help button home button Endocrine Society Molecular Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Molecular Endocrinology, doi:10.1210/me.2007-0065
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
21/6/1267    most recent
Author Manuscript (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow NURSA Molecule Pages Link
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flaster, H.
Right arrow Articles by Bucala, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flaster, H.
Right arrow Articles by Bucala, R.
Molecular Endocrinology 21 (6): 1267-1280
Copyright © 2007 by The Endocrine Society

Minireview

The Macrophage Migration Inhibitory Factor-Glucocorticoid Dyad: Regulation of Inflammation and Immunity

Harry Flaster, Jürgen Bernhagen, Thierry Calandra and Richard Bucala

Institute of Biochemistry (J.B.), University Hospital RWTH, D-52074 Aachen, Germany; Infectious Diseases Service (T.C.), Department of Medicine, Centre Hospitalier Universitaire Vandois, CH-1011 Lausanne, Switzerland; and Yale University School of Medicine (H.F., R.B.), New Haven, Connecticut 06520

Address all correspondence and requests for reprints to: Richard Bucala, Department of Medicine, Pathology, and Epidemiology and Public Health, Yale University School of Medicine, The Anlyan Center, S525, 300 Cedar Street, New Haven, Connecticut 06520-8031. E-mail: Richard.Bucala{at}Yale.edu.

The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.

NURSA Molecule Pages Link:

Ligands:   Dexamethasone  |  Hydrocortisone



This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
P. L. Vera, X. Wang, and K. L. Meyer-Siegler
Upregulation of Macrophage Migration Inhibitory Factor (MIF) and CD74, Receptor for MIF, in Rat Bladder During Persistent Cyclophosphamide-Induced Inflammation
Experimental Biology and Medicine, May 1, 2008; 233(5): 620 - 626.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2007 by The Endocrine Society