help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Molecular Endocrinology, doi:10.1210/me.2003-0116
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow NURSA Molecule Pages Link
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xu, J.
Right arrow Articles by Li, Q.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, J.
Right arrow Articles by Li, Q.
Molecular Endocrinology 17 (9): 1681-1692
Copyright © 2003 by The Endocrine Society

Minireview

Review of the in Vivo Functions of the p160 Steroid Receptor Coactivator Family

Jianming Xu and Qingtian Li

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030

Address all correspondence and requests for reprints to: Jianming Xu, Ph.D., Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030. E-mail: jxu{at}bcm.tmc.edu.

The p160 steroid receptor coactivator (SRC) gene family contains three homologous members, which serve as transcriptional coactivators for nuclear receptors and certain other transcription factors. These coactivators interact with ligand-bound nuclear receptors to recruit histone acetyltransferases and methyltransferases to specific enhancer/promotor regions, which facilitates chromatin remodeling, assembly of general transcription factors, and transcription of target genes. This minireview summarizes our current knowledge about the molecular structures, molecular mechanisms, temporal and spatial expression patterns, and biological functions of the SRC family. In particular, this article highlights the roles of SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NCoA-2) and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1) in development, organ function, endocrine regulation, and nuclear receptor function, which are defined by characterization of the genetically manipulated animal models. Furthermore, this article also reviews our current understanding of the role of SRC-3 in breast cancer and discusses possible mechanisms for functional specificity and redundancy among SRC family members.

NURSA Molecule Pages Link:

Nuclear Receptors:   ERα  |  ERβ
Coregulators:   PGC-1  |  SRC-1  |  GRIP1  |  AIB1



This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
J. Rambaud, J. Desroches, A. Balsalobre, and J. Drouin
TIF1{beta}/KAP-1 Is a Coactivator of the Orphan Nuclear Receptor NGFI-B/Nur77
J. Biol. Chem., May 22, 2009; 284(21): 14147 - 14156.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Qin, Z. Liu, H. Chen, and J. Xu
The Steroid Receptor Coactivator-1 Regulates Twist Expression and Promotes Breast Cancer Metastasis
Cancer Res., May 1, 2009; 69(9): 3819 - 3827.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Karmakar, E. A. Foster, and C. L. Smith
Unique Roles of p160 Coactivators for Regulation of Breast Cancer Cell Proliferation and Estrogen Receptor-{alpha} Transcriptional Activity
Endocrinology, April 1, 2009; 150(4): 1588 - 1596.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Garapaty, C.-F. Xu, P. Trojer, M. A. Mahajan, T. A. Neubert, and H. H. Samuels
Identification and Characterization of a Novel Nuclear Protein Complex Involved in Nuclear Hormone Receptor-mediated Gene Regulation
J. Biol. Chem., March 20, 2009; 284(12): 7542 - 7552.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. M. Redmond, F. T. Bane, A. T. Stafford, M. McIlroy, M. F. Dillon, T. B. Crotty, A. D. Hill, and L. S. Young
Coassociation of Estrogen Receptor and p160 Proteins Predicts Resistance to Endocrine Treatment; SRC-1 is an Independent Predictor of Breast Cancer Recurrence
Clin. Cancer Res., March 15, 2009; 15(6): 2098 - 2106.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
S. A Boorjian, H. V Heemers, I. Frank, S. A Farmer, L. J Schmidt, T. J Sebo, and D. J Tindall
Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder
Endocr. Relat. Cancer, March 1, 2009; 16(1): 123 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
A. Cheng and A. R. Saltiel
Von Gierke's Disease Adopts an Orphan (and Its Partner)
Sci. Signal., February 17, 2009; 2(58): pe8 - pe8.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Wang, Y. Yuan, L. Liao, S.-Q. Kuang, J. C.-Y. Tien, B. W. O'Malley, and J. Xu
Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation
PNAS, January 6, 2009; 106(1): 151 - 156.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Chinenov, M. A. Sacta, A. R. Cruz, and I. Rogatsky
GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression
PNAS, December 23, 2008; 105(51): 20185 - 20190.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Qin, L. Liao, A. Redmond, L. Young, Y. Yuan, H. Chen, B. W. O'Malley, and J. Xu
The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression
Mol. Cell. Biol., October 1, 2008; 28(19): 5937 - 5950.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
Y. Zhang, B. Chen, Y. Li, J. Chen, G. Lou, M. Chen, and D. Zhou
Transcriptional Regulation of the Human PNRC Promoter by NFY in HepG2 Cells
J. Biochem., May 1, 2008; 143(5): 675 - 683.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Liao, X. Chen, S. Wang, A. F. Parlow, and J. Xu
Steroid Receptor Coactivator 3 Maintains Circulating Insulin-Like Growth Factor I (IGF-I) by Controlling IGF-Binding Protein 3 Expression
Mol. Cell. Biol., April 1, 2008; 28(7): 2460 - 2469.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Lodrini, T. Munz, N. Coudevylle, C. Griesinger, S. Becker, and E. Pfitzner
p160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain
Nucleic Acids Res., April 1, 2008; 36(6): 1847 - 1860.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Garapaty, M. A. Mahajan, and H. H. Samuels
Components of the CCR4-NOT Complex Function as Nuclear Hormone Receptor Coactivators via Association with the NRC-interacting Factor NIF-1
J. Biol. Chem., March 14, 2008; 283(11): 6806 - 6816.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D.-H. Kim, G. S. Kim, C. H. Yun, and Y. C. Lee
Functional Conservation of the Glutamine-Rich Domains of Yeast Gal11 and Human SRC-1 in the Transactivation of Glucocorticoid Receptor Tau 1 in Saccharomyces cerevisiae
Mol. Cell. Biol., February 1, 2008; 28(3): 913 - 925.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Schafer, C. Wissmann, J. Hertel, V. Lunyak, and M. Hocker
Regulation of Vascular Endothelial Growth Factor D by Orphan Receptors Hepatocyte Nuclear Factor-4{alpha} and Chicken Ovalbumin Upstream Promoter Transcription Factors 1 and 2
Cancer Res., January 15, 2008; 68(2): 457 - 466.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Germaniuk-Kurowska, A. Nag, X. Zhao, M. Dimri, H. Band, and V. Band
Ada3 Requirement for HAT Recruitment to Estrogen Receptors and Estrogen-Dependent Breast Cancer Cell Proliferation
Cancer Res., December 15, 2007; 67(24): 11789 - 11797.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
H. V. Heemers and D. J. Tindall
Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex
Endocr. Rev., December 1, 2007; 28(7): 778 - 808.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Q. Li, M.-J. Chu, and J. Xu
Tissue- and Nuclear Receptor-Specific Function of the C-Terminal LXXLL Motif of Coactivator NCoA6/AIB3 in Mice
Mol. Cell. Biol., December 1, 2007; 27(23): 8073 - 8086.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Kawagoe, M. Ohmichi, S. Tsutsumi, T. Ohta, K. Takahashi, and H. Kurachi
Mechanism of the Divergent Effects of Estrogen on the Cell Proliferation of Human Umbilical Endothelial Versus Aortic Smooth Muscle Cells
Endocrinology, December 1, 2007; 148(12): 6092 - 6099.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. D. Curtis, V. S. Likhite, I. X. McLeod, J. R. Yates, and A. M. Nardulli
Interaction of the Tumor Metastasis Suppressor Nonmetastatic Protein 23 Homologue H1 and Estrogen Receptor {alpha} Alters Estrogen-Responsive Gene Expression
Cancer Res., November 1, 2007; 67(21): 10600 - 10607.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Yuan, L. Qin, D. Liu, R.-C. Wu, P. Mussi, S. Zhou, Z. Songyang, and J. Xu
Genetic Screening Reveals an Essential Role of p27kip1 in Restriction of Breast Cancer Progression
Cancer Res., September 1, 2007; 67(17): 8032 - 8042.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J.-W. Jeong, K. Y. Lee, S. J. Han, B. J. Aronow, J. P. Lydon, B. W. O'Malley, and F. J. DeMayo
The p160 Steroid Receptor Coactivator 2, SRC-2, Regulates Murine Endometrial Function and Regulates Progesterone-Independent and -Dependent Gene Expression
Endocrinology, September 1, 2007; 148(9): 4238 - 4250.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. M. Lonard, R. B. Lanz, and B. W. O'Malley
Nuclear Receptor Coregulators and Human Disease
Endocr. Rev., August 1, 2007; 28(5): 575 - 587.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. R. Pak, W. C. J. Chung, L. R. Hinds, and R. J. Handa
Estrogen Receptor-{beta} Mediates Dihydrotestosterone-Induced Stimulation of the Arginine Vasopressin Promoter in Neuronal Cells
Endocrinology, July 1, 2007; 148(7): 3371 - 3382.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Y. Yuan and J. Xu
Loss-of-Function Deletion of the Steroid Receptor Coactivator-1 Gene in Mice Reduces Estrogen Effect on the Vascular Injury Response
Arterioscler. Thromb. Vasc. Biol., July 1, 2007; 27(7): 1521 - 1527.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. C-K. Chung, S. Zhou, L. Liao, J. C.-Y. Tien, N. M. Greenberg, and J. Xu
Genetic Ablation of the Amplified-in-Breast Cancer 1 Inhibits Spontaneous Prostate Cancer Progression in Mice
Cancer Res., June 15, 2007; 67(12): 5965 - 5975.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. J. Li, Z. Haque, Q. Lu, L. Li, R. Karas, and M. Mendelsohn
Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation
PNAS, March 6, 2007; 104(10): 4065 - 4070.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
X. Zhao, J. R. Patton, S. K. Ghosh, N. Fischel-Ghodsian, L. Shen, and R. A. Spanjaard
Pus3p- and Pus1p-Dependent Pseudouridylation of Steroid Receptor RNA Activator Controls a Functional Switch that Regulates Nuclear Receptor Signaling
Mol. Endocrinol., March 1, 2007; 21(3): 686 - 699.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. He and S. S. Simons Jr.
STAMP, a Novel Predicted Factor Assisting TIF2 Actions in Glucocorticoid Receptor-Mediated Induction and Repression
Mol. Cell. Biol., February 15, 2007; 27(4): 1467 - 1485.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Wang, C. Zhang, S. K. Nordeen, and D. J. Shapiro
In Vitro Fluorescence Anisotropy Analysis of the Interaction of Full-length SRC1a with Estrogen Receptors {alpha} and beta Supports an Active Displacement Model for Coregulator Utilization
J. Biol. Chem., February 2, 2007; 282(5): 2765 - 2775.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
O. Latchoumanin, V. Mynard, J. Devin-Leclerc, M.-A. Dugue, X. Bertagna, and M. G. Catelli
Reversal of Glucocorticoids-Dependent Proopiomelanocortin Gene Inhibition by Leukemia Inhibitory Factor
Endocrinology, January 1, 2007; 148(1): 422 - 432.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. V. Patchev, D. Fischer, S. S. Wolf, M. Herkenham, F. Gotz, M. Gehin, P. Chambon, V. K. Patchev, and O. F. X. Almeida
Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice
FASEB J, January 1, 2007; 21(1): 231 - 238.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
P. Mussi, C. Yu, B. W. O'Malley, and J. Xu
Stimulation of Steroid Receptor Coactivator-3 (SRC-3) Gene Overexpression by a Positive Regulatory Loop of E2F1 and SRC-3
Mol. Endocrinol., December 1, 2006; 20(12): 3105 - 3119.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Mussi, L. Liao, S.-E. Park, P. Ciana, A. Maggi, B. S. Katzenellenbogen, J. Xu, and B. W. O'Malley
Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland
PNAS, November 7, 2006; 103(45): 16716 - 16721.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. Zhou, J. j. Ye, Y. Li, K. Lui, and S. Chen
The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha
Nucleic Acids Res., November 6, 2006; 34(20): 5974 - 5986.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. D. Heitzer and D. B. DeFranco
Hic-5/ARA55, a LIM Domain-Containing Nuclear Receptor Coactivator Expressed in Prostate Stromal Cells.
Cancer Res., July 15, 2006; 66(14): 7326 - 7333.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. Baldwin, K.-W. Huh, and K. Munger
Human papillomavirus e7 oncoprotein dysregulates steroid receptor coactivator 1 localization and function.
J. Virol., July 1, 2006; 80(13): 6669 - 6677.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Mo, S. M. Rao, and Y.-J. Zhu
Identification of the MLL2 Complex as a Coactivator for Estrogen Receptor {alpha}
J. Biol. Chem., June 9, 2006; 281(23): 15714 - 15720.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Yoshida, Y. Iwasaki, M. Asai, S. Takayasu, T. Taguchi, K. Itoi, K. Hashimoto, and Y. Oiso
Identification of a Functional AP1 Element in the Rat Vasopressin Gene Promoter
Endocrinology, June 1, 2006; 147(6): 2850 - 2863.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Waters, B. Yue, V. Veverka, P. Renshaw, J. Bramham, S. Matsuda, T. Frenkiel, G. Kelly, F. Muskett, M. Carr, et al.
Structural Diversity in p160/CREB-binding Protein Coactivator Complexes
J. Biol. Chem., May 26, 2006; 281(21): 14787 - 14795.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. E. Frigo, A. Basu, E. N. Nierth-Simpson, C. B. Weldon, C. M. Dugan, S. Elliott, B. M. Collins-Burow, V. A. Salvo, Y. Zhu, L. I. Melnik, et al.
p38 Mitogen-Activated Protein Kinase Stimulates Estrogen-Mediated Transcription and Proliferation through the Phosphorylation and Potentiation of the p160 Coactivator Glucocorticoid Receptor-Interacting Protein 1
Mol. Endocrinol., May 1, 2006; 20(5): 971 - 983.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
G. Li, J. H. Heaton, and T. D. Gelehrter
Role of Steroid Receptor Coactivators in Glucocorticoid and Transforming Growth Factor {beta} Regulation of Plasminogen Activator Inhibitor Gene Expression
Mol. Endocrinol., May 1, 2006; 20(5): 1025 - 1034.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J.-W. Jeong, I. Kwak, K. Y. Lee, L. D. White, X.-P. Wang, F. C. Brunicardi, B. W. O'Malley, and F. J. DeMayo
The Genomic Analysis of the Impact of Steroid Receptor Coactivators Ablation on Hepatic Metabolism
Mol. Endocrinol., May 1, 2006; 20(5): 1138 - 1152.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
M.-B. Poirier, L. Laflamme, and M.-F. Langlois
Identification and characterization of RanBPM, a novel coactivator of thyroid hormone receptors.
J. Mol. Endocrinol., April 1, 2006; 36(2): 313 - 325.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Colilla, P. W. Kantoff, S. L. Neuhausen, A. K. Godwin, M. B. Daly, S. A. Narod, J. E. Garber, H. T. Lynch, M. Brown, B. L. Weber, et al.
The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers
Carcinogenesis, March 1, 2006; 27(3): 599 - 605.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. N. Winnay, J. Xu, B. W. O'Malley, and G. D. Hammer
Steroid Receptor Coactivator-1-Deficient Mice Exhibit Altered Hypothalamic-Pituitary-Adrenal Axis Function
Endocrinology, March 1, 2006; 147(3): 1322 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. K. Yang, J. H. Kim, H. Li, and M. R. Stallcup
Differential Use of Functional Domains by Coiled-coil Coactivator in Its Synergistic Coactivator Function with beta-Catenin or GRIP1
J. Biol. Chem., February 10, 2006; 281(6): 3389 - 3397.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Perani, P. Antonson, R. Hamoudi, C. J. E. Ingram, C. S. Cooper, M. D. Garrett, and G. H. Goodwin
The Proto-oncoprotein SYT Interacts with SYT-interacting Protein/Co-activator Activator (SIP/CoAA), a Human Nuclear Receptor Co-activator with Similarity to EWS and TLS/FUS Family of Proteins
J. Biol. Chem., December 30, 2005; 280(52): 42863 - 42876.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. A. Arnold, E. Estebanez-Perpina, M. Togashi, N. Jouravel, A. Shelat, A. C. McReynolds, E. Mar, P. Nguyen, J. D. Baxter, R. J. Fletterick, et al.
Discovery of Small Molecule Inhibitors of the Interaction of the Thyroid Hormone Receptor with Transcriptional Coregulators
J. Biol. Chem., December 30, 2005; 280(52): 43048 - 43055.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Leong, J. R. Sloan, P. D. Nash, and G. L. Greene
Recruitment of Histone Deacetylase 4 to the N-Terminal Region of Estrogen Receptor {alpha}
Mol. Endocrinol., December 1, 2005; 19(12): 2930 - 2942.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. B. Scribner, D. P. Odom, and M. M. McGrane
Vitamin A Status in Mice Affects the Histone Code of the Phosphoenolpyruvate Carboxykinase Gene in Liver
J. Nutr., December 1, 2005; 135(12): 2774 - 2779.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Okamoto and F. Isohashi
Macromolecular Translocation Inhibitor II (Zn2+-binding Protein, Parathymosin) Interacts with the Glucocorticoid Receptor and Enhances Transcription in Vivo
J. Biol. Chem., November 4, 2005; 280(44): 36986 - 36993.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
X. Cui, R. Schiff, G. Arpino, C. K. Osborne, and A. V. Lee
Biology of Progesterone Receptor Loss in Breast Cancer and Its Implications for Endocrine Therapy
J. Clin. Oncol., October 20, 2005; 23(30): 7721 - 7735.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
J. Igarashi-Migitaka, A. Takeshita, N. Koibuchi, S. Yamada, R. Ohtani-Kaneko, and K. Hirata
Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis
Eur. J. Endocrinol., October 1, 2005; 153(4): 595 - 604.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Rochette-Egly
Dynamic Combinatorial Networks in Nuclear Receptor-mediated Transcription
J. Biol. Chem., September 23, 2005; 280(38): 32565 - 32568.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Xie, M. S. Sadim, and Z. Sun
ROR{gamma}t Recruits Steroid Receptor Coactivators to Ensure Thymocyte Survival
J. Immunol., September 15, 2005; 175(6): 3800 - 3809.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S.-Q. Kuang, L. Liao, S. Wang, D. Medina, B. W. O'Malley, and J. Xu
Mice Lacking the Amplified in Breast Cancer 1/Steroid Receptor Coactivator-3 Are Resistant to Chemical Carcinogen-Induced Mammary Tumorigenesis
Cancer Res., September 1, 2005; 65(17): 7993 - 8002.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
W. Li, C. N. Cavasotto, T. Cardozo, S. Ha, T. Dang, S. S. Taneja, S. K. Logan, and M. J. Garabedian
Androgen Receptor Mutations Identified in Prostate Cancer and Androgen Insensitivity Syndrome Display Aberrant ART-27 Coactivator Function
Mol. Endocrinol., September 1, 2005; 19(9): 2273 - 2282.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y.-H. Chen, J. H. Kim, and M. R. Stallcup
GAC63, a GRIP1-Dependent Nuclear Receptor Coactivator
Mol. Cell. Biol., July 15, 2005; 25(14): 5965 - 5972.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Chintharlapalli, R. Burghardt, S. Papineni, S. Ramaiah, K. Yoon, and S. Safe
Activation of Nur77 by Selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes Induces Apoptosis through Nuclear Pathways
J. Biol. Chem., July 1, 2005; 280(26): 24903 - 24914.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Zechel
Requirement of Retinoic Acid Receptor Isotypes {alpha}, {beta}, and {gamma} during the Initial Steps of Neural Differentiation of PCC7 Cells
Mol. Endocrinol., June 1, 2005; 19(6): 1629 - 1645.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R.-C. Wu, C. L. Smith, and B. W. O'Malley
Transcriptional Regulation by Steroid Receptor Coactivator Phosphorylation
Endocr. Rev., May 1, 2005; 26(3): 393 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
J. M. R. Moore and R. K. Guy
Coregulator Interactions with the Thyroid Hormone Receptor
Mol. Cell. Proteomics, April 1, 2005; 4(4): 475 - 482.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. T. Tilli, R. Reiter, A. S. Oh, R. T. Henke, K. McDonnell, G. I. Gallicano, P. A. Furth, and A. T. Riegel
Overexpression of an N-Terminally Truncated Isoform of the Nuclear Receptor Coactivator Amplified in Breast Cancer 1 Leads to Altered Proliferation of Mammary Epithelial Cells in Transgenic Mice
Mol. Endocrinol., March 1, 2005; 19(3): 644 - 656.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. A. Hershberger, A. C. Vasquez, B. Kanterewicz, S. Land, J. M. Siegfried, and M. Nichols
Regulation of Endogenous Gene Expression in Human Non-Small Cell Lung Cancer Cells by Estrogen Receptor Ligands
Cancer Res., February 15, 2005; 65(4): 1598 - 1605.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-Y. Wu, Y. Hamamori, J. Xu, S. C. Chang, T. Saluna, M.-F. Chang, B. W. O'Malley, and L. Kedes
Nuclear Hormone Receptor Coregulator GRIP1 Suppresses, whereas SRC1A and p/CIP Coactivate, by Domain-specific Binding of MyoD
J. Biol. Chem., February 4, 2005; 280(5): 3129 - 3137.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Labhart, S. Karmakar, E. M. Salicru, B. S. Egan, V. Alexiadis, B. W. O'Malley, and C. L. Smith
Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator
PNAS, February 1, 2005; 102(5): 1339 - 1344.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. L. Ruas, L. Poellinger, and T. Pereira
Role of CBP in regulating HIF-1-mediated activation of transcription
J. Cell Sci., January 15, 2005; 118(2): 301 - 311.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. S. Ozers, K. M. Ervin, C. L. Steffen, J. A. Fronczak, C. S. Lebakken, K. A. Carnahan, R. G. Lowery, and T. J. Burke
Analysis of Ligand-Dependent Recruitment of Coactivator Peptides to Estrogen Receptor Using Fluorescence Polarization
Mol. Endocrinol., January 1, 2005; 19(1): 25 - 34.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. H. Kim and M. R. Stallcup
Role of the Coiled-coil Coactivator (CoCoA) in Aryl Hydrocarbon Receptor-mediated Transcription
J. Biol. Chem., November 26, 2004; 279(48): 49842 - 49848.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Zhang, S.-Q. Kuang, L. Liao, S. Zhou, and J. Xu
Haploid Inactivation of the Amplified-in-Breast Cancer 3 Coactivator Reduces the Inhibitory Effect of Peroxisome Proliferator-Activated Receptor {gamma} and Retinoid X Receptor on Cell Proliferation and Accelerates Polyoma Middle-T Antigen-Induced Mammary Tumorigenesis in Mice
Cancer Res., October 1, 2004; 64(19): 7169 - 7177.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Masiello, S.-Y. Chen, Y. Xu, M. C. Verhoeven, E. Choi, A. N. Hollenberg, and S. P. Balk
Recruitment of {beta}-Catenin by Wild-Type or Mutant Androgen Receptors Correlates with Ligand-Stimulated Growth of Prostate Cancer Cells
Mol. Endocrinol., October 1, 2004; 18(10): 2388 - 2401.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Khidekel, S. B. Ficarro, E. C. Peters, and L. C. Hsieh-Wilson
Exploring the O-GlcNAc proteome: Direct identification of O-GlcNAc-modified proteins from the brain
PNAS, September 7, 2004; 101(36): 13132 - 13137.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. H. Ludewig, C. Kober-Eisermann, C. Weitzel, A. Bethke, K. Neubert, B. Gerisch, H. Hutter, and A. Antebi
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging
Genes & Dev., September 1, 2004; 18(17): 2120 - 2133.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
P.-L. Xu, Y.-Q. Liu, S.-F. Shan, Y.-Y. Kong, Q. Zhou, M. Li, J.-P. Ding, Y.-H. Xie, and Y. Wang
Molecular Mechanism for the Potentiation of the Transcriptional Activity of Human Liver Receptor Homolog 1 by Steroid Receptor Coactivator-1
Mol. Endocrinol., August 1, 2004; 18(8): 1887 - 1905.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K.-H. Song, Y.-Y. Park, K. C. Park, C. Y. Hong, J. H. Park, M. Shong, K. Lee, and H.-S. Choi
The Atypical Orphan Nuclear Receptor DAX-1 Interacts with Orphan Nuclear Receptor Nur77 and Represses Its Transactivation
Mol. Endocrinol., August 1, 2004; 18(8): 1929 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Andrin and M. J. Hendzel
F-actin-dependent Insolubility of Chromatin-modifying Components
J. Biol. Chem., June 11, 2004; 279(24): 25017 - 25023.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. J. Lim, I. Moon, and K. Han
Transcriptional Cofactors Exhibit Differential Preference toward Peroxisome Proliferator-Activated Receptors {alpha} and {delta} in Uterine Cells
Endocrinology, June 1, 2004; 145(6): 2886 - 2895.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Goel and R. Janknecht
Concerted Activation of ETS Protein ER81 by p160 Coactivators, the Acetyltransferase p300 and the Receptor Tyrosine Kinase HER2/Neu
J. Biol. Chem., April 9, 2004; 279(15): 14909 - 14916.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Jia, C. S-Y. Choong, C. Ricciardelli, J. Kim, W. D. Tilley, and G. A Coetzee
Androgen Receptor Signaling: Mechanism of Interleukin-6 Inhibition
Cancer Res., April 1, 2004; 64(7): 2619 - 2626.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. Huuskonen, P. E. Fielding, and C. J. Fielding
Role of p160 Coactivator Complex in the Activation of Liver X Receptor
Arterioscler. Thromb. Vasc. Biol., April 1, 2004; 24(4): 703 - 708.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Mark, H. Yoshida-Komiya, M. Gehin, L. Liao, M.-J. Tsai, B. W. O'Malley, P. Chambon, and J. Xu
Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction
PNAS, March 30, 2004; 101(13): 4453 - 4458.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S.-Q. Kuang, L. Liao, H. Zhang, A. V. Lee, B. W. O'Malley, and J. Xu
AIB1/SRC-3 Deficiency Affects Insulin-Like Growth Factor I Signaling Pathway and Suppresses v-Ha-ras-induced Breast Cancer Initiation and Progression in Mice
Cancer Res., March 1, 2004; 64(5): 1875 - 1885.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-F. Mouillet, C. Sonnenberg-Hirche, X. Yan, and Y. Sadovsky
p300 Regulates the Synergy of Steroidogenic Factor-1 and Early Growth Response-1 in Activating Luteinizing Hormone-{beta} Subunit Gene
J. Biol. Chem., February 27, 2004; 279(9): 7832 - 7839.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Tzortzakaki, C. Spilianakis, E. Zika, A. Kretsovali, and J. Papamatheakis
Steroid Receptor Coactivator 1 Links the Steroid and Interferon {gamma} Response Pathways
Mol. Endocrinol., December 1, 2003; 17(12): 2509 - 2518.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2003 by The Endocrine Society