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Molecular Endocrinology Vol. 3, No. 3 603-604
doi:10.1210/mend-3-3-603
Copyright © 1989 by the Endocrine Society.
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SEQUENCES OF INTEREST: Leucine Zipper in Human DNA Topoisomerase II

Leonard A. Zwelling and W. Michael Perry

Department of Medical Oncology, Department of Biochemistry, M.D. Anderson Cancer Center Houston, Texas 77030

Address requests for reprints to: Leonard A. Zwelling, M.D., Box 52,1515 Holcombe Boulevard, Houston, Texas 77030.

Abstract

Examination of the amino acid sequence of human DNA topoisomerase II revealed the presence of a leucine zipper, a novel motif found in several proteins localized to the cell nucleus. The presence of this motif in this unique protein may explain some of the normal functions of topoisomerase II as well as the disruption of those functions by antineoplastic drugs.

FOOTNOTES

This work was supported by PHS Grant CA-40090 awarded by the National Cancer Institute and by American Cancer Society Grant CH-324B.

Received for publication November 29, 1988. Accepted for publication December 9, 1988.




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Copyright © 1989 by The Endocrine Society