This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Greenhalgh, C. J. Articles by Alexander, W. S. Search for Related Content PubMed PubMed Citation Articles by Greenhalgh, C. J. Articles by Alexander, W. S.

Growth Enhancement in Suppressor of Cytokine Signaling 2 (SOCS-2)-Deficient Mice Is Dependent on Signal Transducer and Activator of Transcription 5b (STAT5b)

The Cooperative Research Centre for Cellular Growth Factors and the Walter and Eliza Hall Institute of Medical Research (C.J.G., D.M., J.E.C., N.A.N., D.J.H., W.S.A.) Post Office, Royal Melbourne Hospital, Victoria, Australia; Centenary Institute of Cancer Medicine and Cell Biology (P.B.), Sydney 2042, Australia; Departments of Pathology, University Health Network and Department of Laboratory Medicine and Pathobiology (S.L.A.), University of Toronto, Ontario M5G 2M9, Canada; Commonwealth Scientific and Industrial Research Organization Health Sciences and Nutrition (T.E.A.), Parkville Laboratory, Parkville, Victoria 3052, Australia; AgResearch (H.W.D), Ruakura Research Centre, Hamilton, New Zealand

Address all correspondence and requests for reprints to: Dr. Christopher Greenhalgh, The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia. E-mail: greenhalgh{at}wehi.edu.au.

Mice lacking suppressor of cytokine signaling-2 (SOCS-2) exhibit accelerated postnatal growth resulting in adult mice that are 1.3 to 1.5 times the size of normal mice. In this study we examined the somatotrophic pathway to determine whether the production or actions of GH or IGF-I are altered in these mice. We demonstrated that SOCS-2^-/- mice do not have elevated GH levels and suffer no major pituitary dysmorphogenesis, and that SOCS-2-deficient embryonic fibroblasts do not have altered IGF-I signaling. Primary hepatocytes from SOCS-2^-/- mice, however, did have moderately prolonged signal transducer and activator of transcription 5 signaling in response to GH stimulation. Furthermore, the deletion of SOCS-2 from mice also lacking signal transducer and activator of transcription 5b had little effect on growth, suggesting that the action of SOCS-2 may be the regulation of the GH signaling pathway.

This article has been cited by other articles:

				S. Rieck, P. White, J. Schug, A. J. Fox, O. Smirnova, N. Gao, R. K. Gupta, Z. V. Wang, P. E. Scherer, M. P. Keller, et al. The Transcriptional Response of the Islet to Pregnancy in Mice Mol. Endocrinol., October 1, 2009; 23(10): 1702 - 1712. [Abstract] [Full Text] [PDF]

				I. Uyttendaele, I. Lemmens, A. Verhee, A.-S. De Smet, J. Vandekerckhove, D. Lavens, F. Peelman, and J. Tavernier Mammalian Protein-Protein Interaction Trap (MAPPIT) Analysis of STAT5, CIS, and SOCS2 Interactions with the Growth Hormone Receptor Mol. Endocrinol., November 1, 2007; 21(11): 2821 - 2831. [Abstract] [Full Text] [PDF]

				T. Garma, C. Kobayashi, F. Haddad, G. R. Adams, P. W. Bodell, and K. M. Baldwin Similar acute molecular responses to equivalent volumes of isometric, lengthening, or shortening mode resistance exercise J Appl Physiol, January 1, 2007; 102(1): 135 - 143. [Abstract] [Full Text] [PDF]

				J. Piessevaux, D. Lavens, T. Montoye, J. Wauman, D. Catteeuw, J. Vandekerckhove, D. Belsham, F. Peelman, and J. Tavernier Functional Cross-modulation between SOCS Proteins Can Stimulate Cytokine Signaling J. Biol. Chem., November 3, 2006; 281(44): 32953 - 32966. [Abstract] [Full Text] [PDF]

				D. Lavens, T. Montoye, J. Piessevaux, L. Zabeau, J. Vandekerckhove, K. Gevaert, W. Becker, S. Eyckerman, and J. Tavernier A complex interaction pattern of CIS and SOCS2 with the leptin receptor J. Cell Sci., June 1, 2006; 119(11): 2214 - 2224. [Abstract] [Full Text] [PDF]

				A. N. Bullock, J. E. Debreczeni, A. M. Edwards, M. Sundstrom, and S. Knapp Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase PNAS, May 16, 2006; 103(20): 7637 - 7642. [Abstract] [Full Text] [PDF]

				F. Haddad and G. R. Adams Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy J Appl Physiol, April 1, 2006; 100(4): 1188 - 1203. [Abstract] [Full Text] [PDF]

				C. Z. Michaylira, N. M. Ramocki, J. G. Simmons, C. K. Tanner, K. K. McNaughton, J. T. Woosley, C. J. Greenhalgh, and P. K. Lund Haplotype Insufficiency for Suppressor of Cytokine Signaling-2 Enhances Intestinal Growth and Promotes Polyp Formation in Growth Hormone-Transgenic Mice Endocrinology, April 1, 2006; 147(4): 1632 - 1641. [Abstract] [Full Text] [PDF]

				A. Flores-Morales, C. J. Greenhalgh, G. Norstedt, and E. Rico-Bautista Negative Regulation of Growth Hormone Receptor Signaling Mol. Endocrinol., February 1, 2006; 20(2): 241 - 253. [Abstract] [Full Text] [PDF]

				G. M. Tannahill, J. Elliott, A. C. Barry, L. Hibbert, N. A. Cacalano, and J. A. Johnston SOCS2 Can Enhance Interleukin-2 (IL-2) and IL-3 Signaling by Accelerating SOCS3 Degradation Mol. Cell. Biol., October 15, 2005; 25(20): 9115 - 9126. [Abstract] [Full Text] [PDF]

				S. Fruchtman, J. G. Simmons, C. Z. Michaylira, M. E. Miller, C. J. Greenhalgh, D. M. Ney, and P. K. Lund Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G342 - G350. [Abstract] [Full Text] [PDF]

				E. Rico-Bautista, C. J. Greenhalgh, P. Tollet-Egnell, D. J. Hilton, W. S. Alexander, G. Norstedt, and A. Flores-Morales Suppressor of Cytokine Signaling-2 Deficiency Induces Molecular and Metabolic Changes that Partially Overlap with Growth Hormone-Dependent Effects Mol. Endocrinol., March 1, 2005; 19(3): 781 - 793. [Abstract] [Full Text] [PDF]

				K.-C. Leung, G. Johannsson, G. M. Leong, and K. K. Y. Ho Estrogen Regulation of Growth Hormone Action Endocr. Rev., October 1, 2004; 25(5): 693 - 721. [Abstract] [Full Text] [PDF]

				C. Brender, R. Columbus, D. Metcalf, E. Handman, R. Starr, N. Huntington, D. Tarlinton, N. Odum, S. E. Nicholson, N. A. Nicola, et al. SOCS5 Is Expressed in Primary B and T Lymphoid Cells but Is Dispensable for Lymphocyte Production and Function Mol. Cell. Biol., July 1, 2004; 24(13): 6094 - 6103. [Abstract] [Full Text] [PDF]

				Y. Goldshmit, C. E. Walters, H. J. Scott, C. J. Greenhalgh, and A. M. Turnley SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation J. Biol. Chem., April 16, 2004; 279(16): 16349 - 16355. [Abstract] [Full Text] [PDF]

				A. Yoshimura, H. M. M. Ohishi, D. Aki, and T. Hanada Regulation of TLR signaling and inflammation by SOCS family proteins J. Leukoc. Biol., March 1, 2004; 75(3): 422 - 427. [Abstract] [Full Text] [PDF]

				L. Q. Hong-Brown, C. R. Brown, R. N. Cooney, R. A. Frost, and C. H. Lang Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E63 - E72. [Abstract] [Full Text] [PDF]

				F. Gu, N. Dube, J. W. Kim, A. Cheng, M. d. J. Ibarra-Sanchez, M. L. Tremblay, and Y. R. Boisclair Protein Tyrosine Phosphatase 1B Attenuates Growth Hormone-Mediated JAK2-STAT Signaling Mol. Cell. Biol., June 1, 2003; 23(11): 3753 - 3762. [Abstract] [Full Text] [PDF]

				K. C. Leung, N. Doyle, M. Ballesteros, K. Sjogren, C. K. W. Watts, T. H. Low, G. M. Leong, R. J. M. Ross, and K. K. Y. Ho Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2 PNAS, February 4, 2003; 100(3): 1016 - 1021. [Abstract] [Full Text] [PDF]

				C. J. Greenhalgh, D. Metcalf, A. L. Thaus, J. E. Corbin, R. Uren, P. O. Morgan, L. J. Fabri, J.-G. Zhang, H. M. Martin, T. A. Willson, et al. Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone Signaling J. Biol. Chem., October 18, 2002; 277(43): 40181 - 40184. [Abstract] [Full Text] [PDF]