This Article Full Text Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager NURSA Molecule Pages Link Reprints, Permissions and Rights Google Scholar Articles by Firestone, G. L. Articles by Sundar, S. N. PubMed PubMed Citation Articles by Firestone, G. L. Articles by Sundar, S. N.

Minireview: Modulation of Hormone Receptor Signaling by Dietary Anticancer Indoles

Department of Molecular and Cell Biology and The Cancer Research Laboratory, The University of California at Berkeley, Berkeley, California 94720-3200

Address all correspondence and requests for reprints to: Gary L. Firestone, Department of Molecular and Cell Biology, 591 LSA, The University of California at Berkeley, Berkeley, California 94720-3200. E-mail: glfire{at}berkeley.edu.

Indole-3-carbinol and its diindole condensation product 3-3'-diindolylmethane are dietary phytochemicals that have striking anticarcinogenic properties in human cancer cells. Molecular, cellular, physiological, and clinical studies have documented that both indole-3-carbinol and 3-3'-diindolylmethane have potent endocrine modulating activities through a myriad of mechanisms. The focus of this review is to discuss the evidence that directly links the anticancer actions of these two indole compounds to the control of steroid receptor and growth factor receptor signaling.

NURSA Molecule Pages Link:

Nuclear Receptors:   ER-α  |  ER-β  |  AR

Ligands:   Estriol  |  Estrone  |  17β-estradiol