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The Macrophage Migration Inhibitory Factor-Glucocorticoid Dyad: Regulation of Inflammation and Immunity

Institute of Biochemistry (J.B.), University Hospital RWTH, D-52074 Aachen, Germany; Infectious Diseases Service (T.C.), Department of Medicine, Centre Hospitalier Universitaire Vandois, CH-1011 Lausanne, Switzerland; and Yale University School of Medicine (H.F., R.B.), New Haven, Connecticut 06520

Address all correspondence and requests for reprints to: Richard Bucala, Department of Medicine, Pathology, and Epidemiology and Public Health, Yale University School of Medicine, The Anlyan Center, S525, 300 Cedar Street, New Haven, Connecticut 06520-8031. E-mail: Richard.Bucala{at}Yale.edu.

The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.

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Ligands:   Dexamethasone  |  Hydrocortisone

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