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Molecular Endocrinology, Vol 3, 603-604, Copyright © 1989 by Endocrine Society

ARTICLES

Leucine zipper in human DNA topoisomerase II

LA Zwelling and WM Perry
Department of Medical Oncology, M.D. Anderson Cancer Center, Houston, Texas 77030.

Examination of the amino acid sequence of human DNA topoisomerase II revealed the presence of a leucine zipper, a novel motif found in several proteins localized to the cell nucleus. The presence of this motif in this unique protein may explain some of the normal functions of topoisomerase II as well as the disruption of those functions by antineoplastic drugs.


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