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Molecular Endocrinology 15 (12): 2057-2063
Copyright © 2001 by The Endocrine Society

Minireview

Minireview: Genomic Organization of the Human ER{alpha} Gene Promoter Region

Martin Kos, George Reid, Stefanie Denger and Frank Gannon

European Molecular Biology Laboratory, D-69117 Heidelberg, Germany

Address all correspondence and requests for reprints to: Dr. Martin Kos, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117, Heidelberg, Germany. E-mail: kos{at}embl-heidelberg.de

ABSTRACT

The ER{alpha} gene has been intensively studied for more than a decade. During this long time, multiple promoters used in ER{alpha} expression have been discovered in several species. Although an already large body of literature describing various aspects of the regulation of ER{alpha} expression and utilization of different promoters is constantly growing, the inconsistent terminology used by individual authors makes the interpretation and comparison of data very difficult. Furthermore, completion of the human genome project now allows all known human ER{alpha} promoters to be placed on a physical map. This review describes promoters used in the generation of ER{alpha} transcripts in human and in other species and suggests a consistent nomenclature. The possible role of multiple promoters in the differential expression of ER{alpha} in tissues and during development is also discussed.




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