help button home button Endocrine Society Molecular Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Riegman, P. H.
Right arrow Articles by Trapman, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Riegman, P. H.
Right arrow Articles by Trapman, J.

Molecular Endocrinology, Vol 5, 1921-1930, Copyright © 1991 by Endocrine Society

ARTICLES

The promoter of the prostate-specific antigen gene contains a functional androgen responsive element

PH Riegman, RJ Vlietstra, JA van der Korput, AO Brinkmann and J Trapman
Department of Pathology, Erasmus University, Rotterdam, The Netherlands.

Expression of prostate-specific antigen (PA) mRNA was tested at various time periods after incubation of the human prostate tumor cell line LNCaP with the synthetic androgen R1881. Androgen-stimulated expression was observed within 6 h after addition of R1881 to the cells. Run-on experiments with nuclei isolated from LNCaP cells showed that expression of the PA gene could be regulated by R1881 on the level of transcription. DNase I footprints of the promoter region of the PA gene (-320 to +12) with nuclear protein extracts from LNCaP cells showed at least four protected regions. The protected areas include the TATA-box, a GC-box sequence, and a sequence AGAACAgcaAGTGCT at position -170 to - 156, which closely resembles the reverse complement of the consensus sequence GGTACAnnnTGTTCT for binding of the glucocorticoid receptor and the progesterone receptor. Fragments of the PA promoter region were cloned in front of the chloramphenicol acetyltransferase (CAT) reporter gene and cotransfected with an androgen receptor expression plasmid into COS cells in a transient expression assay. CAT activity of COS cells grown in the presence of 1 nM R1881 was compared to untreated controls. A 110-fold induction of CAT activity was found if a -1600 to +12 PA promoter fragment was used in the construct. By further deletion mapping of the PA promoter a minimal region (-320 to -155) was identified as being essential for androgen-regulated gene expression. Mutation of the sequence AGAACAgcaAGTGCT (at -170 to -156) to AAAAAAgcaAGTGCT almost completely abolished androgen inducibility of the reporter gene constructs. One or more copies of the sequence AGAACAgcaAGTGCT cloned in front of a thymidine kinase promoter-CAT reporter gene confers androgen regulation to the reporter gene. These findings provide strong evidence for transcription regulation of the PA gene by androgens via the sequence AGAACAgcaAGTGCT. Interestingly, in addition to the AGAACAgcaAGTGCT element, an upstream region (-539 to - 320) is needed for optimal androgen inducibility of the PA promoter.


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
C. K. Ratnacaram, M. Teletin, M. Jiang, X. Meng, P. Chambon, and D. Metzger
Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma
PNAS, February 19, 2008; 105(7): 2521 - 2526.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P.-H. Chen, Y.-P. Tsao, C.-C. Wang, and S.-L. Chen
Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability
Nucleic Acids Res., January 17, 2008; 36(1): 51 - 66.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. Lai, M.-A. Kedda, K. Hinze, R. L.G. Smith, J. Yaxley, A. B. Spurdle, C.P. Morris, J. Harris, and J. A. Clements
PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility
Carcinogenesis, May 1, 2007; 28(5): 1032 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
K. Horii, Y. Suzuki, Y. Kondo, M. Akimoto, T. Nishimura, Y. Yamabe, M. Sakaue, T. Sano, T. Kitagawa, S. Himeno, et al.
Androgen-Dependent Gene Expression of Prostate-Specific Antigen Is Enhanced Synergistically by Hypoxia in Human Prostate Cancer Cells
Mol. Cancer Res., April 1, 2007; 5(4): 383 - 391.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. N. Quayle, N. R. Mawji, J. Wang, and M. D. Sadar
Androgen receptor decoy molecules block the growth of prostate cancer
PNAS, January 23, 2007; 104(4): 1331 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. G. Hermans, R. van Marion, H. van Dekken, G. Jenster, W. M. van Weerden, and J. Trapman
TMPRSS2:ERG Fusion by Translocation or Interstitial Deletion Is Highly Relevant in Androgen-Dependent Prostate Cancer, But Is Bypassed in Late-Stage Androgen Receptor-Negative Prostate Cancer.
Cancer Res., November 15, 2006; 66(22): 10658 - 10663.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Zhoul, G. Hernandez, S.-W. Tu, C.-L. Huang, C.-P. Tseng, and J.-T. Hsieh
The Role of DOC-2/DAB2 in Modulating Androgen Receptor-Mediated Cell Growth via the Nongenomic c-Src-Mediated Pathway in Normal Prostatic Epithelium and Cancer
Cancer Res., November 1, 2005; 65(21): 9906 - 9913.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. C. Hsu, J. Zhang, A. Dev, A. Wing, L. F. Bjeldanes, and G. L. Firestone
Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells
Carcinogenesis, November 1, 2005; 26(11): 1896 - 1904.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. Quinkler, I. J. Bujalska, K. Kaur, C. U. Onyimba, S. Buhner, B. Allolio, S. V. Hughes, M. Hewison, and P. M. Stewart
Androgen Receptor-Mediated Regulation of the {alpha}-Subunit of the Epithelial Sodium Channel in Human Kidney
Hypertension, October 1, 2005; 46(4): 787 - 798.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. Collette, T. Burzykowski, K. J. Carroll, D. Newling, T. Morris, and F. H. Schroder
Is Prostate-Specific Antigen a Valid Surrogate End Point for Survival in Hormonally Treated Patients With Metastatic Prostate Cancer? Joint Research of the European Organisation for Research and Treatment of Cancer, the Limburgs Universitair Centrum, and AstraZeneca Pharmaceuticals
J. Clin. Oncol., September 1, 2005; 23(25): 6139 - 6148.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
Y.-S. Zhu, L.-Q. Cai, Y. Huang, J. Fish, L. Wang, Z.-K. Zhang, and J. L. Imperato-McGinley
Receptor Isoform and Ligand-Specific Modulation of Dihydrotestosterone-Induced Prostate Specific Antigen Gene Expression and Prostate Tumor Cell Growth by Estrogens
J Androl, July 1, 2005; 26(4): 500 - 508.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. Goodin, P. Medina, T. Capanna, W. J. Shih, S. Abraham, J. Winnie, S. Doyle-Lindrud, M. Todd, and R. S. DiPaola
Effect of Docetaxel in Patients With Hormone-Dependent Prostate-Specific Antigen Progression After Local Therapy for Prostate Cancer
J. Clin. Oncol., May 20, 2005; 23(15): 3352 - 3357.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
L. Le, K. Chi, S. Tyldesley, S. Flibotte, D. L. Diamond, M. A. Kuzyk, and M. D. Sadar
Identification of Serum Amyloid A as a Biomarker to Distinguish Prostate Cancer Patients with Bone Lesions
Clin. Chem., April 1, 2005; 51(4): 695 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
J. K Oosterhoff, J A. Grootegoed, and L. J Blok
Expression profiling of androgen-dependent and -independent LNCaP cells: EGF versus androgen signalling
Endocr. Relat. Cancer, March 1, 2005; 12(1): 135 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Annals of Clinical & Laboratory ScienceHome page
P. Zhang, J. Zhang, C. Y. F. Young, P. C. Kao, W. Chen, A. Jiang, L. Zhang, and Q. Guo
Decoy Androgen-Responsive Element DNA Can Inhibit Androgen Receptor Transactivation of the PSA Promoter Gene
Ann. Clin. Lab. Sci., January 1, 2005; 35(3): 278 - 284.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Z. Salah, M. Maoz, I. Cohen, G. Pizov, D. Pode, M. S. Runge, and R. Bar-Shavit
Identification of a novel functional androgen response element within hPar1 promoter: implications to prostate cancer progression
FASEB J, January 1, 2005; 19(1): 62 - 72.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Song, S. Pang, Y. Lu, K. K. Yokoyama, J.-Y. Zheng, and R. Chiu
Gene Silencing in Androgen-Responsive Prostate Cancer Cells from the Tissue-Specific Prostate-Specific Antigen Promoter
Cancer Res., November 1, 2004; 64(21): 7661 - 7663.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
K. Steketee, A. C J Ziel-van der Made, H. A G M van der Korput, A. B Houtsmuller, and J. Trapman
A bioinformatics-based functional analysis shows that the specifically androgen-regulated gene SARG contains an active direct repeat androgen response element in the first intron
J. Mol. Endocrinol., October 1, 2004; 33(2): 477 - 491.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
H.-H. Lee, C.-T. Ho, and J.-K. Lin
Theaflavin-3,3'-digallate and penta-O-galloyl-{beta}-D-glucose inhibit rat liver microsomal 5{alpha}-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells
Carcinogenesis, July 1, 2004; 25(7): 1109 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
C. A. Borgono, I. P. Michael, and E. P. Diamandis
Human Tissue Kallikreins: Physiologic Roles and Applications in Cancer
Mol. Cancer Res., May 1, 2004; 2(5): 257 - 280.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. Kishi, A. Soosaipillai, L. Grass, S. P. Little, E. M. Johnstone, and E. P. Diamandis
Development of an Immunofluorometric Assay and Quantification of Human Kallikrein 7 in Tissue Extracts and Biological Fluids
Clin. Chem., April 1, 2004; 50(4): 709 - 716.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Blaszczyk, B. A. Masri, N. R. Mawji, T. Ueda, G. McAlinden, C. P. Duncan, N. Bruchovsky, H.-U. Schweikert, D. Schnabel, E. C. Jones, et al.
Osteoblast-Derived Factors Induce Androgen-Independent Proliferation and Expression of Prostate-Specific Antigen in Human Prostate Cancer Cells
Clin. Cancer Res., March 1, 2004; 10(5): 1860 - 1869.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Wang, H. Deng, I. Basu, and L. Zhu
Induction of Androgen Receptor-Dependent Apoptosis in Prostate Cancer Cells by the Retinoblastoma Protein
Cancer Res., February 15, 2004; 64(4): 1377 - 1385.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. V. Nantermet, J. Xu, Y. Yu, P. Hodor, D. Holder, S. Adamski, M. A. Gentile, D. B. Kimmel, S.-i. Harada, D. Gerhold, et al.
Identification of Genetic Pathways Activated by the Androgen Receptor during the Induction of Proliferation in the Ventral Prostate Gland
J. Biol. Chem., January 9, 2004; 279(2): 1310 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Kim, L. Jia, W. D. Tilley, and G. A. Coetzee
Dynamic methylation of histone H3 at lysine 4 in transcriptional regulation by the androgen receptor
Nucleic Acids Res., December 1, 2003; 31(23): 6741 - 6747.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
Y.-S. Zhu, L.-Q. Cai, X. You, J. J. Cordero, Y. Huang, and J. Imperato-Mcginley
Androgen-Induced Prostate-Specific Antigen Gene Expression Is Mediated via Dihydrotestosterone in LNCaP Cells
J Androl, September 1, 2003; 24(5): 681 - 687.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Wang, F. Yeung, P.-C. Liu, R. M. Attar, J. Geng, L. W. K. Chung, M. Gottardis, and C. Kao
Identification of a Novel Transcription Factor, GAGATA-binding Protein, Involved in Androgen-mediated Expression of Prostate-specific Antigen
J. Biol. Chem., August 22, 2003; 278(34): 32423 - 32430.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. E. Petre-Draviam, S. L. Cook, C. J. Burd, T. W. Marshall, Y. B. Wetherill, and K. E. Knudsen
Specificity of Cyclin D1 for Androgen Receptor Regulation
Cancer Res., August 15, 2003; 63(16): 4903 - 4913.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
T. A. Thompson and G. Wilding
Androgen Antagonist Activity by the Antioxidant Moiety of Vitamin E, 2,2,5,7,8-Pentamethyl-6-chromanol in Human Prostate Carcinoma Cells
Mol. Cancer Ther., August 1, 2003; 2(8): 797 - 803.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Harkonen, S. Torn, R. Kurkela, K. Porvari, A. Pulkka, A. Lindfors, V. Isomaa, and P. Vihko
Sex Hormone Metabolism in Prostate Cancer Cells during Transition to an Androgen-Independent State
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 705 - 712.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. P. Balk, Y.-J. Ko, and G. J. Bubley
Biology of Prostate-Specific Antigen
J. Clin. Oncol., January 15, 2003; 21(2): 383 - 391.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. Trofimova, A. Dimtchev, M. Jung, D. Rosenthal, M. Smulson, A. Dritschilo, and V. Soldatenkov
Gene Therapy for Prostate Cancer by Targeting Poly(ADP-Ribose) Polymerase
Cancer Res., December 1, 2002; 62(23): 6879 - 6883.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. J. James, I. U. Agoulnik, J. M. Harris, G. Buchanan, W. D. Tilley, M. Marcelli, D. J. Lamb, and N. L. Weigel
A Novel Androgen Receptor Mutant, A748T, Exhibits Hormone Concentration-Dependent Defects in Nuclear Accumulation and Activity Despite Normal Hormone-Binding Affinity
Mol. Endocrinol., December 1, 2002; 16(12): 2692 - 2705.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. Maggiolini, A. Vivacqua, A. Carpino, D. Bonofiglio, G. Fasanella, M. Salerno, D. Picard, and S. Ando
The Mutant Androgen Receptor T877A Mediates the Proliferative but Not the Cytotoxic Dose-Dependent Effects of Genistein and Quercetin on Human LNCaP Prostate Cancer Cells
Mol. Pharmacol., November 1, 2002; 62(5): 1027 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Reid, I. Murray, K. Watt, R. Betney, and I. J. McEwan
The Androgen Receptor Interacts with Multiple Regions of the Large Subunit of General Transcription Factor TFIIF
J. Biol. Chem., October 18, 2002; 277(43): 41247 - 41253.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
C. Chen, N. Lamharzi, N. S. Weiss, R. Etzioni, D. A. Dightman, M. Barnett, D. DiTommaso, and G. Goodman
Androgen Receptor Polymorphisms and the Incidence of Prostate Cancer
Cancer Epidemiol. Biomarkers Prev., October 1, 2002; 11(10): 1033 - 1040.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
E. P. Diamandis and G. M. Yousef
Human Tissue Kallikreins: A Family of New Cancer Biomarkers
Clin. Chem., August 1, 2002; 48(8): 1198 - 1205.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Ueda, N. Bruchovsky, and M. D. Sadar
Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways
J. Biol. Chem., February 22, 2002; 277(9): 7076 - 7085.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Qi, C. Fillion, Y. Labrie, J. Grenier, A. Fournier, L. Berger, M. El-Alfy, and C. Labrie
AIbZIP, a Novel bZIP Gene Located on Chromosome 1q21.3 That Is Highly Expressed in Prostate Tumors and of Which the Expression Is Up-Regulated by Androgens in LNCaP Human Prostate Cancer Cells
Cancer Res., February 1, 2002; 62(3): 721 - 733.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. L. Shenk, C. J. Fisher, S.-Y. Chen, X.-F. Zhou, K. Tillman, and L. Shemshedini
p53 Represses Androgen-induced Transactivation of Prostate-specific Antigen by Disrupting hAR Amino- to Carboxyl-terminal Interaction
J. Biol. Chem., October 12, 2001; 276(42): 38472 - 38479.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Nguyen, S. V. Steinberg, E. Rouault, S. Chagnon, B. Gottlieb, L. Pinsky, M. Trifiro, and S. Mader
A G577R Mutation in the Human AR P Box Results in Selective Decreases in DNA Binding and in Partial Androgen Insensitivity Syndrome
Mol. Endocrinol., October 1, 2001; 15(10): 1790 - 1802.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Long. G. Wang, L. Ossowski, and A. C. Ferrari
Overexpressed Androgen Receptor Linked to p21WAF1 Silencing May Be Responsible for Androgen Independence and Resistance to Apoptosis of a Prostate Cancer Cell Line
Cancer Res., October 1, 2001; 61(20): 7544 - 7551.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
G. M. Yousef and E. P. Diamandis
The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease
Endocr. Rev., April 1, 2001; 22(2): 184 - 204.
[Abstract] [Full Text]

Home page
 RadiologyHome page
A. R. Padhani, A. D. MacVicar, C. J. Gapinski, D. P. Dearnaley, G. J. M. Parker, J. Suckling, M. O. Leach, and J. E. Husband
Effects of Androgen Deprivation on Prostatic Morphology and Vascular Permeability Evaluated with MR Imaging
Radiology, February 1, 2001; 218(2): 365 - 374.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
C. Spitzweg, M. K. O’Connor, E. R. Bergert, D. J. Tindall, C. Y. F. Young, and J. C. Morris
Treatment of Prostate Cancer by Radioiodine Therapy after Tissue-specific Expression of the Sodium Iodide Symporter
Cancer Res., November 1, 2000; 60(22): 6526 - 6530.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
M. D. Sadar and M. E. Gleave
Ligand-independent Activation of the Androgen Receptor by the Differentiation Agent Butyrate in Human Prostate Cancer Cells
Cancer Res., October 1, 2000; 60(20): 5825 - 5831.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
S. Lu, G. Jenster, and D. E. Epner
Androgen Induction of Cyclin-Dependent Kinase Inhibitor p21 Gene: Role of Androgen Receptor and Transcription Factor Sp1 Complex
Mol. Endocrinol., May 1, 2000; 14(5): 753 - 760.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
B. Lin, J. T. White, C. Ferguson, R. Bumgarner, C. Friedman, B. Trask, W. Ellis, P. Lange, L. Hood, and P. S. Nelson
PART-1: A Novel Human Prostate-specific, Androgen-regulated Gene that Maps to Chromosome 5q12
Cancer Res., February 1, 2000; 60(4): 858 - 863.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
J. P. F. Latham, P. F. Searle, V. Mautner, and N. D. James
Prostate-specific Antigen Promoter/Enhancer Driven Gene Therapy for Prostate Cancer: Construction and Testing of a Tissue-specific Adenovirus Vector
Cancer Res., January 1, 2000; 60(2): 334 - 341.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
J. M. Grad, J. Le Dai, S. Wu, and K. L. Burnstein
Multiple Androgen Response Elements and a Myc Consensus Site in the Androgen Receptor (AR) Coding Region Are Involved in Androgen-Mediated Up-Regulation of AR Messenger RNA
Mol. Endocrinol., November 1, 1999; 13(11): 1896 - 1911.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. Lapointe and C. Labrie
Identification and Cloning of a Novel Androgen-Responsive Gene, Uridine Diphosphoglucose Dehydrogenase, in Human Breast Cancer Cells
Endocrinology, October 1, 1999; 140(10): 4486 - 4493.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
W. Huang, Y. Shostak, P. Tarr, C. Sawyers, and M. Carey
Cooperative Assembly of Androgen Receptor into a Nucleoprotein Complex That Regulates the Prostate-specific Antigen Enhancer
J. Biol. Chem., September 3, 1999; 274(36): 25756 - 25768.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Lin, C. Ferguson, J. T. White, S. Wang, R. Vessella, L. D. True, L. Hood, and P. S. Nelson
Prostate-localized and Androgen-regulated Expression of the Membrane-bound Serine Protease TMPRSS2
Cancer Res., September 1, 1999; 59(17): 4180 - 4184.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-A. Stephenson, K. Verity, L. K. Ashworth, and J. A. Clements
Localization of a New Prostate-specific Antigen-related Serine Protease Gene, KLK4, Is Evidence for an Expanded Human Kallikrein Gene Family Cluster on Chromosome 19q13.3-13.4
J. Biol. Chem., August 13, 1999; 274(33): 23210 - 23214.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Gupta, N. Ahmad, R. R. Mohan, M. M. Husain, and H. Mukhtar
Prostate Cancer Chemoprevention by Green Tea: In Vitro and in Vivo Inhibition of Testosterone-mediated Induction of Ornithine Decarboxylase
Cancer Res., May 1, 1999; 59(9): 2115 - 2120.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Spitzweg, S. Zhang, E. R. Bergert, M. R. Castro, B. McIver, A. E. Heufelder, D. J. Tindall, C. Y. F. Young, and J. C. Morris
Prostate-specific Antigen (PSA) Promoter-driven Androgen-inducible Expression of Sodium Iodide Symporter in Prostate Cancer Cell Lines
Cancer Res., May 1, 1999; 59(9): 2136 - 2141.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Zhang, M.-L. Hsieh, W. Zhu, G. G. Klee, D. J. Tindall, and C. Y. F. Young
Interactive Effects of Triiodothyronine and Androgens on Prostate Cell Growth and Gene Expression
Endocrinology, April 1, 1999; 140(4): 1665 - 1671.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
M. D. Sadar
Androgen-independent Induction of Prostate-specific Antigen Gene Expression via Cross-talk between the Androgen Receptor and Protein Kinase A Signal Transduction Pathways
J. Biol. Chem., March 19, 1999; 274(12): 7777 - 7783.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Lu, M. Liu, D. E. Epner, S. Y. Tsai, and M.-J. Tsai
Androgen Regulation of the Cyclin-Dependent Kinase Inhibitor p21 Gene through an Androgen Response Element in the Proximal Promoter
Mol. Endocrinol., March 1, 1999; 13(3): 376 - 384.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J. Takeo and S. Yamashita
Two Distinct Isoforms of cDNA Encoding Rainbow Trout Androgen Receptors
J. Biol. Chem., February 26, 1999; 274(9): 5674 - 5680.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
H. I. Scher, W. M. K. Kelly, Z.-F. Zhang, P. Ouyang, M. Sun, M. Schwartz, C. Ding, W. Wang, I. D. Horak, and A. B. Kremer
Post-therapy Serum Prostate-Specific Antigen Level and Survival in Patients With Androgen-Independent Prostate Cancer
J Natl Cancer Inst, February 3, 1999; 91(3): 244 - 251.
[Abstract] [Full Text] [PDF]