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Molecular Endocrinology 13 (5): 764-773
Copyright © 1999 by The Endocrine Society

Transcriptional Activities of the Orphan Nuclear Receptor ERR{alpha} (Estrogen Receptor-Related Receptor-{alpha})

Jean-Marc Vanacker, Edith Bonnelye1, Sandrine Chopin-Delannoy, Cateline Delmarre, Vincent Cavaillès and Vincent Laudet

Centre Nationale de la Recherche Scientifique UMR 49 (J-M.V., V.L.) Ecole Normale Supérieure de Lyon 69364 Lyon, France
Centre Nationale de la Recherche Scientifique UMR 319 (S.C.-D., C.D.) Institut de Biologie de Lille Institut Pasteur de Lille 59021 Lille, France
INSERM U148 (V.C) 34090 Montpellier, France

Estrogen receptor-related receptor {alpha} (ERR{alpha}) is an orphan nuclear receptor closely related to the estrogen receptor (ER), whose expression covers various stages of embryonic development and persists in certain adult tissues. We show that ERR{alpha} binds as a homodimer on a specific target sequence, the SFRE (SF-1 response element), already known to respond to the orphan nuclear receptor SF-1. Target sequences that are related to the SFRE and that discriminate between ERR{alpha} and SF-1 were identified. We have also analyzed the transcriptional properties of the ERR{alpha} originating from various species. All ERR{alpha} orthologs act as potent transactivators through the consensus SFRE. ERR{alpha} activity depends on the putative AF2AD domain, as well as on a serum compound that is withdrawn by charcoal treatment, suggesting the existence of a critical regulating factor brought by serum.




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