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Molecular Endocrinology, doi:10.1210/me.2002-0363
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Molecular Endocrinology 17 (5): 777-791
Copyright © 2003 by The Endocrine Society

Minireview

Vitamin D: More Than a "Bone-a-Fide" Hormone

Amelia L. M. Sutton and Paul N. MacDonald

Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106

Address all correspondence and requests for reprints to: Paul N. MacDonald, Ph.D., Department of Pharmacology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106. E-mail: pnm2{at}po.cwru.edu.

The vitamin D endocrine system is critical for the proper development and maintenance of mineral ion homeostasis and skeletal integrity. Beyond these classical roles, recent evidence suggests that the bioactive metabolite of vitamin D, 1,25-dihydroxyvitamin D3, functions in diverse physiological processes, such as hair follicle cycling, blood pressure regulation, and mammary gland development. This minireview explores the current progress in unraveling the complexities of the vitamin D endocrine system by focusing on four main areas of research: the resolution of the vitamin D receptor crystal structure, the molecular details of 1,25-dihydroxyvitamin D3-mediated transcription, murine knockout models of key genes in the endocrine system, and alternative vitamin D receptors and ligands.

NURSA Molecule Pages Link:

Nuclear Receptors:   VDR
Coregulators:   TRAP220  |  CBP  |  SKIP  |  SRC-1  |  GRIP1  |  AIB1
Ligands:   Calcitriol



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