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MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model

Department of Pharmacology, Division of Molecular Endocrinology, New York University Medical Center New York, New York 10016
Department of Medicine, Division of Molecular Endocrinology, New York University Medical Center New York, New York 10016

Address requests for reprints to: Dr. Herbert H. Samuels, New York University Medical Center, Department of Medicine, Room UH454, 550 First Avenue, New York, New York 10016.

Abstract

The nuclear hormone receptors comprise a super-family of ligand-modulated transcription factors that regulate homeostasis, reproduction, development, and differentiation. Three amino acids within the zinc finger DNA binding motif determine target gene specificity. Groups of receptors exist with similar DNA binding specificity. A complex carboxy terminal region mediates ligand binding, dimerization, and hormone-relieved transcriptional inactivation. We summarize the current understanding of these phenomena and suggest a novel model that structurally and functionally links these events. This "regulatory zipper model" may explain the mechanism by which ligand activates nuclear hormone receptors.

FOOTNOTES

This work was supported by a Medical Scientist Training Program grant (to B.M.F.) and NIH research Grant DK-16636 (to H.H.S.).

Received for publication May 30, 1990. Accepted for publication June 2, 1990.

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