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GRIS: Glycoprotein-Hormone Receptor Information System

Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (J.V.D., S.C., G.Va.), Université Libre de Bruxelles, B-1070 Brussels, Belgium; Commissariat à l’Energie Atomique, Biologie, Informatique et Mathématiques (F.H.), 38054 Grenoble, France; and Centre for Molecular and Biomolecular Informatics (G.Vr.), Radboud University Nijmegen, 6525 ED Nijmegen, The Netherlands

Address all correspondence and requests for reprints to: Dr. Gilbert Vassart, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B-1070 Brussels, Belgium. E-mail: gvassart{at}ulb.ac.be.

ABSTRACT

The glycoprotein-hormone receptor information system (GRIS) presents a comprehensive view on all available molecular data for the lutropin/choriogonadotropin receptor, follitropin receptor, and thyrotropin receptor G protein-coupled receptors. It features a mutation database presently containing 696 point mutations, combined with all sequences and the associated homology models. The mutation information was automatically extracted from the literature and manually augmented with respect to constitutivity, surface expression, sensitivity to hormones, and binding affinity. All information in this integrated system is presented in a G protein-coupled receptor specialist-friendly way. A series of interactive tools such as rotamer analysis, mutation prediction, or cavity visualization aids with the design and interpretation of experiments. A universal residue numbering system has been introduced to ease database searches as well as the use of the information in conjunction with literature data from diverse origins. Users can upload new mutations. GRIS is freely accessible at http://gris.ulb.ac.be/.

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