| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
and Steroid Receptor Coactivator-1
Department of Molecular and Cellular Biology (D.L.S., M.G.M., K.P.,
C.L.S., M.A.M.) Baylor College of Medicine Houston, Texas
77030
Ligand Pharmaceuticals, Inc. (E.A.A.)
San Diego, California 92121
We have *analyzed ligand-dependent, subnuclear
movements of the estrogen receptor-
(ER) in terms of both spatial
distribution and solubility partitioning. Using a transcriptionally
active green fluorescent protein-ER chimera (GFP-ER), we find
that 17ß-estradiol (E2) changes the normally
diffuse nucleoplasmic pattern of GFP-ER to a hyperspeckled
distribution within 10–20 min. A similar reorganization occurs with
the partial antagonist 4-hydroxytamoxifen; only a subtle effect was
observed with the pure antagonist ICI 182,780. To examine the influence
of ligand upon ER association with nuclear structure, MCF-7 cells
were extracted to reveal the nuclear matrix (NM). Addition of
E2, 4-hydroxytamoxifen, or ICI 182,780
causes ER to partition with the NM-bound fraction on a similar time
course (10–20 min) as the spatial reorganization suggesting that the
two events are related. To determine the effects of
E2 on the redistribution and solubility of
GFP-ER, individual cells were directly examined during both hormone
addition and NM extraction and showed that GFP-ER movement and NM
association were coincident. Colocalization experiments were performed
with antibodies to identify sites of transcription (RNA pol IIo) and
splicing domains (SRm160). Using E2 treated
MCF-7 cells, minor overlap was observed with transcription sites and a
small amount of the total ER pool. Experiments performed with
bioluminescent derivatives of ER and steroid receptor
coactivator-1 (SRC-1) demonstrated both proteins colocalize to the same
NM-bound foci in response to E2 but not the
antagonists tested. Deletion mutagenesis and in situ
analyses indicate intranuclear colocalization requires a central SRC-1
domain containing LXXLL motifs. Collectively, our data suggest that
ER transcription function is dependent upon dynamic early events
including intranuclear rearrangement, NM association, and SRC-1
interactions.
This article has been cited by other articles:
 |
|
 |
|
  S. J. Lee, C. Chae, and M. M. Wang p150/Glued Modifies Nuclear Estrogen Receptor Function Mol. Endocrinol., May 1, 2009; 23(5): 620 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Picard, C. Charbonneau, M. Sanchez, A. Licznar, M. Busson, G. Lazennec, and A. Tremblay Phosphorylation of Activation Function-1 Regulates Proteasome-Dependent Nuclear Mobility and E6-Associated Protein Ubiquitin Ligase Recruitment to the Estrogen Receptor {beta} Mol. Endocrinol., February 1, 2008; 22(2): 317 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Damdimopoulos, G. Spyrou, and J.-A. Gustafsson Ligands Differentially Modify the Nuclear Mobility of Estrogen Receptors {alpha} and Endocrinology, January 1, 2008; 149(1): 339 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Wittmann, A. Sherk, and D. P. McDonnell Definition of Functionally Important Mechanistic Differences among Selective Estrogen Receptor Down-regulators Cancer Res., October 1, 2007; 67(19): 9549 - 9560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Amazit, L. Pasini, A. T. Szafran, V. Berno, R.-C. Wu, M. Mielke, E. D. Jones, M. G. Mancini, C. A. Hinojos, B. W. O'Malley, et al. Regulation of SRC-3 Intercompartmental Dynamics by Estrogen Receptor and Phosphorylation Mol. Cell. Biol., October 1, 2007; 27(19): 6913 - 6932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Penttinen, J. Jaehrling, A. E. Damdimopoulos, J. Inzunza, J. G. Lemmen, P. van der Saag, K. Pettersson, G. Gauglitz, S. Makela, and I. Pongratz Diet-Derived Polyphenol Metabolite Enterolactone Is a Tissue-Specific Estrogen Receptor Activator Endocrinology, October 1, 2007; 148(10): 4875 - 4886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Qiu, Y. Huang, G. Chen, Z. Chen, D. J. Tweardy, and S. Dong Aberrant Chromatin Remodeling by Retinoic Acid Receptor {alpha} Fusion Proteins Assessed at the Single-Cell Level Mol. Biol. Cell, October 1, 2007; 18(10): 3941 - 3951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Nonclercq, F. Journe, I. Laios, C. Chaboteaux, R.-A. Toillon, G. Leclercq, and G. Laurent Effect of nuclear export inhibition on estrogen receptor regulation in breast cancer cells J. Mol. Endocrinol., August 1, 2007; 39(2): 105 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sanchez, K. Sauve, N. Picard, and A. Tremblay The Hormonal Response of Estrogen Receptor beta Is Decreased by the Phosphatidylinositol 3-Kinase/Akt Pathway via a Phosphorylation-dependent Release of CREB-binding Protein J. Biol. Chem., February 16, 2007; 282(7): 4830 - 4840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Li, R.-C. Wu, L. Amazit, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley Specific Amino Acid Residues in the Basic Helix-Loop-Helix Domain of SRC-3 Are Essential for Its Nuclear Localization and Proteasome-Dependent Turnover Mol. Cell. Biol., February 15, 2007; 27(4): 1296 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Padron, L. Li, E. M. Kofoed, and F. Schaufele Ligand-Selective Interdomain Conformations of Estrogen Receptor-{alpha} Mol. Endocrinol., January 1, 2007; 21(1): 49 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Arnett-Mansfield, J. D. Graham, A. R. Hanson, P. A. Mote, A. Gompel, L. L. Scurr, N. Gava, A. de Fazio, and C. L. Clarke Focal Subnuclear Distribution of Progesterone Receptor Is Ligand Dependent and Associated with Transcriptional Activity Mol. Endocrinol., January 1, 2007; 21(1): 14 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. D. Sharp, M. G. Mancini, C. A. Hinojos, F. Dai, V. Berno, A. T. Szafran, K. P. Smith, T. T. Lele, D. E. Ingber, and M. A. Mancini Estrogen-receptor-{alpha} exchange and chromatin dynamics are ligand- and domain-dependent J. Cell Sci., October 1, 2006; 119(19): 4101 - 4116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wu, H. Kawate, K. Ohnaka, H. Nawata, and R. Takayanagi Nuclear Compartmentalization of N-CoR and Its Interactions with Steroid Receptors. Mol. Cell. Biol., September 1, 2006; 26(17): 6633 - 6655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. M. Schaaf, L. Willetts, B. P. Hayes, B. Maschera, E. Stylianou, and S. N. Farrow The Relationship between Intranuclear Mobility of the NF-{kappa}B Subunit p65 and Its DNA Binding Affinity J. Biol. Chem., August 4, 2006; 281(31): 22409 - 22420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Grenier, A. Trousson, A. Chauchereau, J. Cartaud, M. Schumacher, and C. Massaad Differential Recruitment of p160 Coactivators by Glucocorticoid Receptor between Schwann Cells and Astrocytes Mol. Endocrinol., February 1, 2006; 20(2): 254 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M-B Debril, L Dubuquoy, J-N Feige, W Wahli, B Desvergne, J Auwerx, and L Gelman Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity J. Mol. Endocrinol., December 1, 2005; 35(3): 503 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-Y. Chen, L.-J. Juan, and B.-c. Chung SF-1 (Nuclear Receptor 5A1) Activity Is Activated by Cyclic AMP via p300-Mediated Recruitment to Active Foci, Acetylation, and Increased DNA Binding Mol. Cell. Biol., December 1, 2005; 25(23): 10442 - 10453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fan, A. Park, and K. P. Nephew CHIP (Carboxyl Terminus of Hsc70-Interacting Protein) Promotes Basal and Geldanamycin-Induced Degradation of Estrogen Receptor-{alpha} Mol. Endocrinol., December 1, 2005; 19(12): 2901 - 2914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kawate, Y. Wu, K. Ohnaka, R.-H. Tao, K.-i. Nakamura, T. Okabe, T. Yanase, H. Nawata, and R. Takayanagi Impaired Nuclear Translocation, Nuclear Matrix Targeting, and Intranuclear Mobility of Mutant Androgen Receptors Carrying Amino Acid Substitutions in the Deoxyribonucleic Acid-Binding Domain Derived from Androgen Insensitivity Syndrome Patients J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6162 - 6169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. F. Zheng, R.-C. Wu, C. L. Smith, and B. W. O'Malley Rapid Estrogen-Induced Phosphorylation of the SRC-3 Coactivator Occurs in an Extranuclear Complex Containing Estrogen Receptor Mol. Cell. Biol., September 15, 2005; 25(18): 8273 - 8284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Farla, R. Hersmus, J. Trapman, and A. B. Houtsmuller Antiandrogens prevent stable DNA-binding of the androgen receptor J. Cell Sci., September 15, 2005; 118(18): 4187 - 4198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takahashi, M. Ohmichi, J. Kawagoe, C. Ohshima, M. Doshida, T. Ohta, M. Saitoh, A. Mori-Abe, B. Du, H. Igarashi, et al. Growth Factors Change Nuclear Distribution of Estrogen Receptor-{alpha} via Mitogen-Activated Protein Kinase or Phosphatidylinositol 3-Kinase Cascade in a Human Breast Cancer Cell Line Endocrinology, September 1, 2005; 146(9): 4082 - 4089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. He, J.-M. Sun, L. Li, and J. R. Davie Differential Intranuclear Organization of Transcription Factors Sp1 and Sp3 Mol. Biol. Cell, September 1, 2005; 16(9): 4073 - 4083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Valley, R. Metivier, N. M. Solodin, A. M. Fowler, M. T. Mashek, L. Hill, and E. T. Alarid Differential Regulation of Estrogen-Inducible Proteolysis and Transcription by the Estrogen Receptor {alpha} N Terminus Mol. Cell. Biol., July 1, 2005; 25(13): 5417 - 5428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Day and F. Schaufele Imaging Molecular Interactions in Living Cells Mol. Endocrinol., July 1, 2005; 19(7): 1675 - 1686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. M. Schaaf, L. J. Lewis-Tuffin, and J. A. Cidlowski Ligand-Selective Targeting of the Glucocorticoid Receptor to Nuclear Subdomains Is Associated with Decreased Receptor Mobility Mol. Endocrinol., June 1, 2005; 19(6): 1501 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Feige, L. Gelman, C. Tudor, Y. Engelborghs, W. Wahli, and B. Desvergne Fluorescence Imaging Reveals the Nuclear Behavior of Peroxisome Proliferator-activated Receptor/Retinoid X Receptor Heterodimers in the Absence and Presence of Ligand J. Biol. Chem., May 6, 2005; 280(18): 17880 - 17890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Singh, C. Song, Z. Yang, and R. Kumar Nuclear Localization and Chromatin Targets of p21-activated Kinase 1 J. Biol. Chem., May 6, 2005; 280(18): 18130 - 18137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Narayanan, D. P. Edwards, and N. L. Weigel Human Progesterone Receptor Displays Cell Cycle-Dependent Changes in Transcriptional Activity Mol. Cell. Biol., April 15, 2005; 25(8): 2885 - 2898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kim, R. Barhoumi, R. Burghardt, and S. Safe Analysis of Estrogen Receptor {alpha}-Sp1 Interactions in Breast Cancer Cells by Fluorescence Resonance Energy Transfer Mol. Endocrinol., April 1, 2005; 19(4): 843 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Ruas, L. Poellinger, and T. Pereira Role of CBP in regulating HIF-1-mediated activation of transcription J. Cell Sci., January 15, 2005; 118(2): 301 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wu, R. Burghardt, and S. Safe Vitamin D-interacting Protein 205 (DRIP205) Coactivation of Estrogen Receptor {alpha} (ER{alpha}) Involves Multiple Domains of Both Proteins J. Biol. Chem., December 17, 2004; 279(51): 53602 - 53612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cui, M. Zhang, R. Pestell, E. M. Curran, W. V. Welshons, and S. A. W. Fuqua Phosphorylation of Estrogen Receptor {alpha} Blocks Its Acetylation and Regulates Estrogen Sensitivity Cancer Res., December 15, 2004; 64(24): 9199 - 9208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Narayanan, V. A. T. Sepulveda, M. Falzon, and N. L. Weigel The Functional Consequences of Cross-talk between the Vitamin D Receptor and ERK Signaling Pathways Are Cell-specific J. Biol. Chem., November 5, 2004; 279(45): 47298 - 47310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Nair, S. K. Mishra, Z. Yang, S. Balasenthil, R. Kumar, and R. K. Vadlamudi Potential Role of a Novel Transcriptional Coactivator PELP1 in Histone H1 Displacement in Cancer Cells Cancer Res., September 15, 2004; 64(18): 6416 - 6423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Damdimopoulos, A. Miranda-Vizuete, E. Treuter, J.-A. Gustafsson, and G. Spyrou An Alternative Splicing Variant of the Selenoprotein Thioredoxin Reductase Is a Modulator of Estrogen Signaling J. Biol. Chem., September 10, 2004; 279(37): 38721 - 38729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dong, D. L. Stenoien, J. Qiu, M. A. Mancini, and D. J. Tweardy Reduced Intranuclear Mobility of APL Fusion Proteins Accompanies Their Mislocalization and Results in Sequestration and Decreased Mobility of Retinoid X Receptor {alpha} Mol. Cell. Biol., May 15, 2004; 24(10): 4465 - 4475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Botos, W. Xian, D. F. Smith, and C. L. Smith Progesterone Receptor Deficient in Chromatin Binding Has an Altered Cellular State J. Biol. Chem., April 9, 2004; 279(15): 15231 - 15239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Elbi, D. A. Walker, G. Romero, W. P. Sullivan, D. O. Toft, G. L. Hager, and D. B. DeFranco Molecular chaperones function as steroid receptor nuclear mobility factors PNAS, March 2, 2004; 101(9): 2876 - 2881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Arnett-Mansfield, A. deFazio, P. A. Mote, and C. L. Clarke Subnuclear Distribution of Progesterone Receptors A and B in Normal and Malignant Endometrium J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1429 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Smith and B. W. O'Malley Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators Endocr. Rev., February 1, 2004; 25(1): 45 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Lonard, S. Y. Tsai, and B. W. O'Malley Selective Estrogen Receptor Modulators 4-Hydroxytamoxifen and Raloxifene Impact the Stability and Function of SRC-1 and SRC-3 Coactivator Proteins Mol. Cell. Biol., January 1, 2004; 24(1): 14 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ochiai, K.-i. Matsuda, M. Nishi, H. Ozawa, and M. Kawata Imaging Analysis of Subcellular Correlation of Androgen Receptor and Estrogen Receptor {alpha} in Single Living Cells Using Green Fluorescent Protein Color Variants Mol. Endocrinol., January 1, 2004; 18(1): 26 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Marsaud, A. Gougelet, S. Maillard, and J.-M. Renoir Various Phosphorylation Pathways, Depending on Agonist and Antagonist Binding to Endogenous Estrogen Receptor {alpha} (ER{alpha}), Differentially Affect ER{alpha} Extractability, Proteasome-Mediated Stability, and Transcriptional Activity in Human Breast Cancer Cells Mol. Endocrinol., October 1, 2003; 17(10): 2013 - 2027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Pilipuk, M. D. Galigniana, and J. Schwartz Subnuclear Localization of C/EBP{beta} Is Regulated by Growth Hormone and Dependent on MAPK J. Biol. Chem., September 12, 2003; 278(37): 35668 - 35677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ben-Yehoyada, I. Ben-Dor, and Y. Shaul c-Abl Tyrosine Kinase Selectively Regulates p73 Nuclear Matrix Association J. Biol. Chem., September 5, 2003; 278(36): 34475 - 34482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Amazit, Y. Alj, R. K. Tyagi, A. Chauchereau, H. Loosfelt, C. Pichon, J. Pantel, E. Foulon-Guinchard, P. Leclerc, E. Milgrom, et al. Subcellular Localization and Mechanisms of Nucleocytoplasmic Trafficking of Steroid Receptor Coactivator-1 J. Biol. Chem., August 22, 2003; 278(34): 32195 - 32203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. De Bosscher, W. Vanden Berghe, and G. Haegeman The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression Endocr. Rev., August 1, 2003; 24(4): 488 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Alarid, M. T. Preisler-Mashek, and N. M. Solodin Thyroid Hormone Is an Inhibitor of Estrogen-Induced Degradation of Estrogen Receptor-{alpha} Protein: Estrogen-Dependent Proteolysis Is Not Essential for Receptor Transactivation Function in the Pituitary Endocrinology, August 1, 2003; 144(8): 3469 - 3476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, L. Liao, S.-Q. Kuang, and J. Xu Spatial Distribution of the Messenger Ribonucleic Acid and Protein of the Nuclear Receptor Coactivator, Amplified in Breast Cancer-3, in Mice Endocrinology, April 1, 2003; 144(4): 1435 - 1443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dan, J. C. Y. Cheung, D. R. L. Scriven, and E. D. W. Moore Epitope-dependent localization of estrogen receptoralpha , but not -beta , in en face arterial endothelium Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1295 - H1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Maruvada, C. T. Baumann, G. L. Hager, and P. M. Yen Dynamic Shuttling and Intranuclear Mobility of Nuclear Hormone Receptors J. Biol. Chem., March 28, 2003; 278(14): 12425 - 12432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. M. Schaaf and J. A. Cidlowski Molecular Determinants of Glucocorticoid Receptor Mobility in Living Cells: the Importance of Ligand Affinity Mol. Cell. Biol., March 15, 2003; 23(6): 1922 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Day, T. C. Voss, J. F. Enwright III, C. F. Booker, A. Periasamy, and F. Schaufele Imaging the Localized Protein Interactions Between Pit-1 and the CCAAT/Enhancer Binding Protein {alpha} in the Living Pituitary Cell Nucleus Mol. Endocrinol., March 1, 2003; 17(3): 333 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kino and G. P. Chrousos Tumor Necrosis Factor alpha Receptor- and Fas-associated FLASH Inhibit Transcriptional Activity of the Glucocorticoid Receptor by Binding to and Interfering with Its Interaction with p160 Type Nuclear Receptor Coactivators J. Biol. Chem., January 24, 2003; 278(5): 3023 - 3029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Figtree, D. McDonald, H. Watkins, and K. M. Channon Truncated Estrogen Receptor {alpha} 46-kDa Isoform in Human Endothelial Cells: Relationship to Acute Activation of Nitric Oxide Synthase Circulation, January 7, 2003; 107(1): 120 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Rivera, C. S. Song, V. E. Centonze, J. D. Lechleiter, B. Chatterjee, and A. K. Roy Role of the Promyelocytic Leukemia Body in the Dynamic Interaction between the Androgen Receptor and Steroid Receptor Coactivator-1 in Living Cells Mol. Endocrinol., January 1, 2003; 17(1): 128 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Ruas, L. Poellinger, and T. Pereira Functional Analysis of Hypoxia-inducible Factor-1alpha -mediated Transactivation. IDENTIFICATION OF AMINO ACID RESIDUES CRITICAL FOR TRANSCRIPTIONAL ACTIVATION AND/OR INTERACTION WITH CREB-BINDING PROTEIN J. Biol. Chem., October 4, 2002; 277(41): 38723 - 38730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Matsuda, I. Ochiai, M. Nishi, and M. Kawata Colocalization and Ligand-Dependent Discrete Distribution of the Estrogen Receptor (ER){alpha} and ER{beta} Mol. Endocrinol., October 1, 2002; 16(10): 2215 - 2230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-B. Lazaro, P. J. Bailey, and A. B. Lassar Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation Genes & Dev., July 15, 2002; 16(14): 1792 - 1805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. DeFranco Navigating Steroid Hormone Receptors through the Nuclear Compartment Mol. Endocrinol., July 1, 2002; 16(7): 1449 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vottero, T. Kino, H. Combe, P. Lecomte, and G. P. Chrousos A Novel, C-Terminal Dominant Negative Mutation of the GR Causes Familial Glucocorticoid Resistance through Abnormal Interactions with p160 Steroid Receptor Coactivators J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2658 - 2667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Nye, R. R. Rajendran, D. L. Stenoien, M. A. Mancini, B. S. Katzenellenbogen, and A. S. Belmont Alteration of Large-Scale Chromatin Structure by Estrogen Receptor Mol. Cell. Biol., May 15, 2002; 22(10): 3437 - 3449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Mulholland, H. Cheng, K. Reid, P. S. Rennie, and C. C. Nelson The Androgen Receptor Can Promote beta -Catenin Nuclear Translocation Independently of Adenomatous Polyposis Coli J. Biol. Chem., May 10, 2002; 277(20): 17933 - 17943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Lloyd, R. C. Trembath, and S. Shackleton A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies Hum. Mol. Genet., April 1, 2002; 11(7): 769 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saitoh, R. Takayanagi, K. Goto, A. Fukamizu, A. Tomura, T. Yanase, and H. Nawata The Presence of Both the Amino- and Carboxyl-Terminal Domains in the AR Is Essential for the Completion of a Transcriptionally Active Form with Coactivators and Intranuclear Compartmentalization Common to the Steroid Hormone Receptors: A Three-Dimensional Imaging Study Mol. Endocrinol., April 1, 2002; 16(4): 694 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Akiyama, C. T. Baumann, S. Sakai, G. L. Hager, and F. J. Gonzalez Selective Intranuclear Redistribution of PPAR Isoforms by RXR{alpha} Mol. Endocrinol., April 1, 2002; 16(4): 707 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. V. Weatherman, C.-Y. Chang, N. J. Clegg, D. C. Carroll, R. N. Day, J. D. Baxter, D. P. McDonnell, T. S. Scanlan, and F. Schaufele Ligand-Selective Interactions of ER Detected in Living Cells by Fluorescence Resonance Energy Transfer Mol. Endocrinol., March 1, 2002; 16(3): 487 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. AEsoy, G. Mellgren, K.-I. Morohashi, and J. Lund Activation of cAMP-Dependent Protein Kinase Increases the Protein Level of Steroidogenic Factor-1 Endocrinology, January 1, 2002; 143(1): 295 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Schaufele, J. F. Enwright III, X. Wang, C. Teoh, R. Srihari, R. Erickson, O. A. MacDougald, and R. N. Day CCAAT/Enhancer Binding Protein {alpha} Assembles Essential Cooperating Factors in Common Subnuclear Domains Mol. Endocrinol., October 1, 2001; 15(10): 1665 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Sunn, T.-A. Cock, L. A. Crofts, J. A. Eisman, and E. M. Gardiner Novel N-Terminal Variant of Human VDR Mol. Endocrinol., September 1, 2001; 15(9): 1599 - 1609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Stenoien, A. C. Nye, M. G. Mancini, K. Patel, M. Dutertre, B. W. O'Malley, C. L. Smith, A. S. Belmont, and M. A. Mancini Ligand-Mediated Assembly and Real-Time Cellular Dynamics of Estrogen Receptor {alpha}-Coactivator Complexes in Living Cells Mol. Cell. Biol., July 1, 2001; 21(13): 4404 - 4412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Yen Physiological and Molecular Basis of Thyroid Hormone Action Physiol Rev, July 1, 2001; 81(3): 1097 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Choi, J. Pratap, A. Javed, S. K. Zaidi, L. Xing, E. Balint, S. Dalamangas, B. Boyce, A. J. van Wijnen, J. B. Lian, et al. Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development PNAS, June 28, 2001; (2001) 151236498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pasqualini, D. Guivarc'h, J.-V. Barnier, B. Guibert, J.-D. Vincent, and P. Vernier Differential Subcellular Distribution and Transcriptional Activity of {{Sigma}}E3, {{Sigma}}E4, and {{Sigma}}E3-4 Isoforms of the Rat Estrogen Receptor-{{alpha}} Mol. Endocrinol., June 1, 2001; 15(6): 894 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Price Jr., C. A. Butler, P. Webb, R. Uht, P. Kushner, and R. J. Handa A Splice Variant of Estrogen Receptor {beta} Missing Exon 3 Displays Altered Subnuclear Localization and Capacity for Transcriptional Activation Endocrinology, May 1, 2001; 142(5): 2039 - 2049. [Abstract] [Full Text]
|
|
|
|
|
|
C. Herrmann and M. Mancini The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions J. Cell Sci., January 4, 2001; 114(8): 1491 - 1503. [Abstract] [PDF]
|
|
|
|
|
|
J Nickerson Experimental observations of a nuclear matrix J. Cell Sci., January 2, 2001; 114(3): 463 - 474. [Abstract] [PDF]
|
|
|
|
|
|
F. Schaufele, C.-y. Chang, W. Liu, J. D. Baxter, S. K. Nordeen, Y. Wan, R. N. Day, and D. P. McDonnell Temporally Distinct and Ligand-Specific Recruitment of Nuclear Receptor-Interacting Peptides and Cofactors to Subnuclear Domains Containing the Estrogen Receptor Mol. Endocrinol., December 1, 2000; 14(12): 2024 - 2039. [Abstract] [Full Text]
|
|
|
|
|
|
R. K. Tyagi, Y. Lavrovsky, S. C. Ahn, C. S. Song, B. Chatterjee, and A. K. Roy Dynamics of Intracellular Movement and Nucleocytoplasmic Recycling of the Ligand-Activated Androgen Receptor in Living Cells Mol. Endocrinol., August 1, 2000; 14(8): 1162 - 1174. [Abstract] [Full Text]
|
|
|
|
|
|
K. Prufer, A. Racz, G. C. Lin, and J. Barsony Dimerization with Retinoid X Receptors Promotes Nuclear Localization and Subnuclear Targeting of Vitamin D Receptors J. Biol. Chem., December 22, 2000; 275(52): 41114 - 41123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Baumann, P. Maruvada, G. L. Hager, and P. M. Yen Nuclear Cytoplasmic Shuttling by Thyroid Hormone Receptors. MULTIPLE PROTEIN INTERACTIONS ARE REQUIRED FOR NUCLEAR RETENTION J. Biol. Chem., March 30, 2001; 276(14): 11237 - 11245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tomura, K. Goto, H. Morinaga, M. Nomura, T. Okabe, T. Yanase, R. Takayanagi, and H. Nawata The Subnuclear Three-dimensional Image Analysis of Androgen Receptor Fused to Green Fluorescence Protein J. Biol. Chem., July 20, 2001; 276(30): 28395 - 28401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Sun, H. Y. Chen, and J. R. Davie Effect of Estradiol on Histone Acetylation Dynamics in Human Breast Cancer Cells J. Biol. Chem., December 21, 2001; 276(52): 49435 - 49442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Choi, J. Pratap, A. Javed, S. K. Zaidi, L. Xing, E. Balint, S. Dalamangas, B. Boyce, A. J. van Wijnen, J. B. Lian, et al. Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development PNAS, July 17, 2001; 98(15): 8650 - 8655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Preisler-Mashek, N. Solodin, B. L. Stark, M. K. Tyriver, and E. T. Alarid Ligand-specific regulation of proteasome-mediated proteolysis of estrogen receptor-alpha Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E891 - E898. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
