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Localization of Inhibin/Activin Subunit mRNAs within the Primate Ovary

Departments of Pharmacological Sciences, Genentech, Inc. South San Francisco, California 94080
Developmental Biology, Genentech, Inc. South San Francisco, California 94080
Cardiovascular Research Genentech, Inc. South San Francisco, California 94080
Departments of Physiology and Obstetrics/Gynecology, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania 15213

Address requests for reprints to: Dr. Anthony J. Zeleznik,Departments of Physiology and Obstetrics/Gynecology, Magee-Womens Hospital, Pittsburgh, Pennsylvania 15213.

Abstract

In order to gain further understanding of the physiology of inhibin and activin in the primate, the expression of inhibin/activin subunit mRNAs in the monkey ovary was examined by in situ hybridization. Granulosa cells of small antral follicles were found to express mRNA for the βB subunit, which decreased to undetectable levels in dominant follicles. In contrast, expression of and βA subunit mRNAs was detected in granulosa cells of dominant follicles and in corpora lutea, but not in small antral follicles. These results indicate that the expression of the βA and βB subunits is differentially regulated during the growth and development of ovarian follicles in the monkey.

FOOTNOTES

This work was supported in part by NIH Grants HD-06810, 12014, and 00531 (to A.J.Z).

Received for publication August 18, 1989. Revision received September 26, 1989. Accepted for publication September 28, 1989.

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