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Puromycin-Sensitive Aminopeptidase Is Essential for the Maternal Recognition of Pregnancy in Mice

Mitsubishi Kasei Institute of Life Sciences (T.O., T.T.) Tokyo,194–8511, Japan
Laboratory of Functional Genomics (T.O., Y.S.), Human Genome Center The Institute of Medical Science University of Tokyo Tokyo 108-8639, Japan
Laboratory of Veterinary Physiology (G.W.) Tokyo University of Agriculture and Technology Tokyo 183-8509, Japan

Maternal recognition of pregnancy in rodents requires semicircadian surges of hypophyseal PRL secretion during early gestation, which are required for the formation of the corpus luteum of pregnancy (CLP). Here we show that puromycin-sensitive aminopeptidase (Psa)-deficient mice display female infertility that results from impaired formation of CLP. Transplantation of mutant ovaries into normal females restored fertility but not vice versa. Psa-deficient females revealed no semicircadian surges of PRL induced after mating stimuli. Pregnancy in the mutant females was restored by grafting intact pituitaries to elevate circulating levels of PRL. Psa is thus required for the appearance of the semicircadian surges of PRL secretion that are crucial for maintaining pregnancy in rodents.

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