help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Robker, R. L.
Right arrow Articles by Richards, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Robker, R. L.
Right arrow Articles by Richards, J. S.
Molecular Endocrinology 12 (7): 924-940
Copyright © 1998 by The Endocrine Society

Hormone-Induced Proliferation and Differentiation of Granulosa Cells: A Coordinated Balance of the Cell Cycle Regulators Cyclin D2 and p27Kip1

Rebecca L. Robker and JoAnne S. Richards

Department of Cell Biology Baylor College of Medicine Houston, Texas 77030

The proliferation and terminal differentiation of granulosa cells are critical for normal follicular growth, ovulation, and luteinization. Therefore, the in situ localization and hormonal regulation of cell cycle activators (cyclin D1, D2, and D3) and cell cycle inhibitors (p27Kip1 and p21Cip1) were analyzed in ovaries of mice and rats at defined stages of follicular growth and differentiation. Cyclin D2 mRNA was specifically localized to granulosa cells of growing follicles, while cyclin D1 and cyclin D3 were restricted to theca cells. In hypophysectomized (H) rats, cyclin D2 mRNA and protein were increased in granulosa cells by treatment with estradiol or FSH and were increased maximally by treatment with both hormones. In serum-free cultures of rat granulosa cells, cyclin D2 mRNA was rapidly elevated in response to FSH, forskolin, and estradiol, indicating that estradiol as well as cAMP can act directly and independently to increase cyclin D2 expression. The levels of p27Kip1 protein were not increased in response to estradiol or FSH. In contrast, when ovulatory doses of human CG (LH) were administered to hormonally primed H rats to stimulate luteinization, cyclin D2 mRNA and protein were rapidly decreased and undetectable within 4 h, specifically in granulosa cells of large follicles. Also in response to LH, the expression of the cell cycle inhibitor p27Kip1 was induced between 12 and 24 h (p21Cip1 was induced within 4 h) and remained elevated specifically in luteal tissue. A critical role for cyclin D2 in the hormone-dependent phase of follicular growth is illustrated by the ovarian follicles of cyclin D2-/- mice, which do not undergo rapid growth in response to hormones, but do express markers of FSH/LH action, cell cycle exit, and terminal differentiation. Collectively, these data indicate that FSH and estradiol regulate granulosa cell proliferation during the development of preovulatory follicles by increasing levels of cyclin D2 relative to p27Kip1 and that LH terminates follicular growth by down-regulating cyclin D2 concurrent with up-regulation of p27Kip1 and p21Cip1.




This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
M. A. Edson, A. K. Nagaraja, and M. M. Matzuk
The Mammalian Ovary from Genesis to Revelation
Endocr. Rev., October 1, 2009; 30(6): 624 - 712.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S.-G. Kim, S.-J. Jang, J. Soh, K. Lee, J.-K. Park, W.-K. Chang, E.-W. Park, and S.-Y. Chun
Expression of Ectodermal Neural Cortex 1 and Its Association with Actin during the Ovulatory Process in the Rat
Endocrinology, August 1, 2009; 150(8): 3800 - 3806.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Ren, R. G. Cowan, R. M. Harman, and S. M. Quirk
Dominant Activation of the Hedgehog Signaling Pathway in the Ovary Alters Theca Development and Prevents Ovulation
Mol. Endocrinol., May 1, 2009; 23(5): 711 - 723.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. K. Nyholt de Prada, Y. S. Lee, K. E. Latham, C. L. Chaffin, and C. A. VandeVoort
Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro
Am J Physiol Endocrinol Metab, May 1, 2009; 296(5): E1049 - E1058.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
S. D. Fiedler, M. Z. Carletti, X. Hong, and L. K. Christenson
Hormonal Regulation of MicroRNA Expression in Periovulatory Mouse Mural Granulosa Cells
Biol Reprod, December 1, 2008; 79(6): 1030 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M. Myers, S. van den Driesche, A. S McNeilly, and W C. Duncan
Activin A reduces luteinisation of human luteinised granulosa cells and has opposing effects to human chorionic gonadotropin in vitro
J. Endocrinol., November 1, 2008; 199(2): 201 - 212.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Andreu-Vieyra, R. Chen, and M. M. Matzuk
Conditional Deletion of the Retinoblastoma (Rb) Gene in Ovarian Granulosa Cells Leads to Premature Ovarian Failure
Mol. Endocrinol., September 1, 2008; 22(9): 2141 - 2161.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H.-Y. Fan, Z. Liu, N. Cahill, and J. S. Richards
Targeted Disruption of Pten in Ovarian Granulosa Cells Enhances Ovulation and Extends the Life Span of Luteal Cells
Mol. Endocrinol., September 1, 2008; 22(9): 2128 - 2140.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
I. Kawashima, T. Okazaki, N. Noma, M. Nishibori, Y. Yamashita, and M. Shimada
Sequential exposure of porcine cumulus cells to FSH and/or LH is critical for appropriate expression of steroidogenic and ovulation-related genes that impact oocyte maturation in vivo and in vitro
Reproduction, July 1, 2008; 136(1): 9 - 21.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E.-S. Park, S. Choi, K. N. Muse, T. E. Curry Jr., and M. Jo
Response Gene to Complement 32 Expression Is Induced by the Luteinizing Hormone (LH) Surge and Regulated by LH-Induced Mediators in the Rodent Ovary
Endocrinology, June 1, 2008; 149(6): 3025 - 3036.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
K. Shkolnik, S. Ben-Dor, D. Galiani, A. Hourvitz, and N. Dekel
Molecular characterization and bioinformatics analysis of Ncoa7B, a novel ovulation-associated and reproduction system-specific Ncoa7 isoform
Reproduction, March 1, 2008; 135(3): 321 - 333.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M Mihm, P J Baker, L M Fleming, A M Monteiro, and P J O'Shaughnessy
Differentiation of the bovine dominant follicle from the cohort upregulates mRNA expression for new tissue development genes
Reproduction, February 1, 2008; 135(2): 253 - 265.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
J. K.X. Maier, S. Balabanian, C. R. Coffill, A. Stewart, L. Pelletier, D. J. Franks, N. H. Gendron, and A. E. MacKenzie
Distribution of Neuronal Apoptosis Inhibitory Protein in Human Tissues
J. Histochem. Cytochem., September 1, 2007; 55(9): 911 - 923.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Andreu-Vieyra, R. Chen, and M. M. Matzuk
Effects of Granulosa Cell-Specific Deletion of Rb in Inha-{alpha} Null Female Mice
Endocrinology, August 1, 2007; 148(8): 3837 - 3849.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
D. L. Russell and R. L. Robker
Molecular mechanisms of ovulation: co-ordination through the cumulus complex
Hum. Reprod. Update, May 1, 2007; 13(3): 289 - 312.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K.N. Fru, M. Cherian-Shaw, M. Puttabyatappa, C.A. VandeVoort, and C.L. Chaffin
Regulation of granulosa cell proliferation and EGF-like ligands during the periovulatory interval in monkeys
Hum. Reprod., May 1, 2007; 22(5): 1247 - 1252.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. Stocco, C. Telleria, and G. Gibori
The Molecular Control of Corpus Luteum Formation, Function, and Regression
Endocr. Rev., February 1, 2007; 28(1): 117 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Jo and T. E. Curry Jr.
Luteinizing Hormone-Induced RUNX1 Regulates the Expression of Genes in Granulosa Cells of Rat Periovulatory Follicles
Mol. Endocrinol., September 1, 2006; 20(9): 2156 - 2172.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
Y. S. Choi, S.-Y. Ku, B.-C. Jee, C.-S. Suh, Y. M. Choi, J. G. Kim, S. Y. Moon, and S. H. Kim
Comparison of follicular fluid IGF-I, IGF-II, IGFBP-3, IGFBP-4 and PAPP-A concentrations and their ratios between GnRH agonist and GnRH antagonist protocols for controlled ovarian stimulation in IVF-embryo transfer patients
Hum. Reprod., August 1, 2006; 21(8): 2015 - 2021.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
L. C. Muniz, G. Yehia, E. Memin, P. V.A.L. Ratnakar, and C. A. Molina
Transcriptional Regulation of Cyclin D2 by the PKA Pathway and Inducible cAMP Early Repressor in Granulosa Cells
Biol Reprod, August 1, 2006; 75(2): 279 - 288.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Assou, T. Anahory, V. Pantesco, T. Le Carrour, F. Pellestor, B. Klein, L. Reyftmann, H. Dechaud, J. De Vos, and S. Hamamah
The human cumulus-oocyte complex gene-expression profile
Hum. Reprod., July 1, 2006; 21(7): 1705 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Shao, B. Weijdegard, K. Ljungstrom, A. Friberg, C. Zhu, X. Wang, Y. Zhu, J. Fernandez-Rodriguez, E. Egecioglu, E. Rung, et al.
Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function
Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E59 - E72.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S. M Quirk, R. G Cowan, and R. M Harman
The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle.
J. Endocrinol., June 1, 2006; 189(3): 441 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
I. Hernandez-Gonzalez, I. Gonzalez-Robayna, M. Shimada, C. M. Wayne, S. A. Ochsner, L. White, and J. S. Richards
Gene Expression Profiles of Cumulus Cell Oocyte Complexes during Ovulation Reveal Cumulus Cells Express Neuronal and Immune-Related Genes: Does this Expand Their Role in the Ovulation Process?
Mol. Endocrinol., June 1, 2006; 20(6): 1300 - 1321.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. A. Pangas, X. Li, E. J. Robertson, and M. M. Matzuk
Premature Luteinization and Cumulus Cell Defects in Ovarian-Specific Smad4 Knockout Mice
Mol. Endocrinol., June 1, 2006; 20(6): 1406 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Mihm, P.J. Baker, J.L.H. Ireland, G.W. Smith, P.M. Coussens, A.C.O. Evans, and J.J. Ireland
Molecular Evidence That Growth of Dominant Follicles Involves a Reduction in Follicle-Stimulating Hormone Dependence and an Increase in Luteinizing Hormone Dependence in Cattle
Biol Reprod, June 1, 2006; 74(6): 1051 - 1059.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. Perlman, T. Bouquin, B. van den Hazel, T.H. Jensen, H.T. Schambye, S. Knudsen, and J.S. Okkels
Transcriptome analysis of FSH and FSH variant stimulation in granulosa cells from IVM patients reveals novel regulated genes
Mol. Hum. Reprod., March 1, 2006; 12(3): 135 - 144.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Boerboom, L. D. White, S. Dalle, J. Courty, and J. S. Richards
Dominant-Stable {beta}-Catenin Expression Causes Cell Fate Alterations and Wnt Signaling Antagonist Expression in a Murine Granulosa Cell Tumor Model
Cancer Res., February 15, 2006; 66(4): 1964 - 1973.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
V. Sriraman, M. D. Rudd, S. M. Lohmann, S. M. Mulders, and J. S. Richards
Cyclic Guanosine 5'-Monophosphate-Dependent Protein Kinase II Is Induced by Luteinizing Hormone and Progesterone Receptor-Dependent Mechanisms in Granulosa Cells and Cumulus Oocyte Complexes of Ovulating Follicles
Mol. Endocrinol., February 1, 2006; 20(2): 348 - 361.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
U. A. Bussmann, L. E. Bussmann, and J. L. Baranao
An Aryl Hydrocarbon Receptor Agonist Amplifies the Mitogenic Actions of Estradiol in Granulosa Cells: Evidence of Involvement of the Cognate Receptors
Biol Reprod, February 1, 2006; 74(2): 417 - 426.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
J. Banerjee and C. M Komar
Effects of luteinizing hormone on peroxisome proliferator-activated receptor {gamma} in the rat ovary before and after the gonadotropin surge
Reproduction, January 1, 2006; 131(1): 93 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. A. MacLean II, M. K. Rao, K. M.H. Doyle, J. S. Richards, and M. F. Wilkinson
Regulation of the Rhox5 Homeobox Gene in Primary Granulosa Cells: Preovulatory Expression and Dependence on SP1/SP3 and GABP
Biol Reprod, December 1, 2005; 73(6): 1126 - 1134.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Hsieh, D. Boerboom, M. Shimada, Y. Lo, A. F. Parlow, U. F.O. Luhmann, W. Berger, and J. S. Richards
Mice Null for Frizzled4 (Fzd4-/-) Are Infertile and Exhibit Impaired Corpora Lutea Formation and Function
Biol Reprod, December 1, 2005; 73(6): 1135 - 1146.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Boerboom, M. Paquet, M. Hsieh, J. Liu, S. P. Jamin, R. R. Behringer, J. Sirois, M. M. Taketo, and J. S. Richards
Misregulated Wnt/{beta}-Catenin Signaling Leads to Ovarian Granulosa Cell Tumor Development
Cancer Res., October 15, 2005; 65(20): 9206 - 9215.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. M. A. Emmen, J. F. Couse, S. A. Elmore, M. M. Yates, G. E. Kissling, and K. S. Korach
In Vitro Growth and Ovulation of Follicles from Ovaries of Estrogen Receptor (ER){alpha} and ER{beta} Null Mice Indicate a Role for ER{beta} in Follicular Maturation
Endocrinology, June 1, 2005; 146(6): 2817 - 2826.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Park, E. T. Maizels, Z. J. Feiger, H. Alam, C. A. Peters, T. K. Woodruff, T. G. Unterman, E. J. Lee, J. L. Jameson, and M. Hunzicker-Dunn
Induction of Cyclin D2 in Rat Granulosa Cells Requires FSH-dependent Relief from FOXO1 Repression Coupled with Positive Signals from Smad
J. Biol. Chem., March 11, 2005; 280(10): 9135 - 9148.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. L. Hahn, J. Johnson, B. J. Beres, S. Howard, and J. Wilson-Rawls
Lunatic fringe null female mice are infertile due to defects in meiotic maturation
Development, February 15, 2005; 132(4): 817 - 828.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. C. Carthon, C. A. Neumann, M. Das, B. Pawlyk, T. Li, Y. Geng, and P. Sicinski
Genetic Replacement of Cyclin D1 Function in Mouse Development by Cyclin D2
Mol. Cell. Biol., February 1, 2005; 25(3): 1081 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. A. Arraztoa, J. Zhou, D. Marcu, C. Cheng, R. Bonner, M. Chen, C. Xiang, M. Brownstein, K. Maisey, M. Imarai, et al.
Identification of genes expressed in primate primordial oocytes
Hum. Reprod., February 1, 2005; 20(2): 476 - 483.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. D. Cannon, M. Cherian-Shaw, and C. L. Chaffin
Proliferation of Rat Granulosa Cells during the Periovulatory Interval
Endocrinology, January 1, 2005; 146(1): 414 - 422.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Cherian-Shaw, R. Das, C. A. VandeVoort, and C. L. Chaffin
Regulation of Steroidogenesis by p53 in Macaque Granulosa Cells and H295R Human Adrenocortical Cells
Endocrinology, December 1, 2004; 145(12): 5734 - 5744.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. M. Quirk, R. G. Cowan, and R. M. Harman
Progesterone Receptor and the Cell Cycle Modulate Apoptosis in Granulosa Cells
Endocrinology, November 1, 2004; 145(11): 5033 - 5043.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
A. Kowalczyk, R. K. Filipkowski, M. Rylski, G. M. Wilczynski, F. A. Konopacki, J. Jaworski, M. A. Ciemerych, P. Sicinski, and L. Kaczmarek
The critical role of cyclin D2 in adult neurogenesis
J. Cell Biol., October 25, 2004; 167(2): 209 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Tomic, K. P. Miller, H. A. Kenny, T. K. Woodruff, P. Hoyer, and J. A. Flaws
Ovarian Follicle Development Requires Smad3
Mol. Endocrinol., September 1, 2004; 18(9): 2224 - 2240.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y.-C. Hu, P.-H. Wang, S. Yeh, R.-S. Wang, C. Xie, Q. Xu, X. Zhou, H.-T. Chao, M.-Y. Tsai, and C. Chang
Subfertility and defective folliculogenesis in female mice lacking androgen receptor
PNAS, August 3, 2004; 101(31): 11209 - 11214.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
X.-H. Pei, F. Bai, T. Tsutsui, H. Kiyokawa, and Y. Xiong
Genetic Evidence for Functional Dependency of p18Ink4c on Cdk4
Mol. Cell. Biol., August 1, 2004; 24(15): 6653 - 6664.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. L. Britt, P. G. Stanton, M. Misso, E. R. Simpson, and J. K. Findlay
The Effects of Estrogen on the Expression of Genes Underlying the Differentiation of Somatic Cells in the Murine Gonad
Endocrinology, August 1, 2004; 145(8): 3950 - 3960.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
D. Choi, S. Hwang, E. Lee, S. Yoon, B.-K. Yoon, and D. Bae
Expression of Mitochondria-Dependent Apoptosis Genes (p53, Bax, and Bcl-2) in Rat Granulosa Cells During Follicular Development
Reproductive Sciences, July 1, 2004; 11(5): 311 - 317.
[Abstract] [PDF]

Home page
 Mol. Endocrinol.Home page
M. A. Cunningham, Q. Zhu, and J. M. Hammond
FoxO1a Can Alter Cell Cycle Progression by Regulating the Nuclear Localization of p27kip in Granulosa Cells
Mol. Endocrinol., July 1, 2004; 18(7): 1756 - 1767.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. J. Hirvonen-Santti, V. Sriraman, M. Anttonen, S. Savolainen, J. J. Palvimo, M. Heikinheimo, J. S. Richards, and O. A. Janne
Small Nuclear RING Finger Protein Expression during Gonad Development: Regulation by Gonadotropins and Estrogen in the Postnatal Ovary
Endocrinology, May 1, 2004; 145(5): 2433 - 2444.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Cecconi, G. Rossi, M. Barberi, L. Scaldaferri, and R. Canipari
Effect of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Polypeptide on Mouse Preantral Follicle Development in Vitro
Endocrinology, April 1, 2004; 145(4): 2071 - 2079.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Takeuchi, Z. Rosenwaks, and G. D. Palermo
A successful model to assess embryo development after transplantation of prophase nuclei
Hum. Reprod., April 1, 2004; 19(4): 975 - 981.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
L. Mittaz, D.L. Russell, T. Wilson, M. Brasted, J. Tkalcevic, L.A. Salamonsen, P.J. Hertzog, and M.A. Pritchard
Adamts-1 Is Essential for the Development and Function of the Urogenital System
Biol Reprod, April 1, 2004; 70(4): 1096 - 1105.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
U. Manne, N. C. Jhala, J. Jones, H. L. Weiss, C. Chatla, S. Meleth, C. Suarez-Cuervo, and W. E. Grizzle
Prognostic Significance of p27kip-1 Expression in Colorectal Adenocarcinomas Is Associated with Tumor Stage
Clin. Cancer Res., March 1, 2004; 10(5): 1743 - 1752.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Sriraman and J. S. Richards
Cathepsin L Gene Expression and Promoter Activation in Rodent Granulosa Cells
Endocrinology, February 1, 2004; 145(2): 582 - 591.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
P. Yang and S. K. Roy
Follicle Stimulating Hormone-Induced DNA Synthesis in the Granulosa Cells of Hamster Preantral Follicles Involves Activation of Cyclin-Dependent Kinase-4 Rather Than Cyclin D2 Synthesis
Biol Reprod, February 1, 2004; 70(2): 509 - 517.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
S. M. Quirk, R. G. Cowan, R. M. Harman, C.-L. Hu, and D. A. Porter
Ovarian follicular growth and atresia: The relationship between cell proliferation and survival
J Anim Sci, January 1, 2004; 82(13_suppl): E40 - 52.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. H. Burns, J. E. Agno, P. Sicinski, and M. M. Matzuk
Cyclin D2 and p27 Are Tissue-Specific Regulators of Tumorigenesis in Inhibin {alpha} Knockout Mice
Mol. Endocrinol., October 1, 2003; 17(10): 2053 - 2069.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Hsieh, S. M. Mulders, R. R. Friis, A. Dharmarajan, and J. S. Richards
Expression and Localization of Secreted Frizzled-Related Protein-4 in the Rodent Ovary: Evidence for Selective Up-Regulation in Luteinized Granulosa Cells
Endocrinology, October 1, 2003; 144(10): 4597 - 4606.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. J. Buzzard, N. G. Wreford, and J. R. Morrison
Thyroid Hormone, Retinoic Acid, and Testosterone Suppress Proliferation and Induce Markers of Differentiation in Cultured Rat Sertoli Cells
Endocrinology, September 1, 2003; 144(9): 3722 - 3731.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Perlman, B. van den Hazel, J. Christiansen, S. Gram-Nielsen, C. B. Jeppesen, K. V. Andersen, T. Halkier, S. Okkels, and H. T. Schambye
Glycosylation of an N-Terminal Extension Prolongs the Half-Life and Increases the in Vivo Activity of Follicle Stimulating Hormone
J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3227 - 3235.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Jirawatnotai, D. S. Moons, C. O. Stocco, R. Franks, D. B. Hales, G. Gibori, and H. Kiyokawa
The Cyclin-dependent Kinase Inhibitors p27Kip1 and p21Cip1 Cooperate to Restrict Proliferative Life Span in Differentiating Ovarian Cells
J. Biol. Chem., May 2, 2003; 278(19): 17021 - 17027.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. L. Chaffin, R. S. Brogan, R. L. Stouffer, and C. A. VandeVoort
Dynamics of Myc/Max/Mad Expression during Luteinization of Primate Granulosa Cells in Vitro: Association with Periovulatory Proliferation
Endocrinology, April 1, 2003; 144(4): 1249 - 1256.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Cottom, L. M. Salvador, E. T. Maizels, S. Reierstad, Y. Park, D. W. Carr, M. A. Davare, J. W. Hell, S. S. Palmer, P. Dent, et al.
Follicle-stimulating Hormone Activates Extracellular Signal-regulated Kinase but Not Extracellular Signal-regulated Kinase Kinase through a 100-kDa Phosphotyrosine Phosphatase
J. Biol. Chem., February 21, 2003; 278(9): 7167 - 7179.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. A. Grieshaber, C. Ko, S. S. Grieshaber, I. Ji, and T. H. Ji
Follicle-Stimulating Hormone-Responsive Cytoskeletal Genes in Rat Granulosa Cells: Class I {beta}-Tubulin, Tropomyosin-4, and Kinesin Heavy Chain
Endocrinology, January 1, 2003; 144(1): 29 - 39.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. A. Ciemerych, A. M. Kenney, E. Sicinska, I. Kalaszczynska, R. T. Bronson, D. H. Rowitch, H. Gardner, and P. Sicinski
Development of mice expressing a single D-type cyclin
Genes & Dev., December 15, 2002; 16(24): 3277 - 3289.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. K. Pradeep, X. Li, H. Peegel, and K. M. J. Menon
Dihydrotestosterone Inhibits Granulosa Cell Proliferation by Decreasing the Cyclin D2 mRNA Expression and Cell Cycle Arrest at G1 Phase
Endocrinology, August 1, 2002; 143(8): 2930 - 2935.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
N. Danilovich, D. Javeshghani, W. Xing, and M. R. Sairam
Endocrine Alterations and Signaling Changes Associated with Declining Ovarian Function and Advanced Biological Aging in Follicle-Stimulating Hormone Receptor Haploinsufficient Mice
Biol Reprod, August 1, 2002; 67(2): 370 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. E. Dumont, S. Dremier, I. Pirson, and C. Maenhaut
Cross signaling, cell specificity, and physiology
Am J Physiol Cell Physiol, July 1, 2002; 283(1): C2 - C28.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
G. E. Owens, R. A. Keri, and J. H. Nilson
Ovulatory Surges of Human CG Prevent Hormone-Induced Granulosa Cell Tumor Formation Leading to the Identification of Tumor-Associated Changes in the Transcriptome
Mol. Endocrinol., June 1, 2002; 16(6): 1230 - 1242.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. Chu, S. Rushdi, E.T. Zumpe, P. Mamers, D.L. Healy, T. Jobling, H.G. Burger, and P.J. Fuller
FSH-regulated gene expression profiles in ovarian tumours and normal ovaries
Mol. Hum. Reprod., May 1, 2002; 8(5): 426 - 433.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. S. Richards, S. C. Sharma, A. E. Falender, and Y. H. Lo
Expression of FKHR, FKHRL1, and AFX Genes in the Rodent Ovary: Evidence for Regulation by IGF-I, Estrogen, and the Gonadotropins
Mol. Endocrinol., March 1, 2002; 16(3): 580 - 599.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Hsieh, M. A. Johnson, N. M. Greenberg, and J. S. Richards
Regulated Expression of Wnts and Frizzleds at Specific Stages of Follicular Development in the Rodent Ovary
Endocrinology, March 1, 2002; 143(3): 898 - 908.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. S. Moons, S. Jirawatnotai, T. Tsutsui, R. Franks, A. F. Parlow, D. B. Hales, G. Gibori, A. T. Fazleabas, and H. Kiyokawa
Intact Follicular Maturation and Defective Luteal Function in Mice Deficient for Cyclin- Dependent Kinase-4
Endocrinology, February 1, 2002; 143(2): 647 - 654.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
D. Choi, S. Yoon, E. Lee, S. Hwang, S. Song, J. Kim, B.-K. Yoon, and J.-H. Lee
Characterization of Cyclin D2 Expression in Human Endometrium
Reproductive Sciences, January 1, 2002; 9(1): 41 - 46.
[Abstract] [PDF]

Home page
 Recent Prog Horm ResHome page
J. S. Richards, D. L. Russell, S. Ochsner, M. Hsieh, K. H. Doyle, A. E. Falender, Y. K. Lo, and S. C. Sharma
Novel Signaling Pathways That Control Ovarian Follicular Development, Ovulation, and Luteinization
Recent Prog. Horm. Res., January 1, 2002; 57(1): 195 - 220.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. M. Salvador, Y. Park, J. Cottom, E. T. Maizels, J. C. R. Jones, R. V. Schillace, D. W. Carr, P. Cheung, C. D. Allis, J. L. Jameson, et al.
Follicle-stimulating Hormone Stimulates Protein Kinase A-mediated Histone H3 Phosphorylation and Acetylation Leading to Select Gene Activation in Ovarian Granulosa Cells
J. Biol. Chem., October 19, 2001; 276(43): 40146 - 40155.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. El-Hefnawy and A. J. Zeleznik
Synergism Between FSH and Activin in the Regulation of Proliferating Cell Nuclear Antigen (PCNA) and Cyclin D2 Expression in Rat Granulosa Cells
Endocrinology, October 1, 2001; 142(10): 4357 - 4362.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. L. Chaffin, K. M. Schwinof, and R. L. Stouffer
Gonadotropin and Steroid Control of Granulosa Cell Proliferation During the Periovulatory Interval in Rhesus Monkeys
Biol Reprod, September 1, 2001; 65(3): 755 - 762.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. H. Burns, C. Yan, T. R. Kumar, and M. M. Matzuk
Analysis of Ovarian Gene Expression in Follicle-Stimulating Hormone {beta} Knockout Mice
Endocrinology, July 1, 2001; 142(7): 2742 - 2751.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. F. Palter, A. B. Tavares, A. Hourvitz, J. D. Veldhuis, and E. Y. Adashi
Are Estrogens of Import to Primate/Human Ovarian Folliculogenesis?
Endocr. Rev., June 1, 2001; 22(3): 389 - 424.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. S. Richards
Perspective: The Ovarian Follicle--A Perspective in 2001
Endocrinology, June 1, 2001; 142(6): 2184 - 2193.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
K. F. Roby
Alterations in Follicle Development, Steroidogenesis, and Gonadotropin Receptor Binding in a Model of Ovulatory Blockade
Endocrinology, June 1, 2001; 142(6): 2328 - 2335.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
R. S. Muraoka, A. E.G. Lenferink, J. Simpson, D. M. Brantley, L. R. Roebuck, F. M. Yakes, and C. L. Arteaga
Cyclin-Dependent Kinase Inhibitor P27Kip1 Is Required for Mouse Mammary Gland Morphogenesis and Function
J. Cell Biol., May 28, 2001; 153(5): 917 - 932.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Waltregny, I. Leav, S. Signoretti, P. Soung, D. Lin, F. Merk, J. Y. Adams, N. Bhattacharya, N. Cirenei, and M. Loda
Androgen-Driven Prostate Epithelial Cell Proliferation and Differentiation in Vivo Involve the Regulation of p27
Mol. Endocrinol., May 1, 2001; 15(5): 765 - 782.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
J. S. Richards
New Signaling Pathways for Hormones and Cyclic Adenosine 3',5'-Monophosphate Action in Endocrine Cells
Mol. Endocrinol., February 1, 2001; 15(2): 209 - 218.
[Abstract] [Full Text]

Home page
 Reproductive SciencesHome page
J. S. Richards
Graafian Follicle Function and Luteinization in Nonprimates
Reproductive Sciences, January 1, 2001; 8(1_suppl): S21 - S23.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
S. K. Roy and L. Albee
Requirement for Follicle-Stimulating Hormone Action in the Formation of Primordial Follicles during Perinatal Ovarian Development in the Hamster
Endocrinology, December 1, 2000; 141(12): 4449 - 4456.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. L. Beumer, H. L. Roepers-Gajadien, I. S. Gademan, H. B. Kal, and D. G. de Rooij
Involvement of the D-Type Cyclins in Germ Cell Proliferation and Differentiation in the Mouse
Biol Reprod, December 1, 2000; 63(6): 1893 - 1898.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
N. A. Grieshaber, S. Boitano, I. Ji, J. P. Mather, and T. H. Ji
Differentiation of Granulosa Cell Line: Follicle-Stimulating Hormone Induces Formation of Lamellipodia and Filopodia via the Adenylyl Cyclase/Cyclic Adenosine Monophosphate Signal
Endocrinology, September 1, 2000; 141(9): 3461 - 3470.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
I. J. Gonzalez-Robayna, A. E. Falender, S. Ochsner, G. L. Firestone, and J. S. Richards
Follicle-Stimulating Hormone (FSH) Stimulates Phosphorylation and Activation of Protein Kinase B (PKB/Akt) and Serum and Glucocorticoid-Induced Kinase (Sgk): Evidence for A Kinase-Independent Signaling by FSH in Granulosa Cells
Mol. Endocrinol., August 1, 2000; 14(8): 1283 - 1300.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
L. L. Espey, T. Ujioka, D. L. Russell, M. Skelsey, B. Vladu, R. L. Robker, H. Okamura, and J. S. Richards
Induction of Early Growth Response Protein-1 Gene Expression in the Rat Ovary in Response to an Ovulatory Dose of Human Chorionic Gonadotropin
Endocrinology, July 1, 2000; 141(7): 2385 - 2391.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. L. Britt, A. E. Drummond, V. A. Cox, M. Dyson, N. G. Wreford, M. E. E. Jones, E. R. Simpson, and J. K. Findlay
An Age-Related Ovarian Phenotype in Mice with Targeted Disruption of the Cyp 19 (Aromatase) Gene
Endocrinology, July 1, 2000; 141(7): 2614 - 2623.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
B. D. Murphy
Models of Luteinization
Biol Reprod, July 1, 2000; 63(1): 2 - 11.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
A. Hampl, J. Pacherník, and P. Dvorák
Levels and Interactions of p27, Cyclin D3, and CDK4 During the Formation and Maintenance of the Corpus Luteum in Mice
Biol Reprod, May 1, 2000; 62(5): 1393 - 1401.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
S Dupont, A Krust, A Gansmuller, A Dierich, P Chambon, and M Mark
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
Development, January 10, 2000; 127(19): 4277 - 4291.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
T. N. Alliston, I. J. Gonzalez-Robayna, P. Buse, G. L. Firestone, and J. S. Richards
Expression and Localization of Serum/Glucocorticoid-Induced Kinase in the Rat Ovary: Relation to Follicular Growth and Differentiation
Endocrinology, January 1, 2000; 141(1): 385 - 395.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1998 by The Endocrine Society