help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flamant, F.
Right arrow Articles by Samarut, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flamant, F.
Right arrow Articles by Samarut, J.
Molecular Endocrinology 16 (1): 24-32
Copyright © 2002 by The Endocrine Society

Congenital Hypothyroid Pax8-/- Mutant Mice Can Be Rescued by Inactivating the TR{alpha} Gene

Frédéric Flamant1, Anne-Lise Poguet1, Michelina Plateroti, Olivier Chassande, Karine Gauthier, Nathalie Streichenberger, Ahmed Mansouri and Jacques Samarut

Laboratoire de Biologie Moléculaire et Cellulaire de l’Ecole Normale Supérieure de Lyon (F.F., A.-L.P., M.P., O.C., K.G., J.S.), Unité Mixte de Recherche Centre National de la Recherche Scientifique 5665 LA INRA913, 69364 Lyon Cedex 07, France; Laboratoire d’Histologie et d’Embryologie Moléculaires (N.S.), Faculté de Médecine Laennec, Université Claude Bernard Lyon I, 69372 Lyon Cedex 08; Max-Planck Institute for Biophysical Chemistry (A.M.), Department of Molecular Cell Biology, D-37077 Gottingen, Germany

Address all correspondence and requests for reprints to: Frédéric Flamant, Laboratoire de Biologie Moléculaire et Cellulaire de l’Ecole Normale Supérieure de Lyon, Unité Mixte de Recherche Centre National de la Recherche Scientifique 5665 LA INRA913, 46 Allée d’Italie, 69364 Lyon Cedex 07, France. E-mail: Frederic.Flamant{at}ens-lyon.fr

Mice devoid of all TRs are viable, whereas Pax8-/- mice, which lack the follicular cells producing T4 and T3 in the thyroid gland, die during the first weeks of postnatal life. A precise comparison between the two types of mutants reveals that their phenotypes are similar, but the defects in spleen, bone, and small intestine are more pronounced in Pax8-/- mice. This is interpreted as the result of a negative effect of the unliganded TR on thyroid hormone target genes expression in the Pax8-/- mutants. Pax8/TR{alpha} compound mutants can survive to adulthood, and the expression of target genes is partially restored. This demonstrates the importance of TR{alpha} aporeceptor activity in several aspects of postnatal development.




This article has been cited by other articles:


Home page
 EndocrinologyHome page
J. Mittag, S. Friedrichsen, A. Strube, H. Heuer, and K. Bauer
Analysis of Hypertrophic Thyrotrophs in Pituitaries of Athyroid Pax8-/- Mice
Endocrinology, September 1, 2009; 150(9): 4443 - 4449.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
J H D. Bassett and G. R Williams
The skeletal phenotypes of TR{alpha} and TR{beta} mutant mice
J. Mol. Endocrinol., April 1, 2009; 42(4): 269 - 282.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Kress, A. Rezza, J. Nadjar, J. Samarut, and M. Plateroti
The Frizzled-related sFRP2 Gene Is a Target of Thyroid Hormone Receptor {alpha}1 and Activates {beta}-Catenin Signaling in Mouse Intestine
J. Biol. Chem., January 9, 2009; 284(2): 1234 - 1241.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Astapova, L. J. Lee, C. Morales, S. Tauber, M. Bilban, and A. N. Hollenberg
The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo
PNAS, December 9, 2008; 105(49): 19544 - 19549.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Kano, C. Marin de Evsikova, J. Young, C. Wnek, T. P. Maddatu, P. M. Nishina, and J. K. Naggert
A Novel Dwarfism with Gonadal Dysfunction Due to Loss-of-Function Allele of the Collagen Receptor Gene, Ddr2, in the Mouse
Mol. Endocrinol., August 1, 2008; 22(8): 1866 - 1880.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. H. D. Bassett, A. J. Williams, E. Murphy, A. Boyde, P. G. T. Howell, R. Swinhoe, M. Archanco, F. Flamant, J. Samarut, S. Costagliola, et al.
A Lack of Thyroid Hormones Rather than Excess Thyrotropin Causes Abnormal Skeletal Development in Hypothyroidism
Mol. Endocrinol., February 1, 2008; 22(2): 501 - 512.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Kress, A. Rezza, J. Nadjar, J. Samarut, and M. Plateroti
The Thyroid Hormone Receptor-{alpha} (TR{alpha}) Gene Encoding TR{alpha}1 Controls Deoxyribonucleic Acid Damage-Induced Tissue Repair
Mol. Endocrinol., January 1, 2008; 22(1): 47 - 55.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J. Mittag, W. Oehr, H. Heuer, T. Hamalainen, B. Brachvogel, E. Poschl, and K. Bauer
Expression and thyroid hormone regulation of annexins in the anterior pituitary
J. Endocrinol., December 1, 2007; 195(3): 385 - 392.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. Quignodon, S. Vincent, H. Winter, J. Samarut, and F. Flamant
A Point Mutation in the Activation Function 2 Domain of Thyroid Hormone Receptor {alpha}1 Expressed after CRE-Mediated Recombination Partially Recapitulates Hypothyroidism
Mol. Endocrinol., October 1, 2007; 21(10): 2350 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
L. Quignodon, C. Grijota-Martinez, E. Compe, R. Guyot, N. Allioli, D. Laperriere, R. Walker, P. Meltzer, S. Mader, J. Samarut, et al.
A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum
J. Mol. Endocrinol., July 1, 2007; 39(1): 17 - 28.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
C. M Villicev, F. R S Freitas, M. S Aoki, C. Taffarel, T. S Scanlan, A. S Moriscot, M. O Ribeiro, A. C Bianco, and C. H A Gouveia
Thyroid hormone receptor {beta}-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats
J. Endocrinol., April 1, 2007; 193(1): 21 - 29.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
F. Flamant, K. Gauthier, and J. Samarut
Thyroid Hormones Signaling Is Getting More Complex: STORMs Are Coming
Mol. Endocrinol., February 1, 2007; 21(2): 321 - 333.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Mittag, E. Winterhager, K. Bauer, and R. Grummer
Congenital Hypothyroid Female Pax8-Deficient Mice Are Infertile Despite Thyroid Hormone Replacement Therapy
Endocrinology, February 1, 2007; 148(2): 719 - 725.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J. Wistuba, J. Mittag, C M. Luetjens, T. G Cooper, C.-H. Yeung, E. Nieschlag, and K. Bauer
Male congenital hypothyroid Pax8-/- mice are infertile despite adequate treatment with thyroid hormone
J. Endocrinol., January 1, 2007; 192(1): 99 - 109.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
F. Flamant, J. D. Baxter, D. Forrest, S. Refetoff, H. Samuels, T. S. Scanlan, B. Vennstrom, and J. Samarut
International Union of Pharmacology. LIX. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Thyroid Hormone Receptors
Pharmacol. Rev., December 1, 2006; 58(4): 705 - 711.
[Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Takabayashi, K. Umeki, E. Yamamoto, T. Suzuki, A. Okayama, and H. Katoh
A Novel Hypothyroid Dwarfism Due to the Missense Mutation Arg479Cys of the Thyroid Peroxidase Gene in the Mouse
Mol. Endocrinol., October 1, 2006; 20(10): 2584 - 2590.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Bernal
Role of Monocarboxylate Anion Transporter 8 (MCT8) in Thyroid Hormone Transport: Answers from Mice.
Endocrinology, September 1, 2006; 147(9): 4034 - 4035.
[Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H. Winter, C. Braig, U. Zimmermann, H.-S. Geisler, J.-T. Franzer, T. Weber, M. Ley, J. Engel, M. Knirsch, K. Bauer, et al.
Thyroid hormone receptors TR{alpha}1 and TR{beta} differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells
J. Cell Sci., July 15, 2006; 119(14): 2975 - 2984.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
M. Nygard, N. Becker, B. Demeneix, K. Pettersson, and M. Bondesson
Thyroid hormone-mediated negative transcriptional regulation of Necdin expression.
J. Mol. Endocrinol., June 1, 2006; 36(3): 517 - 530.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. P. Farwell, S. A. Dubord-Tomasetti, A. Z. Pietrzykowski, and J. L. Leonard
Dynamic Nongenomic Actions of Thyroid Hormone in the Developing Rat Brain
Endocrinology, May 1, 2006; 147(5): 2567 - 2574.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Plateroti, E. Kress, J. I. Mori, and J. Samarut
Thyroid Hormone Receptor {alpha}1 Directly Controls Transcription of the {beta}-Catenin Gene in Intestinal Epithelial Cells
Mol. Cell. Biol., April 15, 2006; 26(8): 3204 - 3214.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. H. D. Bassett, R. Swinhoe, O. Chassande, J. Samarut, and G. R. Williams
Thyroid Hormone Regulates Heparan Sulfate Proteoglycan Expression in the Growth Plate
Endocrinology, January 1, 2006; 147(1): 295 - 305.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. Venero, A. Guadano-Ferraz, A. I. Herrero, K. Nordstrom, J. Manzano, G. M. de Escobar, J. Bernal, and B. Vennstrom
Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor {alpha}1 can be ameliorated by T3 treatment
Genes & Dev., September 15, 2005; 19(18): 2152 - 2163.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Mittag, S. Friedrichsen, H. Heuer, S. Polsfuss, T. J. Visser, and K. Bauer
Athyroid Pax8-/- Mice Cannot Be Rescued by the Inactivation of Thyroid Hormone Receptor {alpha}1
Endocrinology, July 1, 2005; 146(7): 3179 - 3184.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Angelin-Duclos, C. Domenget, A. Kolbus, H. Beug, P. Jurdic, and J. Samarut
Thyroid hormone T3 acting through the thyroid hormone {alpha} receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse
Development, March 1, 2005; 132(5): 925 - 934.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
L Quignodon, C Legrand, N Allioli, A Guadano-Ferraz, J Bernal, J Samarut, and F Flamant
Thyroid hormone signaling is highly heterogeneous during pre- and postnatal brain development
J. Mol. Endocrinol., October 1, 2004; 33(2): 467 - 476.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Mai, M. F. Janier, N. Allioli, L. Quignodon, T. Chuzel, F. Flamant, and J. Samarut
Thyroid hormone receptor {alpha} is a molecular switch of cardiac function between fetal and postnatal life
PNAS, July 13, 2004; 101(28): 10332 - 10337.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Morte, J. Manzano, T. S. Scanlan, B. Vennstrom, and J. Bernal
Aberrant Maturation of Astrocytes in Thyroid Hormone Receptor {alpha}1 Knockout Mice Reveals an Interplay between Thyroid Hormone Receptor Isoforms
Endocrinology, March 1, 2004; 145(3): 1386 - 1391.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R.-Y. Lin, A. Kubo, G. M. Keller, and T. F. Davies
Committing Embryonic Stem Cells to Differentiate into Thyrocyte-Like Cells in Vitro
Endocrinology, June 1, 2003; 144(6): 2644 - 2649.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Mukhopadhyay, M. Plateroti, S. Anant, F. Nassir, J. Samarut, and N. O. Davidson
Thyroid Hormone Regulates Hepatic Triglyceride Mobilization and Apolipoprotein B Messenger Ribonucleic Acid Editing in a Murine Model of Congenital Hypothyroidism
Endocrinology, February 1, 2003; 144(2): 711 - 719.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. M. Sachs, P. L. Jones, E. Havis, N. Rouse, B. A. Demeneix, and Y.-B. Shi
Nuclear Receptor Corepressor Recruitment by Unliganded Thyroid Hormone Receptor in Gene Repression during Xenopus laevis Development
Mol. Cell. Biol., December 15, 2002; 22(24): 8527 - 8538.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Baas, C. Legrand, J. Samarut, and F. Flamant
Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors
PNAS, March 5, 2002; 99(5): 2907 - 2911.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2002 by The Endocrine Society