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Molecular Endocrinology, doi:10.1210/me.2002-0094
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Molecular Endocrinology 16 (11): 2645-2656
Copyright © 2002 by The Endocrine Society

Fetal Brain Progenitor Cells Transdifferentiate to Fates Outside the Nervous System

Hoi Sang U, Warren Alilain and Farid Saljooque

Division of Neurological Surgery, Veterans Administration San Diego Health Care System and the University of California-San Diego, San Diego, California 92037

Address all correspondence and requests for reprints to: Hoi Sang U, M.D., Division of Neurosurgery, The Veteran’s Administration Medical Center, 3350 La Jolla Village Drive, La Jolla, California 92037. E-mail: hoisang{at}ucsd.edu.

Central nervous system stem cells give rise to neurons and glia when exposed to specific trophic factors. In our studies with rat fetal brain-derived stem cells (RSCs), we showed that they could be induced to express the developmentally regulated transcription factors and cell markers characteristic of cells derived from another germ layer, e.g. pituitary cells. Therefore, rat fetal brain-derived stem cells do not seem to be restricted to a defined developmental fate. They may retain pluripotentiality and can be redirected to develop into other cell types not found in the brain provided the correct set of stimuli is present. This multipotent developmental behavior also suggests that instructive signals are operative.




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