partner in Human Hepatoma Cell Lines
J. Virol., December 1, 2009; 83(23): 12545 - 12551.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I. Delhon, S. Gutzwiller, F. Morvan, S. Rangwala, L. Wyder, G. Evans, A. Studer, M. Kneissel, and B. Fournier
Absence of Estrogen Receptor-Related-{alpha} Increases Osteoblastic Differentiation and Cancellous Bone Mineral Density
Endocrinology, October 1, 2009; 150(10): 4463 - 4472.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. L. Grasfeder, S. Gaillard, S. R. Hammes, O. Ilkayeva, C. B. Newgard, R. B. Hochberg, M. A. Dwyer, C.-y. Chang, and D. P. McDonnell
Fasting-Induced Hepatic Production of DHEA Is Regulated by PGC-1{alpha}, ERR{alpha}, and HNF4{alpha}
Mol. Endocrinol., August 1, 2009; 23(8): 1171 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
Mst. H. Akter, T. Chano, H. Okabe, T. Yamaguchi, F. Hirose, and T. Osumi
Target Specificities of Estrogen Receptor-Related Receptors: Analysis of Binding Sequences and Identification of Rb1-Inducible Coiled-Coil 1 (Rb1cc1) as a Target Gene
J. Biochem., March 1, 2008; 143(3): 395 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Gaillard, M. A. Dwyer, and D. P. McDonnell
Definition of the Molecular Basis for Estrogen Receptor-Related Receptor-{alpha}-Cofactor Interactions
Mol. Endocrinol., January 1, 2007; 21(1): 62 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
G. Benoit, A. Cooney, V. Giguere, H. Ingraham, M. Lazar, G. Muscat, T. Perlmann, J.-P. Renaud, J. Schwabe, F. Sladek, et al.
International Union of Pharmacology. LXVI. Orphan Nuclear Receptors
Pharmacol. Rev., December 1, 2006; 58(4): 798 - 836.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
A M Tarrant, S R Greytak, G V Callard, and M E Hahn
Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness.
J. Mol. Endocrinol., August 1, 2006; 37(1): 105 - 120.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. Castet, A. Herledan, S. Bonnet, S. Jalaguier, J.-M. Vanacker, and V. Cavailles
Receptor-Interacting Protein 140 Differentially Regulates Estrogen Receptor-Related Receptor Transactivation Depending on Target Genes
Mol. Endocrinol., May 1, 2006; 20(5): 1035 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. B. Barry, J. Laganiere, and V. Giguere
A Single Nucleotide in an Estrogen-Related Receptor {alpha} Site Can Dictate Mode of Binding and Peroxisome Proliferator-Activated Receptor {gamma} Coactivator 1{alpha} Activation of Target Promoters
Mol. Endocrinol., February 1, 2006; 20(2): 302 - 310.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Herzog, J. Cardenas, R. K. Hall, J. A. Villena, P. J. Budge, V. Giguere, D. K. Granner, and A. Kralli
Estrogen-related Receptor {alpha} Is a Repressor of Phosphoenolpyruvate Carboxykinase Gene Transcription
J. Biol. Chem., January 6, 2006; 281(1): 99 - 106.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Seely, K. S. Amigh, T. Suzuki, B. Mayhew, H. Sasano, V. Giguere, J. Laganiere, B. R. Carr, and W. E. Rainey
Transcriptional Regulation of Dehydroepiandrosterone Sulfotransferase (SULT2A1) by Estrogen-Related Receptor {alpha}
Endocrinology, August 1, 2005; 146(8): 3605 - 3613.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. B. Barry and V. Giguere
Epidermal Growth Factor-Induced Signaling in Breast Cancer Cells Results in Selective Target Gene Activation by Orphan Nuclear Receptor Estrogen-Related Receptor {alpha}
Cancer Res., July 15, 2005; 65(14): 6120 - 6129.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Bonnelye and J. E. Aubin
Estrogen Receptor-Related Receptor {alpha}: A Mediator of Estrogen Response in Bone
J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 3115 - 3121.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. P. Cheung, S. Yu, K. B. Wong, L. W. Chan, F. M. M. Lai, X. Wang, M. Suetsugi, S. Chen, and F. L. Chan
Expression and Functional Study of Estrogen Receptor-Related Receptors in Human Prostatic Cells and Tissues
J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1830 - 1844.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. M. Kennedy, K. L. Shogren, M. Zhang, R. T. Turner, T. C. Spelsberg, and A. Maran
17{beta}-Estradiol-Dependent Activation of Signal Transducer and Activator of Transcription-1 in Human Fetal Osteoblasts Is Dependent on Src Kinase Activity
Endocrinology, January 1, 2005; 146(1): 201 - 207.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Kallen, J.-M. Schlaeppi, F. Bitsch, I. Filipuzzi, A. Schilb, V. Riou, A. Graham, A. Strauss, M. Geiser, and B. Fournier
Evidence for Ligand-independent Transcriptional Activation of the Human Estrogen-related Receptor {alpha} (ERR{alpha}): CRYSTAL STRUCTURE OF ERR{alpha} LIGAND BINDING DOMAIN IN COMPLEX WITH PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR COACTIVATOR-1{alpha}
J. Biol. Chem., November 19, 2004; 279(47): 49330 - 49337.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
B Horard, A Castet, P-L Bardet, V Laudet, V Cavailles, and J-M Vanacker
Dimerization is required for transactivation by estrogen-receptor-related (ERR) orphan receptors: evidence from amphioxus ERR
J. Mol. Endocrinol., October 1, 2004; 33(2): 493 - 509.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. J. Willy, I. R. Murray, J. Qian, B. B. Busch, W. C. Stevens Jr., R. Martin, R. Mohan, S. Zhou, P. Ordentlich, P. Wei, et al.
Regulation of PPAR{gamma} coactivator 1{alpha} (PGC-1{alpha}) signaling by an estrogen-related receptor {alpha} (ERR{alpha}) ligand
PNAS, June 15, 2004; 101(24): 8912 - 8917.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Lammi, J. Huppunen, and P. Aarnisalo
Regulation of the Osteopontin Gene by the Orphan Nuclear Receptor NURR1 in Osteoblasts
Mol. Endocrinol., June 1, 2004; 18(6): 1546 - 1557.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. El-Tanani, A. Platt-Higgins, P. S. Rudland, and F. C. Campbell
Ets Gene PEA3 Cooperates with {beta}-Catenin-Lef-1 and c-Jun in Regulation of Osteopontin Transcription
J. Biol. Chem., May 14, 2004; 279(20): 20794 - 20806.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Laganiere, G. B. Tremblay, C. R. Dufour, S. Giroux, F. Rousseau, and V. Giguere
A Polymorphic Autoregulatory Hormone Response Element in the Human Estrogen-related Receptor {alpha} (ERR{alpha}) Promoter Dictates Peroxisome Proliferator-activated Receptor {gamma} Coactivator-1{alpha} Control of ERR{alpha} Expression
J. Biol. Chem., April 30, 2004; 279(18): 18504 - 18510.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. N. Schreiber, R. Emter, M. B. Hock, D. Knutti, J. Cardenas, M. Podvinec, E. J. Oakeley, and A. Kralli
The estrogen-related receptor {alpha} (ERR{alpha}) functions in PPAR{gamma} coactivator 1{alpha} (PGC-1{alpha})-induced mitochondrial biogenesis
PNAS, April 27, 2004; 101(17): 6472 - 6477.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Luo, R. Sladek, J. Carrier, J.-A. Bader, D. Richard, and V. Giguere
Reduced Fat Mass in Mice Lacking Orphan Nuclear Receptor Estrogen-Related Receptor {alpha}
Mol. Cell. Biol., November 15, 2003; 23(22): 7947 - 7956.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Liu, Z. Zhang, W. Gladwell, and C. T. Teng
Estrogen Stimulates Estrogen-Related Receptor {alpha} Gene Expression through Conserved Hormone Response Elements
Endocrinology, November 1, 2003; 144(11): 4894 - 4904.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. N. Schreiber, D. Knutti, K. Brogli, T. Uhlmann, and A. Kralli
The Transcriptional Coactivator PGC-1 Regulates the Expression and Activity of the Orphan Nuclear Receptor Estrogen-Related Receptor alpha (ERRalpha )
J. Biol. Chem., March 7, 2003; 278(11): 9013 - 9018.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
M. Igarashi, Y. Kawaguchi, K. Hirai, and F. Mizuno
Physical interaction of Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) with human oestrogen-related receptor 1 (hERR1): hERR1 interacts with a conserved domain of EBNA-LP that is critical for EBV-induced B-cell immortalization
J. Gen. Virol., January 1, 2003; 84(2): 319 - 327.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Bidder, J.-S. Shao, N. Charlton-Kachigian, A. P. Loewy, C. F. Semenkovich, and D. A. Towler
Osteopontin Transcription in Aortic Vascular Smooth Muscle Cells Is Controlled by Glucose-regulated Upstream Stimulatory Factor and Activator Protein-1 Activities
J. Biol. Chem., November 8, 2002; 277(46): 44485 - 44496.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. Bonnelye, V. Kung, C. Laplace, D. L. Galson, and J. E. Aubin
Estrogen Receptor-Related Receptor {alpha} Impinges on the Estrogen Axis in Bone: Potential Function in Osteoporosis
Endocrinology, September 1, 2002; 143(9): 3658 - 3670.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. J. Kraus, E. A. Ariazi, M. L. Farrell, and J. E. Mertz
Estrogen-related Receptor alpha 1 Actively Antagonizes Estrogen Receptor-regulated Transcription in MCF-7 Mammary Cells
J. Biol. Chem., June 28, 2002; 277(27): 24826 - 24834.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. El-Tanani, D. G. Fernig, R. Barraclough, C. Green, and P. Rudland
Differential Modulation of Transcriptional Activity of Estrogen Receptors by Direct Protein-Protein Interactions with the T Cell Factor Family of Transcription Factors
J. Biol. Chem., November 2, 2001; 276(45): 41675 - 41682.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. Nilsson, S. Makela, E. Treuter, M. Tujague, J. Thomsen, G. Andersson, E. Enmark, K. Pettersson, M. Warner, and J.-A. Gustafsson
Mechanisms of Estrogen Action
Physiol Rev, October 1, 2001; 81(4): 1535 - 1565.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Lu, Y. Kiriyama, K. Y. Lee, and V. Giguere
Transcriptional Regulation of the Estrogen-inducible pS2 Breast Cancer Marker Gene by the ERR Family of Orphan Nuclear Receptors
Cancer Res., September 1, 2001; 61(18): 6755 - 6761.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Coward, D. Lee, M. V. Hull, and J. M. Lehmann
4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma
PNAS, July 5, 2001; (2001) 151244398.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
E. Bonnelye, L. Merdad, V. Kung, and J.E. Aubin
The Orphan Nuclear Estrogen Receptor-Related Receptor {alpha} (Err{alpha}) Is Expressed Throughout Osteoblast Differentiation and Regulates Bone Formation in Vitro
J. Cell Biol., May 28, 2001; 153(5): 971 - 984.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. J. Heard, P. L. Norby, J. Holloway, and H. Vissing
Human ERR{gamma}, a Third Member of the Estrogen Receptor-Related Receptor (ERR) Subfamily of Orphan Nuclear Receptors: Tissue-Specific Isoforms Are Expressed during Development and in the Adult
Mol. Endocrinol., March 1, 2000; 14(3): 382 - 392.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
W. Xie, H. Hong, N. N. Yang, R. J. Lin, C. M. Simon, M. R. Stallcup, and R. M. Evans
Constitutive Activation of Transcription and Binding of Coactivator by Estrogen-Related Receptors 1 and 2
Mol. Endocrinol., December 1, 1999; 13(12): 2151 - 2162.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
V. Giguère
Orphan Nuclear Receptors: From Gene to Function
Endocr. Rev., October 1, 1999; 20(5): 689 - 725.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
C. Yang and S. Chen
Two Organochlorine Pesticides, Toxaphene and Chlordane, Are Antagonists for Estrogen-related Receptor {{alpha}}-1 Orphan Receptor
Cancer Res., September 1, 1999; 59(18): 4519 - 4524.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Lavrovsky, R. K. Tyagi, S. Chen, C. S. Song, B. Chatterjee, and A. K. Roy
Ribozyme-Mediated Cleavage of the Estrogen Receptor Messenger RNA and Inhibition of Receptor Function in Target Cells
Mol. Endocrinol., June 1, 1999; 13(6): 925 - 934.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
J.-M. Vanacker, E. Bonnelye, S. Chopin-Delannoy, C. Delmarre, V. Cavaillès, and V. Laudet
Transcriptional Activities of the Orphan Nuclear Receptor ERR{alpha} (Estrogen Receptor-Related Receptor-{alpha})
Mol. Endocrinol., May 1, 1999; 13(5): 764 - 773.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
R. B. Vega and D. P. Kelly
A Role for Estrogen-related Receptor alpha  in the Control of Mitochondrial Fatty Acid beta -Oxidation during Brown Adipocyte Differentiation
J. Biol. Chem., December 12, 1997; 272(50): 31693 - 31699.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Zhang and C. T. Teng
Estrogen Receptor-related Receptor alpha 1 Interacts with Coactivator and Constitutively Activates the Estrogen Response Elements of the Human Lactoferrin Gene
J. Biol. Chem., June 30, 2000; 275(27): 20837 - 20846.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Meyer, M. Kneissel, J. Mariani, and B. Fournier
In vitro and in vivo evidence for orphan nuclear receptor RORalpha function in bone metabolism
PNAS, August 1, 2000; 97(16): 9197 - 9202.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Coward, D. Lee, M. V. Hull, and J. M. Lehmann
4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma
PNAS, July 17, 2001; 98(15): 8880 - 8884.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1997 by The Endocrine Society