| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Graduate Program in Cellular and Molecular Biology (R.D.W., S.A.C.), Department of Human Genetics (L.T.R., B.M.S., I.O.N., S.A.C.), Graduate Program in Neuroscience (H.S.), University of Michigan, Ann Arbor, Michigan 48109-0638
Address all correspondence and requests for reprints to: Sally A. Camper, 4301 Medical Science Research Building III, 1500 West Medical Center Drive, Ann Arbor, Michigan 48109-0638. E-mail: scamper{at}umich.edu.
Mutations in the PROP1 transcription factor gene lead to reduced production of thyrotropin, GH, prolactin, and gonadotropins as well as to pituitary hypoplasia in adult humans and mice. Some PROP1-deficient patients initially exhibit pituitary hyperplasia that resolves to hypoplasia. To understand this feature and to explore the mechanism whereby PROP1 regulates anterior pituitary gland growth, we carried out longitudinal studies in normal and Prop1-deficient dwarf mice from early embryogenesis through adulthood, examining the volume of Rathke’s pouch and its derivatives, the position and number of dividing cells, the rate of apoptosis, and cell migration by pulse labeling. The results suggest that anterior pituitary progenitors normally leave the perilumenal region of Rathke’s pouch and migrate to form the anterior lobe as they differentiate. Some of the cells that seed the anterior lobe during organogenesis have proliferative potential, supporting the expansion of the anterior lobe after birth. Prop1-deficient fetal pituitaries are dysmorphic because mutant cells are retained in the perilumenal area and fail to differentiate. After birth, mutant pituitaries exhibit enhanced apoptosis and reduced proliferation, apparently because the mutant anterior lobe is not seeded with progenitors. These studies suggest a mechanism for Prop1 action and an explanation for some of the clinical findings in human patients.
This article has been cited by other articles:
 |
|
 |
|
  G. A. Peters, D. D. Seachrist, R. A. Keri, and G. C. Sen The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation PNAS, June 30, 2009; 106(26): 10696 - 10701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bilodeau, A. Roussel-Gervais, and J. Drouin Distinct Developmental Roles of Cell Cycle Inhibitors p57Kip2 and p27Kip1 Distinguish Pituitary Progenitor Cell Cycle Exit from Cell Cycle Reentry of Differentiated Cells Mol. Cell. Biol., April 1, 2009; 29(7): 1895 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Castinetti, A. Saveanu, R. Reynaud, M. H. Quentien, A. Buffin, R. Brauner, N. Kaffel, F. Albarel, A. M. Guedj, M. El Kholy, et al. A Novel Dysfunctional LHX4 Mutation with High Phenotypical Variability in Patients with Hypopituitarism J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2790 - 2799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Pfaeffle, C. S. Hunter, J. J. Savage, M. Duran-Prado, R. D. Mullen, Z. P. Neeb, U. Eiholzer, V. Hesse, N. G. Haddad, H. M. Stobbe, et al. Three Novel Missense Mutations within the LHX4 Gene Are Associated with Variable Pituitary Hormone Deficiencies J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 1062 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fauquier, K. Rizzoti, M. Dattani, R. Lovell-Badge, and I. C. A. F. Robinson SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland PNAS, February 26, 2008; 105(8): 2907 - 2912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks Physiol Rev, July 1, 2007; 87(3): 933 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Pfaeffle, J. J. Savage, C. S. Hunter, C. Palme, M. Ahlmann, P. Kumar, J. Bellone, E. Schoenau, E. Korsch, J. H. Bramswig, et al. Four Novel Mutations of the LHX3 Gene Cause Combined Pituitary Hormone Deficiencies with or without Limited Neck Rotation J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1909 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. Raetzman, B. S. Wheeler, S. A. Ross, P. Q. Thomas, and S. A. Camper Persistent Expression of Notch2 Delays Gonadotrope Differentiation Mol. Endocrinol., November 1, 2006; 20(11): 2898 - 2908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhu, J. Zhang, J. Tollkuhn, R. Ohsawa, E. H. Bresnick, F. Guillemot, R. Kageyama, and M. G. Rosenfeld Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis Genes & Dev., October 1, 2006; 20(19): 2739 - 2753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Ward, B. M. Stone, L. T. Raetzman, and S. A. Camper Cell Proliferation and Vascularization in Mouse Models of Pituitary Hormone Deficiency Mol. Endocrinol., June 1, 2006; 20(6): 1378 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Vesper, L. T. Raetzman, and S. A. Camper Role of Prophet of Pit1 (PROP1) in Gonadotrope Differentiation and Puberty Endocrinology, April 1, 2006; 147(4): 1654 - 1663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. S. Bhangoo, C. S. Hunter, J. J. Savage, H. Anhalt, S. Pavlakis, E. C. Walvoord, S. Ten, and S. J. Rhodes A Novel LHX3 Mutation Presenting as Combined Pituitary Hormonal Deficiency J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 747 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chen, N. Hersmus, V. V. Duppen, P. Caesens, C. Denef, and H. Vankelecom The Adult Pituitary Contains a Cell Population Displaying Stem/Progenitor Cell and Early Embryonic Characteristics Endocrinology, September 1, 2005; 146(9): 3985 - 3998. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
