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Molecular Endocrinology, doi:10.1210/me.2004-0088
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Molecular Endocrinology 18 (6): 1321-1332
Copyright © 2004 by The Endocrine Society

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Be Fit or Be Sick: Peroxisome Proliferator-Activated Receptors Are Down the Road

Béatrice Desvergne, Liliane Michalik and Walter Wahli

Center for Integrative Genomics, National Centre of Competence in Research Frontiers in Genetics, University of Lausanne, CH-1015 Lausanne, Switzerland

Address all correspondence and requests for reprints to: Beatrice Desvergne or Walter Wahli, Center for Integrative Genomics, University of Lausanne, Biology Building, CH-1015 Lausanne-Dorigny, Switzerland. E-mail: Beatrice.desvergne{at}cig.unil.ch or walter.wahli{at}cig.unil.ch.

Investigating metabolism by unveiling the functions of the nuclear receptors peroxisome proliferator-activated receptors (PPARs) in the numerous intricate pathways ensuring energy homeostasis and fitness has been extremely rewarding. Major lines of research were initially determined by the first-characterized crucial roles of PPAR{alpha} in fatty oxidation and of PPAR{gamma} in adipocyte differentiation and lipid storage. Today, the molecular bases of the functional links between glucose, lipid, and protein metabolism, under the important but nonexclusive control of PPAR{alpha} and PPAR{gamma}, are starting to be uncovered. In addition, in the last couple of years evidence has been provided for an important role of PPARß ({delta}) in lipid metabolism. Inevitably, such actors of metabolic homeostasis are implicated in the physiopathology of complex metabolic disorders, such as those constituting the metabolic syndrome, resulting in atherosclerosis and cardiovascular diseases. This review presents a summary of the recent findings on their dual involvement in health and disease.

NURSA Molecule Pages Link:

Nuclear Receptors:   PPARα  |  PPARδ  |  PPARγ
Coregulators:   PGC-1
Ligands:   Pirinixic acid  |  Rosiglitazone



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