help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Florio, T.
Right arrow Articles by Stork, P. J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Florio, T.
Right arrow Articles by Stork, P. J. S.
Molecular Endocrinology 13 (1): 24-37
Copyright © 1999 by The Endocrine Society

Somatostatin Activation of Mitogen-Activated Protein Kinase via Somatostatin Receptor 1 (SSTR1)

Tullio Florio, Hong Yao, Kendall D. Carey, Tara J. Dillon and Philip J. S. Stork

Vollum Institute (H.Y., K.D.C., T.D., P.J.S.S.) Oregon Health Sciences University Portland, Oregon 97201
Institute of Pharmacology (T.F.) School of Medicine University of Genoa and Service of Pharmacology National Institute for Cancer Research (IST), 16132 Genoa, Italy

Hormones and growth factors regulate cell growth via the mitogen-activated protein (MAP) kinase cascade. Here we examine the actions of the hormone somatostatin on the MAP kinase cascade through one of its two major receptor subtypes, the somatostatin receptor 1 (SSTR1) stably expressed in CHO-K1 cells. Somatostatin antagonizes the proliferative effects of fibroblast growth factor in CHO-SSTR1 cells via the SSTR1 receptor. However, in these cells, somatostatin robustly activates MAP kinase (also called extracellular signal regulated kinase; ERK) and augments fibroblast growth factor-stimulated ERK activity. We show that the activation of ERK via SSTR1 is pertussis toxin sensitive and requires the small G protein Ras, phosphatidylinositol 3-kinase, the serine/threonine kinase Raf-1, and the protein tyrosine phosphatase SHP-2. The activation of ERK by SSTR1 increased the expression of the cyclin-dependent protein kinase inhibitor p21cip1/WAF1. Previous studies have suggested that somatostatin-stimulated protein tyrosine phosphatase activity mediates the growth effects of somatostatin. Our data suggest that SHP-2 stimulation by SSTR1 may mediate some of these effects through the activation of the MAP kinase cascade and the expression of p21cip1/WAF1.




This article has been cited by other articles:


Home page
 Endocr Relat CancerHome page
S. Grozinsky-Glasberg, I. Shimon, M. Korbonits, and A. B Grossman
Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms
Endocr. Relat. Cancer, September 1, 2008; 15(3): 701 - 720.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Barbieri, A. Pattarozzi, M. Gatti, C. Porcile, A. Bajetto, A. Ferrari, M. D. Culler, and T. Florio
Somatostatin Receptors 1, 2, and 5 Cooperate in the Somatostatin Inhibition of C6 Glioma Cell Proliferation in Vitro via a Phosphotyrosine Phosphatase-{eta}-Dependent Inhibition of Extracellularly Regulated Kinase-1/2
Endocrinology, September 1, 2008; 149(9): 4736 - 4746.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. Pattarozzi, M. Gatti, F. Barbieri, R. Wurth, C. Porcile, G. Lunardi, A. Ratto, R. Favoni, A. Bajetto, A. Ferrari, et al.
17 -Estradiol Promotes Breast Cancer Cell Proliferation-Inducing Stromal Cell-Derived Factor-1-Mediated Epidermal Growth Factor Receptor Transactivation: Reversal by Gefitinib Pretreatment
Mol. Pharmacol., January 1, 2008; 73(1): 191 - 202.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. A. Grodnitzky, N. Syed, M. J. Kimber, T. A. Day, J. G. Donaldson, and W. H. Hsu
Somatostatin Receptors Signal through EFA6A-ARF6 to Activate Phospholipase D in Clonal beta-Cells
J. Biol. Chem., May 4, 2007; 282(18): 13410 - 13418.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Arena, A. Pattarozzi, A. Massa, J.-P. Esteve, R. Iuliano, A. Fusco, C. Susini, and T. Florio
An Intracellular Multi-Effector Complex Mediates Somatostatin Receptor 1 Activation of Phospho-Tyrosine Phosphatase {eta}
Mol. Endocrinol., January 1, 2007; 21(1): 229 - 246.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Cordelier, J.-P. Esteve, S. Najib, L. Moroder, N. Vaysse, L. Pradayrol, C. Susini, and L. Buscail
Regulation of Neuronal Nitric-oxide Synthase Activity by Somatostatin Analogs following SST5 Somatostatin Receptor Activation
J. Biol. Chem., July 14, 2006; 281(28): 19156 - 19171.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Theodoropoulou, J. Zhang, S. Laupheimer, M. Paez-Pereda, C. Erneux, T. Florio, U. Pagotto, and G. K. Stalla
Octreotide, a Somatostatin Analogue, Mediates Its Antiproliferative Action in Pituitary Tumor Cells by Altering Phosphatidylinositol 3-Kinase Signaling and Inducing Zac1 Expression
Cancer Res., February 1, 2006; 66(3): 1576 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Arena, A. Pattarozzi, A. Corsaro, G. Schettini, and T. Florio
Somatostatin Receptor Subtype-Dependent Regulation of Nitric Oxide Release: Involvement of Different Intracellular Pathways
Mol. Endocrinol., January 1, 2005; 19(1): 255 - 267.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Massa, F. Barbieri, C. Aiello, S. Arena, A. Pattarozzi, P. Pirani, A. Corsaro, R. Iuliano, A. Fusco, G. Zona, et al.
The Expression of the Phosphotyrosine Phosphatase DEP-1/PTP{eta} Dictates the Responsivity of Glioma Cells to Somatostatin Inhibition of Cell Proliferation
J. Biol. Chem., July 9, 2004; 279(28): 29004 - 29012.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Lahlou, N. Saint-Laurent, J.-P. Esteve, A. Eychene, L. Pradayrol, S. Pyronnet, and C. Susini
sst2 Somatostatin Receptor Inhibits Cell Proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 Activation
J. Biol. Chem., October 10, 2003; 278(41): 39356 - 39371.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
G. Ferjoux, F. Lopez, J.-P. Esteve, A. Ferrand, E. Vivier, F. Vely, N. Saint-Laurent, L. Pradayrol, L. Buscail, and C. Susini
Critical Role of Src and SHP-2 in sst2 Somatostatin Receptor-mediated Activation of SHP-1 and Inhibition of Cell Proliferation
Mol. Biol. Cell, September 1, 2003; 14(9): 3911 - 3928.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-Y. Lin, M. G. Varma, A. Joubel, S. Madabushi, O. Lichtarge, and D. L. Barber
Conserved Motifs in Somatostatin, D2-dopamine, and alpha 2B-Adrenergic Receptors for Inhibiting the Na-H Exchanger, NHE1
J. Biol. Chem., April 18, 2003; 278(17): 15128 - 15135.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Florio, M. Morini, V. Villa, S. Arena, A. Corsaro, S. Thellung, M. D. Culler, U. Pfeffer, D. M. Noonan, G. Schettini, et al.
Somatostatin Inhibits Tumor Angiogenesis and Growth via Somatostatin Receptor-3-Mediated Regulation of Endothelial Nitric Oxide Synthase and Mitogen-Activated Protein Kinase Activities
Endocrinology, April 1, 2003; 144(4): 1574 - 1584.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. Wada and N. Nagano
Control of parathyroid cell growth by calcimimetics
Nephrol. Dial. Transplant., March 1, 2003; 18(90003): iii13 - 17.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. A. Jorda, B. Lowenberg, and R. Delwel
The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation
Blood, February 15, 2003; 101(4): 1336 - 1343.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
T. Florio, S. Arena, A. Pattarozzi, S. Thellung, A. Corsaro, V. Villa, A. Massa, F. Diana, G. Spoto, S. Forcella, et al.
Basic Fibroblast Growth Factor Activates Endothelial Nitric-Oxide Synthase in CHO-K1 Cells via the Activation of Ceramide Synthesis
Mol. Pharmacol., February 1, 2003; 63(2): 297 - 310.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. D. Zapata, R. M. Ropero, A. M. Valencia, L. Buscail, J. I. Lopez, R. M. Martin-Orozco, J. C. Prieto, J. Angulo, C. Susini, P. Lopez-Ruiz, et al.
Autocrine Regulation of Human Prostate Carcinoma Cell Proliferation by Somatostatin through the Modulation of the SH2 Domain Containing Protein Tyrosine Phosphatase (SHP)-1
J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 915 - 926.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Florio, S. Arena, S. Thellung, R. Iuliano, A. Corsaro, A. Massa, A. Pattarozzi, A. Bajetto, F. Trapasso, A. Fusco, et al.
The Activation of the Phosphotyrosine Phosphatase {eta} (r-PTP{eta}) Is Responsible for the Somatostatin Inhibition of PC Cl3 Thyroid Cell Proliferation
Mol. Endocrinol., October 1, 2001; 15(10): 1838 - 1852.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. C. Zatelli, F. Tagliati, J. E. Taylor, R. Rossi, M. D. Culler, and E. C. degli Uberti
Somatostatin Receptor Subtypes 2 and 5 Differentially Affect Proliferation in Vitro of the Human Medullary Thyroid Carcinoma Cell Line TT
J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 2161 - 2169.
[Abstract] [Full Text]

Home page
 Mol. Pharmacol.Home page
F. Alderton, P. P. A. Humphrey, and L. A. Sellers
High-Intensity p38 Kinase Activity Is Critical for p21cip1 Induction and the Antiproliferative Function of Gi Protein-Coupled Receptors
Mol. Pharmacol., April 16, 2001; 59(5): 1119 - 1128.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
J. T. Williams, M. J. Christie, and O. Manzoni
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Physiol Rev, January 1, 2001; 81(1): 299 - 343.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. A. Sellers, F. Alderton, A. M. Carruthers, M. Schindler, and P. P. A. Humphrey
Receptor Isoforms Mediate Opposing Proliferative Effects through Gbeta gamma -Activated p38 or Akt Pathways
Mol. Cell. Biol., August 15, 2000; 20(16): 5974 - 5985.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
P. CORDELIER, J.-P. ESTÈVE, N. RIVARD, M. MARLETTA, N. VAYSSE, C. SUSINI, and L. BUSCAIL
The activation of neuronal NO synthase is mediated by G-protein {beta}{gamma} subunit and the tyrosine phosphatase SHP-2
FASEB J, November 1, 1999; 13(14): 2037 - 2050.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Jaquet, L. Ouafik, A. Saveanu, G. Gunz, F. Fina, H. Dufour, M. D. Culler, J. P. Moreau, and A. Enjalbert
Quantitative and Functional Expression of Somatostatin Receptor Subtypes in Human Prolactinomas
J. Clin. Endocrinol. Metab., September 1, 1999; 84(9): 3268 - 3276.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
N. Hukovic, M. Rocheville, U. Kumar, R. Sasi, S. Khare, and Y. C. Patel
Agonist-dependent Up-regulation of Human Somatostatin Receptor Type 1 Requires Molecular Signals in the Cytoplasmic C-tail
J. Biol. Chem., August 27, 1999; 274(35): 24550 - 24558.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. A. Sellers
Prolonged Activation of Extracellular Signal-regulated Kinase by a Protein Kinase C-dependent and N17Ras-insensitive Mechanism Mediates the Proliferative Response of Gi/o-coupled Somatostatin sst4 Receptors
J. Biol. Chem., August 20, 1999; 274(34): 24280 - 24288.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Schmitt and P. J. S. Stork
beta 2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf
J. Biol. Chem., August 11, 2000; 275(33): 25342 - 25350.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Liu and A. Schonbrunn
Agonist-induced Phosphorylation of Somatostatin Receptor Subtype 1 (Sst1). RELATIONSHIP TO DESENSITIZATION AND INTERNALIZATION
J. Biol. Chem., January 26, 2001; 276(5): 3709 - 3717.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1999 by The Endocrine Society