help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Molecular Endocrinology Vol. 6, No. 7 1163-1169
doi:10.1210/me.6.7.1163
Copyright © 1992 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsutsumi, M.
Right arrow Articles by Sealfon, S. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsutsumi, M.
Right arrow Articles by Sealfon, S. C.

Molecular Endocrinology, Vol 6, 1163-1169, Copyright © 1992 by Endocrine Society

ARTICLES

Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor

M Tsutsumi, W Zhou, RP Millar, PL Mellon, JL Roberts, CA Flanagan, K Dong, B Gillo and SC Sealfon
Fishberg Research Center in Neurobiology, Mount Sinai School of Medicine, New York, New York 10029.

GnRH plays a pivotal role in the reproductive system, and GnRH analogs have wide therapeutic applications ranging from the treatment of prostatic cancer to infertility. Determination of the predicted structure of the GnRH receptor (GnRHR) would illuminate the mechanisms of receptor activation and regulation and allow directed design of improved GnRH analogs. We report the cloning of a cDNA representing the mouse GnRHR and confirm its identity using Xenopus oocyte expression. Injection of sense RNA transcript leads to the expression of a functional, high affinity GnRHR. Expression of the GnRHR using gonadotrope cell line RNA, however, is blocked by an antisense oligonucleotide. In situ hybridization in the rat anterior pituitary reveals a characteristic GnRHR distribution. The nucleotide sequence encodes a 327-amino acid protein which has the seven putative transmembrane domains characteristic of G protein-coupled receptors, but which lacks a typical intracellular C-terminus. The unusual structure and novel potential regulatory domain of the GnRHR may explain unique aspects of its signal transduction and regulation.


This article has been cited by other articles:


Home page
 Integr. Comp. Biol.Home page
J. S. Schneider and E. F. Rissman
Gonadotropin-releasing hormone II: a multi-purpose neuropeptide
Integr. Comp. Biol., November 1, 2008; 48(5): 588 - 595.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
J. A. Tello, S. Wu, J. E. Rivier, and N. M. Sherwood
Four functional GnRH receptors in zebrafish: analysis of structure, signaling, synteny and phylogeny
Integr. Comp. Biol., November 1, 2008; 48(5): 570 - 587.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
K. S. Monkkonen, R. Aflatoonian, K.-F. Lee, W. S.B. Yeung, S.-W. Tsao, J. T. Laitinen, and A. Fazeli
Hormonal regulation of G{alpha}i2 and mPR{alpha} in immortalized human oviductal cell line OE-E6/E7
Mol. Hum. Reprod., December 1, 2007; 13(12): 845 - 851.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. A. Flanagan, C.-C. Chen, M. Coetsee, S. Mamputha, K. E. Whitlock, N. Bredenkamp, L. Grosenick, R. D. Fernald, and N. Illing
Expression, Structure, Function, and Evolution of Gonadotropin-Releasing Hormone (GnRH) Receptors GnRH-R1SHS and GnRH-R2PEY in the Teleost, Astatotilapia burtoni
Endocrinology, October 1, 2007; 148(10): 5060 - 5071.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
B. Faurholm, S. Cochrane, R. R Millar, and A. A Katz
Gene structure and promoter functional analysis of the marmoset type II GnRH receptor
J. Mol. Endocrinol., August 1, 2007; 39(2): 91 - 104.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. S. Monkkonen, R. Aflatoonian, K.-F. Lee, W. S.B. Yeung, S.-W. Tsao, J. T. Laitinen, E. M. Tuckerman, T.C. Li, and A. Fazeli
Localization and variable expression of G{alpha}i2 in human endometrium and Fallopian tubes
Hum. Reprod., May 1, 2007; 22(5): 1224 - 1230.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
R. K. Naz and R. Sellamuthu
Receptors in Spermatozoa: Are They Real?
J Androl, September 1, 2006; 27(5): 627 - 636.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
J. A. Tello, J. E. Rivier, and N. M. Sherwood
Tunicate Gonadotropin-Releasing Hormone (GnRH) Peptides Selectively Activate Ciona intestinalis GnRH Receptors and the Green Monkey Type II GnRH Receptor
Endocrinology, September 1, 2005; 146(9): 4061 - 4073.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. R. Silver, N. V. Nucci, A. R. Root, K. L. Reed, and S. A. Sower
Cloning and Characterization of a Functional Type II Gonadotropin-Releasing Hormone Receptor with a Lengthy Carboxy-Terminal Tail from an Ancestral Vertebrate, the Sea Lamprey
Endocrinology, August 1, 2005; 146(8): 3351 - 3361.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J. H. Li, H. Choe, A. F. Wang, K. Maiti, C. Wang, A. Salam, S. Y. Chun, W.-K. Lee, K. Kim, H. B. Kwon, et al.
Extracellular Loop 3 (EL3) and EL3-Proximal Transmembrane Helix 7 of the Mammalian Type I and Type II Gonadotropin-Releasing Hormone (GnRH) Receptors Determine Differential Ligand Selectivity to GnRH-I and GnRH-II
Mol. Pharmacol., April 1, 2005; 67(4): 1099 - 1110.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Y. Oh, J. A. Song, J. S. Moon, M. J. Moon, J. I. Kim, K. Kim, H. B. Kwon, and J. Y. Seong
Membrane-Proximal Region of the Carboxyl Terminus of the Gonadotropin-Releasing Hormone Receptor (GnRHR) Confers Differential Signal Transduction between Mammalian and Nonmammalian GnRHRs
Mol. Endocrinol., March 1, 2005; 19(3): 722 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Kraus, G. Levy, T. Hanoch, Z. Naor, and R. Seger
Gonadotropin-Releasing Hormone Induces Apoptosis of Prostate Cancer Cells: Role of c-Jun NH2-Terminal Kinase, Protein Kinase B, and Extracellular Signal-Regulated Kinase Pathways
Cancer Res., August 15, 2004; 64(16): 5736 - 5744.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K.-H. Jeong, W. W. Chin, and U. B. Kaiser
Essential Role of the Homeodomain for Pituitary Homeobox 1 Activation of Mouse Gonadotropin-Releasing Hormone Receptor Gene Expression through Interactions with c-Jun and DNA
Mol. Cell. Biol., July 15, 2004; 24(14): 6127 - 6139.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
B. Levavi-Sivan, H. Safarian, H. Rosenfeld, A. Elizur, and A. Avitan
Regulation of Gonadotropin-Releasing Hormone (GnRH)-Receptor Gene Expression in Tilapia: Effect of GnRH and Dopamine
Biol Reprod, June 1, 2004; 70(6): 1545 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. Gonzalez-Martinez, T. Madigou, E. Mananos, J. M. Cerda-Reverter, S. Zanuy, O. Kah, and J. A. Munoz-Cueto
Cloning and Expression of Gonadotropin-Releasing Hormone Receptor in the Brain and Pituitary of the European Sea Bass: An In Situ Hybridization Study
Biol Reprod, May 1, 2004; 70(5): 1380 - 1391.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. P. Millar, Z.-L. Lu, A. J. Pawson, C. A. Flanagan, K. Morgan, and S. R. Maudsley
Gonadotropin-Releasing Hormone Receptors
Endocr. Rev., April 1, 2004; 25(2): 235 - 275.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. R. Finch, L. Green, J. N. Hislop, E. Kelly, and C. A. McArdle
Signaling and Antiproliferative Effects of Type I and II Gonadotropin-Releasing Hormone Receptors in Breast Cancer Cells
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1823 - 1832.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-F. Mouillet, C. Sonnenberg-Hirche, X. Yan, and Y. Sadovsky
p300 Regulates the Synergy of Steroidogenic Factor-1 and Early Growth Response-1 in Activating Luteinizing Hormone-{beta} Subunit Gene
J. Biol. Chem., February 27, 2004; 279(9): 7832 - 7839.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. D. Jacobson and M. A. Ansari
Immunomodulatory Actions of Gonadal Steroids May Be Mediated by Gonadotropin-Releasing Hormone
Endocrinology, January 1, 2004; 145(1): 330 - 336.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y. Yamada, H. Yamamoto, T. Yonehara, H. Kanasaki, H. Nakanishi, E. Miyamoto, and K. Miyazaki
Differential Activation of the Luteinizing Hormone {beta}-Subunit Promoter by Activin and Gonadotropin-Releasing Hormone: A Role for the Mitogen-Activated Protein Kinase Signaling Pathway in L{beta}T2 Gonadotrophs
Biol Reprod, January 1, 2004; 70(1): 236 - 243.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
F. Liu, D. A. Austin, and N. J. G. Webster
Gonadotropin-Releasing Hormone-Desensitized L{beta}T2 Gonadotrope Cells Are Refractory to Acute Protein Kinase C, Cyclic AMP, and Calcium-Dependent Signaling
Endocrinology, October 1, 2003; 144(10): 4354 - 4365.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Couvineau, J.-J. Lacapere, Y.-V. Tan, C. Rouyer-Fessard, P. Nicole, and M. Laburthe
Identification of Cytoplasmic Domains of hVPAC1 Receptor Required for Activation of Adenylyl Cyclase: CRUCIAL ROLE OF TWO CHARGED AMINO ACIDS STRICTLY CONSERVED IN CLASS II G PROTEIN-COUPLED RECEPTORS
J. Biol. Chem., June 27, 2003; 278(27): 24759 - 24766.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Sadie, G. Styger, and J. Hapgood
Expression of the Mouse Gonadotropin-Releasing Hormone Receptor Gene in {alpha}T3-1 Gonadotrope Cells Is Stimulated by Cyclic 3',5'-Adenosine Monophosphate and Protein Kinase A, and Is Modulated by Steroidogenic Factor-1 and Nur77
Endocrinology, May 1, 2003; 144(5): 1958 - 1971.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. S. Ellsworth, B. R. White, A. T. Burns, B. D. Cherrington, A. M. Otis, and C. M. Clay
c-Jun N-Terminal Kinase Activation of Activator Protein-1 Underlies Homologous Regulation of the Gonadotropin-Releasing Hormone Receptor Gene in {alpha}T3-1 Cells
Endocrinology, March 1, 2003; 144(3): 839 - 849.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Y. Seong, L. Wang, D. Y. Oh, O. Yun, K. Maiti, J. H. Li, J. M. Soh, H. S. Choi, K. Kim, H. Vaudry, et al.
Ala/Thr201 in Extracellular Loop 2 and Leu/Phe290 in Transmembrane Domain 6 of Type 1 Frog Gonadotropin-Releasing Hormone Receptor Confer Differential Ligand Sensitivity and Signal Transduction
Endocrinology, February 1, 2003; 144(2): 454 - 466.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. C. Quirk, D. D. Seachrist, and J. H. Nilson
Embryonic Expression of the Luteinizing Hormone beta Gene Appears to Be Coupled to the Transient Appearance of p8, a High Mobility Group-related Transcription Factor
J. Biol. Chem., January 10, 2003; 278(3): 1680 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. D. G. Pfleger, J. Bogerd, and R. P. Millar
Conformational Constraint of Mammalian, Chicken, and Salmon GnRHs, But Not GnRH II, Enhances Binding at Mammalian and Nonmammalian Receptors: Evidence for Preconfiguration of GnRH II
Mol. Endocrinol., September 1, 2002; 16(9): 2155 - 2162.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Yuen, E. Wurmbach, B. J. Ebersole, F. Ruf, R. L. Pfeffer, and S. C. Sealfon
Coupling of GnRH Concentration and the GnRH Receptor-Activated Gene Program
Mol. Endocrinol., June 1, 2002; 16(6): 1145 - 1153.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. R. Ott, B. E. Troskie, R. W. Roeske, N. Illing, C. A. Flanagan, and R. P. Millar
Two Mutations in Extracellular Loop 2 of the Human GnRH Receptor Convert an Antagonist to an Agonist
Mol. Endocrinol., May 1, 2002; 16(5): 1079 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Wang, D. Y. Oh, J. Bogerd, H. S. Choi, R. S. Ahn, J. Y. Seong, and H. B. Kwon
Inhibitory Activity of Alternative Splice Variants of the Bullfrog GnRH Receptor-3 on Wild-Type Receptor Signaling
Endocrinology, September 1, 2001; 142(9): 4015 - 4025.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G. Maya-Nunez and P. Michael Conn
Cyclic Adenosine 3',5'-Monophosphate (cAMP) and cAMP Responsive Element-Binding Protein Are Involved in the Transcriptional Regulation of Gonadotropin-Releasing Hormone (GnRH) Receptor by GnRH and Mitogen-Activated Protein Kinase Signal Transduction Pathway in GGH3 Cells
Biol Reprod, August 1, 2001; 65(2): 561 - 567.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. J. Winters, S. Kawakami, A. Sahu, and T. M. Plant
Pituitary Follistatin and Activin Gene Expression, and the Testicular Regulation of FSH in the Adult Rhesus Monkey (Macaca mulatta)
Endocrinology, July 1, 2001; 142(7): 2874 - 2878.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
R. D. Horvat, D. A. Roess, S. E. Nelson, B. G. Barisas, and C. M. Clay
Binding of Agonist but Not Antagonist Leads to Fluorescence Resonance Energy Transfer between Intrinsically Fluorescent Gonadotropin-Releasing Hormone Receptors
Mol. Endocrinol., May 1, 2001; 15(5): 695 - 703.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
R. R. Robison, R. B. White, N. Illing, B. E. Troskie, M. Morley, R. P. Millar, and R. D. Fernald
Gonadotropin-Releasing Hormone Receptor in the Teleost Haplochromis burtoni: Structure, Location, and Function
Endocrinology, May 1, 2001; 142(5): 1737 - 1743.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
T. Hashizume, W.-H. Yang, C. M. Clay, and T. M. Nett
Internalization Rates of Murine and Ovine Gonadotropin-Releasing Hormone Receptors
Biol Reprod, March 1, 2001; 64(3): 898 - 903.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Wang, J. Bogerd, H. S. Choi, J. Y. Seong, J. M. Soh, S. Y. Chun, M. Blomenröhr, B. E. Troskie, R. P. Millar, W. H. Yu, et al.
Three distinct types of GnRH receptor characterized in the bullfrog
PNAS, December 14, 2000; (2000) 11508498.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. N. Hislop, M. T. Madziva, H. M. Everest, T. Harding, J. B. Uney, G. B. Willars, R. P. Millar, B. E. Troskie, J. S. Davidson, and C. A. McArdle
Desensitization and Internalization of Human and XenopusGonadotropin-Releasing Hormone Receptors Expressed in {{alpha}}T4 Pituitary Cells Using Recombinant Adenovirus
Endocrinology, December 1, 2000; 141(12): 4564 - 4575.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. Madigou, E. Mañanos-Sanchez, S. Hulshof, I. Anglade, S. Zanuy, and O. Kah
Cloning, Tissue Distribution, and Central Expression of the Gonadotropin-Releasing Hormone Receptor in the Rainbow Trout (Oncorhynchus mykiss)
Biol Reprod, December 1, 2000; 63(6): 1857 - 1866.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
M. S. Johnson, E. M. Lutz, C. J. MacKenzie, W. B. Wolbers, D. N. Robertson, P. J. Holland, and R. Mitchell
Gonadotropin-Releasing Hormone Receptor Activation of Extracellular Signal-Regulated Kinase and Tyrosine Kinases in Transfected GH3 Cells and in {alpha}T3-1 Cells
Endocrinology, September 1, 2000; 141(9): 3087 - 3097.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
P. Bull, P. Morales, C. Huyser, T. Socias, and E.A. Castellon
Expression of GnRH receptor in mouse and rat testicular germ cells
Mol. Hum. Reprod., July 1, 2000; 6(7): 582 - 586.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Cui, R. G. Smith, G. R. Mount, J.-L. Lo, J. Yu, T. F. Walsh, S. B. Singh, R. J. DeVita, M. T. Goulet, J. M. Schaeffer, et al.
Identification of Phe313 of the Gonadotropin-Releasing Hormone (GnRH) Receptor as a Site Critical for the Binding of Nonpeptide GnRH Antagonists
Mol. Endocrinol., May 1, 2000; 14(5): 671 - 681.
[Abstract] [Full Text]

Home page
 Mol Hum ReprodHome page
S. Santra, V. S. Rao, Y.G. Shanker, and A.J. Rao
Cloning and characterization of bonnet monkey GnRH receptor
Mol. Hum. Reprod., May 1, 2000; 6(5): 415 - 421.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. B. Gardner, J. Sebastian, and W. L. Miller
Estradiol Induces and Hyperglycosylates the Receptor for Ovine Gonadotropin-Releasing Hormone
Endocrinology, January 1, 2000; 141(1): 91 - 99.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Heding, M. Vrecl, A. C. Hanyaloglu, R. Sellar, P. L. Taylor, and K. A. Eidne
The Rat Gonadotropin-Releasing Hormone Receptor Internalizes via a {beta}-Arrestin-Independent, but Dynamin-Dependent, Pathway: Addition of a Carboxyl-Terminal Tail Confers {beta}-Arrestin Dependency
Endocrinology, January 1, 2000; 141(1): 299 - 306.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. B. Willars, A. Heding, M. Vrecl, R. Sellar, M. Blomenrohr, S. R. Nahorski, and K. A. Eidne
Lack of a C-terminal Tail in the Mammalian Gonadotropin-releasing Hormone Receptor Confers Resistance to Agonist-dependent Phosphorylation and Rapid Desensitization
J. Biol. Chem., October 15, 1999; 274(42): 30146 - 30153.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Kimura, M. Ohmichi, H. Kurachi, H. Ikegami, J. Hayakawa, K. Tasaka, Y. Kanda, Y. Nishio, H. Jikihara, N. Matsuura, et al.
Role of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Cascade in Gonadotropin-releasing Hormone-induced Growth Inhibition of a Human Ovarian Cancer Cell Line
Cancer Res., October 1, 1999; 59(20): 5133 - 5142.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. J. Morris and C. C. Malbon
Physiological Regulation of G Protein-Linked Signaling
Physiol Rev, October 1, 1999; 79(4): 1373 - 1430.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G. B. Call and M. W. Wolfe
Gonadotropin-Releasing Hormone Activates the Equine Luteinizing Hormone {beta} Promoter Through a Protein Kinase C/Mitogen-Activated Protein Kinase Pathway
Biol Reprod, September 1, 1999; 61(3): 715 - 723.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. D. Jacobson, M. A. Ansari, M. Kinealy, and V. Muthukrishnan
Gender-Specific Exacerbation of Murine Lupus by Gonadotropin-Releasing Hormone: Potential Role of G{alpha}q/11
Endocrinology, August 1, 1999; 140(8): 3429 - 3437.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
F. Raga, E. M. Casañ, J. Kruessel, Y. Wen, F. Bonilla-Musoles, and M. L. Polan
The Role of Gonadotropin-Releasing Hormone in Murine Preimplantation Embryonic Development
Endocrinology, August 1, 1999; 140(8): 3705 - 3712.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. M. Cypess, C. G. Unson, C.-R. Wu, and T. P. Sakmar
Two Cytoplasmic Loops of the Glucagon Receptor Are Required to Elevate cAMP or Intracellular Calcium
J. Biol. Chem., July 2, 1999; 274(27): 19455 - 19464.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H.-F. Chen, E.-B. Jeung, M. Stephenson, and P. C. K. Leung
Human Peripheral Blood Mononuclear Cells Express Gonadotropin-Releasing Hormone (GnRH), GnRH Receptor, and Interleukin-2 Receptor {gamma}-Chain Messenger Ribonucleic Acids That Are Regulated by GnRH in Vitro
J. Clin. Endocrinol. Metab., February 1, 1999; 84(2): 743 - 750.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
S. Nelson, R. D. Horvat, J. Malvey, D. A. Roess, B. G. Barisas, and C. M. Clay
Characterization of an Intrinsically Fluorescent Gonadotropin-Releasing Hormone Receptor and Effects of Ligand Binding on Receptor Lateral Diffusion
Endocrinology, February 1, 1999; 140(2): 950 - 957.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
B. D. Strahl, H.-J. Huang, J. Sebastian, B. R. Ghosh, and W. L. Miller
Transcriptional Activation of the Ovine Follicle-Stimulating Hormone {beta}-Subunit Gene by Gonadotropin-Releasing Hormone: Involvement of Two Activating Protein-1-Binding Sites and Protein Kinase C
Endocrinology, November 1, 1998; 139(11): 4455 - 4465.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. Stanislaus, S. Ponder, T. H. Ji, and P. M. Conn
Gonadotropin-Releasing Hormone Receptor Couples to Multiple G Proteins in Rat Gonadotrophs and in GGH3 Cells: Evidence from Palmitoylation and Overexpression of G proteins
Biol Reprod, July 1, 1998; 59(3): 579 - 586.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
D. Stanislaus, J. A. Janovick, T. Ji, T. M. Wilkie, S. Offermanns, and P. M. Conn
Gonadotropin and Gonadal Steroid Release in Response to a Gonadotropin-Releasing Hormone Agonist in Gq{alpha} and G11{alpha} Knockout Mice
Endocrinology, June 1, 1998; 139(6): 2710 - 2717.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Ulloa-Aguirre, D. Stanislaus, V. Arora, J. Vaananen, S. Brothers, J. A. Janovick, and P. M. Conn
The Third Intracellular Loop of the Rat Gonadotropin-Releasing Hormone Receptor Couples the Receptor to Gs- and Gq/11-Mediated Signal Transduction Pathways: Evidence from Loop Fragment Transfection in GGH3 Cells
Endocrinology, May 1, 1998; 139(5): 2472 - 2478.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Ballesteros, S. Kitanovic, F. Guarnieri, P. Davies, B. J. Fromme, K. Konvicka, L. Chi, R. P. Millar, J. S. Davidson, H. Weinstein, et al.
Functional Microdomains in G-protein-coupled Receptors. THE CONSERVED ARGININE-CAGE MOTIF IN THE GONADOTROPIN-RELEASING HORMONE RECEPTOR
J. Biol. Chem., April 24, 1998; 273(17): 10445 - 10453.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. D. Neill, L. W. Duck, L. C. Musgrove, and J. C. Sellers
Potential Regulatory Roles for G Protein-Coupled Receptor Kinases and {beta}-Arrestins in Gonadotropin-Releasing Hormone Receptor Signaling
Endocrinology, April 1, 1998; 139(4): 1781 - 1788.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D Acampora, S Mazan, F Tuorto, V Avantaggiato, J. Tremblay, D Lazzaro, A di Carlo, A Mariano, P. Macchia, G Corte, et al.
Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH
Development, January 4, 1998; 125(7): 1229 - 1239.
[Abstract] [PDF]

Home page