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Molecular Endocrinology Vol. 5, No. 11 1571-1577
doi:10.1210/mend-5-11-1571
Copyright © 1991 by the Endocrine Society.
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MINIREVIEW: Estrogen Receptor Variants in Clinical Breast Cancer

William L. McGuire, Gary C. Chamness and Suzanne A. W. Fuqua

Division of Medical Oncology, University of Texas Health Science Center San Antonio, Texas 78284–7884

Address requests for reprints to: William L. McGuire, M.D., Division of Medical Oncology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78284–7884.

Abstract

We have used the screening techniques of chemical mismatch cleavage, single stranded conformational polymorphism, and gel retardation to discover a number of estrogen receptor RNA variants in clinical breast cancer tissues. We have found basepair insertions, transitions, and deletions as well as alternative splicing, yielding deletions of exon 3, 5, or 7. Using a yeast transactivation assay we have discovered receptors with outlaw function, including both a dominant-positive receptor, which is transcriptionally active in the absence of estrogen, and a dominant-negative receptor, which is itself transcriptionally inactive, but prevents the action of normal estrogen receptor. These variants could have clinical significance, helping to explain breast tumor behavior and patient outcome.

FOOTNOTES

This work was supporeted by NIH Grants CA-30195, CA-52351, and HD-10202.

Received for publication August 30, 1991. Accepted for publication August 30, 1991.




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Copyright © 1991 by The Endocrine Society