help button home button Endocrine Society Molecular Endocrinology ENDO 08 Sessions Library
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morohashi, K.
Right arrow Articles by Omura, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morohashi, K.
Right arrow Articles by Omura, T.

Molecular Endocrinology, Vol 7, 1196-1204, Copyright © 1993 by Endocrine Society

ARTICLES

Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP

K Morohashi, UM Zanger, S Honda, M Hara, MR Waterman and T Omura
Department of Molecular Biology Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.

We have examined the transcriptional activity of four cis-elements, Ad1(CRE), Ad2, Ad3, and Ad4, that are present in the promoter of the bovine CYP11B (11 beta-hydroxylase P-450) gene using beta-globin reporter gene constructs and transient transfection into steroidogenic and nonsteroidogenic cell types. Only Ad1(CRE), a CRE homolog, showed forskolin-dependent transcriptional activity in adrenal tumor Y-1 cells, whereas the other elements were not able to stimulate transcription by themselves. As Ad3 and Ad4 had previously been identified as the cis-elements required for full cAMP-dependent transcription of this gene, we examined the effect of combinations of different cis-elements on the transcription of the reporter gene. In Y- 1 cells, Ad1(CRE) and four tandem copies of any one of the other cis- elements substantially activated transcription in response to forskolin treatment. The template carrying Ad1(CRE) and Ad4 was also active in testicular Leydig cells, I-10, whereas it was inactive in nonsteroidogenic PC-12 cells. Transcriptional activation by the 4xAd4/Ad1(CRE) combination presumably depended on the presence of Ad4- binding protein (Ad4BP), which is absent in PC-12 cells, as shown by immunoblot analysis. This was confirmed by cotransfecting an expression vector for Ad4BP into PC-12 cells, which caused forskolin-dependent transcription to increase in proportion to the amount of expression vector. In Y-1 cells, transcriptional activation by forskolin was mimicked by cotransfection of an expression vector for the catalytic subunit of protein kinase-A.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 EndocrinologyHome page
P. R. Manna, M. T. Dyson, Y. Jo, and D. M. Stocco
Role of Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X Chromosome, Gene 1 in Protein Kinase A- and Protein Kinase C-Mediated Regulation of the Steroidogenic Acute Regulatory Protein Expression in Mouse Leydig Tumor Cells: Mechanism of Action
Endocrinology, January 1, 2009; 150(1): 187 - 199.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I.-C. Guo, C.-Y. Huang, C.-K. L. Wang, and B.-c. Chung
Activating Protein-1 Cooperates with Steroidogenic Factor-1 to Regulate 3',5'-Cyclic Adenosine 5'-Monophosphate-Dependent Human CYP11A1 Transcription in Vitro and in Vivo
Endocrinology, April 1, 2007; 148(4): 1804 - 1812.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
T. Sugawara, N. Sakuragi, and H. Minakami
CREM confers cAMP responsiveness in human steroidogenic acute regulatory protein expression in NCI-H295R cells rather than SF-1/Ad4BP.
J. Endocrinol., October 1, 2006; 191(1): 327 - 337.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. N. Winnay and G. D. Hammer
Adrenocorticotropic Hormone-Mediated Signaling Cascades Coordinate a Cyclic Pattern of Steroidogenic Factor 1-Dependent Transcriptional Activation
Mol. Endocrinol., January 1, 2006; 20(1): 147 - 166.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
S. Fujisaki, A. Sato, T. Toyomoto, T. Hayano, M. Sugai, T. Kubota, and O. Koiwai
Direct binding of TReP-132 with TdT results in reduction of TdT activity
Genes Cells, January 1, 2006; 11(1): 47 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Baba, J. Mimura, N. Nakamura, N. Harada, M. Yamamoto, K.-i. Morohashi, and Y. Fujii-Kuriyama
Intrinsic Function of the Aryl Hydrocarbon (Dioxin) Receptor as a Key Factor in Female Reproduction
Mol. Cell. Biol., November 15, 2005; 25(22): 10040 - 10051.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
G. J. Bouma, K. H. Albrecht, L. L. Washburn, A. K. Recknagel, G. A. Churchill, and E. M. Eicher
Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells
Development, July 1, 2005; 132(13): 3045 - 3054.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Y. Park, J. J. Meeks, G. Raverot, L. E. Pfaff, J. Weiss, G. D. Hammer, and J. L. Jameson
Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development
Development, May 15, 2005; 132(10): 2415 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
M. Matsuyama, H. Mizusaki, A. Shimono, T. Mukai, K. Okumura, K. Abe, K. Shimada, and K.-i. Morohashi
A novel isoform of Vinexin, Vinexin {gamma}, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad
Genes Cells, May 1, 2005; 10(5): 421 - 434.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
Y Kamei, Y Aoyama, T Fujimoto, N Kenmotsu, C Kishi, M Koushi, S Sugano, K Morohashi, R Kamiyama, and R Asakai
A steroidogenic cell line with differentiation potential from mouse granulosa cells, transfected with Ad4BP and SV40 large T antigen genes
J. Endocrinol., April 1, 2005; 185(1): 187 - 195.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Komatsu, H. Mizusaki, T. Mukai, H. Ogawa, D. Baba, M. Shirakawa, S. Hatakeyama, K. I. Nakayama, H. Yamamoto, A. Kikuchi, et al.
Small Ubiquitin-Like Modifier 1 (SUMO-1) Modification of the Synergy Control Motif of Ad4 Binding Protein/Steroidogenic Factor 1 (Ad4BP/SF-1) Regulates Synergistic Transcription between Ad4BP/SF-1 and Sox9
Mol. Endocrinol., October 1, 2004; 18(10): 2451 - 2462.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Granger, V. Ngo-Muller, C. Bleux, C. Guigon, H. Pincas, S. Magre, D. Daegelen, A. Tixier-Vidal, R. Counis, and J.-N. Laverriere
The Promoter of the Rat Gonadotropin-Releasing Hormone Receptor Gene Directs the Expression of the Human Placental Alkaline Phosphatase Reporter Gene in Gonadotrope Cells in the Anterior Pituitary Gland as well as in Multiple Extrapituitary Tissues
Endocrinology, February 1, 2004; 145(2): 983 - 993.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
W. Fan, T. Yanase, Y. Wu, H. Kawate, M. Saitoh, K. Oba, M. Nomura, T. Okabe, K. Goto, J. Yanagisawa, et al.
Protein Kinase A Potentiates Adrenal 4 Binding Protein/Steroidogenic Factor 1 Transactivation by Reintegrating the Subcellular Dynamic Interactions of the Nuclear Receptor with Its Cofactors, General Control Nonderepressed-5/Transformation/ Transcription Domain-Associated Protein, and Suppressor, Dosage-Sensitive Sex Reversal-1: a Laser Confocal Imaging Study in Living KGN Cells
Mol. Endocrinol., January 1, 2004; 18(1): 127 - 141.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Peng, J. W. Kim, W. E. Rainey, B. R. Carr, and G. R. Attia
The Role of the Orphan Nuclear Receptor, Liver Receptor Homologue-1, in the Regulation of Human Corpus Luteum 3{beta}-Hydroxysteroid Dehydrogenase Type II
J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 6020 - 6028.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Kawajiri, T. Ikuta, T. Suzuki, M. Kusaka, M. Muramatsu, K. Fujieda, M. Tachibana, and K.-i. Morohashi
Role of the LXXLL-Motif and Activation Function 2 Domain in Subcellular Localization of Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1)
Mol. Endocrinol., June 1, 2003; 17(6): 994 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Osman, C. Murigande, A. Nadakal, and A. M. Capponi
Repression of DAX-1 and Induction of SF-1 Expression. TWO MECHANISMS CONTRIBUTING TO THE ACTIVATION OF ALDOSTERONE BIOSYNTHESIS IN ADRENAL GLOMERULOSA CELLS
J. Biol. Chem., October 18, 2002; 277(43): 41259 - 41267.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Gizard, B. Lavallee, F. DeWitte, E. Teissier, B. Staels, and D. W. Hum
The Transcriptional Regulating Protein of 132 kDa (TReP-132) Enhances P450scc Gene Transcription through Interaction with Steroidogenic Factor-1 in Human Adrenal Cells
J. Biol. Chem., October 11, 2002; 277(42): 39144 - 39155.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Val, A. Martinez, I. Sahut-Barnola, C. Jean, G. Veyssiere, and A.-M. Lefrancois-Martinez
A 77-Base Pair LINE-Like Sequence Elicits Androgen-Dependent mvdp/akr1-b7 Expression in Mouse Vas Deferens, But Is Dispensable for Adrenal Expression in Rats
Endocrinology, September 1, 2002; 143(9): 3435 - 3448.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Doi, H. Takemori, X.-z. Lin, N. Horike, Y. Katoh, and M. Okamoto
Salt-inducible Kinase Represses cAMP-dependent Protein Kinase-mediated Activation of Human Cholesterol Side Chain Cleavage Cytochrome P450 Promoter through the CREB Basic Leucine Zipper Domain
J. Biol. Chem., May 3, 2002; 277(18): 15629 - 15637.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. B. Sewer and M. R. Waterman
Adrenocorticotropin/Cyclic Adenosine 3',5'-Monophosphate-Mediated Transcription of the Human CYP17 Gene in the Adrenal Cortex Is Dependent on Phosphatase Activity
Endocrinology, May 1, 2002; 143(5): 1769 - 1777.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. H.-C. Shen and H. A. Ingraham
Regulation of the Orphan Nuclear Receptor Steroidogenic Factor 1 by Sox Proteins
Mol. Endocrinol., March 1, 2002; 16(3): 529 - 540.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Koskimies, J. Levallet, P. Sipila, I. Huhtaniemi, and M. Poutanen
Murine Relaxin-Like Factor Promoter: Functional Characterization and Regulation by Transcription Factors Steroidogenic Factor 1 and DAX-1
Endocrinology, March 1, 2002; 143(3): 909 - 919.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. G. Tevosian, K. H. Albrecht, J. D. Crispino, Y. Fujiwara, E. M. Eicher, and S. H. Orkin
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2
Development, January 10, 2002; 129(19): 4627 - 4634.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. AEsoy, G. Mellgren, K.-I. Morohashi, and J. Lund
Activation of cAMP-Dependent Protein Kinase Increases the Protein Level of Steroidogenic Factor-1
Endocrinology, January 1, 2002; 143(1): 295 - 303.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. Lacroix, N. N'Diaye, J. Tremblay, and P. Hamet
Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome
Endocr. Rev., February 1, 2001; 22(1): 75 - 110.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
J. Levallet, P. Koskimies, N. Rahman, and I. Huhtaniemi
The Promoter of Murine Follicle-Stimulating Hormone Receptor: Functional Characterization and Regulation by Transcription Factor Steroidogenic Factor 1
Mol. Endocrinol., January 1, 2001; 15(1): 80 - 92.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
C. Aigueperse, P. Val, C. Pacot, C. Darne, E. Lalli, P. Sassone-Corsi, G. Veyssiere, C. Jean, and A. Martinez
SF-1 (Steroidogenic Factor-1), C/EBP{beta} (CCAAT/Enhancer Binding Protein), and Ubiquitous Transcription Factors NF1 (Nuclear Factor 1) and Sp1 (Selective Promoter Factor 1) Are Required for Regulation of the Mouse Aldose Reductase-Like Gene (AKR1B7) Expression in Adrenocortical Cells
Mol. Endocrinol., January 1, 2001; 15(1): 93 - 111.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
X.-L. Wang, M. Bassett, Y. Zhang, S. Yin, C. Clyne, P. C. White, and W. E. Rainey
Transcriptional Regulation of Human 11{beta}-Hydroxylase (hCYP11B1)
Endocrinology, October 1, 2000; 141(10): 3587 - 3594.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
R. Y. Osamura, S. Tahara, R. Kurotani, N. Sanno, A. Matsuno, and A. Teramoto
Contributions of Immunohistochemistry and In Situ Hybridization to the Functional Analysis of Pituitary Adenomas
J. Histochem. Cytochem., April 1, 2000; 48(4): 445 - 458.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
C. R. Wooton-Kee and B. J. Clark
Steroidogenic Factor-1 Influences Protein-Deoxyribonucleic Acid Interactions within the Cyclic Adenosine 3',5'-Monophosphate-Responsive Regions of the Murine Steroidogenic Acute Regulatory Protein Gene
Endocrinology, April 1, 2000; 141(4): 1345 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M.-C. Hu, S.-J. Chou, Y.-Y. Huang, N.-C. Hsu, H. Li, and B.-c. Chung
Tissue-Specific, Hormonal, and Developmental Regulation of SCC-LacZ Expression in Transgenic Mice Leads to Adrenocortical Zone Characterization
Endocrinology, December 1, 1999; 140(12): 5609 - 5618.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
Y. Kabe, M. Goto, D. Shima, T. Imai, T. Wada, K.-i. Morohashi, M. Shirakawa, S. Hirose, and H. Handa
The Role of Human MBF1 as a Transcriptional Coactivator
J. Biol. Chem., November 26, 1999; 274(48): 34196 - 34202.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Kawabe, T. Shikayama, H. Tsuboi, S. Oka, K. Oba, T. Yanase, H. Nawata, and K.-i. Morohashi
Dax-1 as One of the Target Genes of Ad4BP/SF-1
Mol. Endocrinol., August 1, 1999; 13(8): 1267 - 1284.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
P. Pena, A. T. Reutens, C. Albanese, M. D’Amico, G. Watanabe, A. Donner, I-W. Shu, T. Williams, and R. G. Pestell
Activator Protein-2 Mediates Transcriptional Activation of the CYP11A1 Gene by Interaction with Sp1 Rather than Binding to DNA
Mol. Endocrinol., August 1, 1999; 13(8): 1402 - 1416.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
R. Ahlgren, G. Suske, M. R. Waterman, and J. Lund
Role of Sp1 in cAMP-dependent Transcriptional Regulation of the Bovine CYP11A Gene
J. Biol. Chem., July 2, 1999; 274(27): 19422 - 19428.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Lopez, T. W. Sandhoff, and M. P. McLean
Steroidogenic Factor-1 Mediates Cyclic 3',5'-Adenosine Monophosphate Regulation of the High Density Lipoprotein Receptor
Endocrinology, July 1, 1999; 140(7): 3034 - 3044.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
A. Swain and R. Lovell-Badge
Mammalian sex determination: a molecular drama
Genes & Dev., April 1, 1999; 13(7): 755 - 767.
[Full Text]

Home page
 BloodHome page
K.-i. Morohashi, H. Tsuboi-Asai, S. Matsushita, M. Suda, M. Nakashima, H. Sasano, Y. Hataba, C.-L. Li, J. Fukata, J. Irie, et al.
Structural and Functional Abnormalities in the Spleen of an mFtz-F1 Gene-Disrupted Mouse
Blood, March 1, 1999; 93(5): 1586 - 1594.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Shiratsuchi, Y. Kawasaki, M. Ikemoto, H. Arai, and Y. Nakanishi
Role of Class B Scavenger Receptor Type I in Phagocytosis of Apoptotic Rat Spermatogenic Cells by Sertoli Cells
J. Biol. Chem., February 26, 1999; 274(9): 5901 - 5908.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. L. Asa and S. Ezzat
The Cytogenesis and Pathogenesis of Pituitary Adenomas
Endocr. Rev., December 1, 1998; 19(6): 798 - 827.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
M. Young and M. J. McPhaul
A Steroidogenic Factor-1-Binding Site and Cyclic Adenosine 3',5'-Monophosphate Response Element-Like Elements Are Required for the Activity of the Rat Aromatase Promoter in Rat Leydig Tumor Cell Lines
Endocrinology, December 1, 1998; 139(12): 5082 - 5093.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. A. Crawford, C. Dorn, Y. Sadovsky, and J. Milbrandt
Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1
Mol. Cell. Biol., May 1, 1998; 18(5): 2949 - 2956.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
A. N. Harris and P. L. Mellon
The Basic Helix-Loop-Helix, Leucine Zipper Transcription Factor, USF (Upstream Stimulatory Factor), Is a Key Regulator of SF-1 (Steroidogenic Factor-1) Gene Expression in Pituitary Gonadotrope and Steroidogenic Cells
Mol. Endocrinol., May 1, 1998; 12(5): 714 - 726.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
D. Monte, F. DeWitte, and D. W. Hum
Regulation of the Human P450scc Gene by Steroidogenic Factor 1 Is Mediated by CBP/p300
J. Biol. Chem., February 20, 1998; 273(8): 4585 - 4591.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Ito, R. N. Yu, and J. L. Jameson
Steroidogenic Factor-1 Contains a Carboxy-Terminal Transcriptional Activation Domain That Interacts with Steroid Receptor Coactivator-1
Mol. Endocrinol., February 1, 1998; 12(2): 290 - 301.
[Abstract] [Full Text]

Home page
 Reproductive SciencesHome page
Y. Sadovsky and P. A. Crawford
Developmental and Physiologic Roles of the Nuclear Receptor Steroidogenic Factor-I in the Reproductive System
Reproductive Sciences, January 1, 1998; 5(1): 6 - 12.
[Abstract] [PDF]

Home page
 Endocr. Rev.Home page
A. Amsterdam and N. Selvaraj
Control of Differentiation, Transformation, and Apoptosis in Granulosa Cells by Oncogenes, Oncoviruses, and Tumor Suppressor Genes
Endocr. Rev., August 1, 1997; 18(4): 435 - 461.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
K. L. Parker and B. P. Schimmer
Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function
Endocr. Rev., June 1, 1997; 18(3): 361 - 377.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
F. M. Cammas, G. D. Pullinger, S. Barker, and A. J. L. Clark
The Mouse Adrenocorticotropin Receptor Gene: Cloning and Characterization of Its Promoter and Evidence for a Role for the Orphan Nuclear Receptor Steroidogenic Factor 1
Mol. Endocrinol., June 1, 1997; 11(7): 867 - 876.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
P. Zhang and S. H. Mellon
Multiple Orphan Nuclear Receptors Converge to Regulate Rat P450c17 Gene Transcription: Novel Mechanisms for Orphan Nuclear Receptor Action
Mol. Endocrinol., June 1, 1997; 11(7): 891 - 904.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. S. Ramayya, J. Zhou, T. Kino, J. H. Segars, C. A. Bondy, and G. P. Chrousos
Steroidogenic Factor 1 Messenger Ribonucleic Acid Expression in Steroidogenic and Nonsteroidogenic Human Tissues: Northern Blot and in Situ Hybridization Studies
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1799 - 1806.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Leers-Sucheta, K.-i. Morohashi, J. I. Mason, and M. H. Melner
Synergistic Activation of the Human Type II 3beta -Hydroxysteroid Dehydrogenase/Delta 5-Delta 4 Isomerase Promoter by the Transcription Factor Steroidogenic Factor-1/Adrenal 4-binding Protein and Phorbol Ester
J. Biol. Chem., March 21, 1997; 272(12): 7960 - 7967.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. G. Woodson, P. A. Crawford, Y. Sadovsky, and J. Milbrandt
Characterization of the Promoter of SF-1, an Orphan Nuclear Receptor Required for Adrenal and Gonadal Development
Mol. Endocrinol., February 1, 1997; 11(2): 117 - 126.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
Z. Liu and E. R. Simpson
Steroidogenic Factor 1 (SF-1) and SP1 Are Required for Regulation of Bovine CYP11A Gene Expression in Bovine Luteal Cells and Adrenal Y1 Cells
Mol. Endocrinol., February 1, 1997; 11(2): 127 - 137.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
B. Staels, G. Martin, M. Martinez, C. Albert, J. Peinado-Onsurbe, R. Saladin, D. W. Hum, M. Reina, S. Vilaro, and J. Auwerx
Expression and Regulation of the Lipoprotein Lipase Gene in Human Adrenal Cortex
J. Biol. Chem., July 19, 1996; 271(29): 17425 - 17432.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Nomura, H. Nawata, and K.-i. Morohashi
Autoregulatory Loop in the Regulation of the Mammalian ftz-f1 Gene
J. Biol. Chem., April 5, 1996; 271(14): 8243 - 8249.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. G. Pestell, C. Albanese, G. Watanabe, J. Johnson, N. Eklund, P. Lastowiecki, and J. L. Jameson
Epidermal Growth Factor and c-Jun Act via a Common DNA Regulatory Element to Stimulate Transcription of the Ovine P-450 Cholesterol Side Chain Cleavage (CYP11A1) Promoter
J. Biol. Chem., August 4, 1995; 270(31): 18301 - 18308.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Nomura, S. Bärtsch, H. Nawata, T. Omura, and K.-i. Morohashi
An E Box Element Is Required for the Expression of the ad4bp Gene, a Mammalian Homologue of ftz-f1 Gene, Which Is Essential for Adrenal and Gonadal Development
J. Biol. Chem., March 31, 1995; 270(13): 7453 - 7461.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
O Hatano, K Takayama, T Imai, M. Waterman, A Takakusu, T Omura, and K Morohashi
Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development
Development, January 10, 1994; 120(10): 2787 - 2797.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
T. Mizutani, K. Yamada, T. Minegishi, and K. Miyamoto
Transcriptional Regulation of Rat Scavenger Receptor Class B Type I Gene
J. Biol. Chem., July 14, 2000; 275(29): 22512 - 22519.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Gizard, B. Lavallee, F. DeWitte, and D. W. Hum
A Novel Zinc Finger Protein TReP-132 Interacts with CBP/p300 to Regulate Human CYP11A1 Gene Expression
J. Biol. Chem., August 31, 2001; 276(36): 33881 - 33892.
[Abstract] [Full Text] [PDF]