help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Molecular Endocrinology, doi:10.1210/me.2004-0486
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow NURSA Molecule Pages Link
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Björnström, L.
Right arrow Articles by Sjöberg, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Björnström, L.
Right arrow Articles by Sjöberg, M.
Molecular Endocrinology 19 (4): 833-842
Copyright © 2005 by The Endocrine Society

Minireview

Mechanisms of Estrogen Receptor Signaling: Convergence of Genomic and Nongenomic Actions on Target Genes

Linda Björnström and Maria Sjöberg

Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden

Address all correspondence and requests for reprints to: Maria Sjöberg, Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. E-mail: maria.sjoberg{at}cmb.ki.se.

Estrogen receptors (ERs) act by regulating transcriptional processes. The classical mechanism of ER action involves estrogen binding to receptors in the nucleus, after which the receptors dimerize and bind to specific response elements known as estrogen response elements (EREs) located in the promoters of target genes. However, ERs can also regulate gene expression without directly binding to DNA. This occurs through protein-protein interactions with other DNA-binding transcription factors in the nucleus. In addition, membrane-associated ERs mediate nongenomic actions of estrogens, which can lead both to altered functions of proteins in the cytoplasm and to regulation of gene expression. The latter two mechanisms of ER action enable a broader range of genes to be regulated than the range that can be regulated by the classical mechanism of ER action alone. This review surveys our knowledge about the molecular mechanism by which ERs regulate the expression of genes that do not contain EREs, and it gives examples of the ways in which the genomic and nongenomic actions of ERs on target genes converge. Genomic and nongenomic actions of ERs that do not depend on EREs influence the physiology of many target tissues, and thus, increasing our understanding of the molecular mechanisms behind these actions is highly relevant for the development of novel drugs that target specific receptor actions.

NURSA Molecule Pages Link:

Nuclear Receptors:   ERα  |  ERβ
Coregulators:   STAT3  |  CAV1  |  PELP1
Ligands:   17β-Estradiol



This article has been cited by other articles:


Home page
 EndocrinologyHome page
S.-Y. Kim, J. Weiss, M. Tong, M. M. Laronda, E.-J. Lee, and J. L. Jameson
Foxl2, a Forkhead Transcription Factor, Modulates Nonclassical Activity of the Estrogen Receptor-{alpha}
Endocrinology, November 1, 2009; 150(11): 5085 - 5093.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. Galluzzo, C. Rastelli, P. Bulzomi, F. Acconcia, V. Pallottini, and M. Marino
17{beta}-Estradiol regulates the first steps of skeletal muscle cell differentiation via ER-{alpha}-mediated signals
Am J Physiol Cell Physiol, November 1, 2009; 297(5): C1249 - C1262.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. R. Levin
Membrane oestrogen receptor \#945; signalling to cell functions
J. Physiol., November 1, 2009; 587(21): 5019 - 5023.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. Chen, J. K. Saggar, P. Corey, and L. U. Thompson
Flaxseed and Pure Secoisolariciresinol Diglucoside, but Not Flaxseed Hull, Reduce Human Breast Tumor Growth (MCF-7) in Athymic Mice
J. Nutr., November 1, 2009; 139(11): 2061 - 2066.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Koslowski, O. Tureci, S. Biesterfeld, G. Seitz, C. Huber, and U. Sahin
Selective Activation of Trophoblast-specific PLAC1 in Breast Cancer by CCAAT/Enhancer-binding Protein {beta} (C/EBP{beta}) Isoform 2
J. Biol. Chem., October 16, 2009; 284(42): 28607 - 28615.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I. I. Park, Q. Zhang, V. Liu, J. M. Kozlowski, J. Zhang, and C. Lee
17{beta}-Estradiol at Low Concentrations Acts through Distinct Pathways in Normal Versus Benign Prostatic Hyperplasia-Derived Prostate Stromal Cells
Endocrinology, October 1, 2009; 150(10): 4594 - 4605.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
H. Chen, K. Yang, S. Choi, J. H. Fischer, and H. Jeong
Up-Regulation of UDP-Glucuronosyltransferase (UGT) 1A4 by 17{beta}-Estradiol: A Potential Mechanism of Increased Lamotrigine Elimination in Pregnancy
Drug Metab. Dispos., September 1, 2009; 37(9): 1841 - 1847.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. C. Wu and Y. Zhang
Minireview: Role of Protein Methylation and Demethylation in Nuclear Hormone Signaling
Mol. Endocrinol., September 1, 2009; 23(9): 1323 - 1334.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. Shi, B. Dong, Z. Li, Y. Lu, T. Ouyang, J. Li, T. Wang, Z. Fan, T. Fan, B. Lin, et al.
Expression of ER-{alpha}36, a Novel Variant of Estrogen Receptor {alpha}, and Resistance to Tamoxifen Treatment in Breast Cancer
J. Clin. Oncol., July 20, 2009; 27(21): 3423 - 3429.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. L. Nott, Y. Huang, X. Li, B. R. Fluharty, X. Qiu, W. V. Welshons, S. Yeh, and M. Muyan
Genomic Responses from the Estrogen-responsive Element-dependent Signaling Pathway Mediated by Estrogen Receptor {alpha} Are Required to Elicit Cellular Alterations
J. Biol. Chem., May 29, 2009; 284(22): 15277 - 15288.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. Ohashi, T. Kogai, H. Kagechika, and G. A. Brent
Activation of the PI3 Kinase Pathway By Retinoic Acid Mediates Sodium/Iodide Symporter Induction and Iodide Transport in MCF-7 Breast Cancer Cells
Cancer Res., April 15, 2009; 69(8): 3443 - 3450.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Keay and J. W. Thornton
Hormone-Activated Estrogen Receptors in Annelid Invertebrates: Implications for Evolution and Endocrine Disruption
Endocrinology, April 1, 2009; 150(4): 1731 - 1738.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Pedram, M. Razandi, J. K Kim, F. O'Mahony, E. Y. Lee, U. Luderer, and E. R. Levin
Developmental Phenotype of a Membrane Only Estrogen Receptor {alpha} (MOER) Mouse
J. Biol. Chem., February 6, 2009; 284(6): 3488 - 3495.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. A. Ochsner, D. L. Steffen, S. G. Hilsenbeck, E. S. Chen, C. Watkins, and N. J. McKenna
GEMS (Gene Expression Metasignatures), a Web Resource for Querying Meta-analysis of Expression Microarray Datasets: 17{beta}-Estradiol in MCF-7 Cells
Cancer Res., January 1, 2009; 69(1): 23 - 26.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M. Rotinen, J. Celay, M. M Alonso, A. Arrazola, I. Encio, and J. Villar
Estradiol induces type 8 17{beta}-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor {alpha} and C/EBP{beta}
J. Endocrinol., January 1, 2009; 200(1): 85 - 92.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Katsu, S. Kohno, S. Hyodo, S. Ijiri, S. Adachi, A. Hara, L. J. Guillette Jr., and T. Iguchi
Molecular Cloning, Characterization, and Evolutionary Analysis of Estrogen Receptors from Phylogenetically Ancient Fish
Endocrinology, December 1, 2008; 149(12): 6300 - 6310.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. K. Schnoes, I. Z. Jaffe, L. Iyer, A. Dabreo, M. Aronovitz, B. Newfell, U. Hansen, G. Rosano, and M. E. Mendelsohn
Research Resource: Rapid Recruitment of Temporally Distinct Vascular Gene Sets by Estrogen
Mol. Endocrinol., November 1, 2008; 22(11): 2544 - 2556.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Xu, Y. Cheng, J. R. Keast, and P. B. Osborne
17{beta}-Estradiol Activates Estrogen Receptor {beta}-Signalling and Inhibits Transient Receptor Potential Vanilloid Receptor 1 Activation by Capsaicin in Adult Rat Nociceptor Neurons
Endocrinology, November 1, 2008; 149(11): 5540 - 5548.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. R. Levin
Rapid signaling by steroid receptors
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1425 - R1430.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. W. Bonagura, G. J. Pepe, A. C. Enders, and E. D. Albrecht
Suppression of Extravillous Trophoblast Vascular Endothelial Growth Factor Expression and Uterine Spiral Artery Invasion by Estrogen during Early Baboon Pregnancy
Endocrinology, October 1, 2008; 149(10): 5078 - 5087.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
F. Yasuhara, G. R. O. Gomes, E. R. Siu, C. I. Suenaga, E. Marostica, C. S. Porto, and M. F. M. Lazari
Effects of the Antiestrogen Fulvestrant (ICI 182,780) on Gene Expression of the Rat Efferent Ductules
Biol Reprod, September 1, 2008; 79(3): 432 - 441.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Albanito, D. Sisci, S. Aquila, E. Brunelli, A. Vivacqua, A. Madeo, R. Lappano, D. P. Pandey, D. Picard, L. Mauro, et al.
Epidermal Growth Factor Induces G Protein-Coupled Receptor 30 Expression in Estrogen Receptor-Negative Breast Cancer Cells
Endocrinology, August 1, 2008; 149(8): 3799 - 3808.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Grasselli, S. Nanni, C. Colussi, A. Aiello, V. Benvenuti, G. Ragone, F. Moretti, A. Sacchi, S. Bacchetti, C. Gaetano, et al.
Estrogen Receptor-{alpha} and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase
Circ. Res., July 3, 2008; 103(1): 34 - 42.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
A. P. Kouzmenko, K.-i. Takeyama, Y. Kawasaki, T. Akiyama, and S. Kato
Ligand-dependent interaction between estrogen receptor alpha and adenomatous polyposis coli.
Genes Cells, July 1, 2008; 13(7): 723 - 730.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
X. Long, M. Fan, R. M. Bigsby, and K. P. Nephew
Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-{alpha}-dependent and estrogen receptor-{alpha}-independent mechanisms
Mol. Cancer Ther., July 1, 2008; 7(7): 2096 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Titolo, C. M. Mayer, S. S. Dhillon, F. Cai, and D. D. Belsham
Estrogen Facilitates both Phosphatidylinositol 3-Kinase/Akt and ERK1/2 Mitogen-Activated Protein Kinase Membrane Signaling Required for Long-Term Neuropeptide Y Transcriptional Regulation in Clonal, Immortalized Neurons
J. Neurosci., June 18, 2008; 28(25): 6473 - 6482.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Dimple, S. S. Nair, R. Rajhans, P. R. Pitcheswara, J. Liu, S. Balasenthil, X.-F. Le, M. E. Burow, N. Auersperg, R. R. Tekmal, et al.
Role of PELP1/MNAR Signaling in Ovarian Tumorigenesis
Cancer Res., June 15, 2008; 68(12): 4902 - 4909.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Z. Zeng, M. C. Velarde, F. A. Simmen, and R. C.M. Simmen
Delayed Parturition and Altered Myometrial Progesterone Receptor Isoform A Expression in Mice Null for Kruppel-Like Factor 9
Biol Reprod, June 1, 2008; 78(6): 1029 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
J. K. Nagpal, S. Nair, D. Chakravarty, R. Rajhans, S. Pothana, D. W. Brann, R. R. Tekmal, and R. K. Vadlamudi
Growth Factor Regulation of Estrogen Receptor Coregulator PELP1 Functions via Protein Kinase A Pathway
Mol. Cancer Res., May 1, 2008; 6(5): 851 - 861.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. Rajhans, H. B. Nair, S. S. Nair, V. Cortez, K. Ikuko, N. B. Kirma, D. Zhou, A. E. Holden, D. W Brann, S. Chen, et al.
Modulation of in Situ Estrogen Synthesis by Proline-, Glutamic Acid-, and Leucine-Rich Protein-1: Potential Estrogen Receptor Autocrine Signaling Loop in Breast Cancer Cells
Mol. Endocrinol., March 1, 2008; 22(3): 649 - 664.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Guix, N. de Matos Granja, I. Meszoely, T. B. Adkins, B. M. Wieman, K. E. Frierson, V. Sanchez, M. E. Sanders, A. M. Grau, I. A. Mayer, et al.
Short Preoperative Treatment With Erlotinib Inhibits Tumor Cell Proliferation in Hormone Receptor-Positive Breast Cancers
J. Clin. Oncol., February 20, 2008; 26(6): 897 - 906.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Liu, H. Gao, T. T. Marstrand, A. Strom, E. Valen, A. Sandelin, J.-A. Gustafsson, and K. Dahlman-Wright
The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions
PNAS, February 19, 2008; 105(7): 2604 - 2609.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
A. Vasconsuelo, L. Milanesi, and R. Boland
17{beta}-Estradiol abrogates apoptosis in murine skeletal muscle cells through estrogen receptors: role of the phosphatidylinositol 3-kinase/Akt pathway
J. Endocrinol., February 1, 2008; 196(2): 385 - 397.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Katsu, R. Ichikawa, T. Ikeuchi, S. Kohno, L. J. Guillette Jr., and T. Iguchi
Molecular Cloning and Characterization of Estrogen, Androgen, and Progesterone Nuclear Receptors from a Freshwater Turtle (Pseudemys nelsoni)
Endocrinology, January 1, 2008; 149(1): 161 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. F.G Lucas, E. R Siu, C. A Esteves, H. P Monteiro, C. A Oliveira, C. S Porto, and M. F. M Lazari
17Beta-Estradiol Induces the Translocation of the Estrogen Receptors ESR1 and ESR2 to the Cell Membrane, MAPK3/1 Phosphorylation and Proliferation of Cultured Immature Rat Sertoli Cells
Biol Reprod, January 1, 2008; 78(1): 101 - 114.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Zhu and U. Hansen
HMGN1 Modulates Estrogen-Mediated Transcriptional Activation through Interactions with Specific DNA-Binding Transcription Factors
Mol. Cell. Biol., December 15, 2007; 27(24): 8859 - 8873.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
K. Britt, A. Ashworth, and M. Smalley
Pregnancy and the risk of breast cancer
Endocr. Relat. Cancer, December 1, 2007; 14(4): 907 - 933.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
M. De los Santos, O. Martinez-Iglesias, and A. Aranda
Anti-estrogenic actions of histone deacetylase inhibitors in MCF-7 breast cancer cells
Endocr. Relat. Cancer, December 1, 2007; 14(4): 1021 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. R. Hammes and E. R. Levin
Extranuclear Steroid Receptors: Nature and Actions
Endocr. Rev., December 1, 2007; 28(7): 726 - 741.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. C. Velarde, Z. Zeng, J. R. McQuown, F. A. Simmen, and R. C. M. Simmen
Kruppel-Like Factor 9 Is a Negative Regulator of Ligand-Dependent Estrogen Receptor {alpha} Signaling in Ishikawa Endometrial Adenocarcinoma Cells
Mol. Endocrinol., December 1, 2007; 21(12): 2988 - 3001.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. H. Windahl, M. K. Lagerquist, N. Andersson, C. Jochems, A. Kallkopf, C. Hakansson, J. Inzunza, J.-A. Gustafsson, P. T. van der Saag, H. Carlsten, et al.
Identification of Target Cells for the Genomic Effects of Estrogens in Bone
Endocrinology, December 1, 2007; 148(12): 5688 - 5695.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P.-A. Scott, A. Tremblay, M. Brochu, and J. St-Louis
Vasorelaxant action of 17 -estradiol in rat uterine arteries: role of nitric oxide synthases and estrogen receptors
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3713 - H3719.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
S. C. J. P. Gielen, L. A. M. Santegoets, L. C. M. Kuhne, W. F. J. Van IJcken, B. Boers-Sijmons, P. Hanifi-Moghaddam, T. J. M. Helmerhorst, L. J. Blok, and C. W. Burger
Genomic and Nongenomic Effects of Estrogen Signaling in Human Endometrial Cells: Involvement of the Growth Factor Receptor Signaling Downstream AKT Pathway
Reproductive Sciences, October 1, 2007; 14(7): 646 - 654.
[Abstract] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Jiang, N. Sarwar, D. Peston, E. Kulinskaya, S. Shousha, R. C. Coombes, and S. Ali
Phosphorylation of Estrogen Receptor-{alpha} at Ser167 Is Indicative of Longer Disease-Free and Overall Survival in Breast Cancer Patients
Clin. Cancer Res., October 1, 2007; 13(19): 5769 - 5776.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Kundu, A. Alioua, E. Stefani, and L. Toro
Regulation of Mouse Slo Gene Expression: MULTIPLE PROMOTERS, TRANSCRIPTION START SITES, AND GENOMIC ACTION OF ESTROGEN
J. Biol. Chem., September 14, 2007; 282(37): 27478 - 27492.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
G. P Risbridger, S. J Ellem, and S. J McPherson
Estrogen action on the prostate gland: a critical mix of endocrine and paracrine signaling
J. Mol. Endocrinol., September 1, 2007; 39(3): 183 - 188.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. Chen, K. A. Power, J. Mann, A. Cheng, and L. U. Thompson
Flaxseed Alone or in Combination with Tamoxifen Inhibits MCF-7 Breast Tumor Growth in Ovariectomized Athymic Mice with High Circulating Levels of Estrogen
Experimental Biology and Medicine, September 1, 2007; 232(8): 1071 - 1080.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. J. Pietras and D. C. Marquez-Garban
Membrane-Associated Estrogen Receptor Signaling Pathways in Human Cancers
Clin. Cancer Res., August 15, 2007; 13(16): 4672 - 4676.
[Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
D. Nonclercq, F. Journe, I. Laios, C. Chaboteaux, R.-A. Toillon, G. Leclercq, and G. Laurent
Effect of nuclear export inhibition on estrogen receptor regulation in breast cancer cells
J. Mol. Endocrinol., August 1, 2007; 39(2): 105 - 118.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Dziennis, T. Jia, O. K. Ronnekleiv, P. D. Hurn, and N. J. Alkayed
Role of Signal Transducer and Activator of Transcription-3 in Estradiol-Mediated Neuroprotection
J. Neurosci., July 4, 2007; 27(27): 7268 - 7274.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. M. Silva and M. A. Shupnik
Integration of Steroid and Growth Factor Pathways in Breast Cancer: Focus on Signal Transducers and Activators of Transcription and Their Potential Role in Resistance
Mol. Endocrinol., July 1, 2007; 21(7): 1499 - 1512.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. C. Trainor, S. Lin, M. S. Finy*, M. R. Rowland, and R. J. Nelson
Photoperiod reverses the effects of estrogens on male aggression via genomic and nongenomic pathways
PNAS, June 5, 2007; 104(23): 9840 - 9845.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. O'Lone, K. Knorr, I. Z. Jaffe, M. E. Schaffer, P. G. V. Martini, R. H. Karas, J. Bienkowska, M. E. Mendelsohn, and U. Hansen
Estrogen Receptors {alpha} and {beta} Mediate Distinct Pathways of Vascular Gene Expression, Including Genes Involved in Mitochondrial Electron Transport and Generation of Reactive Oxygen Species
Mol. Endocrinol., June 1, 2007; 21(6): 1281 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
M. E. Wierman and W. M. Kohrt
Review Article: Vascular and Metabolic Effects of Sex Steroids: New Insights Into Clinical Trials
Reproductive Sciences, May 1, 2007; 14(4): 300 - 314.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
A. A. Kazi and R. D. Koos
Estrogen-Induced Activation of Hypoxia-Inducible Factor-1{alpha}, Vascular Endothelial Growth Factor Expression, and Edema in the Uterus Are Mediated by the Phosphatidylinositol 3-Kinase/Akt Pathway
Endocrinology, May 1, 2007; 148(5): 2363 - 2374.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
X. Xu, J. Ding, G. Rao, J. Shen, R. A. Prinz, N. Rana, and W.P. Dmowski
Estradiol induces heparanase-1 expression and heparan sulphate proteoglycan degradation in human endometrium
Hum. Reprod., April 1, 2007; 22(4): 927 - 937.
[Abstract] [Full Text] [PDF]

Home page
 Adv. Physiol. Educ.Home page
M. E. Wierman
Sex steroid effects at target tissues: mechanisms of action
Advan Physiol Educ, March 1, 2007; 31(1): 26 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Kousteni, M. Almeida, L. Han, T. Bellido, R. L. Jilka, and S. C. Manolagas
Induction of Osteoblast Differentiation by Selective Activation of Kinase-Mediated Actions of the Estrogen Receptor
Mol. Cell. Biol., February 15, 2007; 27(4): 1516 - 1530.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. Vasudevan and D. W. Pfaff
Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles
Endocr. Rev., February 1, 2007; 28(1): 1 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Fan, P. S. Yan, C. Hartman-Frey, L. Chen, H. Paik, S. L. Oyer, J. D. Salisbury, A. S.L. Cheng, L. Li, P. H. Abbosh, et al.
Diverse Gene Expression and DNA Methylation Profiles Correlate with Differential Adaptation of Breast Cancer Cells to the Antiestrogens Tamoxifen and Fulvestrant
Cancer Res., December 15, 2006; 66(24): 11954 - 11966.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
U. Ohnemus, M. Uenalan, J. Inzunza, J.-A. Gustafsson, and R. Paus
The Hair Follicle as an Estrogen Target and Source
Endocr. Rev., October 1, 2006; 27(6): 677 - 706.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. K. Iyer, Y.-H. Zhang, and E. R. B. McCabe
Dosage-Sensitive Sex Reversal Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1 (DAX1) (NR0B1) and Small Heterodimer Partner (SHP) (NR0B2) Form Homodimers Individually, as Well as DAX1-SHP Heterodimers
Mol. Endocrinol., October 1, 2006; 20(10): 2326 - 2342.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Z. Zhang, K. Chen, J. C. Shih, and C. T. Teng
Estrogen-Related Receptors-Stimulated Monoamine Oxidase B Promoter Activity Is Down-Regulated by Estrogen Receptors
Mol. Endocrinol., July 1, 2006; 20(7): 1547 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Gao, G. Bryzgalova, E. Hedman, A. Khan, S. Efendic, J.-A. Gustafsson, and K. Dahlman-Wright
Long-Term Administration of Estradiol Decreases Expression of Hepatic Lipogenic Genes and Improves Insulin Sensitivity in ob/ob Mice: A Possible Mechanism Is through Direct Regulation of Signal Transducer and Activator of Transcription 3
Mol. Endocrinol., June 1, 2006; 20(6): 1287 - 1299.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. A. Champagne, I. C. G. Weaver, J. Diorio, S. Dymov, M. Szyf, and M. J. Meaney
Maternal Care Associated with Methylation of the Estrogen Receptor-{alpha}1b Promoter and Estrogen Receptor-{alpha} Expression in the Medial Preoptic Area of Female Offspring
Endocrinology, June 1, 2006; 147(6): 2909 - 2915.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. J. Mhyre, R. A. Shapiro, and D. M. Dorsa
Estradiol Reduces Nonclassical Transcription at Cyclic Adenosine 3',5'-Monophosphate Response Elements in Glioma Cells Expressing Estrogen Receptor Alpha
Endocrinology, April 1, 2006; 147(4): 1796 - 1804.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. E. Gururaj, S. K. Rayala, R. K. Vadlamudi, and R. Kumar
Novel Mechanisms of Resistance to Endocrine Therapy: Genomic and Nongenomic Considerations
Clin. Cancer Res., February 1, 2006; 12(3): 1001s - 1007s.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. F. Allred, E. J. Smart, and M. E. Wilson
Estrogen Receptor-{alpha} Mediates Gender Differences in Atherosclerosis Induced by HIV Protease Inhibitors
J. Biol. Chem., January 20, 2006; 281(3): 1419 - 1425.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Z. T. Ruiz-Cortes, S. Kimmins, L. Monaco, K. H. Burns, P. Sassone-Corsi, and B. D. Murphy
Estrogen Mediates Phosphorylation of Histone H3 in Ovarian Follicle and Mammary Epithelial Tumor Cells via the Mitotic Kinase, Aurora B
Mol. Endocrinol., December 1, 2005; 19(12): 2991 - 3000.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. M. D'Eon, S. C. Souza, M. Aronovitz, M. S. Obin, S. K. Fried, and A. S. Greenberg
Estrogen Regulation of Adiposity and Fuel Partitioning: EVIDENCE OF GENOMIC AND NON-GENOMIC REGULATION OF LIPOGENIC AND OXIDATIVE PATHWAYS
J. Biol. Chem., October 28, 2005; 280(43): 35983 - 35991.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
F. F. Zheng, R.-C. Wu, C. L. Smith, and B. W. O'Malley
Rapid Estrogen-Induced Phosphorylation of the SRC-3 Coactivator Occurs in an Extranuclear Complex Containing Estrogen Receptor
Mol. Cell. Biol., September 15, 2005; 25(18): 8273 - 8284.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. E. Mendelsohn and R. H. Karas
Molecular and Cellular Basis of Cardiovascular Gender Differences
Science, June 10, 2005; 308(5728): 1583 - 1587.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2005 by The Endocrine Society