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Molecular Endocrinology Vol. 3, No. 2 261-272
doi:10.1210/mend-3-2-261
Copyright © 1989 by the Endocrine Society.
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Binding of Transforming Growth Factor-β to Cell Surface Proteins Varies with Cell Type

Patricia R. Segarini, David M. Rosen and Saeid M. Seyedin

Celtrix Laboratories, Collagen Corporation Palo Alto, California 94303

Address requests for reprints to: Dr. Patricia R. Segarini, Department of Cell Biology, Collagen Corporation, 2500 Faber Place, Palo Alto, California 94303.

Abstract

Transforming growth factor-β (TGFβ1 and TGFβ2) bind to several different cell surface proteins, including a high Mr proteoglycan. We found that on primary and early passage cultures of fibroblasts, chondroblasts, and osteoblasts TGFβ1 binds to both the high Mr proteoglycan and to lower Mr components, whereas on epithelial, endothelial, and lymphoid-derived cells TGFβ1 only binds to the lower Mr species. With cell lines, this distinction is lost. Further analysis indicated that binding to the high Mr proteoglycan is not necessary for TGFβ1 induced regulation of DNA, collagen and fibronectin synthesis, change in cell morphology, or reorganization of the actin cytoskeleton. We propose that the lower Mr components are the active receptors mediating these events

Received for publication September 21, 1988. Revision received November 15, 1988. Accepted for publication November 21, 1988.




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