help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Molecular Endocrinology Vol. 4, No. 4 597-603
doi:10.1210/mend-4-4-597
Copyright © 1990 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Windle, J. J.
Right arrow Articles by Mellon, P. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Windle, J. J.
Right arrow Articles by Mellon, P. L.

Cell Lines of the Pituitary Gonadotrope Lineage Derived by Targeted Oncogenesis in Transgenic Mice

Jolene J. Windle*, Richard I. Weiner and Pamela L. Mellon

Regulatory Biology Laboratory, The Salk Institute La Jolla, California 92037
Reproductive Endocrinology Center, University of California San Francisco, California 94143

Address requests for reprints to: Pamela L. Mellon, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037.

Abstract

Study of the molecular and cellular biology of the gonadotropin hormones would be greatly facilitated by the availability of immortalized anterior pituitary gonadotrope cell lines. We directed expression of the simian virus-40 (SV40) T-antigen (Tag) oncogene to specific cells in the anterior pituitary of transgenic mice using the promoter/enhancer region from the human glycoprotein hormone {alpha}-subunit gene. Transgenic mice carrying this fusion gene developed anterior pituitary tumors. Clonal cell lines established from these tumors express the endogenous mouse {alpha}-subunit gene and synthesize and secrete a-subunit protein. However, they do not express β-subunit genes. Alpha-subunit mRNA is induced by GnRH in a dose- and time-dependent manner, but is not regulated by TRH. Thus, we have targeted tumorigenesis in transgenic mice to anterior pituitary cells of the gonadotrope lineage to immortalize this specific endocrine cell while maintaining several highly differentiated functions unique to gonadotropes.

FOOTNOTES

This work was supported by NIH Grant HD-20377 and March of Dimes Grant 1–1182 (to P.L.M.) and NIH Grant HD-08924 (to R.I.W.).

* Supported by the American Cancer Society and the J. Aron Charitable Foundation.

Received for publication November 17, 1989. Revision received January 16, 1990. Accepted for publication January 16, 1990.




This article has been cited by other articles:


Home page
 EndocrinologyHome page
J. Chen, B.-S. An, L. Cheng, G. L. Hammond, and P. C. K. Leung
Gonadotropin-Releasing Hormone-Mediated Phosphorylation of Estrogen Receptor-{alpha} Contributes to fosB Expression in Mouse Gonadotrophs
Endocrinology, October 1, 2009; 150(10): 4583 - 4593.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K.-H. Jeong, J. C. Gill, V. Nose, A. F. Parlow, R. S. Carroll, and U. B. Kaiser
Expression of a Gonadotropin-Releasing Hormone Receptor-Simian Virus 40 T-Antigen Transgene Has Sex-Specific Effects on the Reproductive Axis
Endocrinology, July 1, 2009; 150(7): 3383 - 3391.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
A. F Seasholtz, M. Ohman, A. Wardani, and R. C Thompson
Corticotropin-releasing hormone receptor expression and functional signaling in murine gonadotrope-like cells
J. Endocrinol., February 1, 2009; 200(2): 223 - 232.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. I. Mayer, V. Dexheimer, E. Nishida, S. Kitajima, and G. Thiel
Expression of the Transcriptional Repressor ATF3 in Gonadotrophs Is Regulated by Egr-1, CREB, and ATF2 after Gonadotropin-Releasing Hormone Receptor Stimulation
Endocrinology, December 1, 2008; 149(12): 6311 - 6325.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Lariviere, G. Garrel-Lazayres, V. Simon, N. Shintani, A. Baba, R. Counis, and J. Cohen-Tannoudji
Gonadotropin-Releasing Hormone Inhibits Pituitary Adenylyl Cyclase-Activating Polypeptide Coupling to 3',5'-Cyclic Adenosine-5'-Monophosphate Pathway in L{beta}T2 Gonadotrope Cells through Novel Protein Kinase C Isoforms and Phosphorylation of Pituitary Adenylyl Cyclase-Activating Polypeptide Type I Receptor
Endocrinology, December 1, 2008; 149(12): 6389 - 6398.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Xie, K. H. Allen, A. Marguet, K. A. Berghorn, S. P. Bliss, A. M. Navratil, J. L. Guan, and M. S. Roberson
Analysis of the Calcium-Dependent Regulation of Proline-Rich Tyrosine Kinase 2 by Gonadotropin-Releasing Hormone
Mol. Endocrinol., October 1, 2008; 22(10): 2322 - 2335.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
U. B. Kaiser
Genetic Labeling: New Approaches to Creating a Gonadotroph "ID"
Endocrinology, June 1, 2008; 149(6): 2699 - 2700.
[Full Text] [PDF]

Home page
 J EndocrinolHome page
H. L Henderson, J. Townsend, and D. J Tortonese
Direct effects of prolactin and dopamine on the gonadotroph response to GnRH
J. Endocrinol., May 1, 2008; 197(2): 343 - 350.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Xie and M. S. Roberson
3', 5'-Cyclic Adenosine 5'-Monophosphate Response Element-Dependent Transcriptional Regulation of the Secretogranin II Gene Promoter Depends on Gonadotropin-Releasing Hormone-Induced Mitogen-Activated Protein Kinase Activation and the Transactivator Activating Transcription Factor 3
Endocrinology, February 1, 2008; 149(2): 783 - 792.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Cogliati, P. Delgado-Romero, E. R. Norwitz, J. Guduric-Fuchs, U. B. Kaiser, S. Wray, and I. R. Kirsch
Pubertal Impairment in Nhlh2 Null Mice Is Associated with Hypothalamic and Pituitary Deficiencies
Mol. Endocrinol., December 1, 2007; 21(12): 3013 - 3027.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. L. Chand, G. T. Ooi, C. A. Harrison, A. N. Shelling, and D. M. Robertson
Functional analysis of the human inhibin {alpha} subunit variant A257T and its potential role in premature ovarian failure
Hum. Reprod., December 1, 2007; 22(12): 3241 - 3248.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Gungor, N. Taniguchi-Ishigaki, H. Ma, A. Drung, B. Tursun, H. P. Ostendorff, M. Bossenz, C. G. Becker, T. Becker, and I. Bach
Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors
PNAS, September 18, 2007; 104(38): 15000 - 15005.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Maudsley, Z. Naor, D. Bonfil, L. Davidson, D. Karali, A. J. Pawson, R. Larder, C. Pope, N. Nelson, R. P. Millar, et al.
Proline-Rich Tyrosine Kinase 2 Mediates Gonadotropin-Releasing Hormone Signaling to a Specific Extracellularly Regulated Kinase-Sensitive Transcriptional Locus in the Luteinizing Hormone {beta}-Subunit Gene
Mol. Endocrinol., May 1, 2007; 21(5): 1216 - 1233.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
I. Pellegrini, C. Roche, M.-H. Quentien, M. Ferrand, G. Gunz, S. Thirion, C. Bagnis, A. Enjalbert, and J.-L. Franc
Involvement of the Pituitary-Specific Transcription Factor Pit-1 in Somatolactotrope Cell Growth and Death: An Approach Using Dominant-Negative Pit-1 Mutants
Mol. Endocrinol., December 1, 2006; 20(12): 3212 - 3227.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. S. Ellsworth, N. Egashira, J. L. Haller, D. L. Butts, J. Cocquet, C. M. Clay, R. Y. Osamura, and S. A. Camper
FOXL2 in the Pituitary: Molecular, Genetic, and Developmental Analysis
Mol. Endocrinol., November 1, 2006; 20(11): 2796 - 2805.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Kanasaki, G. Y. Bedecarrats, K.-Y. Kam, S. Xu, and U. B. Kaiser
Gonadotropin-Releasing Hormone Pulse Frequency-Dependent Activation of Extracellular Signal-Regulated Kinase Pathways in Perifused L{beta}T2 Cells
Endocrinology, December 1, 2005; 146(12): 5503 - 5513.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
N. J. Westphal and A. F. Seasholtz
Gonadotropin-Releasing Hormone (GnRH) Positively Regulates Corticotropin-Releasing Hormone-Binding Protein Expression via Multiple Intracellular Signaling Pathways and a Multipartite GnRH Response Element in {alpha}T3-1 Cells
Mol. Endocrinol., November 1, 2005; 19(11): 2780 - 2797.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. S. Roberson, S. P. Bliss, J. Xie, A. M. Navratil, T. A. Farmerie, M. W. Wolfe, and C. M. Clay
Gonadotropin-Releasing Hormone Induction of Extracellular-Signal Regulated Kinase Is Blocked by Inhibition of Calmodulin
Mol. Endocrinol., September 1, 2005; 19(9): 2412 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
Q. Jiang, K.-H. Jeong, C. D Horton, and L. M Halvorson
Pituitary homeobox 1 (Pitx1) stimulates rat LH{beta} gene expression via two functional DNA-regulatory regions
J. Mol. Endocrinol., August 1, 2005; 35(1): 145 - 158.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. P. Hermann and L. L. Heckert
Silencing of Fshr Occurs through a Conserved, Hypersensitive Site in the First Intron
Mol. Endocrinol., August 1, 2005; 19(8): 2112 - 2131.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. D. Cherrington, T. A. Farmerie, C. A. Lents, J. D. Cantlon, M. S. Roberson, and C. M. Clay
Activin Responsiveness of the Murine Gonadotropin-Releasing Hormone Receptor Gene Is Mediated by a Composite Enhancer Containing Spatially Distinct Regulatory Elements
Mol. Endocrinol., April 1, 2005; 19(4): 898 - 912.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K.-Y. Kam, K.-H. Jeong, E. R. Norwitz, E. M. Jorgensen, and U. B. Kaiser
Oct-1 and Nuclear Factor Y Bind to the SURG-1 Element to Direct Basal and Gonadotropin-Releasing Hormone (GnRH)-Stimulated Mouse GnRH Receptor Gene Transcription
Mol. Endocrinol., January 1, 2005; 19(1): 148 - 162.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Rose, P. Froment, V. Perrot, M. J. Quon, D. LeRoith, and J. Dupont
The Luteinizing Hormone-releasing Hormone Inhibits the Anti-apoptotic Activity of Insulin-like Growth Factor-1 in Pituitary {alpha}T3 Cells by Protein Kinase C{alpha}-mediated Negative Regulation of Akt
J. Biol. Chem., December 10, 2004; 279(50): 52500 - 52516.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Xing, W. Lin, M. Jiang, D. Cao, R. V. Myers, M. P. Bernard, and W. R. Moyle
Use of Protein Knobs to Characterize the Position of Conserved {alpha}-Subunit Regions in Lutropin Receptor Complexes
J. Biol. Chem., October 22, 2004; 279(43): 44427 - 44437.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
C. Roche, A. J Zamora, D. Taieb, E. Lavaque, R. Rasolonjanahary, H. Dufour, C. Bagnis, A. Enjalbert, and A. Barlier
Lentiviral vectors efficiently transduce human gonadotroph and somatotroph adenomas in vitro. Targeted expression of transgene by pituitary hormone promoters
J. Endocrinol., October 1, 2004; 183(1): 217 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. R. Manjithaya and R. R. Dighe
The 3' Untranslated Region of Bovine Follicle-Stimulating Hormone {beta} Messenger RNA Downregulates Reporter Expression: Involvement of AU-Rich Elements and Transfactors
Biol Reprod, October 1, 2004; 71(4): 1158 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. Larder, L. Chang, M. Clinton, and P. Brown
Gonadotropin-Releasing Hormone Regulates Expression of the DNA Damage Repair Gene, Fanconi anemia A, in Pituitary Gonadotroph Cells
Biol Reprod, September 1, 2004; 71(3): 828 - 836.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. A. Nguyen, S. J. Santos, M. K. Kreidel, A. L. Diaz, R. Rey, and M. A. Lawson
Acute Regulation of Translation Initiation by Gonadotropin-Releasing Hormone in the Gonadotrope Cell Line L{beta}T2
Mol. Endocrinol., May 1, 2004; 18(5): 1301 - 1312.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Curtin, H. A. Ferris, M. Hakli, M. Gibson, O. A. Janne, J. J. Palvimo, and M. A. Shupnik
Small Nuclear RING Finger Protein Stimulates the Rat Luteinizing Hormone-{beta} Promoter by Interacting with Sp1 and Steroidogenic Factor-1 and Protects from Androgen Suppression
Mol. Endocrinol., May 1, 2004; 18(5): 1263 - 1276.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Roelle, R. Grosse, A. Aigner, H. W. Krell, F. Czubayko, and T. Gudermann
Matrix Metalloproteinases 2 and 9 Mediate Epidermal Growth Factor Receptor Transactivation by Gonadotropin-releasing Hormone
J. Biol. Chem., November 21, 2003; 278(47): 47307 - 47318.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Navratil, S. P. Bliss, K. A. Berghorn, J. M. Haughian, T. A. Farmerie, J. K. Graham, C. M. Clay, and M. S. Roberson
Constitutive Localization of the Gonadotropin-releasing Hormone (GnRH) Receptor to Low Density Membrane Microdomains Is Necessary for GnRH Signaling to ERK
J. Biol. Chem., August 22, 2003; 278(34): 31593 - 31602.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Schausi, C. Tiffoche, and M.-L. Thieulant
Regulation of the Intronic Promoter of Rat Estrogen Receptor {alpha} Gene, Responsible for Truncated Estrogen Receptor Product-1 Expression
Endocrinology, July 1, 2003; 144(7): 2845 - 2855.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Sadie, G. Styger, and J. Hapgood
Expression of the Mouse Gonadotropin-Releasing Hormone Receptor Gene in {alpha}T3-1 Gonadotrope Cells Is Stimulated by Cyclic 3',5'-Adenosine Monophosphate and Protein Kinase A, and Is Modulated by Steroidogenic Factor-1 and Nur77
Endocrinology, May 1, 2003; 144(5): 1958 - 1971.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. A. Cornwall, A. Cameron, I. Lindberg, D. M. Hardy, N. Cormier, and N. Hsia
The Cystatin-Related Epididymal Spermatogenic Protein Inhibits the Serine Protease Prohormone Convertase 2
Endocrinology, March 1, 2003; 144(3): 901 - 908.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Morgan, D. Conklin, A. J. Pawson, R. Sellar, T. R. Ott, and R. P. Millar
A Transcriptionally Active Human Type II Gonadotropin-Releasing Hormone Receptor Gene Homolog Overlaps Two Genes in the Antisense Orientation on Chromosome 1q.12
Endocrinology, February 1, 2003; 144(2): 423 - 436.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. C. Quirk, D. D. Seachrist, and J. H. Nilson
Embryonic Expression of the Luteinizing Hormone beta Gene Appears to Be Coupled to the Transient Appearance of p8, a High Mobility Group-related Transcription Factor
J. Biol. Chem., January 10, 2003; 278(3): 1680 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
X. Wei, M. Sasaki, H. Huang, V. L. Dawson, and T. M. Dawson
The Orphan Nuclear Receptor, Steroidogenic Factor 1, Regulates Neuronal Nitric Oxide Synthase Gene Expression in Pituitary Gonadotropes
Mol. Endocrinol., December 1, 2002; 16(12): 2828 - 2839.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Xiong, W. E. Tapprich, and G. S. Cox
Mechanism of Gonadotropin Gene Expression. IDENTIFICATION OF A NOVEL NEGATIVE REGULATORY ELEMENT AT THE TRANSCRIPTION START SITE OF THE GLYCOPROTEIN HORMONE alpha -SUBUNIT GENE
J. Biol. Chem., October 18, 2002; 277(43): 40235 - 40246.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Kanasaki, T. Yonehara, Y. Yamada, K. Takahashi, K. Hata, R. Fujiwaki, H. Yamamoto, Y. Takeuchi, K. Fukunaga, E. Miyamoto, et al.
Regulation of Gonadotropin {alpha} Subunit Gene Expression by Dopamine D2 Receptor Agonist in Clonal Mouse Gonadotroph {alpha}T3-1 Cells
Biol Reprod, October 1, 2002; 67(4): 1218 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. R. Norwitz, S. Xu, J. Xu, L. B. Spiryda, J. S. Park, K.-H. Jeong, E. A. McGee, and U. B. Kaiser
Direct Binding of AP-1 (Fos/Jun) Proteins to a SMAD Binding Element Facilitates Both Gonadotropin-releasing Hormone (GnRH)- and Activin-mediated Transcriptional Activation of the Mouse GnRH Receptor Gene
J. Biol. Chem., September 27, 2002; 277(40): 37469 - 37478.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. V. Vasilyev, M. A. Lawson, D. Dipaolo, N. J. G. Webster, and P. L. Mellon
Different Signaling Pathways Control Acute Induction versus Long-Term Repression of LH{beta} Transcription by GnRH
Endocrinology, September 1, 2002; 143(9): 3414 - 3426.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. C. Fowkes, P. King, and J. M. Burrin
Regulation of Human Glycoprotein Hormone {alpha}-Subunit Gene Transcription in L{beta}T2 Gonadotropes by Protein Kinase C and Extracellular Signal-Regulated Kinase 1/2
Biol Reprod, September 1, 2002; 67(3): 725 - 734.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. T. Valerius, L. T. Patterson, Y. Feng, and S. S. Potter
Hoxa 11 is upstream of Integrinalpha 8 expression in the developing kidney
PNAS, June 11, 2002; 99(12): 8090 - 8095.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Junoy, H. Maccario, J.-L. Mas, A. Enjalbert, and S. V. Drouva
Proteasome Implication in Phorbol Ester- and GnRH-Induced Selective Down-Regulation of PKC ({alpha}, {epsilon}, {zeta}) in {alpha}T3-1 and L{beta}T2 Gonadotrope Cell Lines
Endocrinology, April 1, 2002; 143(4): 1386 - 1403.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
E. R. Norwitz, S. Xu, K.-H. Jeong, G. Y. Bedecarrats, L. D. Winebrenner, W. W. Chin, and U. B. Kaiser
Activin A Augments GnRH-Mediated Transcriptional Activation of the Mouse GnRH Receptor Gene
Endocrinology, March 1, 2002; 143(3): 985 - 997.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
B.-J. Zhang, K. Kusano, P. Zerfas, A. Iacangelo, W. S. Young III, and H. Gainer
Targeting of Green Fluorescent Protein to Secretory Granules in Oxytocin Magnocellular Neurons and Its Secretion from Neurohypophysial Nerve Terminals in Transgenic Mice
Endocrinology, March 1, 2002; 143(3): 1036 - 1046.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Curtin, S. Jenkins, N. Farmer, A. C. Anderson, D. J. Haisenleder, E. Rissman, E. M. Wilson, and M. A. Shupnik
Androgen Suppression of GnRH-Stimulated Rat LH{beta} Gene Transcription Occurs Through Sp1 Sites in the Distal GnRH-Responsive Promoter Region
Mol. Endocrinol., November 1, 2001; 15(11): 1906 - 1917.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Demay, M. De Monti, C. Tiffoche, C. Vaillant, and M. L. Thieulant
Steroid-Independent Activation of ER by GnRH in Gonadotrope Pituitary Cells
Endocrinology, August 1, 2001; 142(8): 3340 - 3347.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. A. Schreihofer, E. M. Resnick, V. Y. Lin, and M. A. Shupnik
Ligand-Independent Activation of Pituitary ER: Dependence on PKA-Stimulated Pathways
Endocrinology, August 1, 2001; 142(8): 3361 - 3368.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Pernasetti, V. V. Vasilyev, S. B. Rosenberg, J. S. Bailey, H.-J. Huang, W. L. Miller, and P. L. Mellon
Cell-Specific Transcriptional Regulation of Follicle-Stimulating Hormone-{beta} by Activin and Gonadotropin-Releasing Hormone in the L{beta}T2 Pituitary Gonadotrope Cell Model
Endocrinology, June 1, 2001; 142(6): 2284 - 2295.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. L. Heckert
Activation of the Rat Follicle-Stimulating Hormone Receptor Promoter by Steroidogenic Factor 1 Is Blocked by Protein Kinase A and Requires Upstream Stimulatory Factor Binding to a Proximal E Box Element
Mol. Endocrinol., May 1, 2001; 15(5): 704 - 715.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
C. C. Quirk, K. L. Lozada, R. A. Keri, and J. H. Nilson
A Single Pitx1 Binding Site Is Essential for Activity of the LH{beta} Promoter in Transgenic Mice
Mol. Endocrinol., May 1, 2001; 15(5): 734 - 746.
[Abstract] [Full Text]

Home page
 Hum Mol GenetHome page
L. J. Cushman, D. E. Watkins-Chow, M. L. Brinkmeier, L. T. Raetzman, A. L. Radak, R. V. Lloyd, and S. A. Camper
Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility
Hum. Mol. Genet., May 1, 2001; 10(11): 1141 - 1153.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. J. Tremblay and R. S. Viger
Nuclear Receptor Dax-1 Represses the Transcriptional Cooperation Between GATA-4 and SF-1 in Sertoli Cells
Biol Reprod, April 1, 2001; 64(4): 1191 - 1199.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. J. Tremblay and R. S. Viger
GATA Factors Differentially Activate Multiple Gonadal Promoters through Conserved GATA Regulatory Elements
Endocrinology, March 1, 2001; 142(3): 977 - 986.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. M. Sherwood, S. L. Krueckl, and J. E. McRory
The Origin and Function of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)/Glucagon Superfamily
Endocr. Rev., December 1, 2000; 21(6): 619 - 670.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. N. Hislop, M. T. Madziva, H. M. Everest, T. Harding, J. B. Uney, G. B. Willars, R. P. Millar, B. E. Troskie, J. S. Davidson, and C. A. McArdle
Desensitization and Internalization of Human and XenopusGonadotropin-Releasing Hormone Receptors Expressed in {{alpha}}T4 Pituitary Cells Using Recombinant Adenovirus
Endocrinology, December 1, 2000; 141(12): 4564 - 4575.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. Sosnowski, P. L. Mellon, and M. A. Lawson
Activation of Translation in Pituitary Gonadotrope Cells by Gonadotropin-Releasing Hormone
Mol. Endocrinol., November 1, 2000; 14(11): 1811 - 1819.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy
Prolactin: Structure, Function, and Regulation of Secretion
Physiol Rev, October 1, 2000; 80(4): 1523 - 1631.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. S. Johnson, E. M. Lutz, C. J. MacKenzie, W. B. Wolbers, D. N. Robertson, P. J. Holland, and R. Mitchell
Gonadotropin-Releasing Hormone Receptor Activation of Extracellular Signal-Regulated Kinase and Tyrosine Kinases in Transfected GH3 Cells and in {alpha}T3-1 Cells
Endocrinology, September 1, 2000; 141(9): 3087 - 3097.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Grosse, S. Roelle, A. Herrlich, J. Hohn, and T. Gudermann
Epidermal Growth Factor Receptor Tyrosine Kinase Mediates Ras Activation by Gonadotropin-releasing Hormone
J. Biol. Chem., April 14, 2000; 275(16): 12251 - 12260.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
R. Y. Osamura, S. Tahara, R. Kurotani, N. Sanno, A. Matsuno, and A. Teramoto
Contributions of Immunohistochemistry and In Situ Hybridization to the Functional Analysis of Pituitary Adenomas
J. Histochem. Cytochem., April 1, 2000; 48(4): 445 - 458.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
R. Grosse, A. Schmid, T. Schoneberg, A. Herrlich, P. Muhn, G. Schultz, and T. Gudermann
Gonadotropin-releasing Hormone Receptor Initiates Multiple Signaling Pathways by Exclusively Coupling to Gq/11 Proteins
J. Biol. Chem., March 24, 2000; 275(13): 9193 - 9200.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. J. Glenn and R. A. Maurer
MRG1 Binds to the LIM Domain of Lhx2 and May Function as a Coactivator to Stimulate Glycoprotein Hormone alpha -Subunit Gene Expression
J. Biol. Chem., December 17, 1999; 274(51): 36159 - 36167.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. W. Wolfe
The Equine Luteinizing Hormone {beta}-Subunit Promoter Contains Two Functional Steroidogenic Factor-1 Response Elements
Mol. Endocrinol., September 1, 1999; 13(9): 1497 - 1510.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
G. B. Call and M. W. Wolfe
Gonadotropin-Releasing Hormone Activates the Equine Luteinizing Hormone {beta} Promoter Through a Protein Kinase C/Mitogen-Activated Protein Kinase Pathway
Biol Reprod, September 1, 1999; 61(3): 715 - 723.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
E. S. W. Ngan, P. K. W. Cheng, P. C. K. Leung, and B. K. C. Chow
Steroidogenic Factor-1 Interacts with a Gonadotrope-Specific Element within the First Exon of the Human Gonadotropin-Releasing Hormone Receptor Gene to Mediate Gonadotrope-Specific Expression
Endocrinology, June 1, 1999; 140(6): 2452 - 2462.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
H. G. Sutton, A. Fusco, and G. A. Cornwall
Cystatin-Related Epididymal Spermatogenic Protein Colocalizes with Luteinizing Hormone-{beta} Protein in Mouse Anterior Pituitary Gonadotropes
Endocrinology, June 1, 1999; 140(6): 2721 - 2732.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
M. W. Wolfe and G. B. Call
Early Growth Response Protein 1 Binds to the Luteinizing Hormone-{beta} Promoter and Mediates Gonadotropin-Releasing Hormone-Stimulated Gene Expression
Mol. Endocrinol., May 1, 1999; 13(5): 752 - 763.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
C. T. Albarracin, M. P. Frosch, and W. W. Chin
The Gonadotropin-Releasing Hormone Receptor Gene Promoter Directs Pituitary-Specific Oncogene Expression in Transgenic Mice
Endocrinology, May 1, 1999; 140(5): 2415 - 2421.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
J. J. Tremblay and J. Drouin
Egr-1 Is a Downstream Effector of GnRH and Synergizes by Direct Interaction with Ptx1 and SF-1 To Enhance Luteinizing Hormone beta  Gene Transcription
Mol. Cell. Biol., April 1, 1999; 19(4): 2567 - 2576.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. R. White, D. L. Duval, J. M. Mulvaney, M. S. Roberson, and C. M. Clay
Homologous Regulation of the Gonadotropin-Releasing Hormone Receptor Gene Is Partially Mediated by Protein Kinase C Activation of an Activator Protein-1 Element
Mol. Endocrinol., April 1, 1999; 13(4): 566 - 577.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
M. S. Roberson, T. Zhang, H. L. Li, and J. M. Mulvaney
Activation of the p38 Mitogen-Activated Protein Kinase Pathway by Gonadotropin-Releasing Hormone
Endocrinology, March 1, 1999; 140(3): 1310 - 1318.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
J. J. Evans
Modulation of Gonadotropin Levels by Peptides Acting at the Anterior Pituitary Gland
Endocr. Rev., February 1, 1999; 20(1): 46 - 67.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. J. Lee, L. M. Anderson, B. Thimmapaya, and J. L. Jameson
Targeted Expression of Toxic Genes Directed by Pituitary Hormone Promoters: A Potential Strategy for Adenovirus-Mediated Gene Therapy of Pituitary Tumors
J. Clin. Endocrinol. Metab., February 1, 1999; 84(2): 786 - 794.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
D. A. Schreihofer, E. M. Resnick, A. Y. Soh, and M. A. Shupnik
Transcriptional Regulation by a Naturally Occurring Truncated Rat Estrogen Receptor (ER), Truncated ER Product-1 (TERP-1)
Mol. Endocrinol., February 1, 1999; 13(2): 320 - 329.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
S. K. Mahata, M. Mahata, C. V. Livsey, H.-H. Gerdes, W. B. Huttner, and D. T. O’Connor
Neuroendocrine Cell Type-Specific and Inducible Expression of the Secretogranin II Gene: Crucial Role of Cyclic Adenosine Monophosphate and Serum Response Elements
Endocrinology, February 1, 1999; 140(2): 739 - 749.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
S. Nelson, R. D. Horvat, J. Malvey, D. A. Roess, B. G. Barisas, and C. M. Clay
Characterization of an Intrinsically Fluorescent Gonadotropin-Releasing Hormone Receptor and Effects of Ligand Binding on Receptor Lateral Diffusion
Endocrinology, February 1, 1999; 140(2): 950 - 957.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
E. R. Norwitz, G. R. Cardona, K.-H. Jeong, and W. W. Chin
Identification and Characterization of the Gonadotropin-releasing Hormone Response Elements in the Mouse Gonadotropin-releasing Hormone Receptor Gene
J. Biol. Chem., January 8, 1999; 274(2): 867 - 880.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. M. Halvorson, U. B. Kaiser, and W. W. Chin
The Protein Kinase C System Acts through the Early Growth Response Protein 1 to Increase LH{beta} Gene Expression in Synergy with Steroidogenic Factor-1
Mol. Endocrinol., January 1, 1999; 13(1): 106 - 116.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
L. L. Heckert, M. A. F. Daggett, and J. Chen
Multiple Promoter Elements Contribute to Activity of the Follicle-Stimulating Hormone Receptor (FSHR) Gene in Testicular Sertoli Cells
Mol. Endocrinol., October 1, 1998; 12(10): 1499 - 1512.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
C. A. Flanagan, B. J. Fromme, J. S. Davidson, and R. P. Millar
A High Affinity Gonadotropin-Releasing Hormone (GnRH) Tracer, Radioiodinated at Position 6, Facilitates Analysis of Mutant GnRH Receptors
Endocrinology, October 1, 1998; 139(10): 4115 - 4119.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. N. Yu, M. Ito, and J. L. Jameson
The Murine Dax-1 Promoter Is Stimulated by SF-1 (Steroidogenic Factor-1) and Inhibited by COUP-TF (Chicken Ovalbumin Upstream Promoter-Transcription Factor) via a Composite Nuclear Receptor-Regulatory Element
Mol. Endocrinol., July 1, 1998; 12(7): 1010 - 1022.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
T. R. Kumar, K. E. Graham, S. L. Asa, and M. J. Low
Simian Virus 40 T Antigen-Induced Gonadotroph Adenomas: A Model of Human Null Cell Adenomas
Endocrinology, July 1, 1998; 139(7): 3342 - 3351.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. M. Halvorson, M. Ito, J. L. Jameson, and W. W. Chin
Steroidogenic Factor-1 and Early Growth Response Protein 1 Act through Two Composite DNA Binding Sites to Regulate Luteinizing Hormone beta -Subunit Gene Expression
J. Biol. Chem., June 12, 1998; 273(24): 14712 - 14720.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. L. Brinkmeier, D. F. Gordon, J. M. Dowding, T. L. Saunders, S. K. Kendall, V. D. Sarapura, W. M. Wood, E. C. Ridgway, and S. A. Camper
Cell-Specific Expression of the Mouse Glycoprotein Hormone {alpha}-Subunit Gene Requires Multiple Interacting DNA Elements in Transgenic Mice and Cultured Cells
Mol. Endocrinol., May 1, 1998; 12(5): 622 - 633.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
A. N. Harris and P. L. Mellon
The Basic Helix-Loop-Helix, Leucine Zipper Transcription Factor, USF (Upstream Stimulatory Factor), Is a Key Regulator of SF-1 (Steroidogenic Factor-1) Gene Expression in Pituitary Gonadotrope and Steroidogenic Cells
Mol. Endocrinol., May 1, 1998; 12(5): 714 - 726.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Ham, J. Webster, J. A. Bond, B. Jasani, M. D. Lewis, P. J. Hepburn, J. S. Davies, B. M. Lewis, D. W. Thomas, and M. F. Scanlon
Immortalized Human Pituitary Cells Express Glycoprotein {alpha}-Subunit and Thyrotropin {beta} (TSH{beta})
J. Clin. Endocrinol. Metab., May 1, 1998; 83(5): 1598 - 1603.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
S. V. Drouva, B. Poulin, V. Manceau, and A. Sobel
Luteinizing Hormone-Releasing Hormone-Signal Transduction and Stathmin Phosphorylation in the Gonadotrope {alpha}T3-1 Cell Line
Endocrinology, May 1, 1998; 139(5): 2235 - 2239.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
U. B. Kaiser, E. Sabbagh, B. D. Saunders, and W. W. Chin
Identification of cis-Acting Deoxyribonucleic Acid Elements That Mediate Gonadotropin-Releasing Hormone Stimulation of the Rat Luteinizing Hormone {beta}-Subunit Gene
Endocrinology, May 1, 1998; 139(5): 2443 - 2451.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. A. Lawson, A. R. Buhain, J. C. Jovenal, and P. L. Mellon
Multiple Factors Interacting at the GATA Sites of the Gonadotropin-Releasing Hormone Neuron-Specific Enhancer Regulate Gene Expression
Mol. Endocrinol., March 1, 1998; 12(3): 364 - 377.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
J. J. Tremblay, C. Lanctôt, and J. Drouin
The pan-Pituitary Activator of Transcription, Ptx1 (Pituitary Homeobox 1), Acts in Synergy with SF-1 and Pit1 and Is an Upstream Regulator of the Lim-Homeodomain Gene Lim3/Lhx3
Mol. Endocrinol., March 1, 1998; 12(3): 428 - 441.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
M. Ito, R. N. Yu, and J. L. Jameson
Steroidogenic Factor-1 Contains a Carboxy-Terminal Transcriptional Activation Domain That Interacts with Steroid Receptor Coactivator-1
Mol. Endocrinol., February 1, 1998; 12(2): 290 - 301.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
D. L. Duval, S. E. Nelson, and C. M. Clay
The Tripartite Basal Enhancer of the Gonadotropin-Releasing Hormone (GnRH) Receptor Gene Promoter Regulates Cell-Specific Expression Through a Novel GnRH Receptor Activating Sequence
Mol. Endocrinol., November 1, 1997; 11(12): 1814 - 1821.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Hezareh, W. Schlegel, and S. R. Rawlings
Stimulation of Ca2+ influx in alpha T3-1 gonadotrophs via the cAMP/PKA signaling system
Am J Physiol Endocrinol Metab, November 1, 1997; 273(5): E850 - E858.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. A. Cornwall and N. Hsia
ADAM7, A Member of the ADAM (A Disintegrin And Metalloprotease) Gene Family Is Specifically Expressed in the Mouse Anterior Pituitary and Epididymis
Endocrinology, October 1, 1997; 138(10): 4262 - 4272.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. L. Heckert, E. M. Wilson, and J. H. Nilson
Transcriptional Repression of the {alpha}-Subunit Gene by Androgen Receptor Occurs Independently of DNA Binding but Requires the DNA-Binding and Ligand-Binding Domains of the Receptor
Mol. Endocrinol., September 1, 1997; 11(10): 1497 - 1506.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. M. McCue, C. C. Quirk, S. E. Nelson, R. A. Bowen, and C. M. Clay
Expression of a Murine Gonadotropin-Releasing Hormone Receptor-Luciferase Fusion Gene in Transgenic Mice Is Diminished by Immunoneutralization of Gonadotropin-Releasing Hormone
Endocrinology, August 1, 1997; 138(8): 3154 - 3160.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1990 by The Endocrine Society