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Molecular Endocrinology, doi:10.1210/me.2008-0297
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Molecular Endocrinology 22 (12): 2751-2758
Copyright © 2008 by The Endocrine Society

Commentary

Commentary: The Year in Basic Science: Nuclear Receptors and Coregulators

Bert O'Malley

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030-3498

Address all correspondence and requests for reprints to: Dr. Bert O Malley, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston Texas 77030-3498. E-mail: berto{at}bcm.tmc.edu.

ABSTRACT

This article highlights the most significant scientific achievements of June 2007 to June 2008 in nuclear receptors (NRs) and coregulators. These molecules are the subjects of nine studies in three key areas of endocrinology: molecular endocrinology, endocrine metabolism, and endocrine pathology. In each case, the relevant NR or coregulator was found to play an integral role in the study, whether in elucidating a formerly unknown pathway or in initiating or facilitating a disease process. As more NRs and coregulators are researched, more therapeutic approaches to human disease can potentially be developed.

NURSA Molecule Pages Link:

Nuclear Receptors:   PPARα  |  PPARγ  |  REV-ERBα  |  COUP-TFII  |  ERα  |  ERRα  |  PR  |  AR  |  NGFIB  |  NOR1
Coregulators:   PGC-1  |  SRC-1



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