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Molecular Endocrinology, doi:10.1210/me.2005-0459
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Molecular Endocrinology 21 (1): 1-13
Copyright © 2007 by The Endocrine Society

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Estrogen Receptor-ß: Recent Lessons from in Vivo Studies

Heather A. Harris

Women’s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426

Address all correspondence and requests for reprints to: Heather Harris, Women’s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, RN3163, Collegeville, Pennsylvania 19426. E-mail: harrish{at}wyeth.com.

The unexpected discovery of a second form of the estrogen receptor (ER), designated ERß, surprised and energized the field of estrogen research. In the 9 yr since its identification, the remarkable efforts from academic and industrial scientists of many disciplines have made significant progress in elucidating its biology. A powerful battery of tools, including knockout mice as well as a panel of receptor-selective agonists, has allowed an investigation into the role of ERß. To date, in vivo efficacy studies are limited to rodents. Current data indicate that ERß plays a minor role in mediating estrogen action in the uterus, on the hypothalamus/pituitary, the skeleton, and other classic estrogen target tissues. However, a clear role for ERß has been established in the ovary, cardiovascular system, and brain as well as in several animal models of inflammation including arthritis, endometriosis, inflammatory bowel disease, and sepsis. The next phase of research will focus on elucidating, at a molecular level, how ERß exerts these diverse effects and exploring the clinical utility of ERß-selective agonists.

NURSA Molecule Pages Link:

Nuclear Receptors:   ERα  |  ERβ
Ligands:   17β-Estradiol  |  Fulvestrant



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