| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Biochemistry Case Western Reserve University Cleveland, Ohio 44106
The high-mobility group (HMG) box defines a DNA-bending motif of broad interest in relation to human development and disease. Major and minor wings of an L-shaped structure provide a template for DNA bending. As in the TATA-binding protein and a diverse family of factors, insertion of one or more side chains between base pairs induces a DNA kink. The HMG box binds in the DNA minor groove and may be specific for DNA sequence or distorted DNA architecture. Whereas the angular structures of non-sequence-specific domains are well ordered, free SRY and related autosomal SOX domains are in part disordered. Observations suggesting that the minor wing lacks a fixed tertiary structure motivate the hypothesis that DNA bending and stabilization of protein structure define a coupled process. We further propose that mutual induced fit in SOX-DNA recognition underlies the sequence dependence of DNA bending and enables the induction of promoter-specific architectures.
This article has been cited by other articles:
 |
|
 |
|
  D. Sinner, J. J. Kordich, J. R. Spence, R. Opoka, S. Rankin, S.-C. J. Lin, D. Jonatan, A. M. Zorn, and J. M. Wells Sox17 and Sox4 Differentially Regulate {beta}-Catenin/T-Cell Factor Activity and Proliferation of Colon Carcinoma Cells Mol. Cell. Biol., November 15, 2007; 27(22): 7802 - 7815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Guimont, F. Grondin, and C. M. Dubois Sox9-dependent transcriptional regulation of the proprotein convertase furin Am J Physiol Cell Physiol, July 1, 2007; 293(1): C172 - C183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zhang, T. Basta, E. D. Jensen, and M. W. Klymkowsky The {beta}-catenin/VegT-regulated early zygotic gene Xnr5 is a direct target of SOX3 regulation Development, December 1, 2003; 130(23): 5609 - 5624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Klass, F. V. Murphy IV, S. Fouts, M. Serenil, A. Changela, J. Siple, and M. E. A. Churchill The role of intercalating residues in chromosomal high-mobility-group protein DNA binding, bending and specificity Nucleic Acids Res., June 1, 2003; 31(11): 2852 - 2864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Bridgewater, M. D. Walker, G. C. Miller, T. A. Ellison, L. D. Holsinger, J. L. Potter, T. L. Jackson, R. K. Chen, V. L. Winkel, Z. Zhang, et al. Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements Nucleic Acids Res., March 1, 2003; 31(5): 1541 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yuan, M. L. Lu, T. Li, and S. P. Balk SRY Interacts with and Negatively Regulates Androgen Receptor Transcriptional Activity J. Biol. Chem., November 30, 2001; 276(49): 46647 - 46654. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
