This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bernard, D. J. Articles by Woodruff, T. K. Search for Related Content PubMed PubMed Citation Articles by Bernard, D. J. Articles by Woodruff, T. K.

Minireview: Inhibin Binding Protein (InhBP/p120), Betaglycan, and the Continuing Search for the Inhibin Receptor

Department of Neurobiology and Physiology (D.J.B., S.C.C., T.K.W.), Northwestern University, Evanston, Illinois 60208; Department of Medicine (T.K.W.), Northwestern University Medical School, Chicago, Illinois 60657

Address all correspondence and requests for reprints to: Teresa K. Woodruff, Ph.D., Department of Neurobiology and Physiology, Northwestern University, 2153 North Campus Drive, Evanston, Illinois 60208. E-mail: tkw{at}northwestern.edu

ABSTRACT

Betaglycan (the TGFß type III receptor) and InhBP/p120 (a membrane-tethered proteoglycan) were recently identified as putative inhibin receptors. Here, we review the current state of knowledge regarding these two proteins with respect to their potential roles in inhibin biology. Importantly, neither protein appears to satisfy all of the criteria required for classification as a bona fide inhibin receptor. Betaglycan does not appear to be expressed in pituitary gonadotropes, the primary target of circulating inhibins, and InhBP/p120 does not bind inhibins in conventional receptor binding assays. While both proteins appear capable of promoting inhibin-mediated antagonism of activin signaling, neither appears to generate inhibin-specific intracellular signals. Recently, additional inhibin binding proteins were identified in inhibin target tissues, including pituitary and Leydig cells. Characterization of these proteins, coupled with ongoing investigations of betaglycan and InhBP/p120, will lead to a clearer understanding of mechanisms of inhibin action.

This article has been cited by other articles:

				M. Ruiz-Ortega, J. Rodriguez-Vita, E. Sanchez-Lopez, G. Carvajal, and J. Egido TGF-{beta} signaling in vascular fibrosis Cardiovasc Res, May 1, 2007; 74(2): 196 - 206. [Abstract] [Full Text] [PDF]

				C. Itman, S. Mendis, B. Barakat, and K. L. Loveland All in the family: TGF-{beta} family action in testis development. Reproduction, August 1, 2006; 132(2): 233 - 246. [Abstract] [Full Text] [PDF]

				S. Luisi, P. Florio, F. M. Reis, and F. Petraglia Inhibins in female and male reproductive physiology: role in gametogenesis, conception, implantation and early pregnancy Hum. Reprod. Update, March 1, 2005; 11(2): 123 - 135. [Abstract] [Full Text] [PDF]

				S. A. Sweeney and P. A. Johnson Messenger RNA and Protein Expression Analysis of Betaglycan in the Pituitary and Ovary of the Domestic Hen Biol Reprod, January 1, 2005; 72(1): 172 - 178. [Abstract] [Full Text] [PDF]

				D. D. Mruk and C. Y. Cheng Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis Endocr. Rev., October 1, 2004; 25(5): 747 - 806. [Abstract] [Full Text] [PDF]

				H. Dixit, M. Deendayal, and L. Singh Mutational analysis of the mature peptide region of inhibin genes in Indian women with ovarian failure Hum. Reprod., August 1, 2004; 19(8): 1760 - 1764. [Abstract] [Full Text] [PDF]

				V. Sriuranpong, A. Mutirangura, J. W. Gillespie, V. Patel, P. Amornphimoltham, A. A. Molinolo, V. Kerekhanjanarong, S. Supanakorn, P. Supiyaphun, S. Rangdaeng, et al. Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays Clin. Cancer Res., August 1, 2004; 10(15): 4944 - 4958. [Abstract] [Full Text] [PDF]

				R. B. Billiar, J. B. St. Clair, N. C. Zachos, M. G. Burch, E. D. Albrecht, and G. J. Pepe Localization and Developmental Expression of the Activin Signal Transduction Proteins Smads 2, 3, and 4 in the Baboon Fetal Ovary Biol Reprod, March 1, 2004; 70(3): 586 - 592. [Abstract] [Full Text] [PDF]

				S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson The Bone Morphogenetic Protein System In Mammalian Reproduction Endocr. Rev., February 1, 2004; 25(1): 72 - 101. [Abstract] [Full Text] [PDF]

				K. A. Prendergast, L. L. Burger, K. W. Aylor, D. J. Haisenleder, A. C. Dalkin, and J. C. Marshall Pituitary Follistatin Gene Expression in Female Rats: Evidence That Inhibin Regulates Transcription Biol Reprod, February 1, 2004; 70(2): 364 - 370. [Abstract] [Full Text] [PDF]

				D. J. Bernard, K. H. Burns, B. Haupt, M. M. Matzuk, and T. K. Woodruff Normal Reproductive Function in InhBP/p120-Deficient Mice Mol. Cell. Biol., July 15, 2003; 23(14): 4882 - 4891. [Abstract] [Full Text] [PDF]

				R. B. Billiar, N. C. Zachos, M. G. Burch, E. D. Albrecht, and G. J. Pepe Up-Regulation of {alpha}-Inhibin Expression in the Fetal Ovary of Estrogen-Suppressed Baboons Is Associated with Impaired Fetal Ovarian Folliculogenesis Biol Reprod, June 1, 2003; 68(6): 1989 - 1996. [Abstract] [Full Text] [PDF]

				E. Wiater and W. Vale Inhibin Is an Antagonist of Bone Morphogenetic Protein Signaling J. Biol. Chem., February 28, 2003; 278(10): 7934 - 7941. [Abstract] [Full Text] [PDF]

				F. Lopez-Casillas, C. Riquelme, Y. Perez-Kato, M. V. Ponce-Castaneda, N. Osses, J. Esparza-Lopez, G. Gonzalez-Nunez, C. Cabello-Verrugio, V. Mendoza, V. Troncoso, et al. Betaglycan Expression Is Transcriptionally Up-regulated during Skeletal Muscle Differentiation. CLONING OF MURINE BETAGLYCAN GENE PROMOTER AND ITS MODULATION BY MyoD, RETINOIC ACID, AND TRANSFORMING GROWTH FACTOR-beta J. Biol. Chem., January 3, 2003; 278(1): 382 - 390. [Abstract] [Full Text] [PDF]