| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009
Address all correspondence and requests for reprints to: Grady F. Saunders, Department of Biochemistry and Molecular Biology, Unit 117, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030-4009. E-mail: gsaunders{at}mdanderson.org.
DAX-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita-critical region on the X chromosome gene 1; NR0B1) is an orphan nuclear receptor that plays an important role in the development and functioning of the adrenal gland and hypothalamic-pituitary gonadal axis. The DAX-1 protein acts as a transcriptional repressor of genes involved in the steroidogenic pathway. We have identified a novel isoform encoded by the known exon 1 of DAX-1 and a previously unrecognized exon (exon 2
) that lies within intron 1 of DAX-1. This novel transcript, which we designated DAX-1, is terminated at exon 2; the last 70 amino acids of the C-terminal repressor domain encoded by exon 2 are absent. DAX-1 encodes a protein of 401 amino acids; the first 389 amino acids are encoded by exon 1 and the last 12 are encoded by exon 2. Using conventional RT-PCR and real-time RT-PCR analyses, we found that DAX-1 is abundantly expressed in the adrenal gland, brain, kidney, ovary, and testis. We also found that DAX-1 can bind to steroidogenic factor 1 and to DNA but is unable to repress steroidogenic factor 1-mediated transcriptional activation of the reporter gene and acts as an antagonist of DAX-1 under certain conditions.
NURSA Molecule Pages Link:
This article has been cited by other articles:
 |
|
 |
|
  N. Valenzuela Evolution of the gene network underlying gonadogenesis in turtles with temperature-dependent and genotypic sex determination Integr. Comp. Biol., May 13, 2008; (2008) icn031v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Benoit, A. Cooney, V. Giguere, H. Ingraham, M. Lazar, G. Muscat, T. Perlmann, J.-P. Renaud, J. Schwabe, F. Sladek, et al. International Union of Pharmacology. LXVI. Orphan Nuclear Receptors Pharmacol. Rev., December 1, 2006; 58(4): 798 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhao, Z. Yang, J. K. Phelan, D. A. Wheeler, S. Lin, and E. R. B. McCabe Zebrafish dax1 Is Required for Development of the Interrenal Organ, the Adrenal Cortex Equivalent Mol. Endocrinol., November 1, 2006; 20(11): 2630 - 2640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Iyer, Y.-H. Zhang, and E. R. B. McCabe Dosage-Sensitive Sex Reversal Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1 (DAX1) (NR0B1) and Small Heterodimer Partner (SHP) (NR0B2) Form Homodimers Individually, as Well as DAX1-SHP Heterodimers Mol. Endocrinol., October 1, 2006; 20(10): 2326 - 2342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hossain, M. Nixon, M. T. Kuo, and G. F. Saunders N-terminally Truncated WT1 Protein with Oncogenic Properties Overexpressed in Leukemia J. Biol. Chem., September 22, 2006; 281(38): 28122 - 28130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Hammer, K. L. Parker, and B. P. Schimmer Minireview: Transcriptional Regulation of Adrenocortical Development Endocrinology, March 1, 2005; 146(3): 1018 - 1024. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
