help button home button Endocrine Society Molecular Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Greenberg, N. M.
Right arrow Articles by Rosen, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greenberg, N. M.
Right arrow Articles by Rosen, J. M.

Molecular Endocrinology, Vol 8, 230-239, Copyright © 1994 by Endocrine Society

ARTICLES

The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice

NM Greenberg, FJ DeMayo, PC Sheppard, R Barrios, R Lebovitz, M Finegold, R Angelopoulou, JG Dodd, ML Duckworth and JM Rosen
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030.

An expression cassette carrying 426 basepairs of the rat probasin (PB) gene promoter and 28 basepairs of 5'-untranslated region is sufficient to target the expression of the bacterial chloramphenicol acetyltransferase (CAT) gene specifically to the prostate in transgenic mice. The PB-CAT transgene was expressed in three of five (60%) independent lines of mice, and this expression, as reported previously for the endogenous rat gene, was male specific, restricted primarily to the lateral, dorsal, and ventral lobes of the prostate, with only very low levels of CAT activity detected in the anterior prostate and seminal vesicles. The developmental and hormonal regulation of the transgene also paralleled that reported for the rat gene, with a 70- fold increase in CAT activity in the mouse prostate observed between 2- 7 weeks of age, a time corresponding to sexual maturation. PB-CAT activity in the prostate declined after castration to 3.5% of the precastration level, and the CAT activity in castrated males approached precastration levels when mice were supplemented with testosterone. Transgene expression in castrated males was not induced by dexamethasone. Coinjection of PB-CAT with a chicken lysozyme gene matrix attachment region resulted in their cointegration and further restricted the pattern of PB-CAT to the dorsolateral prostate, with suppressed expression observed in the ventral prostate. These studies demonstrate that a minimal rat probasin promoter can target heterologous gene expression specifically to the prostate in a developmentally and hormonally regulated fashion.


This article has been cited by other articles:


Home page
 Cancer Res.Home page
K. Raina, S. Rajamanickam, R. P. Singh, G. Deep, M. Chittezhath, and R. Agarwal
Stage-Specific Inhibitory Effects and Associated Mechanisms of Silibinin on Tumor Progression and Metastasis in Transgenic Adenocarcinoma of the Mouse Prostate Model
Cancer Res., August 15, 2008; 68(16): 6822 - 6830.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. M. Sargeant, R. C. Rengel, S. K. Kulp, R. D. Klein, S. K. Clinton, Y.-C. Wang, and C.-S. Chen
OSU-HDAC42, a Histone Deacetylase Inhibitor, Blocks Prostate Tumor Progression in the Transgenic Adenocarcinoma of the Mouse Prostate Model
Cancer Res., May 15, 2008; 68(10): 3999 - 4009.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Raina, S. Rajamanickam, R. P. Singh, and R. Agarwal
Chemopreventive Efficacy of Inositol Hexaphosphate against Prostate Tumor Growth and Progression in TRAMP Mice
Clin. Cancer Res., May 15, 2008; 14(10): 3177 - 3184.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
K. Raina, S. Rajamanickam, G. Deep, M. Singh, R. Agarwal, and C. Agarwal
Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice
Mol. Cancer Ther., May 1, 2008; 7(5): 1258 - 1267.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
J. H. Suh, E.-Y. Gong, J. B. Kim, I.-K. Lee, H.-S. Choi, and K. Lee
Sterol Regulatory Element-Binding Protein-1c Represses the Transactivation of Androgen Receptor and Androgen-Dependent Growth of Prostatic Cells
Mol. Cancer Res., February 1, 2008; 6(2): 314 - 324.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Raina, M.-J. Blouin, R. P. Singh, N. Majeed, G. Deep, L. Varghese, L. M. Glode, N. M. Greenberg, D. Hwang, P. Cohen, et al.
Dietary Feeding of Silibinin Inhibits Prostate Tumor Growth and Progression in Transgenic Adenocarcinoma of the Mouse Prostate Model
Cancer Res., November 15, 2007; 67(22): 11083 - 11091.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C.-T. Wu, S. Altuwaijri, W. A. Ricke, S.-P. Huang, S. Yeh, C. Zhang, Y. Niu, M.-Y. Tsai, and C. Chang
Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor
PNAS, July 31, 2007; 104(31): 12679 - 12684.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Raina, R. P. Singh, R. Agarwal, and C. Agarwal
Oral Grape Seed Extract Inhibits Prostate Tumor Growth and Progression in TRAMP Mice
Cancer Res., June 15, 2007; 67(12): 5976 - 5982.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. L. Kleinberg, W. Ruan, D. Yee, K. T. Kovacs, and S. Vidal
Insulin-Like Growth Factor (IGF)-I Controls Prostate Fibromuscular Development: IGF-I Inhibition Prevents Both Fibromuscular and Glandular Development in Eugonadal Mice
Endocrinology, March 1, 2007; 148(3): 1080 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
L. Young, R. Salomon, W. Au, C. Allan, P. Russell, and Q. Dong
Ornithine Decarboxylase (ODC) Expression Pattern in Human Prostate Tissues and ODC Transgenic Mice
J. Histochem. Cytochem., February 1, 2006; 54(2): 223 - 229.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. J. Lamb and L. Zhang
Challenges in Prostate Cancer Research: Animal Models for Nutritional Studies of Chemoprevention and Disease Progression
J. Nutr., December 1, 2005; 135(12): 3009S - 3015S.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
C-L Hsieh, Z Xie, Z-Y Liu, J E Green, W D Martin, M W Datta, F Yeung, D Pan, and L W K Chung
A luciferase transgenic mouse model: visualization of prostate development and its androgen responsiveness in live animals
J. Mol. Endocrinol., October 1, 2005; 35(2): 293 - 304.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
A. W. Suttie, G. E. Dinse, A. Nyska, G. J. Moser, T. L. Goldsworthy, and R. R. Maronpot
An Investigation of the Effects of Late-Onset Dietary Restriction on Prostate Cancer Development in the TRAMP Mouse
Toxicol Pathol, April 1, 2005; 33(3): 386 - 397.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Li, Y.-P. Zhang, H.-S. Kim, K.-H. Bae, K. M. Stantz, S.-J. Lee, C. Jung, J. A. Jimenez, T. A. Gardner, M.-H. Jeng, et al.
Gene Therapy for Prostate Cancer by Controlling Adenovirus E1a and E4 Gene Expression with PSES Enhancer
Cancer Res., March 1, 2005; 65(5): 1941 - 1951.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Han, G. Buchanan, M. Ittmann, J. M. Harris, X. Yu, F. J. DeMayo, W. Tilley, and N. M. Greenberg
Mutation of the androgen receptor causes oncogenic transformation of the prostate
PNAS, January 25, 2005; 102(4): 1151 - 1156.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. A. Narayanan, N. K. Narayanan, B. Pittman, and B. S. Reddy
Regression of Mouse Prostatic Intraepithelial Neoplasia by Nonsteroidal Anti-inflammatory Drugs in the Transgenic Adenocarcinoma Mouse Prostate Model
Clin. Cancer Res., November 15, 2004; 10(22): 7727 - 7737.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Zhang, N. Gao, S. Kasper, K. Reid, C. Nelson, and R. J. Matusik
An Androgen-Dependent Upstream Enhancer Is Essential for High Levels of Probasin Gene Expression
Endocrinology, January 1, 2004; 145(1): 134 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
I. Hernandez, L. A. Maddison, Y. Wei, F. DeMayo, T. Petras, B. Li, J. R. Gingrich, J. M. Rosen, and N. M. Greenberg
Prostate-Specific Expression of p53R172L Differentially Regulates p21, Bax, and mdm2 to Inhibit Prostate Cancer Progression and Prolong Survival
Mol. Cancer Res., December 1, 2003; 1(14): 1036 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Krajewska, S. Krajewski, S. Banares, X. Huang, B. Turner, L. Bubendorf, O.-P. Kallioniemi, A. Shabaik, A. Vitiello, D. Peehl, et al.
Elevated Expression of Inhibitor of Apoptosis Proteins in Prostate Cancer
Clin. Cancer Res., October 15, 2003; 9(13): 4914 - 4925.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
N. Gao, J. Zhang, M. A. Rao, T. C. Case, J. Mirosevich, Y. Wang, R. Jin, A. Gupta, P. S. Rennie, and R. J. Matusik
The Role of Hepatocyte Nuclear Factor-3{alpha} (Forkhead Box A1) and Androgen Receptor in Transcriptional Regulation of Prostatic Genes
Mol. Endocrinol., August 1, 2003; 17(8): 1484 - 1507.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Harkonen
Paracrine Prolactin May Cause Prostatic Problems
Endocrinology, June 1, 2003; 144(6): 2266 - 2268.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Kindblom, K. Dillner, L. Sahlin, F. Robertson, C. Ormandy, J. Tornell, and H. Wennbo
Prostate Hyperplasia in a Transgenic Mouse with Prostate-Specific Expression of Prolactin
Endocrinology, June 1, 2003; 144(6): 2269 - 2278.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. R. Logg, A. Logg, R. J. Matusik, B. H. Bochner, and N. Kasahara
Tissue-Specific Transcriptional Targeting of a Replication-Competent Retroviral Vector
J. Virol., November 13, 2002; 76(24): 12783 - 12791.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Zheng, J.-X. Gao, H. Zhang, T. L. Geiger, Y. Liu, and P. Zheng
Clonal Deletion of Simian Virus 40 Large T Antigen-Specific T Cells in the Transgenic Adenocarcinoma of Mouse Prostate Mice: An Important Role for Clonal Deletion in Shaping the Repertoire of T Cells Specific for Antigens Overexpressed in Solid Tumors
J. Immunol., November 1, 2002; 169(9): 4761 - 4769.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Val, A. Martinez, I. Sahut-Barnola, C. Jean, G. Veyssiere, and A.-M. Lefrancois-Martinez
A 77-Base Pair LINE-Like Sequence Elicits Androgen-Dependent mvdp/akr1-b7 Expression in Mouse Vas Deferens, But Is Dispensable for Adrenal Expression in Rats
Endocrinology, September 1, 2002; 143(9): 3435 - 3448.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. He, L. W. Lee, J. T. Minges, and E. M. Wilson
Dependence of Selective Gene Activation on the Androgen Receptor NH2- and COOH-terminal Interaction
J. Biol. Chem., July 5, 2002; 277(28): 25631 - 25639.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Asamoto, N. Hokaiwado, Y.-M. Cho, and T. Shirai
Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control
Carcinogenesis, March 1, 2002; 23(3): 463 - 467.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
F. Andriani, B. Nan, J. Yu, X. Li, N. L. Weigel, M. J. McPhaul, S. Kasper, S. Kagawa, B. Fang, R. J. Matusik, et al.
Use of the Probasin Promoter ARR2PB to Express Bax in Androgen Receptor-Positive Prostate Cancer Cells
J Natl Cancer Inst, September 5, 2001; 93(17): 1314 - 1324.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Stanbrough, I. Leav, P. W. L. Kwan, G. J. Bubley, and S. P. Balk
Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
PNAS, September 4, 2001; (2001) 191235898.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Mentor-Marcel, C. A. Lamartiniere, I.-E. Eltoum, N. M. Greenberg, and A. Elgavish
Genistein in the Diet Reduces the Incidence of Poorly Differentiated Prostatic Adenocarcinoma in Transgenic Mice (TRAMP)
Cancer Res., September 1, 2001; 61(18): 6777 - 6782.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Xie, X. Zhao, Y. Liu, J. Zhang, R. J. Matusik, K. M. Slawin, and D. M. Spencer
Adenovirus-mediated Tissue-targeted Expression of a Caspase-9-based Artificial Death Switch for the Treatment of Prostate Cancer
Cancer Res., September 1, 2001; 61(18): 6795 - 6804.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Asamoto, N. Hokaiwado, Y.-M. Cho, S. Takahashi, Y. Ikeda, K. Imaida, and T. Shirai
Prostate Carcinomas Developing in Transgenic Rats with SV40 T Antigen Expression under Probasin Promoter Control Are Strictly Androgen Dependent
Cancer Res., June 1, 2001; 61(12): 4693 - 4700.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Imasato, T. Onita, M. Moussa, H. Sakai, F. L. Chan, J. Koropatnick, J. L. Chin, and J. W. Xuan
Rodent PSP94 Gene Expression Is More Specific to the Dorsolateral Prostate and Less Sensitive to Androgen Ablation than Probasin
Endocrinology, May 1, 2001; 142(5): 2138 - 2146.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
N. Masumori, T. Z. Thomas, P. Chaurand, T. Case, M. Paul, S. Kasper, R. M. Caprioli, T. Tsukamoto, S. B. Shappell, and R. J. Matusik
A Probasin-Large T Antigen Transgenic Mouse Line Develops Prostate Adenocarcinoma and Neuroendocrine Carcinoma with Metastatic Potential
Cancer Res., March 1, 2001; 61(5): 2239 - 2249.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
X. Li, M. Marani, J. Yu, B. Nan, J. A. Roth, S. Kagawa, B. Fang, L. Denner, and M. Marcelli
Adenovirus-mediated Bax Overexpression for the Induction of Therapeutic Apoptosis in Prostate Cancer
Cancer Res., January 1, 2001; 61(1): 186 - 191.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. Kwong, J. W. Xuan, P. S. F. Chan, S.-M. Ho, and F. L. Chan
A Comparative Study of Hormonal Regulation of Three Secretory Proteins (Prostatic Secretory Protein-PSP94, Probasin, and Seminal Vesicle Secretion II) in Rat Lateral Prostate
Endocrinology, December 1, 2000; 141(12): 4543 - 4551.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Zhang, T. Z. Thomas, S. Kasper, and R. J. Matusik
A Small Composite Probasin Promoter Confers High Levels of Prostate-Specific Gene Expression through Regulation by Androgens and Glucocorticoids in Vitro and in Vivo
Endocrinology, December 1, 2000; 141(12): 4698 - 4710.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
C. Abate-Shen and M. M. Shen
Molecular genetics of prostate cancer
Genes & Dev., October 1, 2000; 14(19): 2410 - 2434.
[Full Text]

Home page
 Cancer Res.Home page
D. K. Vanaja, M. E. Grossmann, E. Celis, and C. Y. F. Young
Tumor Prevention and Antitumor Immunity with Heat Shock Protein 70 Induced by 15-Deoxy-{{Delta}}12,14-prostaglandin J2 in Transgenic Adenocarcinoma of Mouse Prostate Cells
Cancer Res., September 1, 2000; 60(17): 4714 - 4718.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
S. Gupta, N. Ahmad, S. R. Marengo, G. T. MacLennan, N. M. Greenberg, and H. Mukhtar
Chemoprevention of Prostate Carcinogenesis by {{alpha}}-Difluoromethylornithine in TRAMP Mice
Cancer Res., September 1, 2000; 60(18): 5125 - 5133.
[Abstract] [Full Text]

Home page
 CarcinogenesisHome page
C. Voelkel-Johnson, D. J. Voeks, N. M. Greenberg, R. Barrios, F. Maggouta, D. T. Kurtz, D. A. Schwartz, G. M. Keller, T. Papenbrock, G. A. Clawson, et al.
Genomic instability-based transgenic models of prostate cancer
Carcinogenesis, August 1, 2000; 21(8): 1623 - 1627.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Ma, H. Hong, S.-M. Huang, R. A. Irvine, P. Webb, P. J. Kushner, G. A. Coetzee, and M. R. Stallcup
Multiple Signal Input and Output Domains of the 160-Kilodalton Nuclear Receptor Coactivator Proteins
Mol. Cell. Biol., September 1, 1999; 19(9): 6164 - 6173.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D.-C. Yu, Y. Chen, M. Seng, J. Dilley, and D. R. Henderson
The Addition of Adenovirus Type 5 Region E3 Enables Calydon Virus 787 to Eliminate Distant Prostate Tumor Xenografts
Cancer Res., September 1, 1999; 59(17): 4200 - 4203.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. A. Leff, P. N. Epstein, M. A. Doll, A. J. Fretland, U.-S. Devanaboyina, T. D. Rustan, and D. W. Hein
Prostate-Specific Human N-Acetyltransferase 2 (NAT2) Expression in the Mouse
J. Pharmacol. Exp. Ther., July 1, 1999; 290(1): 182 - 187.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
L. Patrikainen, J. Shan, K. Porvari, and P. Vihko
Identification of the Deoxyribonucleic Acid-Binding Site of a Regulatory Protein Involved in Prostate-Specific and Androgen Receptor-Dependent Gene Expression
Endocrinology, May 1, 1999; 140(5): 2063 - 2070.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
J.-J. Lareyre, T. Z. Thomas, W.-L. Zheng, S. Kasper, D. E. Ong, M.-C. Orgebin-Crist, and R. J. Matusik
A 5-Kilobase Pair Promoter Fragment of the Murine Epididymal Retinoic Acid-binding Protein Gene Drives the Tissue-specific, Cell-specific, and Androgen-regulated Expression of a Foreign Gene in the Epididymis of Transgenic Mice
J. Biol. Chem., March 19, 1999; 274(12): 8282 - 8290.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Martinez, A.-M. Lefrançois-Martinez, M. Manin, S. Guyot, C. Jean-Faucher, G. Veyssière, A. Kahn, and C. Jean
5'-Flanking and Intragenic Sequences Confer Androgenic and Developmental Regulation of Mouse Aldose Reductase-Like Gene in Vas Deferens and Adrenal in Transgenic Mice
Endocrinology, March 1, 1999; 140(3): 1338 - 1348.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. A. Hurwitz, T. F.-Y. Yu, D. R. Leach, and J. P. Allison
CTLA-4 blockade synergizes with tumor-derived granulocyte- macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
PNAS, August 18, 1998; 95(17): 10067 - 10071.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Thornton, D. W. Thomas, P. M. Gallagher, and R. E. Ganschow
Androgen Responsiveness of Mouse Kidney {beta}-Glucuronidase Requires 5'-Flanking and Intragenic Gus-s Sequences
Mol. Endocrinol., March 1, 1998; 12(3): 333 - 341.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
K. B. J .M. Cleutjens, H. A. G. M. van der Korput, C. C. Ehren-van Eekelen, R. A. Sikes, C. Fasciana, L. W. Chung, and J. Trapman
A 6-kb Promoter Fragment Mimics in Transgenic Mice the Prostate-Specific and Androgen-Regulated Expression of the Endogenous Prostate-Specific Antigen Gene in Humans
Mol. Endocrinol., August 1, 1997; 11(9): 1256 - 1265.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
B. Frenkel, C. Capparelli, M. van Auken, D. B. , J. Bryan, J. L. Stein, G. S. Stein, and J. B. Lian
Activity of the Osteocalcin Promoter in Skeletal Sites of Transgenic Mice and during Osteoblast Differentiation in Bone Marrow-Derived Stromal Cell Cultures: Effects of Age and Sex
Endocrinology, May 1, 1997; 138(5): 2109 - 2116.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Claessens, P. Alen, A. Devos, B. Peeters, G. Verhoeven, and W. Rombauts
The Androgen-specific Probasin Response Element 2Interacts Differentially with Androgen and Glucocorticoid Receptors
J. Biol. Chem., August 9, 1996; 271(32): 19013 - 19016.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Han, B. A. Foster, S. Mistry, G. Buchanan, J. M. Harris, W. D. Tilley, and N. M. Greenberg
Hormone Status Selects for Spontaneous Somatic Androgen Receptor Variants That Demonstrate Specific Ligand and Cofactor Dependent Activities in Autochthonous Prostate Cancer
J. Biol. Chem., March 30, 2001; 276(14): 11204 - 11213.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Watabe, M. Lin, H. Ide, A. A. Donjacour, G. R. Cunha, O. N. Witte, and R. E. Reiter
Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter
PNAS, January 8, 2002; 99(1): 401 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Stanbrough, I. Leav, P. W. L. Kwan, G. J. Bubley, and S. P. Balk
Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
PNAS, September 11, 2001; 98(19): 10823 - 10828.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1994 by The Endocrine Society