help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reutens, A. T.
Right arrow Articles by Pestell, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reutens, A. T.
Right arrow Articles by Pestell, R. G.
Molecular Endocrinology 15 (5): 797-811
Copyright © 2001 by The Endocrine Society

Cyclin D1 Binds the Androgen Receptor and Regulates Hormone-Dependent Signaling in a p300/CBP-Associated Factor (P/CAF)-Dependent Manner

Anne T. Reutens1, Maofu Fu1, Chenguang Wang, Chris Albanese, Michael J. McPhaul, Zijie Sun, Steven P. Balk, Olli A. Jänne, Jorma J. Palvimo and Richard G. Pestell

The Albert Einstein Comprehensive Cancer Center (A.T.R., M.F., C.W., C.A., R.G.P.) Division of Hormone-Dependent Tumor Biology Department of Developmental and Molecular Biology Albert Einstein College of Medicine Bronx, New York 10461
Department of Internal Medicine (M.J.M.) University of Texas Southwestern Medical Center, Dallas Dallas, Texas 75235-8857
Department of Surgery and Genetics (Z.S.) Stanford University School of Medicine Stanford, California 943054
Hematology-Oncology Division (S.P.B.) Department of Medicine Beth Israel Hospital Boston, Massachusetts 02215
Department of Physiology (O.A.J., J.J.P.) Institute of Biomedicine and Department of Clinical Chemistry University of Helsinki FIN-00014 Helsinki, Finland

The androgen receptor (AR) is a ligand-regulated member of the nuclear receptor superfamily. The cyclin D1 gene product, which encodes the regulatory subunit of holoenzymes that phosphorylate the retinoblastoma protein (pRB), promotes cellular proliferation and inhibits cellular differentiation in several different cell types. Herein the cyclin D1 gene product inhibited ligand-induced AR- enhancer function through a pRB-independent mechanism requiring the cyclin D1 carboxyl terminus. The histone acetyltransferase activity of P/CAF (p300/CBP associated factor) rescued cyclin D1-mediated AR trans-repression. Cyclin D1 and the AR both bound to similar domains of P/CAF, and cyclin D1 displaced binding of the AR to P/CAF in vitro. These studies suggest cyclin D1 binding to the AR may repress ligand-dependent AR activity by directly competing for P/CAF binding.




This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
M. L. Cutress, H. C. Whitaker, I. G. Mills, M. Stewart, and D. E. Neal
Structural basis for the nuclear import of the human androgen receptor
J. Cell Sci., April 1, 2008; 121(7): 957 - 968.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Li, C. Wang, X. Jiao, S. Katiyar, M. C. Casimiro, G. C. Prendergast, M. J. Powell, and R. G. Pestell
Alternate Cyclin D1 mRNA Splicing Modulates p27KIP1 Binding and Cell Migration
J. Biol. Chem., March 14, 2008; 283(11): 7007 - 7015.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. H. Suh, M. Shong, H.-S. Choi, and K. Lee
CR6-Interacting Factor 1 Represses the Transactivation of Androgen Receptor by Direct Interaction
Mol. Endocrinol., January 1, 2008; 22(1): 33 - 46.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
H. V. Heemers and D. J. Tindall
Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex
Endocr. Rev., December 1, 2007; 28(7): 778 - 808.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Zong, Y. Chi, Y. Wang, Y. Yang, L. Zhang, H. Chen, J. Jiang, Z. Li, Y. Hong, H. Wang, et al.
Cyclin D3/CDK11p58 Complex Is Involved in the Repression of Androgen Receptor
Mol. Cell. Biol., October 15, 2007; 27(20): 7125 - 7142.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Casimiro, O. Rodriguez, L. Pootrakul, M. Aventian, N. Lushina, C. Cromelin, G. Ferzli, K. Johnson, S. Fricke, F. Diba, et al.
ErbB-2 Induces the Cyclin D1 Gene in Prostate Epithelial Cells In vitro and In vivo
Cancer Res., May 1, 2007; 67(9): 4364 - 4372.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
N N Chattergoon, G D Giraud, and K L Thornburg
Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro
J. Endocrinol., February 1, 2007; 192(2): R1 - R8.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
C. J Burd, L. M Morey, and K. E Knudsen
Androgen receptor corepressors and prostate cancer
Endocr. Relat. Cancer, December 1, 2006; 13(4): 979 - 994.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Fu, M. Liu, A. A. Sauve, X. Jiao, X. Zhang, X. Wu, M. J. Powell, T. Yang, W. Gu, M. L. Avantaggiati, et al.
Hormonal Control of Androgen Receptor Function through SIRT1
Mol. Cell. Biol., November 1, 2006; 26(21): 8122 - 8135.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
I. R. Logan, L. Gaughan, S. R. C. McCracken, V. Sapountzi, H. Y. Leung, and C. N. Robson
Human PIRH2 Enhances Androgen Receptor Signaling through Inhibition of Histone Deacetylase 1 and Is Overexpressed in Prostate Cancer.
Mol. Cell. Biol., September 1, 2006; 26(17): 6502 - 6510.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Wang, Z. Li, Y. Lu, R. Du, S. Katiyar, J. Yang, M. Fu, J. E. Leader, A. Quong, P. M. Novikoff, et al.
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
PNAS, August 1, 2006; 103(31): 11567 - 11572.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. J. Burd, C. E. Petre, L. M. Morey, Y. Wang, M. P. Revelo, C. A. Haiman, S. Lu, C. M. Fenoglio-Preiser, J. Li, E. S. Knudsen, et al.
Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation
PNAS, February 14, 2006; 103(7): 2190 - 2195.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. J. Mulholland, S. Dedhar, G. A. Coetzee, and C. C. Nelson
Interaction of Nuclear Receptors with the Wnt/{beta}-Catenin/Tcf Signaling Axis: Wnt You Like to Know?
Endocr. Rev., December 1, 2005; 26(7): 898 - 915.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Fu, C. Wang, M. Rao, X. Wu, T. Bouras, X. Zhang, Z. Li, X. Jiao, J. Yang, A. Li, et al.
Cyclin D1 Represses p300 Transactivation through a Cyclin-dependent Kinase-independent Mechanism
J. Biol. Chem., August 19, 2005; 280(33): 29728 - 29742.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Wang, S. Fan, Z. Li, M. Fu, M. Rao, Y. Ma, M. P. Lisanti, C. Albanese, B. S. Katzenellenbogen, P. J. Kushner, et al.
Cyclin D1 Antagonizes BRCA1 Repression of Estrogen Receptor {alpha} Activity
Cancer Res., August 1, 2005; 65(15): 6557 - 6567.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P. J. Martin, V. Lardeux, and P. Lefebvre
The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction
Nucleic Acids Res., July 29, 2005; 33(13): 4311 - 4321.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K.A.L. Tan, K.J. Turner, P.T.K. Saunders, G. Verhoeven, K. De Gendt, N. Atanassova, and R.M. Sharpe
Androgen Regulation of Stage-Dependent Cyclin D2 Expression in Sertoli Cells Suggests a Role in Modulating Androgen Action on Spermatogenesis
Biol Reprod, May 1, 2005; 72(5): 1151 - 1160.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Fu, M. Rao, T. Bouras, C. Wang, K. Wu, X. Zhang, Z. Li, T.-P. Yao, and R. G. Pestell
Cyclin D1 Inhibits Peroxisome Proliferator-activated Receptor {gamma}-mediated Adipogenesis through Histone Deacetylase Recruitment
J. Biol. Chem., April 29, 2005; 280(17): 16934 - 16941.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. T. E. Lim, M. Mansukhani, and I. B. Weinstein
Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells
PNAS, April 5, 2005; 102(14): 5156 - 5161.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
F. Bienvenu, B. Barre, S. Giraud, S. Avril, and O. Coqueret
Transcriptional Regulation by a DNA-associated Form of Cyclin D1
Mol. Biol. Cell, April 1, 2005; 16(4): 1850 - 1858.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. J. Burd, C. E. Petre, H. Moghadam, E. M. Wilson, and K. E. Knudsen
Cyclin D1 Binding to the Androgen Receptor (AR) NH2-Terminal Domain Inhibits Activation Function 2 Association and Reveals Dual Roles for AR Corepression
Mol. Endocrinol., March 1, 2005; 19(3): 607 - 620.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Fu, C. Wang, Z. Li, T. Sakamaki, and R. G. Pestell
Minireview: Cyclin D1: Normal and Abnormal Functions
Endocrinology, December 1, 2004; 145(12): 5439 - 5447.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Emmerich, C. A. Meyer, A. F. A. de la Cruz, B. A. Edgar, and C. F. Lehner
Cyclin D Does Not Provide Essential Cdk4-Independent Functions in Drosophila
Genetics, October 1, 2004; 168(2): 867 - 875.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Fu, M. Rao, K. Wu, C. Wang, X. Zhang, M. Hessien, Y.-G. Yeung, D. Gioeli, M. J. Weber, and R. G. Pestell
The Androgen Receptor Acetylation Site Regulates cAMP and AKT but Not ERK-induced Activity
J. Biol. Chem., July 9, 2004; 279(28): 29436 - 29449.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Jia, C. S-Y. Choong, C. Ricciardelli, J. Kim, W. D. Tilley, and G. A Coetzee
Androgen Receptor Signaling: Mechanism of Interleukin-6 Inhibition
Cancer Res., April 1, 2004; 64(7): 2619 - 2626.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Cifuentes, J. M. Mataraza, B. A. Yoshida, M. Menon, D. B. Sacks, E. R. Barrack, and G. P.-V. Reddy
Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells
PNAS, January 13, 2004; 101(2): 464 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Fu, M. Rao, C. Wang, T. Sakamaki, J. Wang, D. Di Vizio, X. Zhang, C. Albanese, S. Balk, C. Chang, et al.
Acetylation of Androgen Receptor Enhances Coactivator Binding and Promotes Prostate Cancer Cell Growth
Mol. Cell. Biol., December 1, 2003; 23(23): 8563 - 8575.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Wang, N. Pattabiraman, J. N. Zhou, M. Fu, T. Sakamaki, C. Albanese, Z. Li, K. Wu, J. Hulit, P. Neumeister, et al.
Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor {gamma} Expression and Transactivation
Mol. Cell. Biol., September 1, 2003; 23(17): 6159 - 6173.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. E. Petre-Draviam, S. L. Cook, C. J. Burd, T. W. Marshall, Y. B. Wetherill, and K. E. Knudsen
Specificity of Cyclin D1 for Androgen Receptor Regulation
Cancer Res., August 15, 2003; 63(16): 4903 - 4913.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Shin and I. M. Verma
BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription
PNAS, June 10, 2003; 100(12): 7201 - 7206.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Despouy, J.-N. Bastie, S. Deshaies, N. Balitrand, A. Mazharian, C. Rochette-Egly, C. Chomienne, and L. Delva
Cyclin D3 Is a Cofactor of Retinoic Acid Receptors, Modulating Their Activity in the Presence of Cellular Retinoic Acid-binding Protein II
J. Biol. Chem., February 14, 2003; 278(8): 6355 - 6362.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. Comuzzi, L. Lambrinidis, H. Rogatsch, S. Godoy-Tundidor, N. Knezevic, I. Krhen, Z. Marekovic, G. Bartsch, H. Klocker, A. Hobisch, et al.
The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function
Am. J. Pathol., January 1, 2003; 162(1): 233 - 241.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. D. Martinez and M. Danielsen
Loss of Androgen Receptor Transcriptional Activity at the G1/S Transition
J. Biol. Chem., August 9, 2002; 277(33): 29719 - 29729.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Fu, C. Wang, J. Wang, X. Zhang, T. Sakamaki, Y. G. Yeung, C. Chang, T. Hopp, S. A. W. Fuqua, E. Jaffray, et al.
Androgen Receptor Acetylation Governs trans Activation and MEKK1-Induced Apoptosis without Affecting In Vitro Sumoylation and trans-Repression Function
Mol. Cell. Biol., May 15, 2002; 22(10): 3373 - 3388.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. J. Mulholland, H. Cheng, K. Reid, P. S. Rennie, and C. C. Nelson
The Androgen Receptor Can Promote beta -Catenin Nuclear Translocation Independently of Adenomatous Polyposis Coli
J. Biol. Chem., May 10, 2002; 277(20): 17933 - 17943.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Holter, N. Kotaja, S. Makela, L. Strauss, S. Kietz, O. A. Janne, J.-A. Gustafsson, J. J. Palvimo, and E. Treuter
Inhibition of Androgen Receptor (AR) Function by the Reproductive Orphan Nuclear Receptor DAX-1
Mol. Endocrinol., March 1, 2002; 16(3): 515 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Stanbrough, I. Leav, P. W. L. Kwan, G. J. Bubley, and S. P. Balk
Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
PNAS, September 4, 2001; (2001) 191235898.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. E. Petre, Y. B. Wetherill, M. Danielsen, and K. E. Knudsen
Cyclin D1: Mechanism and Consequence of Androgen Receptor Co-repressor Activity
J. Biol. Chem., January 11, 2002; 277(3): 2207 - 2215.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Stanbrough, I. Leav, P. W. L. Kwan, G. J. Bubley, and S. P. Balk
Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
PNAS, September 11, 2001; 98(19): 10823 - 10828.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2001 by The Endocrine Society