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Molecular Endocrinology Vol. 4, No. 2 337-340
doi:10.1210/mend-4-2-337
Copyright © 1990 by the Endocrine Society.
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Widespread Organ Expression of the Rat Proenkephalin Gene during Early Postnatal Development

David Kew and Daniel L. Kilpatrick

Neurobiology Group, Worcester Foundation for Experimental Biology Shrewsbury, Massachussetts 01545

Address requests for reprints to: Dr. Daniel L. Kilpatrick, Worcester Foundation for Experimental Biology, Neurobiology Group, Shrewsbury, Massachussetts 01545.

Abstract

The opioid peptides have been implicated as potential regulators of cell development in nervous and reproductive tissues. A survey of proenkephalin gene expression during rat development showed that the mRNA for this opioid precursor is present at substantial concentrations in several developing tissues (kidney, liver, skin, skeletal muscle, and lung) that have essentially undetectable levels in adults. In neonatal rats, skeletal muscle has greater concentrations of this transcript than brain. Polysomal analysis further demonstrated that proenkephalin mRNA is actively translated in skeletal muscle from newborn rats. These results raise the possibility that proenkephalin and its products perform a general regulatory role in cell proliferation or differentiation.

FOOTNOTES

This work was supported by NIH Grants DK-35855 and DK-36486 (to D.L.K.) and grants to the Worcester Foundation from the Andrew W. Mellon Foundation and the Edward John Noble Foundation.

Received for publication October 9, 1989. Revision received November 14, 1989. Accepted for publication November 16, 1989.




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Copyright © 1990 by The Endocrine Society