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Molecular Endocrinology 13 (8): 1237-1248
Copyright © 1999 by The Endocrine Society

A Requirement for the POU Transcription Factor, Brn-2, in Corticotropin-Releasing Hormone Expression in a Neuronal Cell Line

Thiruvamoor Ramkumar and Stuart Adler

Departments of Obstetrics and Gynecology and Cell Biology and Physiology (S.A.) Division of Biology and Biomedical Sciences (T.R.) Program in Molecular Genetics (T.R., S.A.) Washington University Medical School Saint Louis, Missouri 63110

The expression of the endogenous CRF gene was examined in the human neuroblastoma cell line, BE(2)-M17. In this cell line, treatment with retinoic acid induces CRF mRNA transcription. We examined the requirement for the POU transcription factor, Brn-2, for this response. We confirmed that Brn-2 is expressed in retinoic acid-induced BE(2)-M17 cells. Expression of antisense Brn-2 message aborted the retinoic acid-mediated induction of CRF transcription. However, overexpression of Brn-2 was not sufficient for CRF expression in the absence of retinoic acid. These experiments support the hypothesis that Brn-2 is an intermediary for retinoic acid-induced CRF expression.




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