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Global Business Intelligence Center (E.J.); Department of Molecular Design and Informatics (J.P.); and Target Discovery Unit (C.v.R., C.v.d.H., J.W.), Department of Pharmacology (S.M.), NV Organon, 5340 BH Oss; Center of Reproductive Medicine (J.S.E.L., B.C.J.M.F.), Erasmus Medical Center, 3000 CA Rotterdam; Department of Obstetrics and Gynecology (H.B.R.D.), Flevohospital, 1315 RA Almere; and Department of Reproductive Medicine (B.C.J.M.F.), University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
Address all correspondence and requests for reprints to: Erik Jansen, NV Organon, PO Box 20, 5340 BH Oss, The Netherlands. E-mail: erik.jansen{at}organon.com.
Polycystic ovary syndrome (PCOS) represents the most common cause of anovulatory infertility and affects 5–10% of women of reproductive age. The etiology of PCOS is still unknown. The current study is the first to describe consistent differences in gene expression profiles in human ovaries comparing PCOS patients vs. healthy normoovulatory individuals. The microarray analysis of PCOS vs. normal ovaries identifies dysregulated expression of genes encoding components of several biological pathways or systems such as Wnt signaling, extracellular matrix components, and immunological factors. Resulting data may provide novel clues for ovarian dysfunction in PCOS. Intriguingly, the gene expression profiles of ovaries from (long-term) androgen-treated female-to-male transsexuals (TSX) show considerable overlap with PCOS. This observation provides supportive evidence that androgens play a key role in the pathogenesis of PCOS. Presented data may contribute to a better understanding of dysregulated pathways in PCOS, which might ultimately reveal novel leads for therapeutic intervention.
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