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Metabolic Research Unit (P.W., P.N., J.S., C.A., W.-J.F.,
M.P.N., P.J.K.) University of California School of
Medicine San Francisco, California 94143-0540
Department
of Pathology (D.C., S.-M.H., S.S., M.R.S.) University of Southern
California Los Angeles, California 90033
Department of
Physiology and Biophysics (E.M., B.S.K.) University of Illinois
Urbana, Illinois 61801
Estrogen receptor-
contains two transactivation
functions, a weak constitutive activation function (AF-1) and a
hormone-dependent activation function (AF-2). AF-2 works by recruiting
a large coactivator complex, composed of one or more p160s,
CREB-binding protein (CBP)/p300, and P/CAF (p300 and CBP-associated
factor), via direct contacts with the p160s. We report here that
independent AF-1 activity also requires p160 contacts. Unlike AF-2,
which binds signature NR boxes in the center of the p160 molecule, AF-1
binds to sequences near the p160 C terminus. We propose that the
ability of AF-1 and AF-2 to interact with separate surfaces of the same
coactivator is important for the ability of these transactivation
functions to synergize.
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C. K. Cheng, B. K. C. Chow, and P. C. K. Leung An Activator Protein 1-Like Motif Mediates 17{beta}-Estradiol Repression of Gonadotropin-Releasing Hormone Receptor Promoter via an Estrogen Receptor {alpha}-Dependent Mechanism in Ovarian and Breast Cancer Cells Mol. Endocrinol., December 1, 2003; 17(12): 2613 - 2629. [Abstract] [Full Text] [PDF]
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C. Zhao, A. Koide, J. Abrams, S. Deighton-Collins, A. Martinez, J. A. Schwartz, S. Koide, and D. F. Skafar Mutation of Leu-536 in Human Estrogen Receptor-{alpha} Alters the Coupling between Ligand Binding, Transcription Activation, and Receptor Conformation J. Biol. Chem., July 11, 2003; 278(29): 27278 - 27286. [Abstract] [Full Text] [PDF]
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M. Dutertre and C. L. Smith Ligand-Independent Interactions of p160/Steroid Receptor Coactivators and CREB-Binding Protein (CBP) with Estrogen Receptor-{alpha}: Regulation by Phosphorylation Sites in the A/B Region Depends on Other Receptor Domains Mol. Endocrinol., July 1, 2003; 17(7): 1296 - 1314. [Abstract] [Full Text] [PDF]
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 S. Shin and I. M. Verma BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription PNAS, June 10, 2003; 100(12): 7201 - 7206. [Abstract] [Full Text] [PDF]
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B. J. Cheskis, N. J. McKenna, C.-W. Wong, J. Wong, B. Komm, C. R. Lyttle, and B. W. O'Malley Hierarchical Affinities and a Bipartite Interaction Model for Estrogen Receptor Isoforms and Full-length Steroid Receptor Coactivator (SRC/p160) Family Members J. Biol. Chem., April 4, 2003; 278(15): 13271 - 13277. [Abstract] [Full Text] [PDF]
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P. Webb, P. Nguyen, and P. J. Kushner Differential SERM Effects on Corepressor Binding Dictate ERalpha Activity in Vivo J. Biol. Chem., February 21, 2003; 278(9): 6912 - 6920. [Abstract] [Full Text] [PDF]
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S. Zhou, G. Turgeman, S. E. Harris, D. C. Leitman, B. S. Komm, P. V. N. Bodine, and D. Gazit Estrogens Activate Bone Morphogenetic Protein-2 Gene Transcription in Mouse Mesenchymal Stem Cells Mol. Endocrinol., January 1, 2003; 17(1): 56 - 66. [Abstract] [Full Text] [PDF]
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V. Christiaens, C. L. Bevan, L. Callewaert, A. Haelens, G. Verrijdt, W. Rombauts, and F. Claessens Characterization of the Two Coactivator-interacting Surfaces of the Androgen Receptor and Their Relative Role in Transcriptional Control* J. Biol. Chem., December 13, 2002; 277(51): 49230 - 49237. [Abstract] [Full Text] [PDF]
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Y. He, D. Szapary, and S. S. Simons Jr. Modulation of Induction Properties of Glucocorticoid Receptor-Agonist and -Antagonist Complexes by Coactivators Involves Binding to Receptors but Is Independent of Ability of Coactivators to Augment Transactivation J. Biol. Chem., December 13, 2002; 277(51): 49256 - 49266. [Abstract] [Full Text] [PDF]
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C. Teyssier, D. Chen, and M. R. Stallcup Requirement for Multiple Domains of the Protein Arginine Methyltransferase CARM1 in Its Transcriptional Coactivator Function J. Biol. Chem., November 22, 2002; 277(48): 46066 - 46072. [Abstract] [Full Text] [PDF]
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M. E. Torres-Padilla, F. M. Sladek, and M. C. Weiss Developmentally Regulated N-terminal Variants of the Nuclear Receptor Hepatocyte Nuclear Factor 4alpha Mediate Multiple Interactions through Coactivator and Corepressor-Histone Deacetylase Complexes J. Biol. Chem., November 15, 2002; 277(47): 44677 - 44687. [Abstract] [Full Text] [PDF]
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