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Metastasis-Associated Protein 2 Is a Repressor of Estrogen Receptor Whose Overexpression Leads to Estrogen-Independent Growth of Human Breast Cancer Cells

Departments of Medicine (Y.C., A.N., S.A.W.F.), Breast Center (S.A.W.F.), Molecular and Cellular Biology (S.A.W.F.), Baylor College of Medicine, and the Methodist Hospital, and the Department of Molecular and Cellular Oncology (R.K.), University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030; Department of Cancer Biology (R.P.), Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107; Department of Pediatrics and the Sealy Vaccine Center (E.M.C.), University of Texas Medical Branch, Children’s Hospital, Galveston, Texas 77555; Department of Medical Laboratory Techniques (Y.L.), Tianjin Medical University, Tianjin 300203, China

Address all correspondence and requests for reprints to: Suzanne A.W. Fuqua, Breast Center, Baylor College of Medicine, One Baylor Plaza, BCM 600, Houston, Texas 77030. E-mail: sfuqua{at}breastcenter.tmc.edu.

Estrogen receptor (ER) activity is controlled by the balance of coactivators and corepressors contained within cells that are recruited into transcriptional complexes. The metastasis-associated protein (MTA) family has been demonstrated to be associated with breast tumor cell progression and ER activity. We demonstrate that MTA2 expression is correlated with ER protein expression in invasive breast tumors. We show that the MTA2 family member can bind to ER and repress its activity in human breast cancer cells. Furthermore, it can inhibit ER-mediated colony formation and render breast cancer cells resistant to estradiol and the growth-inhibitory effects of the antiestrogen tamoxifen. MTA2 participates in the deacetylation of ER protein, potentially through its associated histone deacetylase complex 1 activity. We hypothesize that MTA2 is a repressor of ER activity and that it could represent a new therapeutic target of ER action in human breast tumors.

NURSA Molecule Pages Link:

Nuclear Receptors:   ERα

Coregulators:   PGC-1  |  L7/SPA  |  SAF-B  |  MTA2  |  ERBP  |  MICoA

Ligands:   17β-Estradiol  |  9-cis-Retinoic acid  |  R1881  |  R5020  |  Fulvestrant

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