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Molecular Endocrinology Vol. 3, No. 7 1108-1114
doi:10.1210/mend-3-7-1108
Copyright © 1989 by the Endocrine Society.
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Murine Transforming Growth Factor-β2 cDNA Sequence and Expression in Adult Tissues and Embryos

Duncan A. Miller, Angela Lee, Ron W. Pelton, Ellson Y. Chen, Harold L. Moses and Rik Derynck

Department of Cell Biology, Vanderbilt University School of Medicine Nashville, Tennessee 37232
Departments of Developmental Biology and Molecular Biology, Genentech Inc. South San Francisco, California 94080

Address correspondence to: D. A. Miller, Department of Cell Biology, Vanderbilt School of Medicine, Nashville, Tennessee 37232.

Abstract

Murine transforming growth factor-β2 (TGF-β2) cDNAs were isolated from cDNA libraries derived from a differentiated murine embryonic carcinoma cell line, PCC3. The composite cDNA sequence is 4267 nucleotides long, including a 1217 nucleotides 5'-untranslated sequence, and encodes a murine TGF-β2 precursor of 414 amino acids with 96% identity to its human counterpart. Several consensus polyadenylation sequences are present in the 1807 nucleotides 3'-untranslated sequence. Five TGF-β2 mRNA species are observed in the developing mouse fetus and they show different patterns of expression during development. TGF-β2 mRNA expression was also examined in adult mouse tissues, in which four of the five RNA species were observed. TGF-β2 mRNAs were present in all adult mouse tissues examined, except liver, and was most abundant in placenta, the male submaxillary gland and lung. The patterns of expression suggest a physiological role for TGF-β2 both in embryonic development and in the maintenance of adult tissues.

FOOTNOTES

This research was supported by NIH Grant CA-42572 (to D.A.M., H.L.M.) and NIH Grant T32-GM07347 (to R.W.P.).

Received for publication March 17, 1989. Accepted for publication April 18, 1989.




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