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Molecular Endocrinology, Vol 8, 654-662, Copyright © 1994 by Endocrine Society

ARTICLES

Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases

Y Ikeda, WH Shen, HA Ingraham and KL Parker
Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710.

As an initial step toward understanding its role in steroidogenesis, we studied the developmental profile of steroidogenic factor-1 (SF-1), a nuclear receptor that regulates the steroid hydroxylases. SF-1 transcripts first appear on embryonic day 9 (E9) in the urogenital ridge, the probable source of steroidogenic cells of both adrenals and gonads. By E11, after the adrenals and gonads are clearly separate, SF- 1 transcripts are detected throughout the adrenal primordium. Thereafter, adrenal expression of SF-1 localizes to the cortex. Consistent with its proposed role in regulating cholesterol side-chain cleavage enzyme (SCC), SF-1 is expressed before SCC. During the sexually undifferentiated stage of gonadal development (E9-E12), all embryos express SF-1 in the genital ridge. As testicular cords form in males, SF-1 transcripts are diffusely expressed throughout the testis, whereas SCC mRNA is limited to the interstitium. These differences between SF-1 and SCC reflect SF-1 expression by Sertoli cells, as shown by Northern blotting and in situ hybridization. In contrast to its persistent expression in the embryonic testis, SF-1 transcripts disappear from the ovary between E13.5-E16.5, reappearing only during late gestation (E18.5). Thus, expression of SF-1 in the embryonic gonad is sexually dimorphic. Coupled with the demonstration of SF-1 mRNA in Sertoli cells, these data suggest that SF-1 plays a role in gonadal development distinct from regulating the steroidogenic enzymes. Additionally, SF-1 is expressed in the embryonic forebrain, implying a role in neural development.


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Dax-1 as One of the Target Genes of Ad4BP/SF-1
Mol. Endocrinol., August 1, 1999; 13(8): 1267 - 1284.
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 Mol. Endocrinol.Home page
J. J. Tremblay and R. S. Viger
Transcription Factor GATA-4 Enhances Mullerian Inhibiting Substance Gene Transcription through a Direct Interaction with the Nuclear Receptor SF-1
Mol. Endocrinol., August 1, 1999; 13(8): 1388 - 1401.
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 EndocrinologyHome page
E. S. W. Ngan, P. K. W. Cheng, P. C. K. Leung, and B. K. C. Chow
Steroidogenic Factor-1 Interacts with a Gonadotrope-Specific Element within the First Exon of the Human Gonadotropin-Releasing Hormone Receptor Gene to Mediate Gonadotrope-Specific Expression
Endocrinology, June 1, 1999; 140(6): 2452 - 2462.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
J.-M. Vanacker, E. Bonnelye, S. Chopin-Delannoy, C. Delmarre, V. Cavaillès, and V. Laudet
Transcriptional Activities of the Orphan Nuclear Receptor ERR{alpha} (Estrogen Receptor-Related Receptor-{alpha})
Mol. Endocrinol., May 1, 1999; 13(5): 764 - 773.
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 EndocrinologyHome page
P. R. Manna, P. Pakarinen, T. El-Hefnawy, and I. T. Huhtaniemi
Functional Assessment of the Calcium Messenger System in Cultured Mouse Leydig Tumor Cells: Regulation of Human Chorionic Gonadotropin-Induced Expression of the Steroidogenic Acute Regulatory Protein
Endocrinology, April 1, 1999; 140(4): 1739 - 1751.
[Abstract] [Full Text]

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 Genes Dev.Home page
A. Swain and R. Lovell-Badge
Mammalian sex determination: a molecular drama
Genes & Dev., April 1, 1999; 13(7): 755 - 767.
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 Mol. Cell. Biol.Home page
J. Kim, D. Prawitt, N. Bardeesy, E. Torban, C. Vicaner, P. Goodyer, B. Zabel, and J. Pelletier
The Wilms' Tumor Suppressor Gene (wt1) Product Regulates Dax-1 Gene Expression during Gonadal Differentiation
Mol. Cell. Biol., March 1, 1999; 19(3): 2289 - 2299.
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 Pharmacol. Rev.Home page
A. G. Mensah-Nyagan, J.-L. Do-Rego, D. Beaujean, V. Luu-The, G. Pelletier, and H. Vaudry
Neurosteroids: Expression of Steroidogenic Enzymes and Regulation of Steroid Biosynthesis in the Central Nervous System
Pharmacol. Rev., March 1, 1999; 51(1): 63 - 82.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
R. Mamluk, Y. Greber, and R. Meidan
Hormonal Regulation of Messenger Ribonucleic Acid Expression for Steroidogenic Factor-1, Steroidogenic Acute Regulatory Protein, and Cytochrome P450 Side-Chain Cleavage in Bovine Luteal Cells
Biol Reprod, March 1, 1999; 60(3): 628 - 634.
[Abstract] [Full Text]

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 BloodHome page
K.-i. Morohashi, H. Tsuboi-Asai, S. Matsushita, M. Suda, M. Nakashima, H. Sasano, Y. Hataba, C.-L. Li, J. Fukata, J. Irie, et al.
Structural and Functional Abnormalities in the Spleen of an mFtz-F1 Gene-Disrupted Mouse
Blood, March 1, 1999; 93(5): 1586 - 1594.
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 Endocr. Rev.Home page
S. L. Asa and S. Ezzat
The Cytogenesis and Pathogenesis of Pituitary Adenomas
Endocr. Rev., December 1, 1998; 19(6): 798 - 827.
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 EndocrinologyHome page
D. M. Nash, S. A. Hess, B. A. White, and J. J. Peluso
Steroidogenic Factor-1 Regulates the Rate of Proliferation of Normal and Neoplastic Rat Ovarian Surface Epithelial Cells in Vitro
Endocrinology, November 1, 1998; 139(11): 4663 - 4671.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
S. B. Seminara, F. J. Hayes, and W. F. Crowley Jr.
Gonadotropin-Releasing Hormone Deficiency in the Human (Idiopathic Hypogonadotropic Hypogonadism and Kallmann's Syndrome): Pathophysiological and Genetic Considerations
Endocr. Rev., October 1, 1998; 19(5): 521 - 539.
[Abstract] [Full Text]

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 EndocrinologyHome page
N. Pilon, R. Behdjani, I. Daneau, J. G. Lussier, and D. W. Silversides
Porcine Steroidogenic Factor-1 Gene (pSF-1) Expression and Analysis of Embryonic Pig Gonads during Sexual Differentiation
Endocrinology, September 1, 1998; 139(9): 3803 - 3812.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
R. N. Yu, M. Ito, and J. L. Jameson
The Murine Dax-1 Promoter Is Stimulated by SF-1 (Steroidogenic Factor-1) and Inhibited by COUP-TF (Chicken Ovalbumin Upstream Promoter-Transcription Factor) via a Composite Nuclear Receptor-Regulatory Element
Mol. Endocrinol., July 1, 1998; 12(7): 1010 - 1022.
[Abstract] [Full Text]

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 Mol. Cell. Biol.Home page
P. A. Crawford, C. Dorn, Y. Sadovsky, and J. Milbrandt
Nuclear Receptor DAX-1 Recruits Nuclear Receptor Corepressor N-CoR to Steroidogenic Factor 1
Mol. Cell. Biol., May 1, 1998; 18(5): 2949 - 2956.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
A. N. Harris and P. L. Mellon
The Basic Helix-Loop-Helix, Leucine Zipper Transcription Factor, USF (Upstream Stimulatory Factor), Is a Key Regulator of SF-1 (Steroidogenic Factor-1) Gene Expression in Pituitary Gonadotrope and Steroidogenic Cells
Mol. Endocrinol., May 1, 1998; 12(5): 714 - 726.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
D. Monte, F. DeWitte, and D. W. Hum
Regulation of the Human P450scc Gene by Steroidogenic Factor 1 Is Mediated by CBP/p300
J. Biol. Chem., February 20, 1998; 273(8): 4585 - 4591.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
C. Racine, R. Rey, M. G. Forest, F. Louis, A. Ferre, I. Huhtaniemi, N. Josso, and N. di Clemente
Receptors for anti-Mullerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation
PNAS, January 20, 1998; 95(2): 594 - 599.
[Abstract] [Full Text] [PDF]

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 DevelopmentHome page
R. Viger, C Mertineit, J. Trasler, and M Nemer
Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Mullerian inhibiting substance promoter
Development, January 7, 1998; 125(14): 2665 - 2675.
[Abstract] [PDF]

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 Reproductive SciencesHome page
Y. Sadovsky and P. A. Crawford
Developmental and Physiologic Roles of the Nuclear Receptor Steroidogenic Factor-I in the Reproductive System
Reproductive Sciences, January 1, 1998; 5(1): 6 - 12.
[Abstract] [PDF]

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 Physiol. Rev.Home page
C. M. HAQQ and P. K. DONAHOE
Regulation of Sexual Dimorphism in Mammals
Physiol Rev, January 1, 1998; 78(1): 1 - 33.
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 Mol. Endocrinol.Home page
D. L. Duval, S. E. Nelson, and C. M. Clay
The Tripartite Basal Enhancer of the Gonadotropin-Releasing Hormone (GnRH) Receptor Gene Promoter Regulates Cell-Specific Expression Through a Novel GnRH Receptor Activating Sequence
Mol. Endocrinol., November 1, 1997; 11(12): 1814 - 1821.
[Abstract] [Full Text]

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 Endocr. Rev.Home page
K. L. Parker and B. P. Schimmer
Steroidogenic Factor 1: A Key Determinant of Endocrine Development and Function
Endocr. Rev., June 1, 1997; 18(3): 361 - 377.
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 Endocr. Rev.Home page
S. Mesiano and R. B. Jaffe
Developmental and Functional Biology of the Primate Fetal Adrenal Cortex
Endocr. Rev., June 1, 1997; 18(3): 378 - 403.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
F. M. Cammas, G. D. Pullinger, S. Barker, and A. J. L. Clark
The Mouse Adrenocorticotropin Receptor Gene: Cloning and Characterization of Its Promoter and Evidence for a Role for the Orphan Nuclear Receptor Steroidogenic Factor 1
Mol. Endocrinol., June 1, 1997; 11(7): 867 - 876.
[Abstract] [Full Text]

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 Mol. Endocrinol.Home page
D. Liu, Y. Le Drean, M. Ekker, F. Xiong, and C. L. Hew
Teleost FTZ-F1 Homolog and Its Splicing Variant Determine the Expression of the Salmon Gonadotropin II{beta} Subunit Gene
Mol. Endocrinol., June 1, 1997; 11(7): 877 - 890.
[Abstract] [Full Text]

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 J. Clin. Endocrinol. Metab.Home page
M. S. Ramayya, J. Zhou, T. Kino, J. H. Segars, C. A. Bondy, and G. P. Chrousos
Steroidogenic Factor 1 Messenger Ribonucleic Acid Expression in Steroidogenic and Nonsteroidogenic Human Tissues: Northern Blot and in Situ Hybridization Studies
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1799 - 1806.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
K. G. Woodson, P. A. Crawford, Y. Sadovsky, and J. Milbrandt
Characterization of the Promoter of SF-1, an Orphan Nuclear Receptor Required for Adrenal and Gonadal Development
Mol. Endocrinol., February 1, 1997; 11(2): 117 - 126.
[Abstract] [Full Text]

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 DevelopmentHome page
G Giuili, W. Shen, and H. Ingraham
The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian Inhibiting Substance, in vivo
Development, January 5, 1997; 124(9): 1799 - 1807.
[Abstract] [PDF]

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 J. Biol. Chem.Home page
S.-J. Chou, K.-N. Lai, and B.-c. Chung
Characterization of the Upstream Sequence of the Human CYP11A1 Gene for Cell Type-specific Expression
J. Biol. Chem., September 6, 1996; 271(36): 22125 - 22129.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. K. Morris and J. S. Richards
An E-box Region within the Prostaglandin Endoperoxide Synthase-2 (PGS-2) Promoter Is Required for Transcription in Rat Ovarian Granulosa Cells
J. Biol. Chem., July 12, 1996; 271(28): 16633 - 16643.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. Nomura, H. Nawata, and K.-i. Morohashi
Autoregulatory Loop in the Regulation of the Mammalian ftz-f1 Gene
J. Biol. Chem., April 5, 1996; 271(14): 8243 - 8249.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
B Capel, J. Hawkins, E Hirst, D Kioussis, and R Lovell-Badge
Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge
J. Cell Sci., January 5, 1996; 109(5): 899 - 909.
[Abstract] [PDF]


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