| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Molecular Endocrinology, Vol 6, 1249-1258, Copyright © 1992 by Endocrine Society
ARTICLES |
DS Lala, DA Rice and KL Parker
Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710.
We proposed that a cell-selective regulatory protein coordinately regulates the expression of three enzymes that are required for the biosynthesis of corticosteroids: cholesterol side chain cleavage enzyme, steroid 21-hydroxylase, and the aldosterone synthase isozyme of steroid 11 beta-hydroxylase. In this report, we identify a 53- kilodalton protein, termed steroidogenic factor 1 (SF-1), that interacts with the related promoter elements from these steroidogenic enzymes, and we isolate and characterize a cDNA that very likely encodes this protein. We first showed that nuclear extracts from bovine adrenal glands interact with the mouse steroidogenic regulatory elements, forming complexes indistinguishable from those produced by nuclear extracts from mouse Y1 adrenocortical cells. These bovine adrenal extracts were subjected to sequential ion exchange and affinity chromatography to yield a highly enriched preparation of SF-1. The predominant protein in the affinity-purified preparation comigrated with shift activity and had a mol wt of 53,000; UV cross-linking experiments demonstrated directly that this 53-kilodalton protein interacted with the steroidogenic regulatory element. Even with this marked enrichment, affinity-purified SF-1 bound six steroidogenic regulatory elements. These results support strongly the model that a steroidogenic cell-selective protein interacts with related promoter elements from three steroidogenic enzymes to regulate their coordinate expression. The recognition sequence of SF-1 closely resembles those of nuclear hormone receptor family members, suggesting that SF-1 may belong to this supergene family. By screening a Y1 cell cDNA library with the DNA-binding region of the H-2RIIBP nuclear hormone receptor cDNA, we isolated a cDNA that is selectively expressed in steroidogenic cells. When expressed as a glutathione S-transferase fusion protein in Escherichia. coli, the protein encoded by this cDNA interacts with all six related steroidogenic regulatory elements with a binding specificity indistinguishable from that of SF-1. Surprisingly, the sequence of the putative DNA-binding domain of this cDNA matches exactly the corresponding sequence of the mouse homolog of the Drosophila transcription factor fushi tarazu-factor I. The demonstration that a member of the nuclear hormone receptor family interacts with the steroidogenic regulatory elements provides intriguing insights into possible mechanisms by which these essential genes are regulated.
This article has been cited by other articles:
![]() |
A. GLUBA, M. BANACH, D. P. MIKHAILIDIS, and J. RYSZ Genetic Determinants of Cardiovascular Disease: The Renin-Angiotensin-Aldosterone System, Paraoxonases, Endothelin-1, Nitric Oxide Synthase and Adrenergic Receptors In Vivo, September 1, 2009; 23(5): 797 - 812. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Yazawa, Y. Inanoka, T. Mizutani, M. Kuribayashi, A. Umezawa, and K. Miyamoto Liver Receptor Homolog-1 Regulates the Transcription of Steroidogenic Enzymes and Induces the Differentiation of Mesenchymal Stem Cells into Steroidogenic Cells Endocrinology, August 1, 2009; 150(8): 3885 - 3893. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Ye, Y. Nakamura, E. Lalli, and W. E. Rainey Differential Effects of High and Low Steroidogenic Factor-1 Expression on CYP11B2 Expression and Aldosterone Production in Adrenocortical Cells Endocrinology, March 1, 2009; 150(3): 1303 - 1309. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. F. Bouchard, H. Taniguchi, and R. S Viger The effect of human GATA4 gene mutations on the activity of target gonadal promoters J. Mol. Endocrinol., February 1, 2009; 42(2): 149 - 160. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Zubair, K. L. Parker, and K.-i. Morohashi Developmental Links between the Fetal and Adult Zones of the Adrenal Cortex Revealed by Lineage Tracing Mol. Cell. Biol., December 1, 2008; 28(23): 7030 - 7040. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Shima, M. Zubair, T. Komatsu, S. Oka, C. Yokoyama, T. Tachibana, T. A. Hjalt, J. Drouin, and K.-i. Morohashi Pituitary Homeobox 2 Regulates Adrenal4 Binding Protein/Steroidogenic Factor-1 Gene Transcription in the Pituitary Gonadotrope through Interaction with the Intronic Enhancer Mol. Endocrinol., July 1, 2008; 22(7): 1633 - 1646. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Zhao, A. De, Z. Hu, J. Li, S. M. Mulders, M. D. Sollewijn Gelpke, E.-K. Duan, and A. J. W. Hsueh Gonadotropin Stimulation of Ovarian Fractalkine Expression and Fractalkine Augmentation of Progesterone Biosynthesis by Luteinizing Granulosa Cells Endocrinology, June 1, 2008; 149(6): 2782 - 2789. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Utsunomiya, Y.-H. Cheng, Z. Lin, S. Reierstad, P. Yin, E. Attar, Q. Xue, G. Imir, S. Thung, E. Trukhacheva, et al. Upstream Stimulatory Factor-2 Regulates Steroidogenic Factor-1 Expression in Endometriosis Mol. Endocrinol., April 1, 2008; 22(4): 904 - 914. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Aizawa, M. Iemitsu, T. Otsuki, S. Maeda, T. Miyauchi, and N. Mesaki Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats J Appl Physiol, January 1, 2008; 104(1): 67 - 74. [Abstract] [Full Text] [PDF] |
||||
![]() |
W.-Y. Chen, J.-H. Weng, C.-C. Huang, and B.-c. Chung Histone Deacetylase Inhibitors Reduce Steroidogenesis through SCF-Mediated Ubiquitination and Degradation of Steroidogenic Factor 1 (NR5A1) Mol. Cell. Biol., October 15, 2007; 27(20): 7284 - 7290. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. L Reuter, K. Goji, N. C Bingham, M. Matsuo, and K. L Parker A novel mutation in the accessory DNA-binding domain of human steroidogenic factor 1 causes XY gonadal dysgenesis without adrenal insufficiency Eur. J. Endocrinol., August 1, 2007; 157(2): 233 - 238. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Xue, Z. Lin, P. Yin, M. P. Milad, Y.-H. Cheng, E. Confino, S. Reierstad, and S. E. Bulun Transcriptional Activation of Steroidogenic Factor-1 by Hypomethylation of the 5' CpG Island in Endometriosis J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3261 - 3267. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Sher, N. Yivgi-Ohana, and J. Orly Transcriptional Regulation of the Cholesterol Side Chain Cleavage Cytochrome P450 Gene (CYP11A1) Revisited: Binding of GATA, Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein and Activating Protein (AP)-1 Proteins to a Distal Novel Cluster of cis-Regulatory Elements Potentiates AP-2 and Steroidogenic Factor-1-Dependent Gene Expression in the Rodent Placenta and Ovary Mol. Endocrinol., April 1, 2007; 21(4): 948 - 962. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. H. Mellon, S. R. Bair, C. Depoix, J.-L. Vigne, N. B. Hecht, and P. B. Brake Translin Coactivates Steroidogenic Factor-1-Stimulated Transcription Mol. Endocrinol., January 1, 2007; 21(1): 89 - 105. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Makhanova, M. L.S. Sequeira-Lopez, R. A. Gomez, H.-S. Kim, and O. Smithies Disturbed Homeostasis in Sodium-Restricted Mice Heterozygous and Homozygous for Aldosterone Synthase Gene Disruption Hypertension, December 1, 2006; 48(6): 1151 - 1159. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Sugawara, N. Sakuragi, and H. Minakami CREM confers cAMP responsiveness in human steroidogenic acute regulatory protein expression in NCI-H295R cells rather than SF-1/Ad4BP. J. Endocrinol., October 1, 2006; 191(1): 327 - 337. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Rajender, K. Thangaraj, N. J. Gupta, N. Leelavathy, D. S. Rani, R. G. Nambiar, V. Kalavathy, S. T. Santhiya, S. Rajangam, P. M. Gopinath, et al. A Novel Human Sex-Determining Gene Linked to Xp11.21-11.23 J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 4028 - 4036. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Weck and K. E. Mayo Switching of NR5A Proteins Associated with the Inhibin {alpha}-Subunit Gene Promoter after Activation of the Gene in Granulosa Cells Mol. Endocrinol., May 1, 2006; 20(5): 1090 - 1103. [Abstract] [Full Text] [PDF] |
||||
![]() |
S Kuntz, D Chardard, C-I Ko, H Dumond, M Ducatez, M Callier, S Flament, and A Chesnel Female-enriched and thermosensitive expression of steroidogenic factor-1 during gonadal differentiation in Pleurodeles waltl J. Mol. Endocrinol., February 1, 2006; 36(1): 175 - 186. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Shima, M. Zubair, S. Ishihara, Y. Shinohara, S. Oka, S. Kimura, S. Okamoto, Y. Minokoshi, S. Suita, and K.-i. Morohashi Ventromedial Hypothalamic Nucleus-Specific Enhancer of Ad4BP/SF-1 Gene Mol. Endocrinol., November 1, 2005; 19(11): 2812 - 2823. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Tanahashi, T. Mune, Y. Takahashi, M. Isaji, T. Suwa, H. Morita, N. Yamakita, K. Yasuda, T. Deguchi, P. C. White, et al. Association of Lys173Arg Polymorphism with CYP11B2 Expression in Normal Adrenal Glands and Aldosterone-Producing Adenomas J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 6226 - 6231. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Jiang, K.-H. Jeong, C. D Horton, and L. M Halvorson Pituitary homeobox 1 (Pitx1) stimulates rat LH{beta} gene expression via two functional DNA-regulatory regions J. Mol. Endocrinol., August 1, 2005; 35(1): 145 - 158. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Seely, K. S. Amigh, T. Suzuki, B. Mayhew, H. Sasano, V. Giguere, J. Laganiere, B. R. Carr, and W. E. Rainey Transcriptional Regulation of Dehydroepiandrosterone Sulfotransferase (SULT2A1) by Estrogen-Related Receptor {alpha} Endocrinology, August 1, 2005; 146(8): 3605 - 3613. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Y. Park, J. J. Meeks, G. Raverot, L. E. Pfaff, J. Weiss, G. D. Hammer, and J. L. Jameson Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development Development, May 15, 2005; 132(10): 2415 - 2423. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. P. Segal, N. R. Stallings, C. E. Lee, L. Zhao, N. Socci, A. Viale, T. M. Harris, M. B. Soares, G. Childs, J. K. Elmquist, et al. Use of Laser-Capture Microdissection for the Identification of Marker Genes for the Ventromedial Hypothalamic Nucleus J. Neurosci., April 20, 2005; 25(16): 4181 - 4188. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y Kamei, Y Aoyama, T Fujimoto, N Kenmotsu, C Kishi, M Koushi, S Sugano, K Morohashi, R Kamiyama, and R Asakai A steroidogenic cell line with differentiation potential from mouse granulosa cells, transfected with Ad4BP and SV40 large T antigen genes J. Endocrinol., April 1, 2005; 185(1): 187 - 195. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Zheng and C. R. Jefcoate Steroidogenic Factor-1 Interacts with cAMP Response Element-Binding Protein to Mediate cAMP Stimulation of CYP1B1 via a Far Upstream Enhancer Mol. Pharmacol., February 1, 2005; 67(2): 499 - 512. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. H. Payne and D. B. Hales Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones Endocr. Rev., December 1, 2004; 25(6): 947 - 970. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Stokes, B. Alston-Mills, and C. Teng Estrogen response element and the promoter context of the human and mouse lactoferrin genes influence estrogen receptor {alpha}-mediated transactivation activity in mammary gland cells J. Mol. Endocrinol., October 1, 2004; 33(2): 315 - 334. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Komatsu, H. Mizusaki, T. Mukai, H. Ogawa, D. Baba, M. Shirakawa, S. Hatakeyama, K. I. Nakayama, H. Yamamoto, A. Kikuchi, et al. Small Ubiquitin-Like Modifier 1 (SUMO-1) Modification of the Synergy Control Motif of Ad4 Binding Protein/Steroidogenic Factor 1 (Ad4BP/SF-1) Regulates Synergistic Transcription between Ad4BP/SF-1 and Sox9 Mol. Endocrinol., October 1, 2004; 18(10): 2451 - 2462. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Chen, D. J. Eastburn, and M. Han The Caenorhabditis elegans Nuclear Receptor Gene nhr-25 Regulates Epidermal Cell Development Mol. Cell. Biol., September 1, 2004; 24(17): 7345 - 7358. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. V. Correa, S. Domenice, N. C. Bingham, A. E. C. Billerbeck, W. E. Rainey, K. L. Parker, and B. B. Mendonca A Microdeletion in the Ligand Binding Domain of Human Steroidogenic Factor 1 Causes XY Sex Reversal without Adrenal Insufficiency J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1767 - 1772. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. T. MacLaughlin and P. K. Donahoe Sex Determination and Differentiation N. Engl. J. Med., January 22, 2004; 350(4): 367 - 378. [Full Text] [PDF] |
||||
![]() |
B. Borud, G. Mellgren, J. Lund, and M. Bakke Cloning and Characterization of a Novel Zinc Finger Protein that Modulates the Transcriptional Activity of Nuclear Receptors Mol. Endocrinol., November 1, 2003; 17(11): 2303 - 2319. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. Tremblay and R. S. Viger A Mutated Form of Steroidogenic Factor 1 (SF-1 G35E) That Causes Sex Reversal in Humans Fails to Synergize with Transcription Factor GATA-4 J. Biol. Chem., October 24, 2003; 278(43): 42637 - 42642. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. K. Jordan, J. H.-C. Shen, R. Olaso, H. A. Ingraham, and E. Vilain Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/{beta}-catenin synergy PNAS, September 16, 2003; 100(19): 10866 - 10871. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. M. Gummow, J. N. Winnay, and G. D. Hammer Convergence of Wnt Signaling and Steroidogenic Factor-1 (SF-1) on Transcription of the Rat Inhibin {alpha} Gene J. Biol. Chem., July 11, 2003; 278(29): 26572 - 26579. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. LeCouter, R. Lin, G. Frantz, Z. Zhang, K. Hillan, and N. Ferrara Mouse Endocrine Gland-Derived Vascular Endothelial Growth Factor: A Distinct Expression Pattern from Its Human Ortholog Suggests Different Roles as a Regulator of Organ-Specific Angiogenesis Endocrinology, June 1, 2003; 144(6): 2606 - 2616. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Kawajiri, T. Ikuta, T. Suzuki, M. Kusaka, M. Muramatsu, K. Fujieda, M. Tachibana, and K.-i. Morohashi Role of the LXXLL-Motif and Activation Function 2 Domain in Subcellular Localization of Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1) Mol. Endocrinol., June 1, 2003; 17(6): 994 - 1004. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Yoshiura, B. Senthilkumaran, M. Watanabe, Y. Oba, T. Kobayashi, and Y. Nagahama Synergistic Expression of Ad4BP/SF-1 and Cytochrome P-450 Aromatase (Ovarian Type) in the Ovary of Nile Tilapia, Oreochromis niloticus, During Vitellogenesis Suggests Transcriptional Interaction Biol Reprod, May 1, 2003; 68(5): 1545 - 1553. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. K. Vassilatis, J. G. Hohmann, H. Zeng, F. Li, J. E. Ranchalis, M. T. Mortrud, A. Brown, S. S. Rodriguez, J. R. Weller, A. C. Wright, et al. The G protein-coupled receptor repertoires of human and mouse PNAS, April 15, 2003; 100(8): 4903 - 4908. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Mizusaki, K. Kawabe, T. Mukai, E. Ariyoshi, M. Kasahara, H. Yoshioka, A. Swain, and K.-i. Morohashi Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1) Gene Transcription Is Regulated by Wnt4 in the Female Developing Gonad Mol. Endocrinol., April 1, 2003; 17(4): 507 - 519. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Mazaud, C. J. Guigon, A. Lozach, N. Coudouel, M. G. Forest, H. Coffigny, and S. Magre Establishment of the Reproductive Function and Transient Fertility of Female Rats Lacking Primordial Follicle Stock after Fetal {gamma}-Irradiation Endocrinology, December 1, 2002; 143(12): 4775 - 4787. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. M. Wayne, K. Sutton, and M. F. Wilkinson Expression of the Pem Homeobox Gene in Sertoli Cells Increases the Frequency of Adjacent Germ Cells with Deoxyribonucleic Acid Strand Breaks Endocrinology, December 1, 2002; 143(12): 4875 - 4885. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Gizard, B. Lavallee, F. DeWitte, E. Teissier, B. Staels, and D. W. Hum The Transcriptional Regulating Protein of 132 kDa (TReP-132) Enhances P450scc Gene Transcription through Interaction with Steroidogenic Factor-1 in Human Adrenal Cells J. Biol. Chem., October 11, 2002; 277(42): 39144 - 39155. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. Tremblay, F. Hamel, and R. S. Viger Protein Kinase A-Dependent Cooperation between GATA and CCAAT/Enhancer-Binding Protein Transcription Factors Regulates Steroidogenic Acute Regulatory Protein Promoter Activity Endocrinology, October 1, 2002; 143(10): 3935 - 3945. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. von Hofsten, J. Karlsson, I. Jones, and P.-E. Olsson Expression and Regulation of Fushi Tarazu Factor-1 and Steroidogenic Genes During Reproduction in Arctic Char (Salvelinus alpinus) Biol Reprod, October 1, 2002; 67(4): 1297 - 1304. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Kajiyama, J. Tian, and J. Locker Regulation of {alpha}-Fetoprotein Expression by Nkx2.8 Mol. Cell. Biol., September 1, 2002; 22(17): 6122 - 6130. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Y. L. Chiang Bile Acid Regulation of Gene Expression: Roles of Nuclear Hormone Receptors Endocr. Rev., August 1, 2002; 23(4): 443 - 463. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Ben-Zimra, M. Koler, and J. Orly Transcription of Cholesterol Side-Chain Cleavage Cytochrome P450 in the Placenta: Activating Protein-2 Assumes the Role of Steroidogenic Factor-1 by Binding to an Overlapping Promoter Element Mol. Endocrinol., August 1, 2002; 16(8): 1864 - 1880. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. A. Davis, J. H. Miyake, T. Y. Hui, and N. J. Spann Regulation of cholesterol-7{alpha}-hydroxylase: BAREly missing a SHP J. Lipid Res., April 1, 2002; 43(4): 533 - 543. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Borud, T. Hoang, M. Bakke, A. L. Jacob, J. Lund, and G. Mellgren The Nuclear Receptor Coactivators p300/CBP/Cointegrator-Associated Protein (p/CIP) and Transcription Intermediary Factor 2 (TIF2) Differentially Regulate PKA-Stimulated Transcriptional Activity of Steroidogenic Factor 1 Mol. Endocrinol., April 1, 2002; 16(4): 757 - 773. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. C. Achermann, G. Ozisik, M. Ito, U. A. Orun, K. Harmanci, B. Gurakan, and J. L. Jameson Gonadal Determination and Adrenal Development Are Regulated by the Orphan Nuclear Receptor Steroidogenic Factor-1, in a Dose-Dependent Manner J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1829 - 1833. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. B. Sewer, V. Q. Nguyen, C.-J. Huang, P. W. Tucker, N. Kagawa, and M. R. Waterman Transcriptional Activation of Human CYP17 in H295R Adrenocortical Cells Depends on Complex Formation among p54nrb/NonO, Protein-Associated Splicing Factor, and SF-1, a Complex That Also Participates in Repression of Transcription Endocrinology, April 1, 2002; 143(4): 1280 - 1290. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. Logan, J. L. Juengel, and K. P. McNatty Onset of Steroidogenic Enzyme Gene Expression During Ovarian Follicular Development in Sheep Biol Reprod, April 1, 2002; 66(4): 906 - 916. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. J. Agate, W. R. Perlman, and A. P. Arnold Cloning and Expression of Zebra Finch (Taeniopygia guttata) Steroidogenic Factor 1: Overlap with Hypothalamic but Not with Telencephalic Aromatase Biol Reprod, April 1, 2002; 66(4): 1127 - 1133. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Koskimies, J. Levallet, P. Sipila, I. Huhtaniemi, and M. Poutanen Murine Relaxin-Like Factor Promoter: Functional Characterization and Regulation by Transcription Factors Steroidogenic Factor 1 and DAX-1 Endocrinology, March 1, 2002; 143(3): 909 - 919. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Majdic, M. Young, E. Gomez-Sanchez, P. Anderson, L. S. Szczepaniak, R. L. Dobbins, J. D. McGarry, and K. L. Parker Knockout Mice Lacking Steroidogenic Factor 1 Are a Novel Genetic Model of Hypothalamic Obesity Endocrinology, February 1, 2002; 143(2): 607 - 614. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. L. Parker, D. A. Rice, D. S. Lala, Y. Ikeda, X. Luo, M. Wong, M. Bakke, L. Zhao, C. Frigeri, N. A. Hanley, et al. Steroidogenic Factor 1: an Essential Mediator of Endocrine Development Recent Prog. Horm. Res., January 1, 2002; 57(1): 19 - 36. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. AEsoy, G. Mellgren, K.-I. Morohashi, and J. Lund Activation of cAMP-Dependent Protein Kinase Increases the Protein Level of Steroidogenic Factor-1 Endocrinology, January 1, 2002; 143(1): 295 - 303. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Gen, K. Okuzawa, N. Kumakura, S. Yamaguchi, and H. Kagawa Correlation Between Messenger RNA Expression of Cytochrome P450 Aromatase and Its Enzyme Activity During Oocyte Development in the Red Seabream (Pagrus major) Biol Reprod, October 1, 2001; 65(4): 1186 - 1194. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Sugawara, S. Abe, N. Sakuragi, Y. Fujimoto, E. Nomura, K. Fujieda, M. Saito, and S. Fujimoto RIP 140 Modulates Transcription of the Steroidogenic Acute Regulatory Protein Gene through Interactions with Both SF-1 and DAX-1 Endocrinology, August 1, 2001; 142(8): 3570 - 3577. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. B. Seminara and W. F. Crowley Jr. Perspective: The Importance of Genetic Defects in Humans in Elucidating the Complexities of the Hypothalamic-Pituitary-Gonadal Axis Endocrinology, June 1, 2001; 142(6): 2173 - 2177. [Full Text] [PDF] |
||||
![]() |
L. L. Heckert Activation of the Rat Follicle-Stimulating Hormone Receptor Promoter by Steroidogenic Factor 1 Is Blocked by Protein Kinase A and Requires Upstream Stimulatory Factor Binding to a Proximal E Box Element Mol. Endocrinol., May 1, 2001; 15(5): 704 - 715. [Abstract] [Full Text] |
||||
![]() |
K. Yamada, T. Mizutani, Z. Shou, T. Yazawa, T. Sekiguchi, M. Yoshino, T. Inazu, and K. Miyamoto Cloning and Functional Expression of an E Box-Binding Protein from Rat Granulosa Cells Biol Reprod, May 1, 2001; 64(5): 1315 - 1319. [Abstract] [Full Text] |
||||
![]() |
A. Fleming and D. Crews Estradiol and Incubation Temperature Modulate Regulation of Steroidogenic Factor 1 in the Developing Gonad of the Red-Eared Slider Turtle Endocrinology, April 1, 2001; 142(4): 1403 - 1411. [Abstract] [Full Text] |
||||
![]() |
J. J. Tremblay and R. S. Viger GATA Factors Differentially Activate Multiple Gonadal Promoters through Conserved GATA Regulatory Elements Endocrinology, March 1, 2001; 142(3): 977 - 986. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Levallet, P. Koskimies, N. Rahman, and I. Huhtaniemi The Promoter of Murine Follicle-Stimulating Hormone Receptor: Functional Characterization and Regulation by Transcription Factor Steroidogenic Factor 1 Mol. Endocrinol., January 1, 2001; 15(1): 80 - 92. [Abstract] [Full Text] |
||||
![]() |
F. Adam, T. Sourisseau, R. Métivier, Y. Le Page, C. Desbois, D. Michel, and G. Salbert COUP-TFI (Chicken Ovalbumin Upstream Promoter-Transcription Factor I) Regulates Cell Migration and Axogenesis in Differentiating P19 Embryonal Carcinoma Cells Mol. Endocrinol., December 1, 2000; 14(12): 1918 - 1933. [Abstract] [Full Text] |
||||
![]() |
M. Higa, H. Kanda, T. Kitahashi, M. Ito, T. Shiba, and H. Ando Quantitative Analysis of fushi tarazu Factor 1 Homolog Messenger Ribonucleic Acids in the Pituitary of Salmon at Different Prespawning Stages Biol Reprod, December 1, 2000; 63(6): 1756 - 1763. [Abstract] [Full Text] |
||||
![]() |
A. Pask, M. B. Renfree, and J. A. Marshall Graves The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: Implications for the evolution of mammalian sex determination PNAS, November 2, 2000; (2000) 230424497. [Abstract] [Full Text] |
||||
![]() |
X.-L. Wang, M. Bassett, Y. Zhang, S. Yin, C. Clyne, P. C. White, and W. E. Rainey Transcriptional Regulation of Human 11{beta}-Hydroxylase (hCYP11B1) Endocrinology, October 1, 2000; 141(10): 3587 - 3594. [Abstract] [Full Text] [PDF] |
||||
![]() |
U. B. Kaiser, L. M. Halvorson, and M. T. Chen Sp1, Steroidogenic Factor 1 (SF-1), and Early Growth Response Protein 1 (Egr-1) Binding Sites Form a Tripartite Gonadotropin-Releasing Hormone Response Element in the Rat Luteinizing Hormone-{beta} Gene Promoter: an Integral Role for SF-1 Mol. Endocrinol., August 1, 2000; 14(8): 1235 - 1245. [Abstract] [Full Text] |
||||
![]() |
D.R. Corley, X. Li, Z.M. Lei, and Ch.V. Rao Potential regulation of GnRH gene by a steroidogenic factor-1-like protein Mol. Hum. Reprod., August 1, 2000; 6(8): 671 - 676. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Sugawara, M. Saito, and S. Fujimoto Sp1 and SF-1 Interact and Cooperate in the Regulation of Human Steroidogenic Acute Regulatory Protein Gene Expression Endocrinology, August 1, 2000; 141(8): 2895 - 2903. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Y. Osamura, S. Tahara, R. Kurotani, N. Sanno, A. Matsuno, and A. Teramoto Contributions of Immunohistochemistry and In Situ Hybridization to the Functional Analysis of Pituitary Adenomas J. Histochem. Cytochem., April 1, 2000; 48(4): 445 - 458. [Abstract] [Full Text] |
||||
![]() |
C. R. Wooton-Kee and B. J. Clark Steroidogenic Factor-1 Influences Protein-Deoxyribonucleic Acid Interactions within the Cyclic Adenosine 3',5'-Monophosphate-Responsive Regions of the Murine Steroidogenic Acute Regulatory Protein Gene Endocrinology, April 1, 2000; 141(4): 1345 - 1355. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Ito, Y. Park, J. Weck, K. E. Mayo, and J. L. Jameson Synergistic Activation of the Inhibin {alpha}-Promoter by Steroidogenic Factor-1 and Cyclic Adenosine 3',5'-Monophosphate Mol. Endocrinol., January 1, 2000; 14(1): 66 - 81. [Abstract] [Full Text] |
||||
![]() |
S. D. Wijesuriya, G. Zhang, A. Dardis, and W. L. Miller Transcriptional Regulatory Elements of the Human Gene for Cytochrome P450c21 (Steroid 21-Hydroxylase) Lie within Intron 35 of the Linked C4B Gene J. Biol. Chem., December 31, 1999; 274(53): 38097 - 38106. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Giguère Orphan Nuclear Receptors: From Gene to Function Endocr. Rev., October 1, 1999; 20(5): 689 - 725. [Abstract] [Full Text] |
||||
![]() |
G. Cao, L. Zhao, H. Stangl, T. Hasegawa, J. A. Richardson, K. L. Parker, and H. H. Hobbs Developmental and Hormonal Regulation of Murine Scavenger Receptor, Class B, Type 1 Mol. Endocrinol., September 1, 1999; 13(9): 1460 - 1473. [Abstract] [Full Text] |
||||
![]() |
M. W. Wolfe The Equine Luteinizing Hormone {beta}-Subunit Promoter Contains Two Functional Steroidogenic Factor-1 Response Elements Mol. Endocrinol., September 1, 1999; 13(9): 1497 - 1510. [Abstract] [Full Text] |
||||
![]() |
L.-A. Li, E. F-L. Chiang, J.-C. Chen, N.-C. Hsu, Y.-J. Chen, and B.-c. Chung Function of Steroidogenic Factor 1 Domains in Nuclear Localization, Transactivation, and Interaction with Transcription Factor TFIIB and c-Jun Mol. Endocrinol., September 1, 1999; 13(9): 1588 - 1598. [Abstract] [Full Text] |
||||
![]() |
E. P. Fiedler, L. Jr. Plouffe, D. B. Hales, K. H. Hales, and I. Khan Prostaglandin F2{alpha} Induces a Rapid Decline in Progesterone Production and Steroidogenic Acute Regulatory Protein Expression in Isolated Rat Corpus Luteum Without Altering Messenger Ribonucleic Acid Expression Biol Reprod, September 1, 1999; 61(3): 643 - 650. [Abstract] [Full Text] |
||||
![]() |
P. Parma, E. Pailhoux, and C. Cotinot Reverse Transcription-Polymerase Chain Reaction Analysis of Genes Involved in Gonadal Differentiation in Pigs Biol Reprod, September 1, 1999; 61(3): 741 - 748. [Abstract] [Full Text] |
||||
![]() |
Y.-K. Lee, K. L. Parker, H.-S. Choi, and D. D. Moore Activation of the Promoter of the Orphan Receptor SHP by Orphan Receptors That Bind DNA as Monomers J. Biol. Chem., July 23, 1999; 274(30): 20869 - 20873. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Mitani, K. Mukai, H. Miyamoto, M. Suematsu, and Y. Ishimura Development of Functional Zonation in the Rat Adrenal Cortex Endocrinology, July 1, 1999; 140(7): 3342 - 3353. [Abstract] [Full Text] |
||||
![]() |
M. Nitta, S. Ku, C. Brown, A. Y. Okamoto, and B. Shan CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha -hydroxylase gene PNAS, June 8, 1999; 96(12): 6660 - 6665. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. S. W. Ngan, P. K. W. Cheng, P. C. K. Leung, and B. K. C. Chow Steroidogenic Factor-1 Interacts with a Gonadotrope-Specific Element within the First Exon of the Human Gonadotropin-Releasing Hormone Receptor Gene to Mediate Gonadotrope-Specific Expression Endocrinology, June 1, 1999; 140(6): 2452 - 2462. [Abstract] [Full Text] |
||||
![]() |
A. J. Reinhart, S. C. Williams, B. J. Clark, and D. M. Stocco SF-1 (Steroidogenic Factor-1) and C/EBP{beta} (CCAAT/Enhancer Binding Protein-{beta}) Cooperate to Regulate the Murine StAR (Steroidogenic Acute Regulatory) Promoter Mol. Endocrinol., May 1, 1999; 13(5): 729 - 741. [Abstract] [Full Text] |
||||
![]() |
M. W. Wolfe and G. B. Call Early Growth Response Protein 1 Binds to the Luteinizing Hormone-{beta} Promoter and Mediates Gonadotropin-Releasing Hormone-Stimulated Gene Expression Mol. Endocrinol., May 1, 1999; 13(5): 752 - 763. [Abstract] [Full Text] |
||||
![]() |
D. Barkan, H. Jia, A. Dantes, L. Vardimon, A. Amsterdam, and M. Rubinstein Leptin Modulates the Glucocorticoid-Induced Ovarian Steroidogenesis Endocrinology, April 1, 1999; 140(4): 1731 - 1738. [Abstract] [Full Text] |
||||
![]() |
A. Swain and R. Lovell-Badge Mammalian sex determination: a molecular drama Genes & Dev., April 1, 1999; 13(7): 755 - 767. [Full Text] |
||||
![]() |
A. Martinez, A.-M. Lefrançois-Martinez, M. Manin, S. Guyot, C. Jean-Faucher, G. Veyssière, A. Kahn, and C. Jean 5'-Flanking and Intragenic Sequences Confer Androgenic and Developmental Regulation of Mouse Aldose Reductase-Like Gene in Vas Deferens and Adrenal in Transgenic Mice Endocrinology, March 1, 1999; 140(3): 1338 - 1348. [Abstract] [Full Text] |
||||
![]() |
P. R. Manna, M. Tena-Sempere, and I. T. Huhtaniemi Molecular Mechanisms of Thyroid Hormone-stimulated Steroidogenesis in Mouse Leydig Tumor Cells. INVOLVEMENT OF THE STEROIDOGENIC ACUTE REGULATORY () PROTEIN J. Biol. Chem., February 26, 1999; 274(9): 5909 - 5918. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. T. Reutens, J. C. Achermann, M. Ito, M. Ito, W.-X. Gu, R. L. Habiby, P. A. Donohoue, S. Pang, P. C. Hindmarsh, and J. L. Jameson Clinical and Functional Effects of Mutations in the DAX-1 Gene in Patients with Adrenal Hypoplasia Congenita J. Clin. Endocrinol. Metab., February 1, 1999; 84(2): 504 - 511. [Abstract] [Full Text] |
||||
![]() |
L. M. Halvorson, U. B. Kaiser, and W. W. Chin The Protein Kinase C System Acts through the Early Growth Response Protein 1 to Increase LH{beta} Gene Expression in Synergy with Steroidogenic Factor-1 Mol. Endocrinol., January 1, 1999; 13(1): 106 - 116. [Abstract] [Full Text] |
||||
![]() |
S. L. Asa and S. Ezzat The Cytogenesis and Pathogenesis of Pituitary Adenomas Endocr. Rev., December 1, 1998; 19(6): 798 - 827. [Abstract] [Full Text] |
||||
![]() |
M. Young and M. J. McPhaul A Steroidogenic Factor-1-Binding Site and Cyclic Adenosine 3',5'-Monophosphate Response Element-Like Elements Are Required for the Activity of the Rat Aromatase Promoter in Rat Leydig Tumor Cell Lines Endocrinology, December 1, 1998; 139(12): 5082 - 5093. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. De Santa Barbara, N. Bonneaud, B. Boizet, M. Desclozeaux, B. Moniot, P. Sudbeck, G. Scherer, F. Poulat, and P. Berta Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Mullerian Hormone Gene Mol. Cell. Biol., November 1, 1998; 18(11): 6653 - 6665. [Abstract] [Full Text] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |