help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kawabe, K.
Right arrow Articles by Morohashi, K.-i.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kawabe, K.
Right arrow Articles by Morohashi, K.-i.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
*Genetics Home Reference
Molecular Endocrinology 13 (8): 1267-1284
Copyright © 1999 by The Endocrine Society

Dax-1 as One of the Target Genes of Ad4BP/SF-1

Ken Kawabe, Tatsuji Shikayama, Hisae Tsuboi, Sanae Oka, Koichi Oba, Toshihiko Yanase, Hajime Nawata and Ken-ichirou Morohashi

Department of Developmental Biology (K.K., T.S., H.T., S.O., K-i.M.) National Institute for Basic Biology Department of Molecular Biomechanics (K-i.M.) School of Life Science The Graduate University for Advanced Studies Core Research for Evolutional Science and Technology Japan Science and Technology (K-i.M.) Myodaiji-cho, Okazaki 444-8585, Japan
Third Department of Internal Medicine (K.K., K.O., T.Y., H.N.) Faculty of Medicine and Department of Molecular Biology (T.S.) Graduate School of Medical Science Kyushu University Higashi-ku, Fukuoka 812-8582

The DAX-1 (also known as AHC) gene encodes an unusual member of the nuclear hormone receptor superfamily. DAX-1 plays a critical role during gonadal and adrenal differentiation since mutations of the human DAX-1 gene cause X-linked adrenal hypoplasia congenita associated with hypogonadotropic hypogonadism. In recent studies, DAX-1 was reported to function as a transcriptional suppressor of Ad4BP/SF-1, a critical transcription factor in gonadal and adrenal differentiation. With respect to implication of Ad4BP/SF-1 in the transcriptional regulation of the DAX-1 gene, inconsistent findings have been previously reported. We investigated the upstream region of the mouse Dax-1 (also known as Ahch) gene and identified a novel Ad4/SF-1 site by transient transfection and electrophoretic mobility shift assays. In addition, immunohistochemical analyses with a specific antibody to Dax-1 indicated the presence of immunoreactive cells in steroidogenic tissues, pituitary gland, and hypothalamus. Although the distributions of Dax-1 and Ad4BP/SF-1 were very similar, they were not completely identical. The expression of Dax-1 was significantly impaired in knock-out mice of the Ftz-f1 gene, which encodes Ad4BP/SF-1. Taken together, our findings indicate that Ad4BP/SF-1 controls the transcription of the Dax-1 gene.




This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
B. Skinningsrud, E. S. Husebye, G. D. Gilfillan, E. Frengen, A. Erichsen, K. Gervin, E. Ormerod, T. Egeland, and D. E. Undlien
X-Linked Congenital Adrenal Hypoplasia with Hypogonadotropic Hypogonadism Caused by an Inversion Disrupting a Conserved Noncoding Element Upstream of the NR0B1 (DAX1) Gene
J. Clin. Endocrinol. Metab., October 1, 2009; 94(10): 4086 - 4093.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
M. Bielinska, H. Parviainen, S. Kiiveri, M. Heikinheimo, and D. B. Wilson
REVIEW PAPER: Origin and Molecular Pathology of Adrenocortical Neoplasms
Vet. Pathol., March 1, 2009; 46(2): 194 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W.-H. Yang, J. H. Heaton, H. Brevig, S. Mukherjee, J. A. Iniguez-Lluhi, and G. D. Hammer
SUMOylation Inhibits SF-1 Activity by Reducing CDK7-Mediated Serine 203 Phosphorylation
Mol. Cell. Biol., February 1, 2009; 29(3): 613 - 625.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Zubair, K. L. Parker, and K.-i. Morohashi
Developmental Links between the Fetal and Adult Zones of the Adrenal Cortex Revealed by Lineage Tracing
Mol. Cell. Biol., December 1, 2008; 28(23): 7030 - 7040.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. A. Hoivik, L. Aumo, R. Aesoy, H. Lillefosse, A. E. Lewis, R. M. Perrett, N. R. Stallings, N. A. Hanley, and M. Bakke
Deoxyribonucleic Acid Methylation Controls Cell Type-Specific Expression of Steroidogenic Factor 1
Endocrinology, November 1, 2008; 149(11): 5599 - 5609.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
N. Sakai, H. Terami, S. Suzuki, M. Haga, K. Nomoto, N. Tsuchida, K.-i. Morohashi, N. Saito, M. Asada, M. Hashimoto, et al.
Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies
J. Endocrinol., September 1, 2008; 198(3): 489 - 497.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. M. Gummow, J. O. Scheys, V. R. Cancelli, and G. D. Hammer
Reciprocal Regulation of a Glucocorticoid Receptor-Steroidogenic Factor-1 Transcription Complex on the Dax-1 Promoter by Glucocorticoids and Adrenocorticotropic Hormone in the Adrenal Cortex
Mol. Endocrinol., November 1, 2006; 20(11): 2711 - 2723.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Bhangoo, W.-X. Gu, S. Pavlakis, H. Anhalt, L. Heier, S. Ten, and J. L. Jameson
Phenotypic Features Associated with Mutations in Steroidogenic Acute Regulatory Protein
J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6303 - 6309.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Y. Park, J. J. Meeks, G. Raverot, L. E. Pfaff, J. Weiss, G. D. Hammer, and J. L. Jameson
Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development
Development, May 15, 2005; 132(10): 2415 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
O. Zwermann, F. Beuschlein, E. Lalli, A. Klink, P. Sassone-Corsi, and M. Reincke
Clinical and molecular evidence for DAX-1 inhibition of steroidogenic factor-1-dependent ACTH receptor gene expression
Eur. J. Endocrinol., May 1, 2005; 152(5): 769 - 776.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
M. Matsuyama, H. Mizusaki, A. Shimono, T. Mukai, K. Okumura, K. Abe, K. Shimada, and K.-i. Morohashi
A novel isoform of Vinexin, Vinexin {gamma}, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad
Genes Cells, May 1, 2005; 10(5): 421 - 434.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. D. Hammer, K. L. Parker, and B. P. Schimmer
Minireview: Transcriptional Regulation of Adrenocortical Development
Endocrinology, March 1, 2005; 146(3): 1018 - 1024.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K.-H. Song, Y.-Y. Park, K. C. Park, C. Y. Hong, J. H. Park, M. Shong, K. Lee, and H.-S. Choi
The Atypical Orphan Nuclear Receptor DAX-1 Interacts with Orphan Nuclear Receptor Nur77 and Represses Its Transactivation
Mol. Endocrinol., August 1, 2004; 18(8): 1929 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. L. Britt, P. G. Stanton, M. Misso, E. R. Simpson, and J. K. Findlay
The Effects of Estrogen on the Expression of Genes Underlying the Differentiation of Somatic Cells in the Murine Gonad
Endocrinology, August 1, 2004; 145(8): 3950 - 3960.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
V. R. Harley, M. J. Clarkson, and A. Argentaro
The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility Group (HMG) Box 9]
Endocr. Rev., August 1, 2003; 24(4): 466 - 487.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Lalli and P. Sassone-Corsi
DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual Differentiation
Mol. Endocrinol., August 1, 2003; 17(8): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. M. Gummow, J. N. Winnay, and G. D. Hammer
Convergence of Wnt Signaling and Steroidogenic Factor-1 (SF-1) on Transcription of the Rat Inhibin {alpha} Gene
J. Biol. Chem., July 11, 2003; 278(29): 26572 - 26579.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. Sato, T. Suzuki, K. Hidaka, H. Sato, K. Ito, S. Ito, and H. Sasano
Immunolocalization of Nuclear Transcription Factors, DAX-1 and COUP-TF II, in the Normal Human Ovary: Correlation with Adrenal 4 Binding Protein/ Steroidogenic Factor-1 Immunolocalization during the Menstrual Cycle
J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3415 - 3420.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Kawajiri, T. Ikuta, T. Suzuki, M. Kusaka, M. Muramatsu, K. Fujieda, M. Tachibana, and K.-i. Morohashi
Role of the LXXLL-Motif and Activation Function 2 Domain in Subcellular Localization of Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1)
Mol. Endocrinol., June 1, 2003; 17(6): 994 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. Yazawa, T. Mizutani, K. Yamada, H. Kawata, T. Sekiguchi, M. Yoshino, T. Kajitani, Z. Shou, and K. Miyamoto
Involvement of Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein, Steroidogenic Factor 1, and Dax-1 in the Regulation of Gonadotropin-Inducible Ovarian Transcription Factor 1 Gene Expression by Follicle-Stimulating Hormone in Ovarian Granulosa Cells
Endocrinology, May 1, 2003; 144(5): 1920 - 1930.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y. Yoshiura, B. Senthilkumaran, M. Watanabe, Y. Oba, T. Kobayashi, and Y. Nagahama
Synergistic Expression of Ad4BP/SF-1 and Cytochrome P-450 Aromatase (Ovarian Type) in the Ovary of Nile Tilapia, Oreochromis niloticus, During Vitellogenesis Suggests Transcriptional Interaction
Biol Reprod, May 1, 2003; 68(5): 1545 - 1553.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Mizusaki, K. Kawabe, T. Mukai, E. Ariyoshi, M. Kasahara, H. Yoshioka, A. Swain, and K.-i. Morohashi
Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1) Gene Transcription Is Regulated by Wnt4 in the Female Developing Gonad
Mol. Endocrinol., April 1, 2003; 17(4): 507 - 519.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Brown, G. A. Scobie, J. Townsend, R. A. L. Bayne, J. R. Seckl, P. T. K. Saunders, and R. A. Anderson
Identification of a Novel Missense Mutation That Is as Damaging to DAX-1 Repressor Function as a Nonsense Mutation
J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1341 - 1349.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Suzuki, M. Kasahara, H. Yoshioka, K.-i. Morohashi, and K. Umesono
LXXLL-Related Motifs in Dax-1 Have Target Specificity for the Orphan Nuclear Receptors Ad4BP/SF-1 and LRH-1
Mol. Cell. Biol., January 1, 2003; 23(1): 238 - 249.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
S. Kiiveri, J. Liu, M. Westerholm-Ormio, N. Narita, D. B. Wilson, R. Voutilainen, and M. Heikinheimo
Differential Expression of GATA-4 and GATA-6 in Fetal and Adult Mouse and Human Adrenal Tissue
Endocrinology, August 1, 2002; 143(8): 3136 - 3143.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
D. Wilhelm and C. Englert
The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1
Genes & Dev., July 15, 2002; 16(14): 1839 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Hoyle, V. Narvaez, G. Alldus, R. Lovell-Badge, and A. Swain
Dax1 Expression Is Dependent on Steroidogenic Factor 1 in the Developing Gonad
Mol. Endocrinol., April 1, 2002; 16(4): 747 - 756.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Holter, N. Kotaja, S. Makela, L. Strauss, S. Kietz, O. A. Janne, J.-A. Gustafsson, J. J. Palvimo, and E. Treuter
Inhibition of Androgen Receptor (AR) Function by the Reproductive Orphan Nuclear Receptor DAX-1
Mol. Endocrinol., March 1, 2002; 16(3): 515 - 528.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. S. Babu, D. L. Bavers, F. Beuschlein, S. Shah, B. Jeffs, J. L. Jameson, and G. D. Hammer
Interaction Between Dax-1 and Steroidogenic Factor-1 in Vivo: Increased Adrenal Responsiveness to ACTH in the Absence of Dax-1
Endocrinology, February 1, 2002; 143(2): 665 - 673.
[Abstract] [Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
K. L. Parker, D. A. Rice, D. S. Lala, Y. Ikeda, X. Luo, M. Wong, M. Bakke, L. Zhao, C. Frigeri, N. A. Hanley, et al.
Steroidogenic Factor 1: an Essential Mediator of Endocrine Development
Recent Prog. Horm. Res., January 1, 2002; 57(1): 19 - 36.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. Lacroix, N. N'Diaye, J. Tremblay, and P. Hamet
Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome
Endocr. Rev., February 1, 2001; 22(1): 75 - 110.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
J. Levallet, P. Koskimies, N. Rahman, and I. Huhtaniemi
The Promoter of Murine Follicle-Stimulating Hormone Receptor: Functional Characterization and Regulation by Transcription Factor Steroidogenic Factor 1
Mol. Endocrinol., January 1, 2001; 15(1): 80 - 92.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
C. Aigueperse, P. Val, C. Pacot, C. Darne, E. Lalli, P. Sassone-Corsi, G. Veyssiere, C. Jean, and A. Martinez
SF-1 (Steroidogenic Factor-1), C/EBP{beta} (CCAAT/Enhancer Binding Protein), and Ubiquitous Transcription Factors NF1 (Nuclear Factor 1) and Sp1 (Selective Promoter Factor 1) Are Required for Regulation of the Mouse Aldose Reductase-Like Gene (AKR1B7) Expression in Adrenocortical Cells
Mol. Endocrinol., January 1, 2001; 15(1): 93 - 111.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. L. Bland, C. A. M. Jamieson, S. F. Akana, S. R. Bornstein, G. Eisenhofer, M. F. Dallman, and H. A. Ingraham
Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response
PNAS, December 19, 2000; 97(26): 14488 - 14493.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Boerboom, N. Pilon, R. Behdjani, D. W. Silversides, and J. Sirois
Expression and Regulation of Transcripts Encoding Two Members of the NR5A Nuclear Receptor Subfamily of Orphan Nuclear Receptors, Steroidogenic Factor-1 and NR5A2, in Equine Ovarian Cells during the Ovulatory Process
Endocrinology, December 1, 2000; 141(12): 4647 - 4656.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Zhang, J. S. Thomsen, L. Johansson, J.-A. Gustafsson, and E. Treuter
DAX-1 Functions as an LXXLL-containing Corepressor for Activated Estrogen Receptors
J. Biol. Chem., December 15, 2000; 275(51): 39855 - 39859.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1999 by The Endocrine Society